54809-74-4
54809-74-4
Chemical Structure
Oxysophoridine
Synonym(s): Sophoridine N-oxide
- CAS 番号: 54809-74-4
- Formula:C15H24N2O2
- Molecular Weight:264.36
IUPAC Name: (41S,7aR,13aR,13bR)-10-oxododecahydro-1H,5H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridine 4(41H)-oxide
InChIKey: XVPBINOPNYFXID-ACTGZQEFSA-N
SMILES: O=N12[C@]3([H])[C@@](CCC2)([H])[C@]4([H])N(C(CCC4)=O)C[C@@]3([H])CCC1
Biological Activity: Oxysophoridine (Sophoridine N-oxide) is a bioactive alkaloid extracted from the Sophora alopecuroides Linn. Oxysophoridine (Sophoridine N-oxide) shows anti inflammatory, anti oxidative stress and anti apoptosis effects[1][2].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Oxysophoridine | 99.18% | Oxysophoridine (Sophoridine N-oxide) is a bioactive alkaloid extracted from the Sophora alopecuroides Linn. Oxysophoridine (Sophoridine N-oxide) shows anti inflammatory, anti oxidative stress and anti apoptosis effects. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Leontine | Leontine is a biochemical assay reagent. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Allomatrine | 99.98% | Allomatrine ((+)-Allomatrine) is an alkaloid from the bark of Sophora japonica. Allomatrine has antinociceptive properties mediated mainly through the activation ofκ-opioid receptors. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Oxymatrine (Standard) | ≥98% | Oxymatrine (Standard) is the analytical standard of Oxymatrine. This product is intended for research and analytical applications. Oxymatrine, an alkaloid from Sophora flavescens Alt. with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. Oxymatrine inhibits bocavirus minute virus of canines (MVC) replication, reduces viral gene expression and decreases apoptosis induced by viral infection. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Matrine (Standard) | ≥98% | Matrine (Standard) is the analytical standard of Matrine. This product is intended for research and analytical applications. Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus that can act as a kappa opioid receptor and u-receptor agonist. Matrine has a variety of pharmacological effects, including anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. Matrine is potential in the research of disease like human non-small cell lung cancer, hepatoma, papillary thyroid cancer and acute kidney injury (AKI). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Oxysophocarpine (Standard) | ≥98% | Oxysophocarpine (Standard) is the analytical standard of Oxysophocarpine. This product is intended for research and analytical applications. Oxysophocarpine is an alkaloid extracted from Sophora alopecuroides. Oxysophocarpine has neuroprotective and anti-nociceptive effects on the central and peripheral nervous systems. Oxysophocarpine inhibits the growth and metastasis of oral squamous cell carcinoma (OSCC). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
9α-Hydroxymatrine | 9α-Hydroxymatrine is a quinolizidine alkaloid that can be found in the leaves of Sophora macrocarpa. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Sophoridine | 99.66% | Sophoridine is a quinolizidine alkaloid isolated from Leguminous plant Sophora flavescens. Sophoridine induces apoptosis. Sophoridine has the potential to be a novel, potent and selective antitumor agent candidate for pancreatic cancer with well-tolerated toxicity. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
d-Sophoridine | d-Sophoridine ((+)-Sophoridine) is the dextro isoform of Sophoridine (HY-N1373), which is a quinolizidine alkaloid isolated from Leguminous plant Sophora flavescens. Sophoridine induces apoptosis. Sophoridine has the potential to be a novel, potent and selective antitumor agent candidate for pancreatic cancer with well-tolerated toxicity. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Lupanine | 98.2% | Lupanine (D-Lupanine) is a natural ketonic derivative of Sparteine (HY-W008350) with a ganglioplegic activity. Lupanine shows binding affinity for nicotinic receptor with a Ki value of 500 nM. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Lupanine hydrochloride | Lupanine (D-Lupanine) hydrochloride is a natural ketonic derivative of Sparteine (HY-W008350) with a ganglioplegic activity. Lupanine hydrochloride shows binding affinity for nicotinic receptor with a Ki value of 500 nM. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Cao Z, et al. Oxysophoridine rescues spinal cord injury via anti inflammatory, anti oxidative stress and anti apoptosis effects. Mol Med Rep. 2018 Feb;17(2):2523-2528. [Content Brief]
- [2]. Wang YS, et al. Anti-inflammation Effects of Oxysophoridine on Cerebral Ischemia-Reperfusion Injury in Mice. Inflammation. 2015 Dec;38(6):2259-68. [Content Brief]
