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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

SiHa cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (3) Aminopeptidase (1) Antibiotic (2) Apoptosis (7) Autophagy (3) Bacterial (3) Bcl-2 Family (2) Caspase (1) CDK (1) DNA/RNA Synthesis (1) Drug Metabolite (2) Endogenous Metabolite (3) HIF/HIF Prolyl-Hydroxylase (1) HSP (1) ICMT (1) IKK (1) Lactate Dehydrogenase (2) MDM-2/p53 (1) MMP (1) Monoamine Oxidase (3) mTOR (2) NF-κB (2) Nucleoside Antimetabolite/Analog (1) p38 MAPK (2) PARP (1) PI3K (3) PROTACs (1) Reactive Oxygen Species (ROS) (1) Reference Standards (3) Transmembrane Glycoprotein (1) VEGFR (1)
By Research Areas:	Cancer (20) Cardiovascular Disease (3) Infection (5) Inflammation/Immunology (1) Metabolic Disease (3) Neurological Disease (1)

By Targets:

Akt (3)

Aminopeptidase (1)

Antibiotic (2)

Apoptosis (7)

Autophagy (3)

Bacterial (3)

Bcl-2 Family (2)

Caspase (1)

CDK (1)

DNA/RNA Synthesis (1)

Drug Metabolite (2)

Endogenous Metabolite (3)

HIF/HIF Prolyl-Hydroxylase (1)

HSP (1)

ICMT (1)

IKK (1)

Lactate Dehydrogenase (2)

MDM-2/p53 (1)

MMP (1)

Monoamine Oxidase (3)

mTOR (2)

NF-κB (2)

Nucleoside Antimetabolite/Analog (1)

p38 MAPK (2)

PARP (1)

PI3K (3)

PROTACs (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (3)

Transmembrane Glycoprotein (1)

VEGFR (1)

By Research Areas:

Cancer (20)

Cardiovascular Disease (3)

Infection (5)

Inflammation/Immunology (1)

Metabolic Disease (3)

Neurological Disease (1)

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Targets Recommended: Nuclear Factor of activated T Cells (NFAT) TREM receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y1750

β-Aminopropionitrile Maximum Cited Publications 13 Publications Verification BAPN	Monoamine Oxidase Endogenous Metabolite	Metabolic Disease Cancer
β-Aminopropionitrile (BAPN) is a specific, irreversible and orally active lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile targets the active site of LOX or LOXL isoenzymes .

HY-N0124

Dioscin 10+ Cited Publications Collettiside III; CCRIS 4123	Autophagy Apoptosis	Cardiovascular Disease Cancer
Dioscin (CCRIS 4123; Collettiside III) is a natural plant-derived steroidal saponin that has good anti-cancer activity against a variety of cancer cells. Dioscin causes DNA damage and induces apoptosis in HeLa and SiHa cells. Dioscin regulates ROS-mediated DNA damage and mitochondrial signaling pathways, exerting anticancer activity .

HY-16160

Cysmethynil 1 Publications Verification	Autophagy ICMT	Neurological Disease Cancer
Cysmethynil is an Icmt inhibitor(IC₅₀ = 2.4 μM). Cysmethynil inhibites RAS membrane binding and EGF signal transduction. Cysmethynil prevents the cells in the G1 phase and induces autophagy. Cysmethynil inhibits PC3 cells proliferation, has synergistic effect with Paclitaxel (HY-B0015) and Doxorubicin (HY-15142A). Cysmethynil has anti-tumor effects and can be used for solid tumor (such as prostate cancer et al.) research .

HY-N3651

Curzerenone 1 Publications Verification	Bacterial Reactive Oxygen Species (ROS) Apoptosis PI3K Akt mTOR	Infection Cancer
Curzerenone is an orally active sesquiterpene compound and Antibacterial agent. Curzerenone can be isolated from Curcuma zedoaria and Curcuma aeruginosa plants. Curzerenone increases ROS levels, activates Apoptotic signaling pathways, and attenuates the PI3K/AKT/mTOR signaling pathway. Curzerenone exhibits anticancer activity against liver cancer and cervical cancer. Curzerenone has antioxidant effects. Curzerenone shows weak antibacterial activity against Escherichia coli. Curzerenone can be used in research related to hepatocellular carcinoma, cervical cancer, and Escherichia coli infection .

HY-108638

NSC 146109 hydrochloride 2 Publications Verification XI-011 hydrochloride	MDM-2/p53 Apoptosis PARP	Cancer
NSC 146109 hydrochloride (XI-011 hydrochloride) is a p53 activator and MDMX inhibitor. NSC 146109 hydrochloride inhibits MDMX gene transcription, downregulates MDMX mRNA and protein levels, stabilizes p53 and activates the transcriptional activity of p53. NSC 146109 hydrochloride induces cancer cell apoptosis (apoptosis) and inhibits the growth of transformed cells. NSC 146109 hydrochloride inhibits the growth of xenograft tumors. NSC 146109 hydrochloride can be used in research related to breast cancer and cervical cancer .

HY-N0124R

Dioscin (Standard) Collettiside III (Standard); CCRIS 4123 (Standard)	Reference Standards Autophagy Apoptosis	Cardiovascular Disease Cancer
Dioscin (Standard) is the analytical standard of Dioscin. This product is intended for research and analytical applications. Dioscin (CCRIS 4123; Collettiside III) is a natural plant-derived steroidal saponin that has good anti-cancer activity against a variety of cancer cells. Dioscin causes DNA damage and induces apoptosis in HeLa and SiHa cells. Dioscin regulates ROS-mediated DNA damage and mitochondrial signaling pathways, exerting anticancer activity .

HY-Y1750A

β-Aminopropionitrile hydrochloride Maximum Cited Publications 13 Publications Verification BAPN hydrochloride	Monoamine Oxidase Endogenous Metabolite	Metabolic Disease Cancer
β-Aminopropionitrile (BAPN) hydrochloride is a specific, irreversible and orally active lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile hydrochloride targets the active site of LOX or LOXL isoenzymes .

HY-162589

Lw13	PROTACs HSP Apoptosis	Cancer
Lw13 is a Hsp90-targeting PROTAC and achieves maximum degradation at a concentration of 0.05 μM in Siha cells. Lw13 induces cell apoptosis and exhibits potent anti-tumor activity both in vitro and in vivo(Sturcture Note:(Blue: Cereblon ligand (HY-A0003), Black: linker；Pink: Hsp90 inhibitor SNX-5422 (HY-10213)) .

HY-169915

ERAP1 modulator-2	Aminopeptidase	Inflammation/Immunology Cancer
ERAP1 modulator-2 (compound 10) is a potent ERAP1 inhibitor with an IC₅₀ value of <100 nM .

HY-169100

Antiproliferative agent-57	VEGFR PI3K Akt mTOR p38 MAPK HIF/HIF Prolyl-Hydroxylase	Cancer
Antiproliferative agent-57 (compound M2) is a tumor angiogenesis inhibitor. Antiproliferative agent-57 inhibits the secretion of VEGF in SiHa cells under hypoxic conditions (IC₅₀=0.68 μM) without inducing cytotoxicity. Antiproliferative agent-57 can modulate the PI3K/AKT/mTOR and MAPK signaling pathways in tumor cells to inhibit the expression of HIF-1α and VEGF in tumor tissues .

HY-Y1750R

β-Aminopropionitrile (Standard)	Reference Standards Monoamine Oxidase Endogenous Metabolite	Metabolic Disease Cancer
β-Aminopropionitrile (BAPN) is a specific, irreversible and orally active lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile targets the active site of LOX or LOXL isoenzymes .

HY-N4308

Hexamethylquercetagetin Hexa-O-methylquercetagetin; Quercetagetin hexamethyl ether; 3,5,6,7,3',4'-Hexamethoxyflavone	NF-κB IKK Bcl-2 Family	Cancer
Hexamethylquercetagetin (Hexa-O-methylquercetagetin; Quercetagetin hexamethyl ether; 3,5,6,7,3',4'-Hexamethoxyflavone) is an orally active NF-κB inhibitor. Hexamethylquercetagetin inhibits NF-κB-derived luciferase activity, reduces phosphorylated p65 and IκBα, Cyclin D1, Bcl-2 and blocks TNFα-induced NF-κB activation. Hexamethylquercetagetin inhibits survival and proliferation of cervical carcinoma cells. Hexamethylquercetagetin suppresses tumor volume and weight in BALB/c nude mouse xenograft models of cervical carcinoma. Hexamethylquercetagetin can be used for the research of cancer, such as cervical carcinoma .

HY-N14752

Hydroxymycotrienin A	Antibiotic Bacterial	Infection Cancer
Hydroxymycotrienin A is an Ansa antibiotic. Hydroxymycotrienin A has the activity of inhibiting human neck tumor cell line, and its inhibitory effect on human papillomavirus (HPV) gene positive neck tumor cells (such as HeLa, CaSK_i, SiHa, etc.) is stronger than HPV gene negative cells .

HY-N15103

Hydroxymycotrienin B	Antibiotic Bacterial	Infection Cancer
Hydroxymycotrienin B is an Ansa antibiotic. Hydroxymycotrienin B has the activity of inhibiting human neck tumor cell line, and its inhibitory effect on human papillomavirus (HPV) gene positive neck tumor cells (such as HeLa, CaSK_i, SiHa, etc.) is stronger than HPV gene negative cells .

HY-16445BR

CNDAC hydrochloride (Standard)	Reference Standards Nucleoside Antimetabolite/Analog Drug Metabolite Apoptosis DNA/RNA Synthesis	Cancer
Dioscin (Standard) is the analytical standard of Dioscin. This product is intended for research and analytical applications. Dioscin (CCRIS 4123; Collettiside III) is a natural plant-derived steroidal saponin that has good anti-cancer activity against a variety of cancer cells. Dioscin causes DNA damage and induces apoptosis in HeLa and SiHa cells. Dioscin regulates ROS-mediated DNA damage and mitochondrial signaling pathways, exerting anticancer activity .

HY-101677

cPrPMEDAP	Drug Metabolite	Infection
cPrPMEDAP is an intermediate metabolite of GS-9219. cpr-PMEDAP functions as a proagent of the guanine nucleotide analog PMEG and has antiproliferative activity. cPrPMEDAP is negatively charged at physiologic pH and has poor permeability into the skin .

HY-154865

Anticancer agent 121	Lactate Dehydrogenase	Cancer
Anticancer agent 121, an inhibitor of human lactate dehydrogenase A enzyme (hLDHA), has good anticancer activities and can be used for anticancer research .

HY-154866

Anticancer agent 122	Lactate Dehydrogenase	Cancer
Anticancer agent 122, an inhibitor of human lactate dehydrogenase A enzyme (hLDHA), has good anticancer activities and can be used for anticancer research .

HY-183698

CDK9-IN-51	CDK	Cancer
CDK9-IN-51 is a CDK9 inhibitor. CDK9-IN-51 binds stably to purified CDK9 protein via interactions with key active-site residues Cys106, Asp109, and Phe103. CDK9-IN-51 exhibits antiproliferative activity against multiple cancer cells. CDK9-IN-51 can be used for the research of cancer, such as lung carcinoma, cervical carcinoma and breast carcinoma .

HY-P992200

Anti-CD146 Antibody (AA98)	Transmembrane Glycoprotein PI3K Akt p38 MAPK NF-κB MMP Apoptosis Caspase Bcl-2 Family	Cardiovascular Disease Cancer
Anti-CD146 Antibody (AA98) is an antibody targeting CD146 and an angiogenesis inhibitor. Anti-CD146 Antibody (AA98) blocks the dimerization of CD146 as well as its downstream PI3K/AKT, p38 MAPK and NF-κB signaling pathways; it inhibits the expression of MMP9 and ICAM1, epithelial-mesenchymal transition (EMT), and the proliferation, migration and tube formation of endothelial cells. Anti-CD146 Antibody (AA98) enhances radiation-induced cancer cell apoptosis and survival inhibition, reduces tumor microvessel density, and suppresses tumor growth, invasion and vasculogenic mimicry. Anti-CD146 Antibody (AA98) can be used in research related to cervical cancer, liver cancer, malignant phyllodes tumor of the breast, uveal melanoma, leiomyosarcoma, pancreatic cancer, other tumors and angiogenesis .

HY-N17533

Sargentodoside D	Others	Infection Cancer
Sargentodoside D is a phenolic glycoside. Sargentodoside D occurs in the stems of Sargentodoxa cuneata. Sargentodoside D is applicable to research on infections caused by Acinetobacter baumannii, Candida albicans and Staphylococcus aureus, as well as research on cervical cancer .

Cat. No.	Product Name	Target	Research Area	Image

HY-P992200

Anti-CD146 Antibody (AA98)	Transmembrane Glycoprotein PI3K Akt p38 MAPK NF-κB MMP Apoptosis Caspase Bcl-2 Family	Cardiovascular Disease Cancer
Anti-CD146 Antibody (AA98) is an antibody targeting CD146 and an angiogenesis inhibitor. Anti-CD146 Antibody (AA98) blocks the dimerization of CD146 as well as its downstream PI3K/AKT, p38 MAPK and NF-κB signaling pathways; it inhibits the expression of MMP9 and ICAM1, epithelial-mesenchymal transition (EMT), and the proliferation, migration and tube formation of endothelial cells. Anti-CD146 Antibody (AA98) enhances radiation-induced cancer cell apoptosis and survival inhibition, reduces tumor microvessel density, and suppresses tumor growth, invasion and vasculogenic mimicry. Anti-CD146 Antibody (AA98) can be used in research related to cervical cancer, liver cancer, malignant phyllodes tumor of the breast, uveal melanoma, leiomyosarcoma, pancreatic cancer, other tumors and angiogenesis .

β-Aminopropionitrile Maximum Cited Publications 13 Publications Verification BAPN	Structural Classification Natural Products Microorganisms Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Monoamine Oxidase Endogenous Metabolite
β-Aminopropionitrile (BAPN) is a specific, irreversible and orally active lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile targets the active site of LOX or LOXL isoenzymes .

Dioscin 10+ Cited Publications Collettiside III; CCRIS 4123	other families Classification of Application Fields Plants Disease Research Fields Steroids Source Classification Cancer	Autophagy Apoptosis
Dioscin (CCRIS 4123; Collettiside III) is a natural plant-derived steroidal saponin that has good anti-cancer activity against a variety of cancer cells. Dioscin causes DNA damage and induces apoptosis in HeLa and SiHa cells. Dioscin regulates ROS-mediated DNA damage and mitochondrial signaling pathways, exerting anticancer activity .

Curzerenone 1 Publications Verification	Infection Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Curcuma phaeocaulis Valeton Plants Disease Research Fields Source Classification Zingiberaceae	Bacterial Reactive Oxygen Species (ROS) Apoptosis PI3K Akt mTOR
Curzerenone is an orally active sesquiterpene compound and Antibacterial agent. Curzerenone can be isolated from Curcuma zedoaria and Curcuma aeruginosa plants. Curzerenone increases ROS levels, activates Apoptotic signaling pathways, and attenuates the PI3K/AKT/mTOR signaling pathway. Curzerenone exhibits anticancer activity against liver cancer and cervical cancer. Curzerenone has antioxidant effects. Curzerenone shows weak antibacterial activity against Escherichia coli. Curzerenone can be used in research related to hepatocellular carcinoma, cervical cancer, and Escherichia coli infection .

Dioscin (Standard) Collettiside III (Standard); CCRIS 4123 (Standard)	Structural Classification other families Plants Steroids Source Classification	Reference Standards Autophagy Apoptosis
Dioscin (Standard) is the analytical standard of Dioscin. This product is intended for research and analytical applications. Dioscin (CCRIS 4123; Collettiside III) is a natural plant-derived steroidal saponin that has good anti-cancer activity against a variety of cancer cells. Dioscin causes DNA damage and induces apoptosis in HeLa and SiHa cells. Dioscin regulates ROS-mediated DNA damage and mitochondrial signaling pathways, exerting anticancer activity .

β-Aminopropionitrile hydrochloride Maximum Cited Publications 13 Publications Verification BAPN hydrochloride	Alkaloids Classification of Application Fields Other Alkaloids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification Cancer	Monoamine Oxidase Endogenous Metabolite
β-Aminopropionitrile (BAPN) hydrochloride is a specific, irreversible and orally active lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile hydrochloride targets the active site of LOX or LOXL isoenzymes .

β-Aminopropionitrile (Standard)	Structural Classification Natural Products Microorganisms Endogenous metabolite Source Classification	Reference Standards Monoamine Oxidase Endogenous Metabolite
β-Aminopropionitrile (BAPN) is a specific, irreversible and orally active lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile targets the active site of LOX or LOXL isoenzymes .

Hexamethylquercetagetin Hexa-O-methylquercetagetin; Quercetagetin hexamethyl ether; 3,5,6,7,3',4'-Hexamethoxyflavone	Flavonols Structural Classification Flavonoids other families Classification of Application Fields Plants Disease Research Fields Source Classification Cancer	NF-κB IKK Bcl-2 Family
Hexamethylquercetagetin (Hexa-O-methylquercetagetin; Quercetagetin hexamethyl ether; 3,5,6,7,3',4'-Hexamethoxyflavone) is an orally active NF-κB inhibitor. Hexamethylquercetagetin inhibits NF-κB-derived luciferase activity, reduces phosphorylated p65 and IκBα, Cyclin D1, Bcl-2 and blocks TNFα-induced NF-κB activation. Hexamethylquercetagetin inhibits survival and proliferation of cervical carcinoma cells. Hexamethylquercetagetin suppresses tumor volume and weight in BALB/c nude mouse xenograft models of cervical carcinoma. Hexamethylquercetagetin can be used for the research of cancer, such as cervical carcinoma .

Hydroxymycotrienin A	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Hydroxymycotrienin A is an Ansa antibiotic. Hydroxymycotrienin A has the activity of inhibiting human neck tumor cell line, and its inhibitory effect on human papillomavirus (HPV) gene positive neck tumor cells (such as HeLa, CaSK_i, SiHa, etc.) is stronger than HPV gene negative cells .

Hydroxymycotrienin B	Natural Products Microorganisms Source Classification	Antibiotic Bacterial
Hydroxymycotrienin B is an Ansa antibiotic. Hydroxymycotrienin B has the activity of inhibiting human neck tumor cell line, and its inhibitory effect on human papillomavirus (HPV) gene positive neck tumor cells (such as HeLa, CaSK_i, SiHa, etc.) is stronger than HPV gene negative cells .

Sargentodoside D	Structural Classification Monophenols Phenols Sargentodoxa cuneata (Oliv.) Rehd. et Wils. Plants Sargentodoxaceae Source Classification	Others
Sargentodoside D is a phenolic glycoside. Sargentodoside D occurs in the stems of Sargentodoxa cuneata. Sargentodoside D is applicable to research on infections caused by Acinetobacter baumannii, Candida albicans and Staphylococcus aureus, as well as research on cervical cancer .

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