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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
54 Results for "
Pin1
" in MedChemExpress (MCE) Product Catalog:
Products (54)
54 Results for "Pin1" in MCE Product Catalog:
3
Sulfopin (PIN1-3) is a highly selective covalent inhibitor of Pin1 with an apparent Ki of 17 nM. Sulfopin blocks Myc-driven tumors in vivo. The peptidyl-prolyl isomerase, Pin1, is exploited in cancer to activate oncogenes and inactivate tumor suppressors [1].
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2 Cited Publications
KPT-6566 is a selective and covalent prolyl isomerase PIN1 inhibitor, covalently binds to the catalytic site of PIN1, selectively inhibits and degrades PIN1. KPT-6566 shows an IC50 value of 640 nM and a Ki value of 625.2 nM for PIN1 PPIase domain. KPT-6566 can be used for the research of cancer [1].
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2 Cited Publications
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yGsy2p-IN-1 is a potent inhibitor for yeast glycogen synthase 2 (yGsy2p). yGsy2p-IN-1 is a competitive human glycogen synthase 1 (hGYS1) inhibitor with an IC50 of 2.75 μM and a Ki of 1.31 μM for wild-type hGYS1. yGsy2p-IN-H23 a pyrazole inhibitor, is used for glycogen storage diseases (GSDs) [1].
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1 Cited Publications
PIN1 inhibitor API-1 is a specific Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) inhibitor (API-1) with an IC50 of 72.3 nM. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase (PPIase) domain and potently inhibits Pin1 cis-trans isomerizing activity. PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development [1].
Cat. No.: HY-P4202
CAS No.: 128802-76-6
Synonyms: Suc-AEPF-pNA
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Cat. No.: HY-164895
CAS No.: 3080918-50-6
PIN1 degrader-1 is a covalent PIN1 degrader with an IC50 of 21.5 nM. PIN1 degrader-1 induces a decrease in the thermal stability of PIN1, and triggers PIN1 degradation in a concentration- and time-dependent manner across various cancer cells. PIN1 degrader-1 also reduces the viability of pancreatic cancer, breast cancer, prostate cancer and lung cancer cells. PIN1 degrader-1 can be used for research on pancreatic cancer, breast cancer, prostate cancer and non-small cell lung cancer [1].
Cat. No.: HY-168038
CAS No.: 3038591-92-0
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PIN1 ligand-1 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). PIN1 ligand-1 can be used for synthesis PROTAC PIN1 degrader-1 (HY-168037) [1].
Cat. No.: HY-49597
CAS No.: 301688-74-4
Pin1 modulator 1 (compound IIb-219) is a modulator that specifically targets β-Catenin and inhibits the Wnt pathway. Pin1 modulator 1 can be used in the study of Wnt-mediated related diseases, such as cancer [1].
Cat. No.: HY-W843265
CAS No.: 637325-53-2
PIN1 inhibitor 6 (compound 38) is a Pin1 inhibitor. PIN1 inhibitor 6 can be utilized in cancer research [1].
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S100P-IN-1 is a S100P inhibitor, and S100P is a calcium-binding protein. S100P-IN-1 potently inhibits the interaction between purified human S100P and RAGE-Fc protein, with an IC50 value of 22.7 nM. S100P-IN-1 exerts anti-metastatic effects on pancreatic cancer cells. S100P-IN-1 can be used for the research of pancreatic cancer [1].
PPIase-Parvulin inhibitor (compound B) is a cell-permeable inhibitor targeting PPIase Pin1 and Par14, with IC50s of 1.5 and 1.0 µM, respectively. PPIase-Parvulin inhibitor has anticancer activity and inhibits the growth and proliferation of mouse embryonic fibroblasts (MEFs) [1].
Cat. No.: HY-168036
CAS No.: 3039570-04-9
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PIN1 inhibitor 3 (Compound A0) is a PIN1 inhibitor, with a KD of 25 nM and an IC50 of 150 nM. PIN1 inhibitor 3 can be used as a target protein ligand for the synthesis of PROTAC. PIN1 inhibitor 3 can be utilized in cancer research [1].
Cat. No.: HY-129310
CAS No.: 884033-66-3
PIN1 inhibitor 5 (compound 7) is a PIN1 inhibitor (Ki=0.08 μM) ,which can be used in cancer research [1].
Cat. No.: HY-171442
CAS No.: 2957895-02-0
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PIN1 ligand-2 (Intermediate M6) is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). PIN1 ligand-2 can be used for synthesizing PROTACT (Rac)-P1D-34 (HY-171334) [1].
Cat. No.: HY-RS10557
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PIN1 Human Pre-designed siRNA Set A contains three designed siRNAs for PIN1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17025
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Pin1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pin1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-179577
CAS No.: 3101950-55-1
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PIN1 degrader-3 is a Pin1 (peptidyl-prolyl isomerase protein) (IC50=4.65 nM) molecular glue degrader. PIN1 degrader-3 bound covalently to Pin1. PIN1 degrader-3-induced Pin1 degradation reduced cell viability. PIN1 degrader-3 can destabilize Pin1 in vitro, causing its degradation in cells. PIN1 degrader-3 can be used for the study of pancreatic cancer [1].
Cat. No.: HY-P4359
CAS No.: 142997-30-6
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
