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Cat. No.: HY-136606

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SARS-CoV MPro-IN-1

SARS-CoV MPro-IN-1 is a SARS-CoV-2 3CLpro covalent inhibitor, with an IC₅₀ of 40 nM. SARS-CoV MPro-IN-1 shows good anti-SARS-CoV-2-infection activity in cell culture with an EC₅₀ of 0.33 μM. SARS-CoV MPro-IN-1 has the potential for COVID-19 research.

For research use only. We do not sell to patients.

CAS No.: 2413716-71-7
Formula: C₂₅H₂₅FN₄O₄
Molecular Weight:464.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

SARS-CoV MPro-IN-1 Chemical Structure

CAS No.: 2413716-71-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	CC₅₀	>100 μM Compound: 92	Cytotoxicity against human Huh-7 cells assessed as reduction of cell viability Cytotoxicity against human Huh-7 cells assessed as reduction of cell viability	[PMID: 34798775]
L929	CC₅₀	>100 μM Compound: 92	Cytotoxicity against mouse L929 cells assessed as reduction of cell viability Cytotoxicity against mouse L929 cells assessed as reduction of cell viability	[PMID: 34798775]
Vero C1008	CC₅₀	>100 μM Compound: 11b	Cytotoxicity against African green monkey Vero E6 cells assessed as cell growth inhibition incubated for 24 hrs by CCK8 assay Cytotoxicity against African green monkey Vero E6 cells assessed as cell growth inhibition incubated for 24 hrs by CCK8 assay	[PMID: 32771797]
Vero C1008	CC₅₀	>100 μM Compound: 22	Cytotoxicity against African green monkey Vero E6 cells by CCK-8 assay Cytotoxicity against African green monkey Vero E6 cells by CCK-8 assay	[PMID: 33486200]
Vero C1008	CC₅₀	>100 μM Compound: 6	Cytotoxicity against African green monkey Vero E6 cells by CCK-8 assay Cytotoxicity against African green monkey Vero E6 cells by CCK-8 assay	[PMID: 33186044]
Vero C1008	CC₅₀	>100 μM Compound: 92	Cytotoxicity against African green monkey Vero E6 cells assessed as reduction of cell viability by CellTiterGlo assay Cytotoxicity against African green monkey Vero E6 cells assessed as reduction of cell viability by CellTiterGlo assay	[PMID: 34798775]
Vero C1008	EC₅₀	0.72 μM Compound: 22	Antiviral activity against SARS-CoV-2 infected in Vero E6 cells assessed as reduction in viral replication measured after 24 hrs by plaque-reduction assay Antiviral activity against SARS-CoV-2 infected in Vero E6 cells assessed as reduction in viral replication measured after 24 hrs by plaque-reduction assay	[PMID: 33486200]
Vero C1008	EC₅₀	0.72 μM Compound: 73	Antiviral activity against SARS CoV-2 nCoV-2019BetaCoV/Wuhan/WIV04/2019 infected in African green monkey Vero E6 cells by CCK8 assay Antiviral activity against SARS CoV-2 nCoV-2019BetaCoV/Wuhan/WIV04/2019 infected in African green monkey Vero E6 cells by CCK8 assay	[PMID: 37244162]

In Vivo

SARS-CoV MPro-IN-1 (compound 11b) (5 mg/kg; intravenous drip administration) shows the t_1/2 is <1.65 hours and the clearance rate is 20.6 mL/min/mg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2413716-71-7
Molecular Weight 464.49
Formula C₂₅H₂₅FN₄O₄
SMILES

O=C(C1=CC2=CC=CC=C2N1)N[C@H](C(N[C@H](C=O)C[C@H](CCN3)C3=O)=O)CC4=CC(F)=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dai W, et al. Structure-Based Design, Synthesis and Biological Evaluation of Peptidomimetic Aldehydes as a Novel Series of Antiviral Drug Candidates Targeting the SARS-CoV-2 Main Protease. bioRxiv; 2020.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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