2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Sophoramine

Sophoramine ((-)-Sophoramine) is a prejunctional α2-adrenoceptor inhibitor that can be found in the seeds of Sophora alopecuroides. Sophoramine inhibits prejunctional α2-adrenoceptors to facilitate norepinephrine release from adrenergic nerves. Sophoramine shows cytotoxic activity against human cancer cells, positive inotropic activity, and activity in rodent arrhythmia models. Sophoramine can be used for the research of arrhythmias.

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Sophoramine

Sophoramine Chemical Structure

CAS No. : 6882-66-2

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Based on 1 publication(s) in Google Scholar

Other Forms of Sophoramine:

Sophoramine Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Sophoramine

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α adrenergic receptor β adrenergic receptor

  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

Sophoramine ((-)-Sophoramine) is a prejunctional α2-adrenoceptor inhibitor that can be found in the seeds of Sophora alopecuroides. Sophoramine inhibits prejunctional α2-adrenoceptors to facilitate norepinephrine release from adrenergic nerves. Sophoramine shows cytotoxic activity against human cancer cells, positive inotropic activity, and activity in rodent arrhythmia models. Sophoramine can be used for the research of arrhythmias[1][2].

IC50 & Target[1]

α2-adrenergic receptor

 

Cellular Effect
Cell Line Type Value Description References
A549 IC50
>40 μM
Compound: 4
Antiproliferative activity against human A549 cells after 3 days by SRB assay
Antiproliferative activity against human A549 cells after 3 days by SRB assay
[PMID: 26865176]
KB IC50
>40 μM
Compound: 4
Antiproliferative activity against human KB cells after 3 days by SRB assay
Antiproliferative activity against human KB cells after 3 days by SRB assay
[PMID: 26865176]
MDA-MB-231 IC50
>40 μM
Compound: 4
Antiproliferative activity against human MDA-MB-231 cells after 3 days by SRB assay
Antiproliferative activity against human MDA-MB-231 cells after 3 days by SRB assay
[PMID: 26865176]
MDCK IC50
63.07 μM
Compound: 17
Antiviral activity against influenza A virus (A/Hanfang/359/95(H3N2)) infected in MDCK cells assessed as inhibition of virus-induced cytopathogenic effect dosed 1 hr after viral adsorption
Antiviral activity against influenza A virus (A/Hanfang/359/95(H3N2)) infected in MDCK cells assessed as inhibition of virus-induced cytopathogenic effect dosed 1 hr after viral adsorption
[PMID: 26132528]
In Vitro

Sophoramine (10-4-10-3 M) produces a concentration-dependent relaxation in dog vessels and coronary[2].
Sophoramine (10-4 M) potentiates the contractile response to ransmuraf stimulation in dog mesenteric arteries and veins[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sophoramine Related Antibodies
Molecular Weight

244.33

Formula

C15H20N2O
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1N2C([C@]3([H])[C@]4([H])[C@](CCCN4CCC3)([H])C2)=CC=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 99%

SDS (251 KB)

COA (254 KB)

Handling Instructions (2659 KB)
References
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Sophoramine Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sophoramine6882-66-2(-)-SophoramineAdrenergic ReceptorBeta Receptorcanine mesenteric veinsrodent arrhythmia modelsguinea pig papillary musclecanine arterial stripscanine venous stripscanine mesenteric arteriesadrenergic nerveshuman cancer cellsα2-adrenoceptornorepinephrineInhibitorinhibitorinhibit

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