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Cat. No.: HY-151990

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SARS-CoV-2/MERS Mpro-IN-1

SARS-CoV-2/MERS Mpro-IN-1 (compound 9c) is a potent SARS-CoV-2 and MERS main protease inhibitor with IC₅₀ values of 0.10, 0.06 µM, respectively.

For research use only. We do not sell to patients.

Formula: C₃₀H₃₆N₄O₇
Molecular Weight:564.63

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

SARS-CoV-2/MERS Mpro-IN-1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

SARS-CoV-2/MERS Mpro-IN-1 (compound 9c) is a potent SARS-CoV-2 and MERS main protease inhibitor with IC₅₀ values of 0.10, 0.06 µM, respectively^[1].

IC₅₀ & Target

IC₅₀: 0.10 µM (SARS-CoV-2); 0.06 µM (MERS)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
Vero C1008	CC₅₀	>100 μM Compound: 9c	Cytotoxicity against African green monkey GFP tagged Vero E6 cells assessed as reduction in cell viability by measuring fluoroscence in presence of CP1003 at 2 uM after 72 hrs Cytotoxicity against African green monkey GFP tagged Vero E6 cells assessed as reduction in cell viability by measuring fluoroscence in presence of CP1003 at 2 uM after 72 hrs	[PMID: 36332546]

Chemical Information

Molecular Weight 564.63
Formula C₃₀H₃₆N₄O₇
SMILES

O=C(N1[C@H](C(N[C@H](C(C(NCCC2=CC=CC=C2OC)=O)=O)C[C@H]3C(NCC3)=O)=O)CCC1)OCC4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Pelliccia S, et al. Easy access to α-ketoamides as SARS-CoV-2 and MERS Mpro inhibitors via the PADAM oxidation route. Eur J Med Chem. 2022 Dec 15;244:114853. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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