182798-83-0
182798-83-0
Chemical Structure
cPrPMEDAP
- CAS No.: 182798-83-0
- Formula:C11H17N6O4P
- Molecular Weight:328.26
IUPAC Name: ((2-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)ethoxy)methyl)phosphonic acid
InChIKey: PDHWTDJKKJYOGD-UHFFFAOYSA-N
SMILES: NC1=NC(NC2CC2)=C3N=CN(CCOCP(O)(O)=O)C3=N1
Biological Activity: cPrPMEDAP is an intermediate metabolite of GS-9219. cpr-PMEDAP functions as a proagent of the guanine nucleotide analog PMEG and has antiproliferative activity. cPrPMEDAP is negatively charged at physiologic pH and has poor permeability into the skin[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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cPrPMEDAP | 99.62% | cPrPMEDAP is an intermediate metabolite of GS-9219. cpr-PMEDAP functions as a proagent of the guanine nucleotide analog PMEG and has antiproliferative activity. cPrPMEDAP is negatively charged at physiologic pH and has poor permeability into the skin. | ||||||||||||||||||||
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References
- [1]. Compton ML, et al. 9-(2-Phosphonylmethoxyethyl)-N6-cyclopropyl-2,6-diaminopurine (cpr-PMEDAP) as a prodrug of 9-(2-phosphonylmethoxyethyl)guanine (PMEG). Biochem Pharmacol. 1999;58(4):709-714. [Content Brief]
- [2]. Wolfgang GH, et al. GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. Antimicrob Agents Chemother. 2009;53(7):2777-2784. [Content Brief]
Keywords
