1. Anti-infection
  2. SARS-CoV
  3. SARS-CoV MPro-IN-1

SARS-CoV MPro-IN-1 

Cat. No.: HY-136606
Handling Instructions

SARS-CoV MPro-IN-1 is a SARS-CoV-2 3CLpro covalent inhibitor, with an IC50 of 40 nM. SARS-CoV MPro-IN-1 shows good anti-SARS-CoV-2-infection activity in cell culture with an EC50 of 0.33 μM. SARS-CoV MPro-IN-1 has the potential for COVID-19 research.

For research use only. We do not sell to patients.

SARS-CoV MPro-IN-1 Chemical Structure

SARS-CoV MPro-IN-1 Chemical Structure

CAS No. : 2413716-71-7

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Description

SARS-CoV MPro-IN-1 is a SARS-CoV-2 3CLpro covalent inhibitor, with an IC50 of 40 nM. SARS-CoV MPro-IN-1 shows good anti-SARS-CoV-2-infection activity in cell culture with an EC50 of 0.33 μM. SARS-CoV MPro-IN-1 has the potential for COVID-19 research[1].

In Vivo

SARS-CoV MPro-IN-1 (compound 11b) (5 mg/kg; intravenous drip administration) shows the t1/2 is <1.65 hours and the clearance rate is 20.6 mL/min/mg[1].

Molecular Weight

464.49

Formula

C₂₅H₂₅FN₄O₄

CAS No.

2413716-71-7

SMILES

O=C(C1=CC2=CC=CC=C2N1)N[[email protected]](C(N[[email protected]](C=O)C[[email protected]](CCN3)C3=O)=O)CC4=CC(F)=CC=C4

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SARS-CoV MPro-IN-1SARS-CoVSARS coronavirusCOVID-19SARS-CoV-23CLproantiviralvirusInhibitorinhibitorinhibit

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