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Pathways Recommended: Stem Cell/Wnt Cell Cycle/DNA Damage
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SU-DHL-10 cells

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-160945
    NMT-IN-7

    		ADC Payload N-myristoyltransferase Cancer
    NMT-IN-7 is a N-myristoyl transferase (NMT) inhibitor, with IC50s of 2.1 nM for HsNMT1M, 0.6 nM for SU-DHL-10 cell. NMT-IN-7 can be used as a ADC cytotoxin .
    NMT-IN-7
  • HY-170762
    Mcl-1 inhibitor 21

    		Apoptosis Bcl-2 Family Cancer
    Mcl-1 inhibitor 21 (Example 1-36) is a Mcl-1 inhibitor with an IC50 of 328 nM. Mcl-1 inhibitor 21 exhibits proapototic and anti-proliferation activities against SUDHL5 and SUDHL10 cell lines and can be utilized in cancer research .
    Mcl-1 inhibitor 21
  • HY-170762A
    (+)-Mcl-1 inhibitor 21

    		Apoptosis Bcl-2 Family Cancer
    (+)-Mcl-1 inhibitor 21 (Example 1-37) is a Mcl-1 inhibitor with an IC50 of 172 nM. (+)-Mcl-1 inhibitor 21 exhibits proapototic and anti-proliferation activities against SUDHL5 and SUDHL10 cell lines and can be utilized in cancer research .
    (+)-Mcl-1 inhibitor 21
  • HY-170762B
    (-)-Mcl-1 inhibitor 21

    		Apoptosis Bcl-2 Family Cancer
    (-)-Mcl-1 inhibitor 21 (Example 1-38) is a Mcl-1 inhibitor with an IC50 of 7.51 μM. (-)-Mcl-1 inhibitor 21 exhibits proapototic and anti-proliferation activities against SUDHL5 and SUDHL10 cell lines and can be utilized in cancer research .
    (-)-Mcl-1 inhibitor 21
  • HY-181459
    PARP1-IN-55

    		PARP DNA/RNA Synthesis Reactive Oxygen Species (ROS) Apoptosis Cancer
    PARP1-IN-55 is a potent and selective PARP1 inhibitor with an IC50 value of 0.019 μM. PARP1-IN-55 exhibits anti-proliferative selective activity against MCF-7 breast cancer cells (IC50 = 3.6 μM). PARP1-IN-55 inhibits the PARP1-mediated DNA damage repair pathway, induces ROS accumulation, disrupts mitochondrial membrane potential, induced apoptosis and suppresses cancer cell migration, invasion, and colony formation. PARP1-IN-55 can be used for the study of breast cancer .
    PARP1-IN-55

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