A novel alkaloid from the seeds of Sophora alopecuroides L

  • Nat Prod Res. 2022 Apr;36(7):1864-1869. doi: 10.1080/14786419.2020.1824226.
Zi-Jian Rong  1 ,  Xiao-Xu Gao  1 ,  Gao-Sheng Hu  1 ,  Ting Yan  1 ,  Jing-Ming Jia  1 ,  An-Hua Wang  1
Affiliations
  • 1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
PMID: 32962440 DOI: 10.1080/14786419.2020.1824226
Abstract

A new cytisine-type alkaloid, along with five known Alkaloids was obtained from the seeds of Sophora alopecuroides. Their structures were determined to be (-)-N-(2'-hydroxy-3',5'-di-tert-butyl-toluene)-cytisine (1), (-)-lupanine (2), (+)-matrine (3), (+)-sophoramine (4), (+)-lehmannine (5) and (-)-sophocarpine (6). Their structures were established by NMR, ECD and HRESIMS data analyses. Their cytotoxicity effects against five human tumor cell lines were tested by MTT assay. Compound 1 has showed a wide range of cytotoxicity activities against varied tumor cells in vitro.

Keywords
Sophora alopecuroides L.; cytisine-type alkaloid; cytotoxicity activity.
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