6882-66-2
Chemical Structure
Sophoramine
Synonym(s): (-)-Sophoramine
- CAS No.: 6882-66-2
- Formula:C15H20N2O
- Molecular Weight:244.33
IUPAC Name: (41S,7aS,13bS)-2,3,41,6,7,7a,8,13b-octahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one
InChIKey: MMCQRJPAMIHLQX-ZOWXZIJZSA-N
SMILES: O=C1N2C([C@]3([H])[C@]4([H])[C@](CCCN4CCC3)([H])C2)=CC=C1
Biological Activity: Sophoramine ((-)-Sophoramine) is a prejunctional α2-adrenoceptor inhibitor that can be found in the seeds of Sophora alopecuroides. Sophoramine inhibits prejunctional α2-adrenoceptors to facilitate norepinephrine release from adrenergic nerves. Sophoramine shows cytotoxic activity against human cancer cells, positive inotropic activity, and activity in rodent arrhythmia models. Sophoramine can be used for the research of arrhythmias[1][2].
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Sophoramine | 99% | Sophoramine ((-)-Sophoramine) is a prejunctional α2-adrenoceptor inhibitor that can be found in the seeds of Sophora alopecuroides. Sophoramine inhibits prejunctional α2-adrenoceptors to facilitate norepinephrine release from adrenergic nerves. Sophoramine shows cytotoxic activity against human cancer cells, positive inotropic activity, and activity in rodent arrhythmia models. Sophoramine can be used for the research of arrhythmias. | ||||||||||||||||||||
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- [1]. Rong ZJ, et al. A novel alkaloid from the seeds of Sophora alopecuroides L. Nat Prod Res. 2022 Apr;36(7):1864-1869. [Content Brief]
- [2]. Bian K, et al. Effects of sophoramine, an alkaloid from Sophora alopecuroides on isolated dog blood vessels. J Ethnopharmacol. 1988;24(2-3):167-178. [Content Brief]
Keywords
