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Pyranocoumarin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (1) Calcium Channel (1) Cytochrome P450 (1) Drug Derivative (1) Interleukin Related (1) NF-κB (1) Pregnane X Receptor (PXR) (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (2) Neurological Disease (1)

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Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N6066

Praeruptorin E	Calcium Channel NF-κB Pregnane X Receptor (PXR) Cytochrome P450 Interleukin Related	Cardiovascular Disease Inflammation/Immunology
Praeruptorin E is an orally active pyranocoumarin compound. Praeruptorin E can be isolated from the dried roots of Peucedanum praeruptorum Dunn. Praeruptorin E reduces the expression of NF-κB. Praeruptorin E upregulates the expression of PXR and CYP3A4. Praeruptorin E inhibits Th2 cytokines, TNF-α, IL6, MPO, and blocks the Ca ²⁺ slow channel. Praeruptorin E promotes pulmonary tissue repair and relaxes porcine coronary artery strips. Praeruptorin E protects mice from lipopolysaccharide- and hydrochloric acid-induced acute lung injury. Praeruptorin E can be used in studies related to asthma and acute lung injury .

HY-W923644

(-)-Decursinol Aegelinol; (-)-Smyrinol	Bacterial	Infection
(-)-Decursinol (Aegelinol; (-)-Smyrinol) is a natural pyranocoumarin compound tant can be isolated from the roots of Apiaceae plants such as Ferulago campestris. (-)-Decursinol inhibits both Gram-positive bacteria (Staphylococcus aureus ATCC 13709, Enterococcus faecalis ATCC 14428) and Gram-negative bacteria (Salmonella typhii ATCC 19430, Enterobacter cloacae ATCC 10699, Enterobacter aerogenes ATCC 13048) with minimum inhibitory concentrations (MIC) ranging from 16 to 64 μg/mL. (-)-Decursinol possesses antioxidant activity. (-)-Decursinol can be used for the study of bacterial infections .

HY-N10589

(+)-trans-3'-Acetyl-4'-isobutyrylkhellactone	Others	Others
(+)-trans-3'-Acetyl-4'-isobutyrylkhellactone, an angular-type pyranocoumarin is a natural product that can be isolated from Peucedani Radix. .

HY-N8637

Qianhucoumarin E	Others	Others
Qianhucoumarin E is an angular-type pyranocoumarin from the roots of Peucedanum praeruptorum Dunn .

HY-N12098

d-Laserpitin	Others	Neurological Disease
d-Laserpitin, pyranocoumarin, is a nature product with anxiolytic activity. d-Laserpitin can be isolated from the fruits of Seseli devenyense Simonk .

HY-N12097

Qianhucoumarin D	Others	Infection Cancer
Qianhucoumarin D, pyranocoumarin, is a nature product. Qianhucoumarin D can be isolated from the roots of Peucedanum praeruptorum. Qianhucoumarin D can be used for the research of inflammation and cancer .

HY-N12101

Anti-inflammatory agent 57	Others	Inflammation/Immunology
Anti-inflammatory agent 57 (Compound 13), pyranocoumarin, is a nature product. Anti-inflammatory agent 57 can be isolated from the roots of Peucedanum praeruptorum. Anti-inflammatory agent 57 has multidrug-resistance (MDR) reversal and anti-inflammatory effect .

HY-N7482

*Pyranocoumarin*	Drug Derivative	Others
Pyranocoumarin (Compound 13) is a heterocyclic scaffold (coumarin + pyran ring fusion). Pyranocoumarin inhibits the S-warfarin hydroxylation catalyzed by CYP2C9 .

HY-N17574

3-(1,1-Dimethylallyl)xanthyletin		Others
3-(1,1-Dimethylallyl) xanthyletin (compound 2) is a pyranocoumarin present in the roots of Stauranthus perforatus. 3-(1,1-Dimethylallyl) xanthyletin inhibits the uncoupled electron transport from water to ferricyanide in spinach thylakoids. 3-(1,1-Dimethylallyl) xanthyletin act as a Hill reaction inhibitor. 3-(1,1-Dimethylallyl) xanthyletin interferes with plant energy metabolism at the photosynthetic level .

HY-N18173

(±)-Toddanin	Others	Others
(±)-Toddanin is a pyranocoumarin compound identified from Toddalia asiatica .

HY-N17559

Praeroside V	Others	Others
Praeroside V is an angular-type pyranocoumarm glycoside. Praeroside V can be isolated from the n-butanol extracts of Bai-Hua Qian-Hu, the root of Peucedanum praeruptorum Dunn .

Praeruptorin E	Cardiovascular Disease Structural Classification Classification of Application Fields Coumarins Salvia hypargeia Fisch. & C.A.Mey. Phenylpropanoids Umbelliferae Plants Disease Research Fields Source Classification	Calcium Channel NF-κB Pregnane X Receptor (PXR) Cytochrome P450 Interleukin Related
Praeruptorin E is an orally active pyranocoumarin compound. Praeruptorin E can be isolated from the dried roots of Peucedanum praeruptorum Dunn. Praeruptorin E reduces the expression of NF-κB. Praeruptorin E upregulates the expression of PXR and CYP3A4. Praeruptorin E inhibits Th2 cytokines, TNF-α, IL6, MPO, and blocks the Ca ²⁺ slow channel. Praeruptorin E promotes pulmonary tissue repair and relaxes porcine coronary artery strips. Praeruptorin E protects mice from lipopolysaccharide- and hydrochloric acid-induced acute lung injury. Praeruptorin E can be used in studies related to asthma and acute lung injury .

(-)-Decursinol Aegelinol; (-)-Smyrinol	Structural Classification Wyethia glabra A.Gray Coumarins Phenylpropanoids Umbelliferae Plants Source Classification	Bacterial
(-)-Decursinol (Aegelinol; (-)-Smyrinol) is a natural pyranocoumarin compound tant can be isolated from the roots of Apiaceae plants such as Ferulago campestris. (-)-Decursinol inhibits both Gram-positive bacteria (Staphylococcus aureus ATCC 13709, Enterococcus faecalis ATCC 14428) and Gram-negative bacteria (Salmonella typhii ATCC 19430, Enterobacter cloacae ATCC 10699, Enterobacter aerogenes ATCC 13048) with minimum inhibitory concentrations (MIC) ranging from 16 to 64 μg/mL. (-)-Decursinol possesses antioxidant activity. (-)-Decursinol can be used for the study of bacterial infections .

(+)-trans-3'-Acetyl-4'-isobutyrylkhellactone	Ketones, Aldehydes, Acids Phenols Polyphenols Plants Symphytum officinale L. Boraginaceae	Others
(+)-trans-3'-Acetyl-4'-isobutyrylkhellactone, an angular-type pyranocoumarin is a natural product that can be isolated from Peucedani Radix. .

Qianhucoumarin E	Chrysanthemum × morifolium (Ramat.) Hemsl. Coumarins Phenylpropanoids Plants Umbelliferae Source Classification	Others
Qianhucoumarin E is an angular-type pyranocoumarin from the roots of Peucedanum praeruptorum Dunn .

d-Laserpitin	Coumarins Sphagneticola calendulacea (L.) Pruski Phenylpropanoids Plants Umbelliferae Source Classification	Others
d-Laserpitin, pyranocoumarin, is a nature product with anxiolytic activity. d-Laserpitin can be isolated from the fruits of Seseli devenyense Simonk .

Qianhucoumarin D	Chrysanthemum × morifolium (Ramat.) Hemsl. Coumarins Phenylpropanoids Plants Umbelliferae Source Classification	Others
Qianhucoumarin D, pyranocoumarin, is a nature product. Qianhucoumarin D can be isolated from the roots of Peucedanum praeruptorum. Qianhucoumarin D can be used for the research of inflammation and cancer .

Anti-inflammatory agent 57	Chrysanthemum × morifolium (Ramat.) Hemsl. Coumarins Phenylpropanoids Plants Umbelliferae Source Classification	Others
Anti-inflammatory agent 57 (Compound 13), pyranocoumarin, is a nature product. Anti-inflammatory agent 57 can be isolated from the roots of Peucedanum praeruptorum. Anti-inflammatory agent 57 has multidrug-resistance (MDR) reversal and anti-inflammatory effect .

3-(1,1-Dimethylallyl)xanthyletin	Structural Classification Boenninghausenia albiflora (Hook.) Reichb. ex Meisn. Rutaceae Coumarins Phenylpropanoids Plants Source Classification
3-(1,1-Dimethylallyl) xanthyletin (compound 2) is a pyranocoumarin present in the roots of Stauranthus perforatus. 3-(1,1-Dimethylallyl) xanthyletin inhibits the uncoupled electron transport from water to ferricyanide in spinach thylakoids. 3-(1,1-Dimethylallyl) xanthyletin act as a Hill reaction inhibitor. 3-(1,1-Dimethylallyl) xanthyletin interferes with plant energy metabolism at the photosynthetic level .

(±)-Toddanin	Toddalia asiatica (L.) Lam. Structural Classification Ketones, Aldehydes, Acids Rutaceae Plants Source Classification	Others
(±)-Toddanin is a pyranocoumarin compound identified from Toddalia asiatica .

Praeroside V	Structural Classification Terpenoids Labiatae Tamarindus indica L. Diterpenoids Plants Source Classification	Others
Praeroside V is an angular-type pyranocoumarm glycoside. Praeroside V can be isolated from the n-butanol extracts of Bai-Hua Qian-Hu, the root of Peucedanum praeruptorum Dunn .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Pyranocoumarin

Inhibitors & Agonists

NaturalProducts

Natural
Products