Glucoraphenin potassium

Cat. No.: HY-N9348A Purity: 99.9%: Data Sheet
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Glucoraphenin potassium is an orally effective glucosinolate. Glucoraphenin potassium can be isolated from radish sprouts. Glucoraphenin potassium enhances the enzymatic activity of Glutathione S-transferase. Glucoraphenin potassium enhances the activity of cytochrome P450-related monooxygenase.

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Glucoraphenin potassium Chemical Structure

CAS No. : 108844-81-1

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Other Forms of Glucoraphenin potassium:

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View All Cytochrome P450 Isoform Specific Products:

View All Isoforms

CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

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Description

IC₅₀ & Target

XME^[2]

In Vivo

Glucoraphenin (24-120 mg/kg; p.o.; single dose; daily for four consecutive days) potassium modulates hepatic xenobiotic metabolizing enzymes in male Sprague Dawley rats, with the single 24 mg/kg oral dose producing the strongest inductive effects, including a 3.2-fold increase in glutathione S-transferase activity and a 2-fold increase in CYP1A2-linked methoxyresorufin O-demethylase activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sprague Dawley (male, 280 g)^[1]
Dosage:	24 mg/kg (single dose; repeated daily for four days); 120 mg/kg (single dose; repeated daily for four days)
Administration:	p.o.; single dose; daily for four consecutive days
Result:	Increased CYP3A1/2-linked aminopyrine N-demethylase activity to 9.67 nmol mg^-1 min^-1 (single 24 mg/kg), 9.67 nmol mg^-1 min^-1 (single 120 mg/kg), 7.11 nmol mg^-1 min^-1 (repeated 24 mg/kg), and 7.22 nmol mg^-1 min^-1 (repeated 120 mg/kg) from control 5.50 nmol mg^-1 min^-1. Increased CYP1A2-linked methoxyresorufin O-demethylase activity to 20.67 pmol mg^-1 min^-1 (single 24 mg/kg) and 17.90 pmol mg^-1 min^-1 (repeated 24 mg/kg) from control 10.33 pmol mg^-1 min^-1; slightly increased it to 11.71 pmol mg^-1 min^-1 (single 120 mg/kg), while repeated 120 mg/kg showed no significant change. Showed no significant changes in CYP1A1-linked ethoxyresorufin O-deethylase activity across any dose or schedule compared to control 33.34 pmol mg^-1 min^-1.

Molecular Weight

473.58

Formula

C₁₂H₂₀KNO₁₀S₃

CAS No.

108844-81-1

Appearance

Solid

Color

White to off-white

SMILES

CS(/C=C/CC/C(S[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO)=N/OS(=O)(O[K])=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: 99.9%

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Data Sheet (274 KB) SDS (393 KB)

COA (252 KB) HNMR (111 KB) CNMR (108 KB) RP-HPLC (208 KB) MS (148 KB)

Handling Instructions (2659 KB)

References

[1]. Barillari J, et al. Glucoraphasatin and glucoraphenin, a redox pair of glucosinolates of brassicaceae, differently affect metabolizing enzymes in rats. J Agric Food Chem. 2007;55(14):5505-5511. [Content Brief]

[2]. Li R, et al. Glucoraphenin, sulforaphene, and antiproliferative capacity of radish sprouts in germinating and thermal processes[J]. European Food Research and Technology, 2017, 243(4): 547-554.