69506-79-2
Chemical Structure
Americanin A
- CAS No.: 69506-79-2
- Formula:C18H16O6
- Molecular Weight:328.32
InChIKey: NTXXGPYGMQQSML-QLJMBOKNSA-N
SMILES: OC[C@H]1[C@H](C2=CC(O)=C(C=C2)O)OC3=CC=C(/C=C/C=O)C=C3O1
Biological Activity: Americanin A is a Neolignan. Americanin A can be isolated from the seeds of Phytolacca americana. Americanin A activates ATM and ATR, initiating the subsequent signal transduction cascades that include Chk1, Chk2, and tumor suppressor p53. Americanin A targets selectively Skp2 for degradation and thereby stabilizes p27. Americanin A suppresses the activity of Cyclin B1 and its partner cdc2 to prevent entry into Mitosis. Americanin A induces Apoptosis by producing excessive ROS. Americanin A has anti-cancer activity against colorectal cancer[1].
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Americanin A | Americanin A is a Neolignan. Americanin A can be isolated from the seeds of Phytolacca americana. Americanin A activates ATM and ATR, initiating the subsequent signal transduction cascades that include Chk1, Chk2, and tumor suppressor p53. Americanin A targets selectively Skp2 for degradation and thereby stabilizes p27. Americanin A suppresses the activity of Cyclin B1 and its partner cdc2 to prevent entry into Mitosis. Americanin A induces Apoptosis by producing excessive ROS. Americanin A has anti-cancer activity against colorectal cancer. | |||||||||||||||||||||
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