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Results for "

Sophora

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) AMPK (1) AP-1 (1) Apoptosis (16) Autophagy (6) Bacterial (3) Beta-secretase (1) Carboxylesterase (CES) (1) Cytochrome P450 (1) Drug Derivative (1) Enterovirus (1) ERK (2) Estrogen Receptor/ERR (1) Ferroptosis (3) Filovirus (2) Fungal (2) Glycosidase (1) HIV (2) Indoleamine 2,3-Dioxygenase (IDO) (1) Interleukin Related (1) Isotope-Labeled Compounds (2) JNK (1) Mitophagy (3) mTOR (1) NF-κB (4) NOD-like Receptor (NLR) (2) Opioid Receptor (3) p38 MAPK (1) Phosphodiesterase (PDE) (1) PINK1/Parkin (3) RANKL/RANK (1) Reference Standards (10) TGF-beta/Smad (3) TNF Receptor (2) Tyrosinase (5) β-glucuronidase (1)
By Research Areas:	Cancer (27) Cardiovascular Disease (4) Infection (12) Inflammation/Immunology (19) Metabolic Disease (4) Neurological Disease (2)

By Targets:

Adrenergic Receptor (1)

AMPK (1)

AP-1 (1)

Apoptosis (16)

Autophagy (6)

Bacterial (3)

Beta-secretase (1)

Carboxylesterase (CES) (1)

Cytochrome P450 (1)

Drug Derivative (1)

Enterovirus (1)

ERK (2)

Estrogen Receptor/ERR (1)

Ferroptosis (3)

Filovirus (2)

Fungal (2)

Glycosidase (1)

HIV (2)

Indoleamine 2,3-Dioxygenase (IDO) (1)

Interleukin Related (1)

Isotope-Labeled Compounds (2)

JNK (1)

Mitophagy (3)

mTOR (1)

NF-κB (4)

NOD-like Receptor (NLR) (2)

Opioid Receptor (3)

p38 MAPK (1)

Phosphodiesterase (PDE) (1)

PINK1/Parkin (3)

RANKL/RANK (1)

Reference Standards (10)

TGF-beta/Smad (3)

TNF Receptor (2)

Tyrosinase (5)

β-glucuronidase (1)

By Research Areas:

Cancer (27)

Cardiovascular Disease (4)

Infection (12)

Inflammation/Immunology (19)

Metabolic Disease (4)

Neurological Disease (2)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0164

Matrine 15+ Cited Publications Matridin-15-one; Vegard; α-Matrine	PINK1/Parkin Opioid Receptor Autophagy Mitophagy Ferroptosis Apoptosis	Inflammation/Immunology Cancer
Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus that can act as a kappa opioid receptor and u-receptor agonist. Matrine has a variety of pharmacological effects, including anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. Matrine is potential in the research of disease like human non-small cell lung cancer, hepatoma, papillary thyroid cancer and acute kidney injury (AKI) .

HY-13516

Aloperine 5+ Cited Publications	Apoptosis Autophagy Filovirus HIV	Infection Inflammation/Immunology Cancer
Aloperine is an alkaloid in sophora plants such as Sophora alopecuroides L, which has shown anti-cancer, anti-inflammatory and anti-virus properties . Aloperine is widely used to treat patients with allergic contact dermatitis eczema and other skin inflammation in China . Aloperine induces apoptosis and autophagy in HL-60 cells .

HY-N0158

Oxymatrine Maximum Cited Publications 20 Publications Verification	TGF-beta/Smad Apoptosis	Infection Inflammation/Immunology Cancer
Oxymatrine, an alkaloid from Sophora flavescens Alt. with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. Oxymatrine inhibits bocavirus minute virus of canines (MVC) replication, reduces viral gene expression and decreases apoptosis induced by viral infection .

HY-N0423

Sophoricoside 4 Publications Verification	Others	Inflammation/Immunology Cancer
Sophoricoside is an isoflavone glycoside isolated from Sophora japonica and has anti-inflammatory, anti-cancer and immunosuppressive effects.

HY-N1231

Sophoraflavanone G 3 Publications Verification Kushenol F	Apoptosis	Cancer
Sophoraflavanone G (Kushenol F) is iaolated from Sophora flavescens and shows anti-tumor and anti-inflammatory properties.? Sophoraflavanone G (Kushenol F) induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways .

HY-N2278

Kushenol A 4 Publications Verification Leachianone E	Tyrosinase Glycosidase	Cancer
Kushenol A (Leachianone E) is isolated from the root of Sophora flavescent. Kushenol A is a non-competitive tyrosinase inhibitor to block the conversion of L-tyrosine to L-DOPA, shows IC₅₀ and K_ivalues of 1.1 μM and 0.4 μM, respectively . Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase (IC₅₀: 45 μM; K_i: 6.8 μM) and β-amylase . Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging .

HY-N0616

Trifolirhizin	Tyrosinase TNF Receptor Bacterial Apoptosis Autophagy AMPK mTOR ERK NF-κB	Infection Metabolic Disease Inflammation/Immunology Cancer
Trifolirhizin is a pterocarpan flavonoid found in the roots of Sophora flavescens. Trifolirhizin is a tyrosinase inhibitor with an IC₅₀ value of 506.77 μM. Trifolirhizin reduces intracellular melanin production and modulates multiple signaling pathways including NFκB-MAPK, AMPK/mTOR, PI3K/Akt, MAPK-NFATc1 and EGFR-MAPK. Trifolirhizin targets biological molecules including PTK6 and COX-2, inhibits the activities of hyaluronidase, collagenase and elastase, induces apoptosis, autophagy and cell cycle arrest, and suppresses the proliferation, migration and invasion of cancer cells. Trifolirhizin exerts diverse pharmacological effects including anti-inflammatory, anti-asthmatic, bone-protective, renoprotective, antibacterial, antifungal, hepatoprotective, antiplatelet, estrogenic and wound-healing activities. Trifolirhizin can be used to investigate a broad range of malignant, inflammatory, metabolic and infectious disorders .

HY-N1373

Sophoridine 5+ Cited Publications	Apoptosis	Cancer
Sophoridine is a quinolizidine alkaloid isolated from Leguminous plant Sophora flavescens. Sophoridine induces apoptosis. Sophoridine has the potential to be a novel, potent and selective antitumor agent candidate for pancreatic cancer with well-tolerated toxicity .

HY-N6051

(-)-Maackiain	Fungal NOD-like Receptor (NLR) NF-κB	Infection Inflammation/Immunology
(-)-Maackiain is a pterocarpan phytoalexin produced from Sophora flavescens. (-)-Maackiain is toxic to several genera of fungal pathogens of legume and non legume hosts. (-)-Maackiain enhances the activation of NLRP3 inflammasome, inhibits the activation of NF-κB pathway, exhibiting thereby immunostimulatory and anti-inflammatory activities. (-)-Maackiain is orally active .

HY-N1402

Oxysophoridine Sophoridine N-oxide	Apoptosis	Inflammation/Immunology
Oxysophoridine (Sophoridine N-oxide) is a bioactive alkaloid extracted from the Sophora alopecuroides Linn. Oxysophoridine (Sophoridine N-oxide) shows anti inflammatory, anti oxidative stress and anti apoptosis effects .

HY-N0746

Oxysophocarpine 5+ Cited Publications	Others	Cancer
Oxysophocarpine is an alkaloid extracted from Sophora alopecuroides.?Oxysophocarpine has neuroprotective and anti-nociceptive effects on the central and peripheral nervous systems . Oxysophocarpine inhibits the?growth?and?metastasis?of ?oral?squamous?cell?carcinoma?(OSCC) .

HY-N2463

Kushenol E 1 Publications Verification	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
Kushenol E is a class of flavonoids isolated from Sophora flavescens and is a non-competitive indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC₅₀ of 7.7 µM and a K_i of 9.5 µM, has anti-tumor activity .

HY-N1746

(2S)-2'-Methoxykurarinone 2'-O-Methylkurarinone	RANKL/RANK	Metabolic Disease Inflammation/Immunology Cancer
(2S)-2'-Methoxykurarinone, a compound isolated from the roots of Sophora flavescens, has anti-inflammatory, antipyretic, antidiabetic, and antineoplastic effects. (2S)-2'-Methoxykurarinone (MK) inhibits osteoclastogenesis and bone resorption through down-regulation of RANKL signaling. (2S)-2'-Methoxykurarinone (MK) displays cytotoxic activity against human myeloid leukemia HL-60 cells .

HY-N2529

Sophoranone (-)-Sophoranone; Sophoranon	Others	Neurological Disease
Sophoranone is a flavonoid compound that can be isolated from the root of Sophora subprostrata .

HY-N0050

Allomatrine (+)-Allomatrine	Others	Neurological Disease
Allomatrine ((+)-Allomatrine) is an alkaloid from the bark of Sophora japonica. Allomatrine has antinociceptive properties mediated mainly through the activation ofκ-opioid receptors .

HY-N8097

Kushenol W	Bacterial	Infection
Kushenol W is a prenylated flavonoid that can be isolated from the root of Sophora flavescens. Kushenol W has antimicrobial effect, with a MIC of 10 μg/mL for Staphylococcus aureus .

HY-N5096

Sophorabioside	Others	Others
Sophorabioside is a flavonoid-glycoside isolated from Sophora japonica .

HY-108966

Kushenol C	Beta-secretase	Inflammation/Immunology
Kushenol C, isolated from the roots of Sophora flavescens, shows anti-Inflammatory and anti-oxidative stress activities. Kushenol C inhibits BACE1 (β-site APP cleaving enzyme 1) with an IC₅₀ of 5.45 µM .

HY-N8228

17-Hydroxyneomatrine	Bacterial	Infection Inflammation/Immunology Cancer
17-Hydroxyneomatrine, extracted from Sophora flavescens, can well inhibit the growth of human cervical carcinoma Hela cells, has the wide-range antibacterial, anti-allergy, anti-tumor, anti-arrhythmia, swelling-subsiding diuresis, immunizing, and biological regulation functions .

HY-N16616

9α-Hydroxysophocarpine	Enterovirus	Infection
9α-Hydroxysophocarpine ((-)-9α-hydroxysophocarpine) is an alkaloid. 9α-Hydroxysophocarpine can be isolated from the rhizomes of Sophora tonkinensis. 9α-Hydroxysophocarpine exhibits antiviral activity against the Coxsackie virus B3 (CVB3) .

HY-N3198A

Sophoramine 1 Publications Verification (-)-Sophoramine	Adrenergic Receptor	Cardiovascular Disease
Sophoramine ((-)-Sophoramine) is a prejunctional α₂-adrenoceptor inhibitor that can be found in the seeds of Sophora alopecuroides. Sophoramine inhibits prejunctional α2-adrenoceptors to facilitate norepinephrine release from adrenergic nerves. Sophoramine shows cytotoxic activity against human cancer cells, positive inotropic activity, and activity in rodent arrhythmia models. Sophoramine can be used for the research of arrhythmias .

HY-121381

Kuraridine	Phosphodiesterase (PDE)	Others
Kuraridine is a prenylated flavonol extract from the roots of Sophora flavescens. Kuraridine has an inhibitory effect on cGMP specific phosphodiesterase type 5 (PDE5) (IC₅₀=0.64 μM) .

HY-N2286

Kushenol I 1 Publications Verification	Others	Inflammation/Immunology
Kushenol I is a natural compound isolated from the roots of Sophora flavescens .

HY-N11671

9α-Hydroxymatrine	Others	Others
9α-Hydroxymatrine is a quinolizidine alkaloid that can be found in the leaves of Sophora macrocarpa .

HY-N6052

(+)-Medicarpin	Estrogen Receptor/ERR	Cancer
(+)-Medicarpin, a pterocarpan, is a type of isoflavonoid isolated from several medicinal plant species with various biological effects, including Sophora japonica, Zollernia paraensis and Platymiscium yucatamun, Machaerium aristulatum, Platymiscium floribundum, and so on. (+)-Medicarpin potently inhibits osteoclastogenesis and promotes bone healing and increases bone mass by osteoblast differentiation with estrogen receptor (ER) β-mediated osteogenic action .

HY-N6051R

(-)-Maackiain (Standard)	Reference Standards Fungal NOD-like Receptor (NLR) NF-κB	Infection Inflammation/Immunology
(-)-Maackiain (Standard) is the analytical standard of (-)-Maackiain. This product is intended for research and analytical applications. (-)-Maackiain is a pterocarpan phytoalexin produced from Sophora flavescens. (-)-Maackiain is toxic to several genera of fungal pathogens of legume and non legume hosts. (-)-Maackiain enhances the activation of NLRP3 inflammasome, inhibits the activation of NF-κB pathway, exhibiting thereby immunostimulatory and anti-inflammatory activities. (-)-Maackiain is orally active .

HY-N8095

Kushenol N	Others	Cardiovascular Disease
Kushenol N is a prenylated flavonoid that can be isolated from the root of Sophora flavescens. Kushenol N has anti-allergic and vasorelaxation activities .

HY-N3413

Kushenol X	Carboxylesterase (CES) β-glucuronidase	Metabolic Disease
Kushenol X, a flavonoid compound isolated from the roots of Sophora flavescens. Kushenol X is a potent β-glucuronidase and human carboxylesterase 2 (hCE2) inhibitor with IC₅₀s of 2.07 μM and 3.05 μM, respectively .

HY-N1373A

d-Sophoridine (+)-Sophoridine	Apoptosis	Cancer
d-Sophoridine ((+)-Sophoridine) is the dextro isoform of Sophoridine (HY-N1373), which is a quinolizidine alkaloid isolated from Leguminous plant Sophora flavescens. Sophoridine induces apoptosis. Sophoridine has the potential to be a novel, potent and selective antitumor agent candidate for pancreatic cancer with well-tolerated toxicity .

HY-N0746R

Oxysophocarpine (Standard)	Reference Standards Others	Cancer
Oxysophocarpine (Standard) is the analytical standard of Oxysophocarpine. This product is intended for research and analytical applications. Oxysophocarpine is an alkaloid extracted from Sophora alopecuroides. Oxysophocarpine has neuroprotective and anti-nociceptive effects on the central and peripheral nervous systems . Oxysophocarpine inhibits the growth and metastasis of oral squamous cell carcinoma (OSCC) .

HY-W654256

Matrine-d3 Matridin-15-one-d₃; Vegard-d₃; α-Matrine-d₃	Isotope-Labeled Compounds PINK1/Parkin Opioid Receptor Autophagy Mitophagy Ferroptosis Apoptosis	Inflammation/Immunology Cancer
Matrine-d₃ (Matridin-d₃) is a deuterium labeled Matrine (HY-N0164). Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus that can act as a kappa opioid receptor and u-receptor agonist. Matrine has a variety of pharmacological effects, including anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. Matrine is potential in the research of disease like human non-small cell lung cancer, hepatoma, papillary thyroid cancer and acute kidney injury (AKI) .

HY-N8998

Sophoraflavanone I	Others	Others
Sophoraflavanone I the seeds of Sophora moorcroftiana BENTH. ex. BAKER (Leguminosae) .

HY-N7806

7,3'-Di-O-Methylorobol	Others	Others
7,3'-Di-O-Methylorobol is a flavone that can be isolated from Sophora japonica .

HY-N13187

7,3'-Dihydroxy flavonone-4'-O-β-D-glucopyranoside	Others	Others
7,3'-Dihydroxy flavonone-4'-O-β-D-glucopyranoside is derivated from the seeds of Sophora alopecuroides L. .

HY-N1344

Robtin	Others	Cardiovascular Disease
Robtin (Compound 4) is a natural product isolated and purified from Sophora yunnanensis. Robtin has cardiotonic activity .

HY-N2779

8-Lavandulylkaempferol	Others	Cancer
8-Lavandulylkaempferol is a flavonoid that can be isolated from Sophora flaWescens. 8-Lavandulylkaempferol exhibits cytotoxic activity against the KB epidermoid carcinoma cell line with an IC₅₀ of 15.1 μg/mL .

HY-N1287

Sepinol	Others	Others
Sepinol is a Flavonoids product that can be isolated from the herbs of Sophora viciifolia .

HY-N8964

Sophoraflavanone H	Others	Others
Sophoraflavanone H is a Flavonoids product that can be isolated from the roots of Sophora moorcroftiana. .

HY-N1574

Puerol A	Others	Others
Puerol A is a Phenols product that can be isolated from the stem barks of Sophora japonica. .

HY-N10787

Methylkushenol C	Others	Others
Methylkushenol C is a phenolic substance. Methylkushenol C can be isolated from Sophora flavescens .

HY-N2847

alpha-Isowighteone	Others	Others
alpha-Isowighteone is a Flavonoids product that can be isolated from the roots of Sophora flavescens .

HY-N8899

Daidzein-4'-glucoside	Others	Others
Daidzein-4'-glucoside is a Flavonoids product that can be isolated from the fruits of Sophora japonica L. .

HY-N9083

8α-Hydroxy-α-gurjunene	Others	Others
8α-Hydroxy-α-gurjunene is a Flavonoids product that can be isolated from the aerial parts of Sophora tomentosa L. .

HY-122933

Kurarinol	Tyrosinase Apoptosis	Cardiovascular Disease Cancer
Kurarinol is a flavanone found in the root of Sophora flavescens. Kurarinol is a competitive tyrosinase inhibitor, with IC₅₀ of 0.1 μM for mushroom tyrosinase .

HY-13516R

Aloperine (Standard)	Apoptosis Autophagy Filovirus HIV Reference Standards	Infection Inflammation/Immunology Cancer
Aloperine (Standard) is the analytical standard of Aloperine. This product is intended for research and analytical applications. Aloperine is an alkaloid in sophora plants such as Sophora alopecuroides L, which has shown anti-cancer, anti-inflammatory and anti-virus properties . Aloperine is widely used to treat patients with allergic contact dermatitis eczema and other skin inflammation in China . Aloperine induces apoptosis and autophagy in HL-60 cells .

HY-N0423R

Sophoricoside (Standard)	Reference Standards Others	Inflammation/Immunology Cancer
Sophoricoside (Standard) is the analytical standard of Sophoricoside. This product is intended for research and analytical applications. Sophoricoside is an isoflavone glycoside isolated from Sophora japonica and has anti-inflammatory, anti-cancer and immunosuppressive effects.

HY-N8094

Kushenol M	Cytochrome P450	Others
Kushenol M is a flavonoid from Sophora flavescens. Kushenol M is a cytochrome P450 (CYP) inhibitor, with IC₅₀ values of 1.29 μM for CYP3A4 in human liver microsomes .

HY-N5143

(2R)-3α,7,4'-Trihydroxy-5-methoxy-8-prenylflavanone	Others	Others
(2R)-3α,7,4'-Trihydroxy-5-methoxy-8-prenylflavanone is isolated from the roots of Sophora flavescens .

HY-N3414

Kushenol L	Others	Metabolic Disease
Kushenol L is one of the main components of EtOA cextracts from Kushen, a traditional medicinal herb derived from the dried roots of Sophora flavescens Ait. Kushenol L is a flavonoid and plays an important role in anti-diabeticeffects .

HY-N5129

Genistein 7-O-β-D-glucopyranoside-4'-O-[α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside]	Others	Others
Genistein 7-O-β-D-glucopyranoside-4'-O-[α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside] is an isoflavone triglycoside that could be isolated from Sophora japonica .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0164

Matrine 15+ Cited Publications Matridin-15-one; Vegard; α-Matrine	Alkaloids Piperidine Alkaloids Classification of Application Fields Leguminosae Sophora flavescens Aiton Plants Inflammation/Immunology Disease Research Fields Biological Pesticide Research Source Classification Cancer Agricultural Research	PINK1/Parkin Opioid Receptor Autophagy Mitophagy Ferroptosis Apoptosis
Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus that can act as a kappa opioid receptor and u-receptor agonist. Matrine has a variety of pharmacological effects, including anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. Matrine is potential in the research of disease like human non-small cell lung cancer, hepatoma, papillary thyroid cancer and acute kidney injury (AKI) .

HY-13516

Aloperine 5+ Cited Publications	Infection Alkaloids Piperidine Alkaloids Classification of Application Fields Leguminosae Sophora alopecuroides L Plants Inflammation/Immunology Disease Research Fields Source Classification	Apoptosis Autophagy Filovirus HIV
Aloperine is an alkaloid in sophora plants such as Sophora alopecuroides L, which has shown anti-cancer, anti-inflammatory and anti-virus properties . Aloperine is widely used to treat patients with allergic contact dermatitis eczema and other skin inflammation in China . Aloperine induces apoptosis and autophagy in HL-60 cells .

HY-N0158

Oxymatrine Maximum Cited Publications 20 Publications Verification	Infection Alkaloids Piperidine Alkaloids Classification of Application Fields Leguminosae Sophora flavescens Aiton Plants Inflammation/Immunology Disease Research Fields Source Classification	TGF-beta/Smad Apoptosis
Oxymatrine, an alkaloid from Sophora flavescens Alt. with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. Oxymatrine inhibits bocavirus minute virus of canines (MVC) replication, reduces viral gene expression and decreases apoptosis induced by viral infection .

HY-N0423

Sophoricoside 4 Publications Verification	Flavonoids Classification of Application Fields Leguminosae Sophora japonica (L.) Schott Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Isoflavones Source Classification	Others
Sophoricoside is an isoflavone glycoside isolated from Sophora japonica and has anti-inflammatory, anti-cancer and immunosuppressive effects.

HY-N1231

Sophoraflavanone G 3 Publications Verification Kushenol F	Flavonoids Classification of Application Fields Leguminosae Flavonones Phenols Polyphenols Sophora flavescens Aiton Plants Disease Research Fields Source Classification Cancer	Apoptosis
Sophoraflavanone G (Kushenol F) is iaolated from Sophora flavescens and shows anti-tumor and anti-inflammatory properties.? Sophoraflavanone G (Kushenol F) induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways .

HY-N2278

Kushenol A 4 Publications Verification Leachianone E	Flavonoids Classification of Application Fields Leguminosae Flavonones Phenols Polyphenols Sophora flavescens Aiton Plants Disease Research Fields Source Classification Cancer	Tyrosinase Glycosidase
Kushenol A (Leachianone E) is isolated from the root of Sophora flavescent. Kushenol A is a non-competitive tyrosinase inhibitor to block the conversion of L-tyrosine to L-DOPA, shows IC₅₀ and K_ivalues of 1.1 μM and 0.4 μM, respectively . Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase (IC₅₀: 45 μM; K_i: 6.8 μM) and β-amylase . Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging .

HY-N0616

Trifolirhizin	Structural Classification Flavonoids Classification of Application Fields Leguminosae Trifolium pratense Linn. Sophora flavescens Aiton Plants Other Flavonoids Inflammation/Immunology Disease Research Fields Source Classification Cancer	Tyrosinase TNF Receptor Bacterial Apoptosis Autophagy AMPK mTOR ERK NF-κB
Trifolirhizin is a pterocarpan flavonoid found in the roots of Sophora flavescens. Trifolirhizin is a tyrosinase inhibitor with an IC₅₀ value of 506.77 μM. Trifolirhizin reduces intracellular melanin production and modulates multiple signaling pathways including NFκB-MAPK, AMPK/mTOR, PI3K/Akt, MAPK-NFATc1 and EGFR-MAPK. Trifolirhizin targets biological molecules including PTK6 and COX-2, inhibits the activities of hyaluronidase, collagenase and elastase, induces apoptosis, autophagy and cell cycle arrest, and suppresses the proliferation, migration and invasion of cancer cells. Trifolirhizin exerts diverse pharmacological effects including anti-inflammatory, anti-asthmatic, bone-protective, renoprotective, antibacterial, antifungal, hepatoprotective, antiplatelet, estrogenic and wound-healing activities. Trifolirhizin can be used to investigate a broad range of malignant, inflammatory, metabolic and infectious disorders .

HY-N1373

Sophoridine 5+ Cited Publications	Alkaloids Classification of Application Fields Leguminosae Pyridine Alkaloids Sophora flavescens Aiton Plants Disease Research Fields Source Classification Cancer	Apoptosis
Sophoridine is a quinolizidine alkaloid isolated from Leguminous plant Sophora flavescens. Sophoridine induces apoptosis. Sophoridine has the potential to be a novel, potent and selective antitumor agent candidate for pancreatic cancer with well-tolerated toxicity .

HY-N6051

(-)-Maackiain	Infection Structural Classification Monophenols Classification of Application Fields Leguminosae Terpenoids Phenols Diterpenoids Sophora flavescens Aiton Plants Disease Research Fields Source Classification	Fungal NOD-like Receptor (NLR) NF-κB
(-)-Maackiain is a pterocarpan phytoalexin produced from Sophora flavescens. (-)-Maackiain is toxic to several genera of fungal pathogens of legume and non legume hosts. (-)-Maackiain enhances the activation of NLRP3 inflammasome, inhibits the activation of NF-κB pathway, exhibiting thereby immunostimulatory and anti-inflammatory activities. (-)-Maackiain is orally active .

HY-N1402

Oxysophoridine Sophoridine N-oxide	Alkaloids other families Classification of Application Fields Pyridine Alkaloids Plants Inflammation/Immunology Disease Research Fields Source Classification	Apoptosis
Oxysophoridine (Sophoridine N-oxide) is a bioactive alkaloid extracted from the Sophora alopecuroides Linn. Oxysophoridine (Sophoridine N-oxide) shows anti inflammatory, anti oxidative stress and anti apoptosis effects .

HY-N0746

Oxysophocarpine 5+ Cited Publications	Alkaloids Piperidine Alkaloids Classification of Application Fields Leguminosae Sophora alopecuroides L Plants Disease Research Fields Source Classification Cancer	Others
Oxysophocarpine is an alkaloid extracted from Sophora alopecuroides.?Oxysophocarpine has neuroprotective and anti-nociceptive effects on the central and peripheral nervous systems . Oxysophocarpine inhibits the?growth?and?metastasis?of ?oral?squamous?cell?carcinoma?(OSCC) .

HY-N2463

Kushenol E 1 Publications Verification	Flavonoids Classification of Application Fields Leguminosae Flavonones Phenols Polyphenols Moghania philippinensis (Merr. Et Rolfe) L. Plants Disease Research Fields Cancer Source Classification	Indoleamine 2,3-Dioxygenase (IDO)
Kushenol E is a class of flavonoids isolated from Sophora flavescens and is a non-competitive indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC₅₀ of 7.7 µM and a K_i of 9.5 µM, has anti-tumor activity .

HY-N1746

(2S)-2'-Methoxykurarinone 2'-O-Methylkurarinone	Flavonoids Classification of Application Fields Leguminosae Flavonones Phenols Polyphenols Metabolic Disease Sophora flavescens Aiton Plants Inflammation/Immunology Disease Research Fields Source Classification	RANKL/RANK
(2S)-2'-Methoxykurarinone, a compound isolated from the roots of Sophora flavescens, has anti-inflammatory, antipyretic, antidiabetic, and antineoplastic effects. (2S)-2'-Methoxykurarinone (MK) inhibits osteoclastogenesis and bone resorption through down-regulation of RANKL signaling. (2S)-2'-Methoxykurarinone (MK) displays cytotoxic activity against human myeloid leukemia HL-60 cells .

HY-N2529

Sophoranone (-)-Sophoranone; Sophoranon	Flavonoids Leguminosae Flavonones Sophora tonkinensis Gagnep. Plants Source Classification	Others
Sophoranone is a flavonoid compound that can be isolated from the root of Sophora subprostrata .

HY-N0050

Allomatrine (+)-Allomatrine	Alkaloids Piperidine Alkaloids Leguminosae Sophora japonica L. Plants Source Classification	Others
Allomatrine ((+)-Allomatrine) is an alkaloid from the bark of Sophora japonica. Allomatrine has antinociceptive properties mediated mainly through the activation ofκ-opioid receptors .

HY-N8097

Kushenol W	Infection Flavonoids Classification of Application Fields Leguminosae Flavonones Phenols Polyphenols Plants Sophora flavescens Aiton Disease Research Fields Source Classification	Bacterial
Kushenol W is a prenylated flavonoid that can be isolated from the root of Sophora flavescens. Kushenol W has antimicrobial effect, with a MIC of 10 μg/mL for Staphylococcus aureus .

HY-N5096

Sophorabioside	Flavonoids Classification of Application Fields Leguminosae Other Diseases Sophora japonica (L.) Schott Phenols Polyphenols Plants Disease Research Fields Isoflavones Source Classification	Others
Sophorabioside is a flavonoid-glycoside isolated from Sophora japonica .

HY-108966

Kushenol C	Flavonols Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Plants Sophora flavescens Aiton Disease Research Fields Inflammation/Immunology Source Classification	Beta-secretase
Kushenol C, isolated from the roots of Sophora flavescens, shows anti-Inflammatory and anti-oxidative stress activities. Kushenol C inhibits BACE1 (β-site APP cleaving enzyme 1) with an IC₅₀ of 5.45 µM .

HY-N8228

17-Hydroxyneomatrine	Alkaloids Leguminosae Other Alkaloids Plants Sophora flavescens Aiton Source Classification	Bacterial
17-Hydroxyneomatrine, extracted from Sophora flavescens, can well inhibit the growth of human cervical carcinoma Hela cells, has the wide-range antibacterial, anti-allergy, anti-tumor, anti-arrhythmia, swelling-subsiding diuresis, immunizing, and biological regulation functions .

HY-N16616

9α-Hydroxysophocarpine	Structural Classification Alkaloids Leguminosae Quinolizidine Alkaloids Sophora tonkinensis Gagnep. Plants Source Classification	Enterovirus
9α-Hydroxysophocarpine ((-)-9α-hydroxysophocarpine) is an alkaloid. 9α-Hydroxysophocarpine can be isolated from the rhizomes of Sophora tonkinensis. 9α-Hydroxysophocarpine exhibits antiviral activity against the Coxsackie virus B3 (CVB3) .

HY-N3198A

Sophoramine 1 Publications Verification (-)-Sophoramine	Alkaloids Structural Classification Classification of Application Fields Leguminosae Other Diseases Pyridine Alkaloids Sophora flavescens Aiton Plants Disease Research Fields Source Classification	Adrenergic Receptor
Sophoramine ((-)-Sophoramine) is a prejunctional α₂-adrenoceptor inhibitor that can be found in the seeds of Sophora alopecuroides. Sophoramine inhibits prejunctional α2-adrenoceptors to facilitate norepinephrine release from adrenergic nerves. Sophoramine shows cytotoxic activity against human cancer cells, positive inotropic activity, and activity in rodent arrhythmia models. Sophoramine can be used for the research of arrhythmias .

HY-121381

Kuraridine	Chalcones Flavonoids Classification of Application Fields Leguminosae Other Diseases Phenols Polyphenols Sophora flavescens Aiton Plants Disease Research Fields Source Classification	Phosphodiesterase (PDE)
Kuraridine is a prenylated flavonol extract from the roots of Sophora flavescens. Kuraridine has an inhibitory effect on cGMP specific phosphodiesterase type 5 (PDE5) (IC₅₀=0.64 μM) .

HY-N2286

Kushenol I 1 Publications Verification	Flavanonols Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Plants Sophora flavescens Aiton Disease Research Fields Inflammation/Immunology Source Classification	Others
Kushenol I is a natural compound isolated from the roots of Sophora flavescens .

HY-N11671

9α-Hydroxymatrine	Alkaloids Leguminosae Artemisia carvifolia Buch.-Ham. ex Roxb. Plants Source Classification	Others
9α-Hydroxymatrine is a quinolizidine alkaloid that can be found in the leaves of Sophora macrocarpa .

HY-N6052

(+)-Medicarpin	Monophenols other families Classification of Application Fields Terpenoids Phenols Diterpenoids Plants Disease Research Fields Cancer Source Classification	Estrogen Receptor/ERR
(+)-Medicarpin, a pterocarpan, is a type of isoflavonoid isolated from several medicinal plant species with various biological effects, including Sophora japonica, Zollernia paraensis and Platymiscium yucatamun, Machaerium aristulatum, Platymiscium floribundum, and so on. (+)-Medicarpin potently inhibits osteoclastogenesis and promotes bone healing and increases bone mass by osteoblast differentiation with estrogen receptor (ER) β-mediated osteogenic action .

HY-N6051R

(-)-Maackiain (Standard)	Structural Classification Monophenols Leguminosae Terpenoids Phenols Diterpenoids Sophora flavescens Aiton Plants Source Classification	Reference Standards Fungal NOD-like Receptor (NLR) NF-κB
(-)-Maackiain (Standard) is the analytical standard of (-)-Maackiain. This product is intended for research and analytical applications. (-)-Maackiain is a pterocarpan phytoalexin produced from Sophora flavescens. (-)-Maackiain is toxic to several genera of fungal pathogens of legume and non legume hosts. (-)-Maackiain enhances the activation of NLRP3 inflammasome, inhibits the activation of NF-κB pathway, exhibiting thereby immunostimulatory and anti-inflammatory activities. (-)-Maackiain is orally active .

HY-N8095

Kushenol N	Cardiovascular Disease Flavanonols Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Plants Sophora flavescens Aiton Disease Research Fields Source Classification	Others
Kushenol N is a prenylated flavonoid that can be isolated from the root of Sophora flavescens. Kushenol N has anti-allergic and vasorelaxation activities .

HY-N3413

Kushenol X	Flavanonols Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Metabolic Disease Sophora flavescens Aiton Plants Disease Research Fields Source Classification	Carboxylesterase (CES) β-glucuronidase
Kushenol X, a flavonoid compound isolated from the roots of Sophora flavescens. Kushenol X is a potent β-glucuronidase and human carboxylesterase 2 (hCE2) inhibitor with IC₅₀s of 2.07 μM and 3.05 μM, respectively .

HY-N1373A

d-Sophoridine (+)-Sophoridine	Alkaloids Leguminosae Other Alkaloids Plants Sophora flavescens Aiton Source Classification	Apoptosis
d-Sophoridine ((+)-Sophoridine) is the dextro isoform of Sophoridine (HY-N1373), which is a quinolizidine alkaloid isolated from Leguminous plant Sophora flavescens. Sophoridine induces apoptosis. Sophoridine has the potential to be a novel, potent and selective antitumor agent candidate for pancreatic cancer with well-tolerated toxicity .

HY-N0746R

Oxysophocarpine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Leguminosae Sophora alopecuroides L Plants Source Classification	Reference Standards Others
Oxysophocarpine (Standard) is the analytical standard of Oxysophocarpine. This product is intended for research and analytical applications. Oxysophocarpine is an alkaloid extracted from Sophora alopecuroides. Oxysophocarpine has neuroprotective and anti-nociceptive effects on the central and peripheral nervous systems . Oxysophocarpine inhibits the growth and metastasis of oral squamous cell carcinoma (OSCC) .

HY-N8998

Sophoraflavanone I	Leguminosae Phenols Polyphenols Inula nervosa Wall. Plants Source Classification	Others
Sophoraflavanone I the seeds of Sophora moorcroftiana BENTH. ex. BAKER (Leguminosae) .

HY-N7806

7,3'-Di-O-Methylorobol	Flavonoids Flavones Leguminosae Sophora japonica (L.) Schott Plants Source Classification	Others
7,3'-Di-O-Methylorobol is a flavone that can be isolated from Sophora japonica .

HY-N13187

7,3'-Dihydroxy flavonone-4'-O-β-D-glucopyranoside	Flavonoids Leguminosae Flavonones Sophora alopecuroides L Plants Source Classification	Others
7,3'-Dihydroxy flavonone-4'-O-β-D-glucopyranoside is derivated from the seeds of Sophora alopecuroides L. .

HY-N1344

Robtin	Flavonoids Leguminosae Flavonones Plants Sophora yunnanensis C. Y. Ma Source Classification	Others
Robtin (Compound 4) is a natural product isolated and purified from Sophora yunnanensis. Robtin has cardiotonic activity .

HY-N2779

8-Lavandulylkaempferol	Flavonoids Flavones Leguminosae Plants Sophora flavescens Aiton Source Classification	Others
8-Lavandulylkaempferol is a flavonoid that can be isolated from Sophora flaWescens. 8-Lavandulylkaempferol exhibits cytotoxic activity against the KB epidermoid carcinoma cell line with an IC₅₀ of 15.1 μg/mL .

HY-N1287

Sepinol	Sophora davidii Kom. ex Pavol. Flavonoids Plants Fabaceae Source Classification	Others
Sepinol is a Flavonoids product that can be isolated from the herbs of Sophora viciifolia .

HY-N8964

Sophoraflavanone H	Flavonoids Leguminosae Flavonones Inula nervosa Wall. Plants Source Classification	Others
Sophoraflavanone H is a Flavonoids product that can be isolated from the roots of Sophora moorcroftiana. .

HY-N1574

Puerol A	Phenols Polyphenols Styphnolobium japonicum (L.) Schott Plants Fabaceae Source Classification	Others
Puerol A is a Phenols product that can be isolated from the stem barks of Sophora japonica. .

HY-N10787

Methylkushenol C	Flavonoids Leguminosae Plants Sophora flavescens Aiton Isoflavones Source Classification	Others
Methylkushenol C is a phenolic substance. Methylkushenol C can be isolated from Sophora flavescens .

HY-N2847

alpha-Isowighteone	Flavonoids Leguminosae Sophora flavescens Aiton Plants Source Classification	Others
alpha-Isowighteone is a Flavonoids product that can be isolated from the roots of Sophora flavescens .

HY-N8899

Daidzein-4'-glucoside	Flavonoids Styphnolobium japonicum (L.) Schott Plants Isoflavones Fabaceae Source Classification	Others
Daidzein-4'-glucoside is a Flavonoids product that can be isolated from the fruits of Sophora japonica L. .

HY-N9083

8α-Hydroxy-α-gurjunene	Flavonoids Leguminosae Plants Sophora tomentosa L. Source Classification	Others
8α-Hydroxy-α-gurjunene is a Flavonoids product that can be isolated from the aerial parts of Sophora tomentosa L. .

HY-122933

Kurarinol	Cardiovascular Disease Flavonoids Classification of Application Fields Leguminosae Flavonones Phenols Polyphenols Plants Sophora flavescens Aiton Disease Research Fields Source Classification	Tyrosinase Apoptosis
Kurarinol is a flavanone found in the root of Sophora flavescens. Kurarinol is a competitive tyrosinase inhibitor, with IC₅₀ of 0.1 μM for mushroom tyrosinase .

HY-13516R

Aloperine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Leguminosae Sophora alopecuroides L Plants Source Classification	Apoptosis Autophagy Filovirus HIV Reference Standards
Aloperine (Standard) is the analytical standard of Aloperine. This product is intended for research and analytical applications. Aloperine is an alkaloid in sophora plants such as Sophora alopecuroides L, which has shown anti-cancer, anti-inflammatory and anti-virus properties . Aloperine is widely used to treat patients with allergic contact dermatitis eczema and other skin inflammation in China . Aloperine induces apoptosis and autophagy in HL-60 cells .

HY-N0423R

Sophoricoside (Standard)	Structural Classification Flavonoids Leguminosae Sophora japonica (L.) Schott Phenols Polyphenols Plants Isoflavones Source Classification	Reference Standards Others
Sophoricoside (Standard) is the analytical standard of Sophoricoside. This product is intended for research and analytical applications. Sophoricoside is an isoflavone glycoside isolated from Sophora japonica and has anti-inflammatory, anti-cancer and immunosuppressive effects.

HY-N8094

Kushenol M	Flavanonols Flavonoids Classification of Application Fields Leguminosae Other Diseases Phenols Polyphenols Plants Sophora flavescens Aiton Disease Research Fields Source Classification	Cytochrome P450
Kushenol M is a flavonoid from Sophora flavescens. Kushenol M is a cytochrome P450 (CYP) inhibitor, with IC₅₀ values of 1.29 μM for CYP3A4 in human liver microsomes .

HY-N5143

(2R)-3α,7,4'-Trihydroxy-5-methoxy-8-prenylflavanone	Flavonoids Classification of Application Fields Leguminosae Isoflavanones Other Diseases Phenols Polyphenols Plants Sophora flavescens Aiton Disease Research Fields Source Classification	Others
(2R)-3α,7,4'-Trihydroxy-5-methoxy-8-prenylflavanone is isolated from the roots of Sophora flavescens .

HY-N3414

Kushenol L	Flavanonols Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Metabolic Disease Sophora flavescens Aiton Plants Disease Research Fields Source Classification	Others
Kushenol L is one of the main components of EtOA cextracts from Kushen, a traditional medicinal herb derived from the dried roots of Sophora flavescens Ait. Kushenol L is a flavonoid and plays an important role in anti-diabeticeffects .

HY-N5129

Genistein 7-O-β-D-glucopyranoside-4'-O-[α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside]	Flavonoids Classification of Application Fields Leguminosae Other Diseases Sophora japonica (L.) Schott Phenols Polyphenols Plants Disease Research Fields Isoflavones Source Classification	Others
Genistein 7-O-β-D-glucopyranoside-4'-O-[α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside] is an isoflavone triglycoside that could be isolated from Sophora japonica .

HY-N0616R

Trifolirhizin (Standard)	Structural Classification Flavonoids Leguminosae Trifolium pratense Linn. Sophora flavescens Aiton Plants Other Flavonoids Source Classification	TNF Receptor Reference Standards Tyrosinase
Trifolirhizin (Standard) is the analytical standard of Trifolirhizin. This product is intended for research and analytical applications. Trifolirhizin is a pterocarpan flavonoid isolated from the roots of Sophora flavescens. Trifolirhizin possesses potent tyrosinase inhibitory activity with an IC₅₀ of 506 μM . Trifolirhizin exhibits potential anti-inflammatory and anticancer activities .

Cat. No.	Product Name	Chemical Structure

HY-W654256

Matrine-d3

Matrine-d₃ (Matridin-d₃) is a deuterium labeled Matrine (HY-N0164). Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus that can act as a kappa opioid receptor and u-receptor agonist. Matrine has a variety of pharmacological effects, including anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. Matrine is potential in the research of disease like human non-small cell lung cancer, hepatoma, papillary thyroid cancer and acute kidney injury (AKI) .

HY-W750902

Oxymatrine-d3

Oxymatrine-d₃ is the deuterium labeled Oxymatrine (HY-N0158). Oxymatrine, an alkaloid from Sophora flavescens Alt. with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. Oxymatrine inhibits bocavirus minute virus of canines (MVC) replication, reduces viral gene expression and decreases apoptosis induced by viral infection .

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