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Results for "

S-Transferase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Glutathione S-transferase (49) Apoptosis (8) Autophagy (1) Bacterial (3) Bcl-2 Family (1) Biochemical Assay Reagents (2) Calcium Channel (4) CaMK (1) Cholinesterase (ChE) (2) COX (1) Cytochrome P450 (2) DNA Alkylator/Crosslinker (1) DNA-PK (1) DNA/RNA Synthesis (1) Endogenous Metabolite (2) Environmental Pollutants (2) Estrogen Receptor/ERR (3) FXR (2) Herbicide (3) IFNAR (1) iGluR (1) Influenza Virus (1) Insecticide (1) Interleukin Related (1) Isotope-Labeled Compounds (1) Keap1-Nrf2 (2) Lactate Dehydrogenase (1) NF-κB (4) NO Synthase (2) Oxidative Phosphorylation (1) P-glycoprotein (1) p38 MAPK (1) Parasite (2) Pregnane X Receptor (PXR) (2) Prostaglandin Receptor (1) PROTAC Linkers (2) Reactive Oxygen Species (ROS) (5) Reference Standards (6) SOD (1) STAT (1) Topoisomerase (1) Wnt (1)
By Research Areas:	Cancer (38) Cardiovascular Disease (3) Endocrinology (2) Infection (7) Inflammation/Immunology (12) Metabolic Disease (13) Neurological Disease (4)
Click Chemistry:	Alkynes (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Targets Recommended: Glutathione S-transferase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1640

Ethacrynic acid Maximum Cited Publications 9 Publications Verification Etacrynic acid	Wnt Glutathione S-transferase NF-κB Calcium Channel NO Synthase	Cardiovascular Disease Inflammation/Immunology Cancer
Ethacrynic acid has anti-inflammatory and anticancer activity. Ethacrynic acid is an orally active diuretic. Ethacrynic acid is an inhibitor of *glutathione S-transferase* (GSTs) and Wnt** signaling pathways. Ethacrynic acid is a radiosensitizer. Ethacrynic acid can inhibit airway smooth muscle (ASM) contraction in mice. Ethacrynic acid can increase the outflow of aqueous humor from the eye for the study of glaucoma .

HY-13634A

Ezatiostat 5+ Cited Publications TER199free base; TLK199	Glutathione S-transferase Apoptosis	Cancer
Ezatiostat (TER199 free base; TLK199) is a tripeptide analog of glutathione and is a selective and orally active *glutathione S-transferase* P1-1 (GSTP1) inhibitor. Ezatiostat leads to JNK activation by inhibiting GSTP1**. Ezatiostat stimulates both lymphocyte production and bone marrow progenitor proliferation. Ezatiostat has the potential for myelodysplastic syndrome (MDS) treatment .

HY-Y1147

Diethyl maleate 1 Publications Verification Maleic acid diethyl ester	Biochemical Assay Reagents	Others
Diethyl maleate (DEM) is an orally available, effective glutathione (GSH) depletor that crosses the blood-brain barrier. Diethyl maleate covalently binds irreversibly to GSH via glutathione S-transferase with an in vitro IC50 of 0.1-0.5 mM. Diethyl maleate selectively depletes GSH in liver, lung, and brain tissues, exacerbating oxidative stress and enhancing hyperbaric oxygen toxicity. Diethyl maleate promotes precursor amino acid uptake and in turn promotes GSH synthesis by upregulating the activity of the cystine-glutamate transporter X_{O ^-}. Diethyl maleate can be used to study redox homeostasis and GSH protection mechanisms in oxidative stress-related diseases such as hyperbaric oxygen injury and metabolic diseases[1][2][3].

HY-115673

LAS17 1 Publications Verification	Glutathione S-transferase	Cancer
LAS17 is a potent and selective tyrosine-directed irreversible inhibitor for glutathione S-Transferase Pi (GSTP1) . LAS17 inhibits GSTP1 activity with an IC₅₀ of 0.5 μM . LAS17 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-126752

Ophthalmic acid	Reactive Oxygen Species (ROS)	Neurological Disease Metabolic Disease Inflammation/Immunology
Ophthalmic acid is a ubiquitous metabolite and glutathione modulator, with a K_i of 0.95 mM for glyoxalase I. Ophthalmic acid competitively inhibits glyoxalase I, glutathione S-transferase, glutaredoxin, glutamate-cysteine ligase, protein disulfide reductase (glutathione), as well as non-selective cation channels. Ophthalmic acid is applicable in diabetes-related research .

HY-111530

GSTO1-IN-1 4 Publications Verification	Glutathione S-transferase	Cancer
GSTO1-IN-1 is a potent *glutathione S-transferase* omega 1 (GSTO1) inhibitor with an IC₅₀** of 31 nM.

HY-13634B

TLK117 1 Publications Verification TER117	Glutathione S-transferase	Inflammation/Immunology Cancer
TLK117, the active metabolite of TLK199, selective inhibits *Glutathione S-transferase* P1–1 (GSTP1-1) with a K_i of 0.4 μM for GSTP. TLK117 also competitively inhibits glyoxalase I with a K_i** of 0.56 μM.

HY-135318

NBDHEX 2 Publications Verification	Apoptosis Autophagy Glutathione S-transferase	Cancer
NBDHEX is a potent *glutathione S-transferase* P1-1 (GSTP1-1) inhibitor. NBDHEX induces apoptosis of tumor cells. NBDHEX acts as an anticancer agent by inhibiting GSTs catalytic activity, avoiding inconvenience of the inhibitor extrusion from the cell by specific pumps and disrupting the interaction between the GSTP1-1 and key signaling effectors. NBDHEX can also act as late-phase autophagy** inhibitor .

HY-N1916

Coniferyl ferulate 1 Publications Verification	Glutathione S-transferase P-glycoprotein Apoptosis iGluR CaMK p38 MAPK Reactive Oxygen Species (ROS) Bacterial	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Coniferyl ferulate is an orally active phenolic acid compound. Coniferyl ferulate is a potent inhibitor of glutathione S-transferase (GST) (IC₅₀ = 0.3 μM), which downregulates P-gp expression, induces apoptosis in B-MD-C1 (ADR+/+) cells, and reverses multidrug resistance. Coniferyl ferulate blocks the NMDAR/NR2B-CaMKII-MAPKs signaling pathway, inhibits ROS production and mitochondrial apoptosis, while reshapes the intestinal microbiota and microbial metabolism, ameliorates colonic inflammation and alleviates depressive symptoms in mice. Coniferyl ferulate can alleviate the toxicity of xylene to hematopoietic stem and progenitor cells by targeting Mgst2. Coniferyl ferulate exhibits antibacterial activity against the Gram-positive Bacillus subtilis and Staphylococcus aureus .

HY-N2853

D-α-Tocopherylquinone α-Tocopherylquinone	Reactive Oxygen Species (ROS)	Others
D-α-Tocopherylquinone (α-Tocopherylquinone) is a quinone, can be isolated from Phaeodactylum tricornutum. D-α-Tocopherylquinone is an oxidation product of α-Tocopherol (vitamin E). D-α-Tocopherylquinone can act as an anticoagulant and as an antioxidant. D-α-Tocopherylquinone reduces cellular oxidative damage produced by oxidized lipids. D-α-Tocopherylquinone binds to a liver cytosolic protein with a molecular mass of about 40 kDa. D-α-Tocopherylquinone binds to glurathione-S-transferase (GST) and can be transported to the site of metabolism or excreted in the bile .

HY-N2560

Senecionine Senecionan-11,16-dione, 12-hydroxy-; Aureine; Senecionin	Others	Metabolic Disease
Senecionine (Senecionan-11,16-dione, 12-hydroxy-) is a pyrrolizidine alkaloid could be isolated from Senecio vulgaris. Senecionine decreases the activities of glutathione S-transferase, aminopyrine demethylase and arylhydrocarbon hydroxylase (AHH) .

HY-W017960

Diludine Et-HE; 1,4-DHP	SOD	Endocrinology
Diludine (BNP-7787) is an orally effective feed additive. Diludine reduces the activity of G6PD and increases the level of superoxide dismutase (SOD). Diludine reduces the mutagenic effect of environmental pollutants, protects parental reproductive systems and improves offspring quality. Diludine is mainly applied during the transition period of dairy cows to increase milk yield and milk fat content, and improve health status during parturition. Diludine can be used in animal feeding research .

HY-P2961

Glutathione S-transferase	Glutathione S-transferase	Cancer
Glutathione S-transferase is a phase II metabolic enzyme consisting of three superfamilies: cytosolic, mitochondrial, and microsomal. Glutathione S-transferase possesses various catalytic activities such as catalytic detoxification and thiol transfer, as well as chaperone function. GSTP1, a subtype of Glutathione S-transferase, is highly expressed in malignant tissues and serves as a tumor marker .

HY-N9348A

Glucoraphenin potassium	Glutathione S-transferase Cytochrome P450	Metabolic Disease
Glucoraphenin potassium is an orally effective glucosinolate. Glucoraphenin potassium can be isolated from radish sprouts. Glucoraphenin potassium enhances the enzymatic activity of Glutathione S-transferase. Glucoraphenin potassium enhances the activity of cytochrome P450-related monooxygenase .

HY-147517

Keap1-Nrf2-IN-9	Keap1-Nrf2	Neurological Disease Inflammation/Immunology
Keap1-Nrf2-IN-9 (Compound 11) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) inhibitor with an IC₅₀ of 0.575 μM. Keap1-Nrf2-IN-9 increases the expression of Nrf2 target genes including heme oxygenase 1 (Hmox1), glutathione S-transferase P (GstP), and glutamate-cysteine ligase catalytic (Gclc) and modulatory (Gclm) subunits. Keap1-Nrf2-IN-9 shows no cytotoxic activity in ARPE19 cells .

HY-N7227

Anonaine	Glutathione S-transferase Parasite	Infection Cancer
Anonaine is an antiparasitic agent. Anonaine also is a *glutathione S-transferase* (GST)** inhibitor .

HY-136376

Mefenpyr-diethyl	Environmental Pollutants Herbicide	Others
Mefenpyr-diethyl is a pyrazoline-type herbicide safener that functions to enhance lipid biosynthesis. Mefenpyr-diethyl effectively prevents herbicide-induced phytotoxic damage caused by herbicides such as fenoxaprop-p-ethyl (HY-B2013) and mesosulfuron-methyl (HY-126987) by protecting cereal crops including wheat. Mefenpyr-diethyl significantly increases lipid content in wheat either when applied alone or in combination with the herbicide fenoxaprop-p-ethyl. The mechanism of action of Mefenpyr-diethyl does not involve the induction of glutathione S-transferase (GST) activity in wheat .

HY-W013754

S-Hexylglutathione	Glutathione S-transferase	Others
S-Hexylglutathione is an S-substituted glutathione in which the hydrogen of the thiol has been replaced by a hexyl group. S-Hexylglutathione is also an competitive inhibitor against *glutathione-S-transferase. S-Hexylglutathione can be used as an affinity chromatographic ligand for glutathione-S-transferase* and glutathione peroxidase .

HY-167920

Glutathione sulfonate S-Sulfoglutathione	Endogenous Metabolite	Cancer
Glutathione sulfonate (S-Sulfoglutathione) is a multifunctional bioactive compound that inhibits angiogenesis and tumor growth. Glutathione sulfonate is a competitive inhibitor of glutathione S-transferase and is involved in the detoxification process and the binding of a variety of exogenous and endogenous compounds. Glutathione sulfonate acts in the substrate binding site of Escherichia coli glutathione S-transferase, affecting the catalytic mechanism. The structural characteristics of Glutathione sulfonate contribute to its inhibitory effect by hydrogen bonding in the active center of the enzyme .

HY-N7436

Methyl propyl disulfide	Glutathione S-transferase	Cancer
Methyl propyl disulfide is an orally administrable volatile sulfide present in onions. Methyl propyl disulfide reduces the activity of spermine N'1-acetyltransferase (SAT), inhibits cell proliferation, and decreases the induction of placental glutathione S-transferase (GST-P)-positive hepatocyte foci in rat livers. Methyl propyl disulfide can be used in studies related to the mechanism of hepatocarcinogenesis .

HY-112534

GSTO-IN-2 2 Publications Verification	Glutathione S-transferase	Cancer
GSTO-IN-2 is a glutathione S-transferase inhibitor with IC₅₀s of 3.6, 16.3, and 1.4 μM for GSTA2, GSTM1, and GSTP1-1.

HY-126329

AZD9898 1 Publications Verification	Glutathione S-transferase	Inflammation/Immunology
AZD9898 is an orally active *leukotriene-C4 synthetase (LTC4S, glutathione S-transferase* II) inhibitor, with an IC₅₀** of 0.28 nM. AZD9898 mitigates the GABA binding and hepatic toxicity signal. AZD9898 has the potential to treat asthma .

HY-16124

Canfosfamide TLK-286; TER286	DNA-PK Apoptosis	Cancer
Canfosfamide (TLK-286, TER286) is a glutathione analogue prodrug that is activated by glutathione S-transferase P1-1 and induces apoptosis. Canfosfamide also inhibits the catalytic kinase activity of DNA-dependent protein kinase (DNA-PK). Canfosfamide produces an anticancer alkylating agent and a glutathione derivative after activation. Canfosfamide can be used to research malignancies .

HY-B1640R

Ethacrynic acid (Standard) Maximum Cited Publications 9 Publications Verification Etacrynic acid (Standard)	Reference Standards Glutathione S-transferase NF-κB Calcium Channel	Inflammation/Immunology Cancer
Ethacrynic acid (Standard) is the analytical standard of Ethacrynic acid. This product is intended for research and analytical applications. Ethacrynic acid (Etacrynic acid) is a diuretic. Ethacrynic acid is an inhibitor of *glutathione S-transferases* (GSTs). Ethacrynic acid is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid also inhibits L-type voltage-dependent and store-operated calcium channel**, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice .

HY-W020788

Benoxacor CGA 154281	Environmental Pollutants Glutathione S-transferase Estrogen Receptor/ERR Pregnane X Receptor (PXR) FXR	Metabolic Disease Cancer
Benoxacor (CGA 154281) is a herbicide safener and xenobiotic metabolism regulator. Benoxacor protects maize from the toxicity of metolachlor mainly by inducing detoxifying enzymes such as Glutathione S-transferase. Benoxacor also activates FXR, PXR and ERRα, and inhibits aromatase (aromatase). However, Benoxacor exhibits potential subacute oral toxicity and a high risk of hepatotoxicity in animal models. Benoxacor induces reactive oxygen species accumulation, interferes with embryonic heart development, and causes increased liver and kidney weights as well as alterations in gut microbiota in mice. Benoxacor can be used in studies related to hepatic steatosis, infertility, breast cancer and developmental toxicity .

HY-132281

16-Oxokahweol	Glutathione S-transferase	Metabolic Disease
16-Oxokahweol, a Kahweol (HY-N6258) derivative, is a glutathione S-transferase inducer .

HY-138164

Cafestol palmitate	Glutathione S-transferase COX	Cancer
Cafestol palmitate is an active constituent of green coffee beans. Cafestol palmitate can enhance glutathione S-transferase activity in the mouse. Cafestol palmitate also exhibits weak COX-2 inhibitory activity .

HY-W024365

3-tert-Butyl-4-methoxyphenol	PROTAC Linkers	Cancer
3-tert-Butyl-4-methoxyphenol is a PROTAC linker, belongs to alkyl/ether class, with insecticidal activity. 3-tert-Butyl-4-methoxyphenol also induced increased activities of glutathione (GSH) S-transferase and epoxide hydrolase in the liver and forestomach tissues of A/HeJ mice, regulating the carcinogen metabolism system .

HY-137330

S-(2,4-Dinitrophenyl)glutathione	Endogenous Metabolite	Metabolic Disease
S-(2,4-Dinitrophenyl)glutathione is a substrate for glutathione-S-transferase. (2,4-Dinitrophenyl)glutathione can be used as an irreversible glutathione reductase inhibitor with an K_i value of 30 µM .

HY-W013744

S-Octylglutathione	Glutathione S-transferase	Others
S-Octylglutathione is a competitive glutathione S-transferase (GST) inhibitor .

HY-160875

GST-FH.1	Glutathione S-transferase	Metabolic Disease
GST-FH.1 is a GST-FH compound, a complex that produces frequent false positive hits (FH) in the interaction between glutathione S-transferase (GST) and glutathione (GSH) . GST-FH.4 inhibits glutathione S-transferase (GST) activity with an IC₅₀ of 0.32 μM .

HY-W681867

Fluxofenim CGA-133205	Herbicide Glutathione S-transferase	Others
Fluxofenim (CGA-133205) is a herbicide safener, with activity against Pyroxasulfone (HY-136633) and Metolachlor (HY-B1871). Fluxofenim enhances the activity of needle glutathione S-transferase (GST) towards the substrate 1-chloro-2,4-dinitrobenzene (CDNB) .

HY-177695

GSTO1-IN-5	Glutathione S-transferase	Cancer
GSTO1-IN-5 is a potent and selective *glutathione S-transferase* omega 1 (GSTO1) inhibitor with an IC₅₀**of 0.22 nM. GSTO1-IN-5 can be used for the researches of cancer and inflammation, such as colon cancer .

HY-160926

16-Oxocafestol	Glutathione S-transferase	Cancer
16-Oxocafestol enhances levels of glutathione S-transferase (GST) and tissue sulfhydryl in liver and in small bowel mucosa .

HY-W019780

Bromodichloromethane Dichlorobromomethane	Glutathione S-transferase	Metabolic Disease Cancer
Bromodichloromethane (Dichlorobromomethane) is a type of trihalomethane, commonly found in chlorinated drinking water for disinfection, and is a disinfection by-product. The bromination of bromodichloromethane can cause the formation of mutagenic intermediates through the transformation mediated by glutathione S-transferase (GST). Bromodichloromethane inhibits the differentiation of human placental trophoblast cells and reduces the secretion of chorionic gonadotropin (CG). Bromodichloromethane has potential reproductive toxicity and carcinogenicity .

HY-149419

GST-IN-1	Glutathione S-transferase	Others
GST-IN-1 (compound 16) is a glutathione S-transferase (GST) inhibitor with IC50s of 1.55 μM (sjGST) and 2.02 μM (hGSTM2), respectively.

HY-116726

Crambene	Glutathione S-transferase	Cancer
Crambene is an orally active cyanide compound isolated from cruciferous vegetables. Crambene has a cancer-preventive effect and induces significant upregulation of quinone reductase and glutathione S-transferase in vitro and in vivo .

HY-160455

GSTP1-1 inhibitor 1	Glutathione S-transferase	Cancer
GSTP1-1 inhibitor 1 (compound 6b) is an irreversible, long-acting, glutathione S-transferase inhibitor with an IC₅₀ of 21 μM targeting GSTP_1-1 . GSTP_1-1 is a key tumor suppressor target, and GSTP1-1 inhibitor 1 has potential anticancer activity .

HY-175398

OZO-Cl	Glutathione S-transferase	Cancer
OZO-Cl is an OZO derivative. OZO-Cl has anti-cancer activity. OZO-Cl significantly decreases the intracellular *glutathion S-transferase* Pi (GST) activity. OZO-Cl exhibits cytotoxicity to cancer cell lines, with IC₅₀**s of 150 and 120 μmol/L in Panc-1 and K562 cells respectively .

HY-W975966

CPDT	Keap1-Nrf2	Neurological Disease
CPDT is an orally active and highly potent inducer of phase 2 enzymes and an activator of Nrf2. The activities of key phase 2 enzymes, including glutathione S-transferase, NAD(P)H:quinone:oxidoreductase 1 and glutamate cysteine synthetase, and levels of glutathione were elevated by CPDT in rat bladder in vivo and in cultured bladder cells in vitro [2].

HY-13634

Ezatiostat hydrochloride TER199; TLK199 hydrochloride	Glutathione S-transferase Apoptosis	Cancer
Ezatiostat hydrochloride (TER199; TLK199 hydrochloride) is a tripeptide analog of glutathione and is a selective and orally active *glutathione S-transferase* P1-1 (GSTP1) inhibitor. Ezatiostat hydrochloride leads to JNK activation by inhibiting GSTP1**. Ezatiostat hydrochloride stimulates both lymphocyte production and bone marrow progenitor proliferation. Ezatiostat hydrochloride has the potential for myelodysplastic syndrome (MDS) treatment .

HY-W020788R

Benoxacor (Standard) CGA 154281 (Standard)	Reference Standards Glutathione S-transferase Estrogen Receptor/ERR Pregnane X Receptor (PXR) FXR	Others
Benoxacor (Standard) is the analytical standard of Benoxacor. This product is intended for research and analytical applications. Benoxacor (CGA 154281) is a herbicide safener and xenobiotic metabolism regulator. Benoxacor protects maize from the toxicity of metolachlor mainly by inducing detoxifying enzymes such as Glutathione S-transferase. Benoxacor also activates FXR, PXR and ERRα, and inhibits aromatase (aromatase). However, Benoxacor exhibits potential subacute oral toxicity and a high risk of hepatotoxicity in animal models. Benoxacor induces reactive oxygen species accumulation, interferes with embryonic heart development, and causes increased liver and kidney weights as well as alterations in gut microbiota in mice. Benoxacor can be used in studies related to hepatic steatosis, infertility, breast cancer and developmental toxicity .

HY-N1282R

Seneciphylline (Standard)	Reference Standards Glutathione S-transferase Cytochrome P450	Cancer
Seneciphylline (Standard) is the analytical standard of Seneciphylline. This product is intended for research and analytical applications. Seneciphylline is a toxic pyrrolizidine alkaloid in Gynura japonica . Seneciphylline significantly increases the activities of epoxide hydrase and glutathione-S-transferase but causes reduction of cytochrome P-450 and related monooxygenase activities .

HY-N2560R

Senecionine (Standard) Senecionan-11,16-dione, 12-hydroxy- (Standard); Aureine (Standard); Senecionin (Standard)	Reference Standards Others	Metabolic Disease
Senecionine (Standard) is the analytical standard of Senecionine. This product is intended for research and analytical applications. Senecionine (Senecionan-11,16-dione, 12-hydroxy-) is a pyrrolizidine alkaloid could be isolated from Senecio vulgaris. Senecionine decreases the activities of glutathione S-transferase, aminopyrine demethylase and arylhydrocarbon hydroxylase (AHH) .

HY-160874

GST-FH.4	Glutathione S-transferase	Metabolic Disease
GST-FH.4 is a GST-FH compound, a complex that produces frequent false positive hits (FH) in the interaction between glutathione S-transferase (GST) and glutathione (GSH) . GST-FH.4 inhibits glutathione S-transferase (GST) activity with an IC₅₀ of 24.38 μM .

HY-W017785

Phorone Diisopropylidene acetone	Glutathione S-transferase	Metabolic Disease Cancer
Phorone (Diisopropylidene acetone) is a glutathione (GSH) depletor. Phorone specifically and reversibly depletes free GSH through enzymatic binding (Glutathione S-transferase) (K_m = 0.9 mM). Phorone reversibly reduces the binding and nuclear uptake of glucocorticoid receptors in rat liver, and this effect is related to the temporal changes in GSH levels. Phorone can be used for studying liver toxicity.

HY-133199

Benastatin A	Glutathione S-transferase	Others
Benastatin A is an inhibitor of glutathione S-transferase, which can be isolated from Streptomyces MI384-DF12 .

HY-16123

Canfosfamide hydrochloride	DNA Alkylator/Crosslinker	Cancer
Canfosfamide (hydrochloride) is a prodrug that upon activation by glutathione s-transferase P1-1 (GSTP1-1) yields an anticancer alkylating agent and a glutathione derivative.

HY-N11778

Bequinostatin C	Bacterial	Infection
Bequinostatin C is a naphthoquinone originally isolated from Streptomyces and a glutathione S-transferase pi 1 (GSTP1) inhibitor (IC₅₀=40 μg/mL for human GSTP1).

HY-N11699

Bequinostatin A	Glutathione S-transferase	Inflammation/Immunology
Bequinostatin A is a benzo[a]naphthacenequinone metabolite that can be isolated from Streptomyces sp. MI384-DF12. Bequinostatin A shows considerable inhibitory activity against human pi class glutathione S-transferase (GST pi) .

Cat. No.	Product Name	Type

HY-Y1147

Diethyl maleate

1 Publications Verification

Maleic acid diethyl ester

Biochemical Assay Reagents

Diethyl maleate (DEM) is an orally available, effective glutathione (GSH) depletor that crosses the blood-brain barrier. Diethyl maleate covalently binds irreversibly to GSH via glutathione S-transferase with an in vitro IC50 of 0.1-0.5 mM. Diethyl maleate selectively depletes GSH in liver, lung, and brain tissues, exacerbating oxidative stress and enhancing hyperbaric oxygen toxicity. Diethyl maleate promotes precursor amino acid uptake and in turn promotes GSH synthesis by upregulating the activity of the cystine-glutamate transporter X_{O ^-}. Diethyl maleate can be used to study redox homeostasis and GSH protection mechanisms in oxidative stress-related diseases such as hyperbaric oxygen injury and metabolic diseases[1][2][3].

Cat. No.	Product Name	Target	Research Area

HY-13634A

Ezatiostat 5+ Cited Publications TER199free base; TLK199	Glutathione S-transferase Apoptosis	Cancer
Ezatiostat (TER199 free base; TLK199) is a tripeptide analog of glutathione and is a selective and orally active *glutathione S-transferase* P1-1 (GSTP1) inhibitor. Ezatiostat leads to JNK activation by inhibiting GSTP1**. Ezatiostat stimulates both lymphocyte production and bone marrow progenitor proliferation. Ezatiostat has the potential for myelodysplastic syndrome (MDS) treatment .

HY-13634B

TLK117 1 Publications Verification TER117	Glutathione S-transferase	Inflammation/Immunology Cancer
TLK117, the active metabolite of TLK199, selective inhibits *Glutathione S-transferase* P1–1 (GSTP1-1) with a K_i of 0.4 μM for GSTP. TLK117 also competitively inhibits glyoxalase I with a K_i** of 0.56 μM.

HY-137330

S-(2,4-Dinitrophenyl)glutathione	Endogenous Metabolite	Metabolic Disease
S-(2,4-Dinitrophenyl)glutathione is a substrate for glutathione-S-transferase. (2,4-Dinitrophenyl)glutathione can be used as an irreversible glutathione reductase inhibitor with an K_i value of 30 µM .

HY-13634

Ezatiostat hydrochloride TER199; TLK199 hydrochloride	Glutathione S-transferase Apoptosis	Cancer
Ezatiostat hydrochloride (TER199; TLK199 hydrochloride) is a tripeptide analog of glutathione and is a selective and orally active *glutathione S-transferase* P1-1 (GSTP1) inhibitor. Ezatiostat hydrochloride leads to JNK activation by inhibiting GSTP1**. Ezatiostat hydrochloride stimulates both lymphocyte production and bone marrow progenitor proliferation. Ezatiostat hydrochloride has the potential for myelodysplastic syndrome (MDS) treatment .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-126752

Ophthalmic acid	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reactive Oxygen Species (ROS)
Ophthalmic acid is a ubiquitous metabolite and glutathione modulator, with a K_i of 0.95 mM for glyoxalase I. Ophthalmic acid competitively inhibits glyoxalase I, glutathione S-transferase, glutaredoxin, glutamate-cysteine ligase, protein disulfide reductase (glutathione), as well as non-selective cation channels. Ophthalmic acid is applicable in diabetes-related research .

HY-N1916

Coniferyl ferulate 1 Publications Verification	Classification of Application Fields Simple Phenylpropanols Phenols Polyphenols Dicerothamnus rhinocerotis Phenylpropanoids Umbelliferae Plants Disease Research Fields Source Classification Cancer	Glutathione S-transferase P-glycoprotein Apoptosis iGluR CaMK p38 MAPK Reactive Oxygen Species (ROS) Bacterial
Coniferyl ferulate is an orally active phenolic acid compound. Coniferyl ferulate is a potent inhibitor of glutathione S-transferase (GST) (IC₅₀ = 0.3 μM), which downregulates P-gp expression, induces apoptosis in B-MD-C1 (ADR+/+) cells, and reverses multidrug resistance. Coniferyl ferulate blocks the NMDAR/NR2B-CaMKII-MAPKs signaling pathway, inhibits ROS production and mitochondrial apoptosis, while reshapes the intestinal microbiota and microbial metabolism, ameliorates colonic inflammation and alleviates depressive symptoms in mice. Coniferyl ferulate can alleviate the toxicity of xylene to hematopoietic stem and progenitor cells by targeting Mgst2. Coniferyl ferulate exhibits antibacterial activity against the Gram-positive Bacillus subtilis and Staphylococcus aureus .

HY-N2853

D-α-Tocopherylquinone α-Tocopherylquinone	Quinones Microorganisms Classification of Application Fields Benzene Quinones Disease Research Fields Source Classification Cancer	Reactive Oxygen Species (ROS)
D-α-Tocopherylquinone (α-Tocopherylquinone) is a quinone, can be isolated from Phaeodactylum tricornutum. D-α-Tocopherylquinone is an oxidation product of α-Tocopherol (vitamin E). D-α-Tocopherylquinone can act as an anticoagulant and as an antioxidant. D-α-Tocopherylquinone reduces cellular oxidative damage produced by oxidized lipids. D-α-Tocopherylquinone binds to a liver cytosolic protein with a molecular mass of about 40 kDa. D-α-Tocopherylquinone binds to glurathione-S-transferase (GST) and can be transported to the site of metabolism or excreted in the bile .

HY-N2560

Senecionine Senecionan-11,16-dione, 12-hydroxy-; Aureine; Senecionin	Pterogyne nitens Tul. Alkaloids Structural Classification Pyrrole Alkaloids Erinacea anthyllis Link Classification of Application Fields Metabolic Disease Plants Compositae Disease Research Fields Source Classification	Others
Senecionine (Senecionan-11,16-dione, 12-hydroxy-) is a pyrrolizidine alkaloid could be isolated from Senecio vulgaris. Senecionine decreases the activities of glutathione S-transferase, aminopyrine demethylase and arylhydrocarbon hydroxylase (AHH) .

HY-N7227

Anonaine	Alkaloids Annona crassiflora Mart. Quinoline Alkaloids Plants Annonaceae Source Classification	Glutathione S-transferase Parasite
Anonaine is an antiparasitic agent. Anonaine also is a *glutathione S-transferase* (GST)** inhibitor .

HY-N7436

Methyl propyl disulfide	Structural Classification Natural Products Liliaceae Classification of Application Fields Allium cepa L. Plants Disease Research Fields Source Classification Cancer	Glutathione S-transferase
Methyl propyl disulfide is an orally administrable volatile sulfide present in onions. Methyl propyl disulfide reduces the activity of spermine N'1-acetyltransferase (SAT), inhibits cell proliferation, and decreases the induction of placental glutathione S-transferase (GST-P)-positive hepatocyte foci in rat livers. Methyl propyl disulfide can be used in studies related to the mechanism of hepatocarcinogenesis .

HY-W024365

3-tert-Butyl-4-methoxyphenol	Monophenols Jatropha curcas Linn. Phenols Euphorbiaceae Plants Source Classification	PROTAC Linkers
3-tert-Butyl-4-methoxyphenol is a PROTAC linker, belongs to alkyl/ether class, with insecticidal activity. 3-tert-Butyl-4-methoxyphenol also induced increased activities of glutathione (GSH) S-transferase and epoxide hydrolase in the liver and forestomach tissues of A/HeJ mice, regulating the carcinogen metabolism system .

HY-137330

S-(2,4-Dinitrophenyl)glutathione	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
S-(2,4-Dinitrophenyl)glutathione is a substrate for glutathione-S-transferase. (2,4-Dinitrophenyl)glutathione can be used as an irreversible glutathione reductase inhibitor with an K_i value of 30 µM .

HY-N1282R

Seneciphylline (Standard)	Alkaloids Structural Classification other families Pyrrole Alkaloids Plants Compositae Sophora yunnanensis C. Y. Ma Source Classification	Reference Standards Glutathione S-transferase Cytochrome P450
Seneciphylline (Standard) is the analytical standard of Seneciphylline. This product is intended for research and analytical applications. Seneciphylline is a toxic pyrrolizidine alkaloid in Gynura japonica . Seneciphylline significantly increases the activities of epoxide hydrase and glutathione-S-transferase but causes reduction of cytochrome P-450 and related monooxygenase activities .

HY-N2560R

Senecionine (Standard) Senecionan-11,16-dione, 12-hydroxy- (Standard); Aureine (Standard); Senecionin (Standard)	Pterogyne nitens Tul. Alkaloids Structural Classification Pyrrole Alkaloids Erinacea anthyllis Link Plants Compositae Source Classification	Reference Standards Others
Senecionine (Standard) is the analytical standard of Senecionine. This product is intended for research and analytical applications. Senecionine (Senecionan-11,16-dione, 12-hydroxy-) is a pyrrolizidine alkaloid could be isolated from Senecio vulgaris. Senecionine decreases the activities of glutathione S-transferase, aminopyrine demethylase and arylhydrocarbon hydroxylase (AHH) .

HY-W017785

Phorone Diisopropylidene acetone	Structural Classification Crocus sativus Linn. Iridaceae Ketones, Aldehydes, Acids Plants Source Classification	Glutathione S-transferase
Phorone (Diisopropylidene acetone) is a glutathione (GSH) depletor. Phorone specifically and reversibly depletes free GSH through enzymatic binding (Glutathione S-transferase) (K_m = 0.9 mM). Phorone reversibly reduces the binding and nuclear uptake of glucocorticoid receptors in rat liver, and this effect is related to the temporal changes in GSH levels. Phorone can be used for studying liver toxicity.

HY-133199

Benastatin A	Microorganisms Antibiotics Other Antibiotics Source Classification	Glutathione S-transferase
Benastatin A is an inhibitor of glutathione S-transferase, which can be isolated from Streptomyces MI384-DF12 .

HY-N11778

Bequinostatin C	Microorganisms Ketones, Aldehydes, Acids Source Classification	Bacterial
Bequinostatin C is a naphthoquinone originally isolated from Streptomyces and a glutathione S-transferase pi 1 (GSTP1) inhibitor (IC₅₀=40 μg/mL for human GSTP1).

HY-N11699

Bequinostatin A	Quinones Microorganisms Anthraquinones Source Classification	Glutathione S-transferase
Bequinostatin A is a benzo[a]naphthacenequinone metabolite that can be isolated from Streptomyces sp. MI384-DF12. Bequinostatin A shows considerable inhibitory activity against human pi class glutathione S-transferase (GST pi) .

HY-N12261

Benastatin B	Microorganisms Phenols Polyphenols Source Classification	Glutathione S-transferase Bacterial
Benastatin B is an inhibitor for glutathione S-transferase, that inhibits human pi class GST with an IC₅₀ of 1.10 μg/mL. Benastatin B exhibits board-spectrum antibacterial efficacy, inhibits MRSA with MIC 3.1 μg/mL. Benastatin B exhibits anti-inflammatory efficacy through inhibition of IgE mediated β-hexosaminidase release with an IC₅₀ of 79 μg/mL .

HY-W024365R

3-tert-Butyl-4-methoxyphenol (Standard)	Monophenols Jatropha curcas Linn. Phenols Euphorbiaceae Plants Source Classification	PROTAC Linkers Reference Standards
3-tert-Butyl-4-methoxyphenol (Standard) is the analytical standard of 3-tert-Butyl-4-methoxyphenol. This product is intended for research and analytical applications. 3-tert-Butyl-4-methoxyphenol is a PROTAC linker, belongs to alkyl/ether class, with insecticidal activity. 3-tert-Butyl-4-methoxyphenol also induced increased activities of glutathione (GSH) S-transferase and epoxide hydrolase in the liver and forestomach tissues of A/HeJ mice, regulating the carcinogen metabolism system .

HY-114585A

Sperabillin A dihydrochloride	Microorganisms Classification of Application Fields Antibiotics Other Diseases Disease Research Fields Other Antibiotics Source Classification	Glutathione S-transferase
Sperabillin A (dihydrochloride)is new inhibitors ofglutathione S-transferaseisolated from the culture broth ofStreptomyces sp .

HY-N2853R

D-α-Tocopherylquinone (Standard) α-Tocopherylquinone (Standard)	Quinones Microorganisms Benzene Quinones Source Classification	Reference Standards Reactive Oxygen Species (ROS)
D-α-Tocopherylquinone (α-Tocopherylquinone) (Standard) is the analytical standard of D-α-Tocopherylquinone. This product is intended for research and analytical applications. D-α-Tocopherylquinone is a quinone, can be isolated from Phaeodactylum tricornutum. D-α-Tocopherylquinone is an oxidation product of α-Tocopherol (vitamin E). D-α-Tocopherylquinone can act as an anticoagulant and as an antioxidant. D-α-Tocopherylquinone reduces cellular oxidative damage produced by oxidized lipids. D-α-Tocopherylquinone binds to a liver cytosolic protein with a molecular mass of about 40 kDa. D-α-Tocopherylquinone binds to glurathione-S-transferase (GST) and can be transported to the site of metabolism or excreted in the bile .

HY-N19312

Diospyrin	Quinones Structural Classification Ebenaceae Phenols Polyphenols Benzene Quinones Plants Source Classification	Apoptosis Glutathione S-transferase Topoisomerase
Diospyrin is a dinaphthoquinone anticancer agent with pro-apoptotic (apoptosis) activity, glutathione S-transferase (Glutathione S-transferase) inhibitory activity, and topoisomerase (Topoisomerase) I inhibitory activity. Diospyrin is present in the heartwood of various Diospyros plants and can be used for research on Ehrlich ascites carcinoma, acute myeloid leukemia, chronic myeloid leukemia, mammary adenocarcinoma, cervical epithelial carcinoma, malignant cutaneous melanoma, laryngeal epidermoid carcinoma, human osteosarcoma, and human lymphoblastic carcinoma .

HY-N9348

Glucoraphenin	Structural Classification Classification of Application Fields Metabolic Disease Glucosinolates Plants Brassicaceae Disease Research Fields Source Classification Raphanus sativus Linn.	Others
Glucoraphenin, the predominant and orally active glucosinolate in radish sprouts, is hydrolyzed by myrosinase to sulforaphene that is implicated to exert anticancerogenic effects. Glucoraphenin induces xenobiotic metabolizing enzymes (XMEs) .

HY-N17963

Cappariloside A	Structural Classification Alkaloids Capparaceae Plants Maerua siamensis (Kurz) Pax Indole Alkaloids Source Classification	Glutathione S-transferase Influenza Virus Interleukin Related IFNAR STAT
Cappariloside A is a larvicide that exhibits larvicidal activity against Aedes aegypti larvae and reduces larval *glutathione-S-transferase* activity. Cappariloside A also possesses antiviral activity, decreases the level of phosphorylated STAT1 in cells, inhibits the replication of influenza viruses H1N1, H3N2, PIV3 and ADV, and downregulates the expression of IL-6, IP-10, MIG, RANTES/CCL-5, IFN-β and IL-29. Cappariloside A suppresses the inflammatory response induced by mouse lung-adapted influenza virus strains. Cappariloside A can be used in studies related to larvicidal applications and influenza virus infection .

HY-N18024

Kaempferol-3-O-glu-rha-glu	Structural Classification Myrsine stolonifera(Koidz.) E. Walker Phenols Polyphenols Plants Primulaceae Source Classification	Insecticide Cholinesterase (ChE) Glutathione S-transferase Oxidative Phosphorylation Reactive Oxygen Species (ROS)
Kaempferol-3-O-glu-rha-glu is an insecticide. Kaempferol-3-O-glu-rha-glu inhibits activities of the enzymes CarE, GSTs, MFO, and AChE. Kaempferol-3-O-glu-rha-glu exhibits cytotoxicity and disrupts mitochondrial membrane potential and increases ROS production. Kaempferol-3-O-glu-rha-glu can be used for the infection .

Species:	Human (12) Rat (1)
Tag:	His (13) Tag Free (3) Myc (2) GST (2)
Source:	HEK293 (3) Sf9 insect cells (1) E. coli (13)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P75800

	GSTK1 Protein, Human Glutathione S-Transferase kappa 1; GST 13-13; GSTK1-1; Glutathione S-Transferase subunit 13	Human	E. coli
	The GSTK1 protein acts as a glutathione S-transferase, promoting the binding of glutathione to exogenous and endogenous compounds, mainly through the model substrate 1-chloro-2,4-dinitrobenzene (CDNB). active activity. This enzymatic activity plays a vital role in the detoxification process, assisting in the binding of glutathione to various substrates. GSTK1 Protein, Human is the recombinant human-derived GSTK1 protein, expressed by E. coli , with tag free.

HY-P70150

	GSTP1 Protein, Human rHuGlutathione S-Transferase P/GSTP1; Glutathione S-Transferase P; GSTP1; GST class-pi; GSTP1-1; FAEES3; GST3;	Human	E. coli
	Glutathione S-transferase P (GSTP1) is a member of GSTs family and plays an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. GSTP1 enables JUN kinase binding activity; glutathione transferase activity; and kinase regulator activity and is involved in negative regulation of cell population proliferation, intracellular signal transduction and macromolecule metabolic process as well. GSTP1 Protein, Human is the recombinant human-derived GSTP1 protein, expressed by E. coli , with tag free.

HY-P700381

	GSTK1 Protein, Human (GST) Glutathione S-Transferase kappa 1; GST 13-13; GSTK1-1; Glutathione S-Transferase subunit 13	Human	E. coli
	The GSTK1 protein acts as a glutathione S-transferase, promoting the binding of glutathione to exogenous and endogenous compounds, mainly through the model substrate 1-chloro-2,4-dinitrobenzene (CDNB). active activity. This enzymatic activity plays a vital role in the detoxification process, assisting in the binding of glutathione to various substrates. GSTK1 Protein, Human (GST) is the recombinant human-derived Glutathione S-transferase kappa 1/GSTK1 protein, expressed by E. coli , with N-GST labeled tag.

HY-P70270

	GST Protein, Schistosoma Japonicum 5 Publications Verification rSchGlutathione S-Transferase class-mu 26 kDa isozyme; Glutathione S-Transferase class-mu 26 kDa isozyme; GST 26; Sj26 antigen; SjGST	Others	E. coli
	The GST (Glutathione S-transferase) protein is vital for conjugating reduced glutathione to hydrophobic electrophiles, essential for cellular detoxification and defense. GST isoenzymes play a central role in parasites' detoxification systems, indicating a crucial defense role. Additionally, GST may enhance haematin solubility in parasite guts, highlighting its multifaceted contributions to cellular and organismal processes. GST Protein, Schistosoma Japonicum is the recombinant GST protein, expressed by E. coli , with tag free.

HY-P72215

	GSTP1 Protein, Human (His) Deafness; Deafness X-linked 7; DFN7; FAEES3; Fatty Acid Ethyl Ester Synthase III ; Glutathione S Transferase 3; Glutathione S Transferase Pi; Glutathione S-Transferase P; Glutathione S-Transferase pi 1; GST class-pi; GST3; GSTP; Gstp1; GSTP1-1; GSTP1_HUMAN; PI; X linked 7	Human	E. coli
	The GSTP1 protein is critical for binding reduced glutathione to a variety of hydrophobic electrophiles, actively forming glutathione conjugates of PGA2 and PGJ2. Documented studies highlight its involvement in hepoxilin regioisomer synthesis, emphasizing the versatility of GSTP1 in processing substrates. GSTP1 Protein, Human (His) is the recombinant human-derived GSTP1 protein, expressed by E. coli , with N-10*His labeled tag.

HY-P75153A

	GSTA1 Protein, Human (HEK293, His) 1 Publications Verification Glutathione S-Transferase A1; GST-epsilon; GSTA1-1; GTH1; GSTA1	Human	HEK293
	The GSTA1 protein catalyzes the attack of glutathione on various compounds, forming conjugates of PGA2 and PGJ2. It also converts AD into D4-androstene-3,17-dione, contributing to hormone biosynthesis. Additionally, it participates in the metabolism of oxidized linoleic acid through its peroxidase activity against 13-HPODE. GSTA1 Protein, Human (HEK293, His) is the recombinant human-derived GSTA1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P72214

	GSTP1 Protein, Cricetulus longicaudatus (His-Myc) GSTP1Glutathione S-Transferase P; EC 2.5.1.18; GST class-pi	Others	E. coli
	GSTP1, a key protein, aids in cellular detoxification by conjugating reduced glutathione to hydrophobic electrophiles. It also forms glutathione conjugates for PGA2 and PGJ2 and contributes to hepoxilin synthesis. Additionally, GSTP1 regulates CDK5 activity, preventing neurodegeneration. This versatile enzyme safeguards cellular homeostasis and plays a crucial role in various biochemical pathways. GSTP1 Protein, Cricetulus longicaudatus (His-Myc) is the recombinant GSTP1 protein, expressed by E. coli , with N-10*His, C-Myc labeled tag.

HY-P72215Y

	GSTP1 Protein, Human (His, solution) Deafness; Deafness X-linked 7; DFN7; FAEES3; Fatty Acid Ethyl Ester Synthase III ; Glutathione S Transferase 3; Glutathione S Transferase Pi; Glutathione S-Transferase P; Glutathione S-Transferase pi 1; GST class-pi; GST3; GSTP; Gstp1; GSTP1-1; GSTP1_HUMAN; PI; X linked 7	Human	E. coli
	The GSTP1 protein is critical for binding reduced glutathione to a variety of hydrophobic electrophiles, actively forming glutathione conjugates of PGA2 and PGJ2. Documented studies highlight its involvement in hepoxilin regioisomer synthesis, emphasizing the versatility of GSTP1 in processing substrates. GSTP1 Protein, Human (His) is the recombinant human-derived GSTP1 protein, expressed by E. coli , with N-10*His labeled tag.

HY-P75153

	GSTA1 Protein, Human (HEK293, His, solution) Glutathione S-Transferase A1; GST-epsilon; GSTA1-1; GTH1; GSTA1	Human	HEK293
	The GSTA1 protein catalyzes the attack of glutathione on various compounds, forming conjugates of PGA2 and PGJ2. It also converts AD into D4-androstene-3,17-dione, contributing to hormone biosynthesis. Additionally, it participates in the metabolism of oxidized linoleic acid through its peroxidase activity against 13-HPODE. GSTA1 Protein, Human (HEK293, His, solution) is the recombinant human-derived GSTA1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P72050

	GSTP1 Protein, Cricetulus longicaudatus (sf9, His-Myc) GSTP1Glutathione S-Transferase P; EC 2.5.1.18; GST class-pi	Others	Sf9 insect cells
	GSTP1, a key protein, aids in cellular detoxification by conjugating reduced glutathione to hydrophobic electrophiles. It also forms glutathione conjugates for PGA2 and PGJ2 and contributes to hepoxilin synthesis. Additionally, GSTP1 regulates CDK5 activity, preventing neurodegeneration. This versatile enzyme safeguards cellular homeostasis and plays a crucial role in various biochemical pathways. GSTP1 Protein, Cricetulus longicaudatus (sf9, His-Myc) is the recombinant GSTP1 protein, expressed by Sf9 insect cells , with N-10*His, C-Myc labeled tag.

HY-P75802

	GSTT2B Protein, Human (HEK293, His) Glutathione S-Transferase theta-2B; GST class-theta-2; GSTT2B; GSTT2	Human	HEK293
	GSTT2B protein, crucial in conjugating reduced glutathione to hydrophobic electrophiles, is essential for cellular detoxification. Its sulfatase activity adds to its multifunctional role in cellular processes. The combined glutathione conjugation and sulfatase function underscore GSTT2B's versatility in handling diverse substrates, emphasizing its significance in cellular detoxification mechanisms. GSTT2B Protein, Human (HEK293, His) is the recombinant human-derived GSTT2B protein, expressed by HEK293 , with C-His labeled tag.

HY-P75152A

	GSTM2 Protein, Human (His) 1 Publications Verification Glutathione S-Transferase Mu 2; GST class-mu 2; GSTM2-2; GST4	Human	E. coli
	GSTM2 protein is pivotal in conjugating reduced glutathione to diverse hydrophobic electrophiles and actively participates in synthesizing hepoxilin regioisomers, as documented. This underscores GSTM2's multifunctional nature, emphasizing its role in detoxification and forming unique molecular species, contributing to the broader cellular response to various electrophilic compounds. GSTM2 Protein, Human (His) is the recombinant human-derived GSTM2, expressed by E. coli, with N-6*His labeled tag.

HY-P72217

	GSTP1 Protein, Rat (His) Gstp1; Glutathione S-Transferase P; EC 2.5.1.18; Chain 7; GST 7-7; GST class-pi	Rat	E. coli
	GSTP1 protein conjugates reduced glutathione to hydrophobic electrophiles, forms glutathione conjugates of PGA2 and PGJ2, and contributes to hepoxilin production.It also regulates CDK5 activity by facilitating p25/p35 translocation, preventing neurodegeneration.GSTP1 Protein, Rat (His) is the recombinant rat-derived GSTP1 protein, expressed by E.coli , with N-6*His labeled tag.

HY-P75152

	GSTM2 Protein, Human (His, solution) Glutathione S-Transferase Mu 2; GST class-mu 2; GSTM2-2; GST4	Human	E. coli
	GSTM2 protein is pivotal in conjugating reduced glutathione to diverse hydrophobic electrophiles and actively participates in synthesizing hepoxilin regioisomers, as documented. This underscores GSTM2's multifunctional nature, emphasizing its role in detoxification and forming unique molecular species, contributing to the broader cellular response to various electrophilic compounds. GSTM2 Protein, Human (His, solution) is the recombinant human-derived GSTM2 protein, expressed by E. coli , with N-His labeled tag.

HY-P75801

	GSTM5 Protein, Human (N-His) Glutathione S-Transferase Mu 5; GST class-mu 5; GSTM5-5; GSTM5	Human	E. coli
	GSTM5 protein is pivotal in conjugating reduced glutathione to diverse hydrophobic electrophiles, crucial for cellular detoxification. Its enzymatic activity, addressing both exogenous and endogenous compounds, is essential for eliminating harmful substances and maintaining cellular homeostasis, highlighting GSTM5's protective role against toxic insults. GSTM5 Protein, Human (N-His) is the recombinant human-derived GSTM5 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P70206A

	Maleylacetoacetate isomerase/GSTZ1 Protein, Human (N-His) rHuMaleylacetoacetate isomerase/GSTZ1, His; Maleylacetoacetate Isomerase; MAAI; GSTZ1-1; Glutathione S-Transferase Zeta 1; GSTZ1	Human	E. coli
	The maleylacetoacetate isomerase/GSTZ1 protein is a member of the GST superfamily and detoxifies electrophilic molecules. It converts maleylacetoacetate to fumarylacetoacetate, a key step in phenylalanine/tyrosine degradation. Maleylacetoacetate isomerase/GSTZ1 Protein, Human (N-His) is the recombinant human-derived Maleylacetoacetate isomerase/GSTZ1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P705551

	GST Protein, Schistosoma Japonicum (His) Glutathione S-Transferase class-mu 26 kDa isozyme; GST 26; Sj26 antigen; SjGST; EC:2.5.1.18	Others	E. coli

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Source
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Cat. No.	Product Name	Chemical Structure

HY-W100026S

Galaxolide-d6 (mixture of diastereomers) (>80%)
Galaxolide-d₆ (mixture of diastereomers) (>80%) is the deuterium labeled Galaxolide (HY-W100026). Galaxolide can induce estrogenic activity (Estrogen Receptor/ERR), trigger oxidative stress and genotoxicity, and induce EROD and GST (Glutathione S-transferase) enzyme activity .

Host:	Mouse (5) Rabbit (7)
Reactivity:	Human (11) Rat (1) Mouse (2) Species independent (1) Hamster (2)
Application:	IHC-P (6) ICC/IF (6) IP (1) IHC-F (1) WB (8) FC (3) ELISA (1)
Isotype:	IgG (7) IgG1 (1) IgG2a (2) IgG2b (1)
Conjugation:	Non-conjugated (12)
Clonality:	Monoclonal (9) Recombinant (5)
Modification:	Unmodified (9)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85935

	GST-Pi Antibody (YA5627) Deafness; Deafness X-linked 7; DFN7; FAEES3; Fatty Acid Ethyl Ester Synthase III; Glutathione S Transferase 3; Glutathione S Transferase Pi; Glutathione S-Transferase P; Glutathione S-Transferase pi 1; GST class-pi; GST3; GSTP; Gstp1; GSTP1-1; GSTP1_HUMAN; PI; X linked 7	IHC-P, WB, ICC/IF, ELISA	Human, Mouse
	GST-Pi Antibody (YA5627) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to GST-Pi.

HY-P80148A

	GST-Tag Antibody (YA863) Glutathione S Transferase antibody; Glutathione S-Transferase class-mu 26 kDa isozyme antibody; GST antibody; Sj26 antigen antibody; SjGST antibody	WB, ICC/IF, IP	Species independent
	GST-Tag Antibody (YA863) is an unconjugated, mouse-derived, anti-GST-Tag IgG1 monoclonal antibody.

HY-P81277

	GST-Pi Antibody (YA975) GSTP1; FAEES3; GST3; Glutathione S-Transferase P; GST class-pi; GSTP1-1	WB, IHC-F, IHC-P, ICC/IF, FC	Human
	GST-Pi Antibody (YA975) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GST-Pi.

HY-P81277A

	GST-Pi Antibody (YA976) GSTP1; FAEES3; GST3; Glutathione S-Transferase P; GST class-pi; GSTP1-1	IHC-P	Human
	GST-Pi Antibody (YA976) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GST-Pi.

HY-P81277AA

	GST-Pi Antibody (YA976)(PBS only) GSTP1; FAEES3; GST3; Glutathione S-Transferase P; GST class-pi; GSTP1-1	IHC-P	Human
	GST-Pi Antibody (YA976) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GST-Pi.

HY-P86890

	GSTA4 Antibody (YA6583) DKFZp686D21185 antibody; Glutathione S alkylTransferase A4 antibody; Glutathione S aralkylTransferase A4 antibody; Glutathione S arylTransferase A4 antibody; Glutathione S Transferase A4 4 antibody; Glutathione S Transferase A4 antibody; Glutathione S Transferase alpha 4 antibody; Glutathione S-Transferase A4 antibody; Glutathione S-Transferase A4-4 antibody; Glutathione Transferase A4 4 antibody; DKFZp686D21185 antibody; Glutathione S alkylTransferase A4 antibody; Glutathione S aralkylTransferase A4 antibody; Glutathione S arylTransferase A4 antibody; Glutathione S Transferase A4 4 antibody; Glutathione S Transferase A4 antibody; Glutathione S Transferase alpha 4 antibody; Glutathione S-Transferase A4 antibody; Glutathione S-Transferase A4-4 antibody; Glutathione Transferase A4 4 antibody; GST class alpha member 4 antibody; GST class-alpha member 4 antibody; GSTA4 4 antibody; GSTA4 antibody; GSTA4_HUMAN antibody; GTA4 antibody; OTTHUMP00000016624 antibody; OTTHUMP00000016625 antibody; S (hydroxyalkyl)glutathione lyase A4 antibody;	WB	Human
	GSTA4 Antibody (YA6583) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GSTA4.

HY-P88758

	*GSTT2 (Glutathione S Transferase* theta 2) Antibody (YA8442)** GSTT2B	IHC-P, ICC/IF, FC	Human
	GSTT2 (Glutathione S Transferase theta 2) Antibody (YA8442) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to GSTT2 (Glutathione S Transferase theta 2).

HY-P88758A

	*GSTT2 (Glutathione S Transferase* theta 2) Antibody (YA8442)(PBS only)** GSTT2B	IHC-P, ICC/IF, FC	Human
	GSTT2 (Glutathione S Transferase theta 2) Antibody (YA8442) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to GSTT2 (Glutathione S Transferase theta 2).

HY-P82563

	*Glutathione S Transferase* mu 1 Antibody (YA2308)** MU; H-B; GST1; GTH4; GTM1; MU-1; GSTM1-1; MGC26563; GSTM1a-1a; GSTM1b-1b	WB	Human, Mouse, Rat
	Glutathione S Transferase mu 1 Antibody (YA2308) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Glutathione S Transferase mu 1.

HY-P83183

	*Glutathione S Transferase* mu 1 Antibody (YA2928)** MU; H-B; GST1; GTH4; GTM1; MU-1; GSTM1-1; MGC26563; GSTM1a-1a; GSTM1b-1b	WB	Human, Hamster
	Glutathione S Transferase mu 1 Antibody (YA2928) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Glutathione S Transferase mu 1.

HY-P83183A

	*Glutathione S Transferase* mu 1 Antibody (YA2928)(PBS only)** MU; H-B; GST1; GTH4; GTM1; MU-1; GSTM1-1; MGC26563; GSTM1a-1a; GSTM1b-1b	WB	Human, Hamster
	Glutathione S Transferase mu 1 Antibody (YA2928) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Glutathione S Transferase mu 1.

HY-P85538

	SAFB1 Antibody (YA5230) DKFZp779C1727; glutathione S Transferase fusion protein; HAP; HET; HSP27 ERE TATA binding protein; HSP27 ERE-TATA-binding protein; HSP27 estrogen response element-TATA box-binding protein; SAF B; SAF-B1; SAFB 1; SAFB; SAFB1; SAFB1_HUMAN; scaffold attachment factor B1.	WB, ICC/IF	Human
	SAFB1 Antibody (YA5230) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to SAFB1.

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Cat. No.	Product Name		Classification

HY-115673

LAS17 1 Publications Verification		Alkynes
LAS17 is a potent and selective tyrosine-directed irreversible inhibitor for glutathione S-Transferase Pi (GSTP1) . LAS17 inhibits GSTP1 activity with an IC₅₀ of 0.5 μM . LAS17 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-132913

Cyclopropenone probe 1		Alkynes
Cyclopropenone probe 1 can specifically and efficiently modify a triple-negative breast cancer driver, *glutathione S-transferase* pi-1 (GSTP1)**, by covalently binding at the catalytic active site. Cyclopropenone probe 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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