6882-66-2
6882-66-2
Chemical Structure
Sophoramine
Synonym(s): (-)-Sophoramine
- CAS No.: 6882-66-2
- Formula:C15H20N2O
- Molecular Weight:244.33
IUPAC Name: (41S,7aS,13bS)-2,3,41,6,7,7a,8,13b-octahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one
InChIKey: MMCQRJPAMIHLQX-ZOWXZIJZSA-N
SMILES: O=C1N2C([C@]3([H])[C@]4([H])[C@](CCCN4CCC3)([H])C2)=CC=C1
Biological Activity: Sophoramine ((-)-Sophoramine) is a prejunctional α2-adrenoceptor inhibitor that can be found in the seeds of Sophora alopecuroides. Sophoramine inhibits prejunctional α2-adrenoceptors to facilitate norepinephrine release from adrenergic nerves. Sophoramine shows cytotoxic activity against human cancer cells, positive inotropic activity, and activity in rodent arrhythmia models. Sophoramine can be used for the research of arrhythmias[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Sophoramine | 99% | Sophoramine ((-)-Sophoramine) is a prejunctional α2-adrenoceptor inhibitor that can be found in the seeds of Sophora alopecuroides. Sophoramine inhibits prejunctional α2-adrenoceptors to facilitate norepinephrine release from adrenergic nerves. Sophoramine shows cytotoxic activity against human cancer cells, positive inotropic activity, and activity in rodent arrhythmia models. Sophoramine can be used for the research of arrhythmias. | ||||||||||||||||||||
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Anagyrine | 99.9% | Anagyrine ((-)-Anagyrine) is a quinolizidine alkaloid that has been found in Lupinus albus. Anagyrine binds to muscarinic and nicotinic acetylcholine receptors with IC50 values of 132 and 2096 µM respectively. Anagyrine is a potent and effective desensitizer of nAChR, and Anagyrine can directly, without metabolism, desensitize nAChR. | ||||||||||||||||||||
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Anagyrine hydrochloride | Anagyrine ((-)-Anagyrine) hydrochloride is a quinolizidine alkaloid that has been found in Lupinus albus. Anagyrine hydrochloride binds to muscarinic and nicotinic acetylcholine receptors with IC50 values of 132 and 2096 µM respectively. Anagyrine hydrochloride is a potent and effective desensitizer of nAChR, and Anagyrine hydrochloride can directly, without metabolism, desensitize nAChR. | |||||||||||||||||||||
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Cytisinicline (Standard) | 99.90% | Cytisinicline (Standard) is the analytical standard of Cytisinicline. This product is intended for research and analytical applications. Cytisinicline (Cytisine) is an alkaloid. Cytisinicline (Cytisine) is a partial agonist of α4β2 nAChRs, and partial to full agonist at β4 containing receptors and α7 receptors. Has been used medically to help with smoking cessation. | ||||||||||||||||||||
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N-Methylcytisine (Standard) | ≥98% | N-Methylcytisine (Standard) is the analytical standard of N-Methylcytisine. This product is intended for research and analytical applications. N-Methylcytisine (Caulophylline), a tricyclic quinolizidine alkaloid, exerts hypoglycaemic, analgesic and anti-inflammatory activities. N-methylcytisine is a selective ligand of nicotinic receptors of acetylcholine in the central nervous system and has a high affinity (Kd = 50 nM) to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia. | ||||||||||||||||||||
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N-Acetylcytisine | N-Acetylcytisine is a kind of alkaloid. N-Acetylcytisine can be isolated from T. maderensis. | |||||||||||||||||||||
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(R)-Sophoramine | (R)-Sophoramine ((R)-(-)-Sophoramine) is a natural alkaloid. | |||||||||||||||||||||
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Thermopsine | 99.31% | Thermopsine is a quinolone-type alkaloid. Thermopsine exhibits low to moderate anti-E. faecalis activity. | ||||||||||||||||||||
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N-Formylcytisine | 99.17% | N-Formylcytisine is a cytisine-type alkaloid from the stem bark of Maackia amurensis. | ||||||||||||||||||||
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Rhombifoline | 96.06% | Rhombifoline is an alkaloid isolated for the first time from the leaves and stems of A. foetida L.. | ||||||||||||||||||||
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Baptifoline | 99.0% | Baptifoline is an alkaloid isolated from the rhizome of Caulophyllum thalictroides. | ||||||||||||||||||||
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References
- [1]. Rong ZJ, et al. A novel alkaloid from the seeds of Sophora alopecuroides L. Nat Prod Res. 2022 Apr;36(7):1864-1869. [Content Brief]
- [2]. Bian K, et al. Effects of sophoramine, an alkaloid from Sophora alopecuroides on isolated dog blood vessels. J Ethnopharmacol. 1988;24(2-3):167-178. [Content Brief]
