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SARS-CoV-2 Mpro-IN-1

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-144464
    SARS-CoV-2 Mpro-IN-1

    		SARS-CoV Infection
    SARS-CoV-2 Mpro-IN-1 (compound 16b-3) is a potent, selective and irreversible inhibitor of SARS-CoV-2 main protease (Mpro), with an IC50 of 116 nM [1].
    SARS-CoV-2 Mpro-IN-1
  • HY-151990
    SARS-CoV-2/MERS Mpro-IN-1

    		SARS-CoV Infection
    SARS-CoV-2/MERS Mpro-IN-1 (compound 9c) is a potent SARS-CoV-2 and MERS main protease inhibitor with IC50 values of 0.10, 0.06 µM, respectively [1].
    SARS-CoV-2/MERS Mpro-IN-1
  • HY-W004812
    BOC-(1R,3S)-3-aminocyclopentane carboxylic acid

    (1S,3S)-3-[(tert-Butoxycarbonyl)amINo]cyclopentanecarboxylic acid

    		 Drug Intermediate SARS-CoV Infection
    BOC-(1R,3S)-3-aminocyclopentane carboxylic acid ((1S,3S)-3-[(tert-Butoxycarbonyl)amino]cyclopentanecarboxylic acid) is a conformationally constrained peptide building block and a key component of SARS-CoV-2 main protease (Mpro) inhibitors. When incorporated into macrocyclic peptides, BOC-(1R,3S)-3-aminocyclopentane carboxylic acid not only helps generate high-affinity Mpro inhibitors by preorganizing the secondary structure of peptides, but also exerts sequence-dependent functional inhibition on the hydrolytic activity of Mpro. BOC-(1R,3S)-3-aminocyclopentane carboxylic is widely used in COVID-19-related research [1].
    BOC-(1R,3S)-3-aminocyclopentane carboxylic acid
  • HY-N12697A
    Polycarpine hydrochloride

    		SARS-CoV Virus Protease Influenza Virus Fungal Infection
    Polycarpine hydrochloride (1a) is a broad-spectrum Mpro inhibitor (IC50 = 30 nM) that can be isolated from the Polycarpa aurata and also serves as an anti-coronaviral agent. Polycarpine hydrochloride possesses antiviral and antifungal activities, with IC50 values of 30.0 nM and 0.12 μM against SARS-CoV-2 Mpro and PEDV Mpro, respectively .
    Polycarpine hydrochloride
  • HY-136606
    SARS-CoV MPro-IN-1

    		SARS-CoV Infection
    SARS-CoV MPro-IN-1 is a SARS-CoV-2 3CLpro covalent inhibitor, with an IC50 of 40 nM. SARS-CoV MPro-IN-1 shows good anti-SARS-CoV-2-infection activity in cell culture with an EC50 of 0.33 μM. SARS-CoV MPro-IN-1 has the potential for COVID-19 research [1].
    SARS-CoV MPro-IN-1
  • HY-169260
    SARS-CoV-2 Mpro-IN-27

    		SARS-CoV Infection
    SARS-CoV-2 Mpro-IN-27 (Compound 4h) is a potent SARS-CoV-2 Mpro inhibitor .
    SARS-CoV-2 Mpro-IN-27
  • HY-176442
    SARS-CoV-2 Mpro ligand 1

    		Ligands for Target Protein for PROTAC Infection
    SARS-CoV-2 Mpro ligand 1 (Compound S15) is a PROTAC target protein ligand. SARS-CoV-2 Mpro ligand 1 can be used to synthesize BP-198 (HY-176440) [1].
    SARS-CoV-2 Mpro ligand 1
  • HY-157804
    PROTAC SARS-CoV-2 Mpro degrader-1

    		PROTACs SARS-CoV Infection
    PROTAC SARS-CoV-2 Mpro degrader-1 (compound 5) is a PROTAC degrader targeting the major SARS-CoV-2 protease with broad-spectrum antiviral activity [1].
    PROTAC SARS-CoV-2 Mpro degrader-1
  • HY-178772
    SARS-CoV-2 Mpro-IN-50

    		SARS-CoV Infection
    SARS-CoV-2 Mpro-IN-50 (Compound 30) is a noncovalent SARS-CoV-2 Mpro inhibitor with an IC50 of 14  nM. SARS-CoV-2 Mpro-IN-50 is also a pan-CoV Mpro inhibitor with IC50 s of 20-190 nM for SARS-CoV-1 Mpro, 229E Mpro, HKU1 Mpro, MERS Mpro, NL63 Mpro and OC43 Mpro. SARS-CoV-2 Mpro-IN-50 has significant antiviral activity against the SARS-CoV-2 omicron variant (EC50 : 22  nM). SARS-CoV-2 Mpro-IN-50 can be used for coronavirus infections research [1].
    SARS-CoV-2 Mpro-IN-50
  • HY-161790
    Mpro ligand 1

    		Ligands for Target Protein for PROTAC SARS-CoV Virus Protease Infection
    Mpro ligand 1 is the ligand for target protein for PROTAC SARS-CoV-2 Mpro degrader-3 (HY-161789). Mpro ligand 1 is the active form of Mpro ligand 2 (HY-161791) [1].
    Mpro ligand 1
  • HY-155144
    CDD-1845

    		SARS-CoV Infection
    CDD-1845 is a non-covalent and non-peptide potent SARS-CoV-2 Mpro inhibitor with a Ki of 3 nM. CDD-1845 also inhibits ΔP168, A173V, and ΔP168/A173V Mpro variants .
    CDD-1845
  • HY-155142
    CDD-1819

    		SARS-CoV Infection
    CDD-1819 is a non-covalent and non-peptide potent SARS-CoV-2 Mpro inhibitor with a Ki of 5 nM. CDD-1819 also inhibits ΔP168, A173V, and ΔP168/A173V Mpro variants .
    CDD-1819
  • HY-155143
    CDD-1733

    		SARS-CoV Infection
    CDD-1733 is a non-covalent and non-peptide potent SARS-CoV-2 Mpro inhibitor with a Ki of 12 nM. CDD-1733 also inhibits ΔP168, A173V, and ΔP168/A173V Mpro variants .
    CDD-1733
  • HY-176441
    E3 ligase Ligand 66

    		Ligands for E3 Ligase Infection
    E3 ligase Ligand 66 is an E3 ligase ligand that can be used to recruit IAP proteins. E3 ligase Ligand 66 can be linked to SARS-CoV-2 Mpro ligand 1 (HY-176442) through a linker to form PROTAC BP-198 (HY-176440) [1].
    E3 ligase Ligand 66
  • HY-178374
    BACE-1/Mpro-IN-1

    		Beta-secretase SARS-CoV Infection Neurological Disease
    BACE-1/Mpro-IN-1 is a high brain-penetrant BACE-1 (IC50 = 0.26 μM) and SARS-CoV-2 Mpro (IC50 = 0.91 μM) dual inhibitor. BACE-1/Mpro-IN-1 binds to the aspartyl protease and cysteine protease as a mixed-type inhibitor. BACE-1/Mpro-IN-1 exhibits the most favorable docking score and a strong interaction profile. BACE-1/Mpro-IN-1 can be used for the study of COVID-19 exacerbated Neuroinflammation and Alzheimer’s disease [1].
    BACE-1/Mpro-IN-1

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