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Sulfonylurea

" in MedChemExpress (MCE) Product Catalog:

90

Inhibitors & Agonists

1

Fluorescent Dyes

4

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3

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17

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0089
    Acarbose
    5+ Cited Publications

    BAY g 5421

    		 Glycosidase Infection Metabolic Disease Cancer
    Acarbose (BAY g 5421), antihyperglycemic agent, is an orally active alpha-glucosidase inhibitor (IC50=11 nM). Acarbose can potentiate the hypoglycemic effects of sulfonylureas or insulin .
    Acarbose
  • HY-B0104
    Glimepiride
    5+ Cited Publications

    Glimperide; HOE-490

    		 Amyloid-β Neurological Disease Metabolic Disease
    Glimepiride (Glimperide) is a medium-to-long acting sulfonylurea anti-diabetic compound with an ED50 of 182 μg/kg.
    Glimepiride
  • HY-B0920
    Tolazamide
    2 Publications Verification

    U-17835

    		 Potassium Channel Metabolic Disease Endocrinology
    Tolazamide (U-17835) is an orally active sulfonylurea agent that inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (IC50 = 4.2 µM in HEK293 cells transfected with the human receptor). Tolazamide has anti-diabetic properties. Tolazamide can lower blood glucose in sulfonylurea class. Tolazamide decreases insulin dose while continuing to maintain adequate metabolic control. Tolazamide is able to improve or normalize hyperglycemia and HbA .
    Tolazamide
  • HY-137245
    Emlenoflast

    MCC7840

    		 NOD-like Receptor (NLR) Inflammation/Immunology
    Emlenoflast (MCC7840), a sulfonylurea, is a potent and selective inhibitor of NLRP3 inflammasome, with an IC50 of <100 nM. Emlenoflast can be used for the research of inflammatory diseases .
    Emlenoflast
  • HY-156798
    ADS032
    3 Publications Verification

    		 NOD-like Receptor (NLR) Interleukin Related Inflammation/Immunology
    ADS032 is a sulfonylurea compound that is an NLRP1 and NLRP3 inflammasome inhibitor. ADS032 reduces the secretion of inflammatory factors and inhibits the oligomerization of ASC. ADS032 has anti-inflammatory effects in a variety of inflammatory models and can be used in the study of inflammatory diseases .
    ADS032
  • HY-D2468
    HRP-Streptavidin
    1 Publications Verification

    		 Fluorescent Dye Others
    Sulfonylurea Receptor HRP-Streptavidin is a biotin-binding signal amplifier designed to bind tightly with biotinylated anti-TSH monoclonal antibodies, thereby constituting a key component of the signal amplification system in immunoassays. HRP-Streptavidin is formed by the covalent coupling of Horseradish Peroxidase (HRP) with Streptavidin; it combines the highly efficient catalytic activity of the enzyme with the high affinity of Streptavidin for biotin, making it a potent and sensitive tool for signal amplification. HRP-Streptavidin is suitable for use in Western Blotting, ELISA, and other detection techniques .
    HRP-Streptavidin
  • HY-B0254
    Glipizide
    2 Publications Verification

    CP 28720; K 4024

    		 Potassium Channel Metabolic Disease Cancer
    Glipizide (CP 2872; K 4024)?a potent, orally active and sulfonylurea class anti-diabetic agent and can be used for type 2?diabetes mellitus research but not type 1. Glipizide acts by partially blocking ATP-sensitive potassium?(KATP) channels among β cells of pancreatic islets of Langerhans .
    Glipizide
  • HY-118742
    Benzobicyclon

    		Environmental Pollutants HPPD Others
    Benzobicyclon is a 4-HPPD inhibitor and herbicide that reacts with water to form a hydrolysate of the active herbicide benzobicycline, causing bleaching and death of weeds. Benzobicyclon is effective against grass, sedge and broadleaf weeds. Benzobicyclon effectively targets sulfonylurea herbicide-resistant biotypes as well as wild-type weeds .
    Benzobicyclon
  • HY-108573
    P-1075
    1 Publications Verification

    		 Potassium Channel Cardiovascular Disease
    P-1075 is a potent activator of sulfonylurea receptor 2-associated ATP-sensitive potassium channels (SUR2-KIR6), with an EC50 value of 45 nM for SUR2B-KIR6 channel activation . P-1075 also P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts .
    P-1075
  • HY-B1876
    Nicosulfuron

    		Environmental Pollutants Acetolactate Synthase (ALS) Others
    Nicosulfuron is efficient, harmless, antifungal and selective herbicide belonging to the sulfonylurea family. Nicosulfuron is also a photosynthetic system inhibitor and inhibits acetolactate synthase (ALS) enzyme activity. Nicosulfuron degradation by Plectosphaerella cucumerina AR1 is glucose concentration dependent in planktonic lifestyle. Nicosulfuron enhances the glycolysis pathway and tricarboxylic acid cycle to improve the adaptability of sweet maize. Nicosulfuron reduces the synthesis of branched-chain amino acids (BCAAs), which is proming for maize cultivation .
    Nicosulfuron
  • HY-W011651
    Carbutamide

    BZ-55

    		 Phosphatase Metabolic Disease
    Carbutamide (BZ-55) is an orally active and first-generation sulfonylurea with hypoglycemic activity .
    Carbutamide
  • HY-B0881
    Acetohexamide
    2 Publications Verification

    		 Potassium Channel Metabolic Disease Cancer
    Acetohexamide is an orally active first-generation sulfonylurea agent used in research related to type 2 diabetes and cancer. Acetohexamide exerts reductase activity in human erythrocytes. Acetohexamide stimulates the pancreas to secrete insulin. Acetohexamide inhibits ATP-sensitive potassium channels in the β cells of the pancreas. Acetohexamide can inhibit the formation of circular chemorepellent induced defects (CCIDs) in lymphendothelial cell (LEC) monolayers. Acetohexamide inhibits markers of epithelial-to-mesenchymal-transition and migration. Acetohexamide suppresses the synthesis of 12(S)-HETE. Acetohexamide can potentiate hypoglycaemic action .
    Acetohexamide
  • HY-100641
    4-Hydroxytolbutamide

    Hydroxytolbutamide

    		 Potassium Channel Autophagy Metabolic Disease Cancer
    4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic .
    4-Hydroxytolbutamide
  • HY-137245A
    Emlenoflast sodium

    MCC7840 sodium

    		 NOD-like Receptor (NLR) Inflammation/Immunology
    Emlenoflast (MCC7840) sodium, a sulfonylurea, is a potent and selective inhibitor of NLRP3 inflammasome, with an IC50 of <100 nM. Emlenoflast sodium can be used for the research of inflammatory diseases .
    Emlenoflast sodium
  • HY-P5290
    HYNIC-PSMA

    		Radionuclide-Drug Conjugates (RDCs) PSMA Cancer
    HYNIC-PSMA is a ligand for molecular imaging of tumors. Hynic-psma consists of two components: HYNIC (6-hydrazinonicotinamide) and PSMA (Prostate-Specific Membrane Antigen). HYNIC is a compound used to attach radioactive isotopes to targeted molecules, such as 188Re-HYNIC-PSMA. PSMA is a membrane antigen that is specifically expressed on the surface of prostate cancer cells. HYNIC-PSMA can be used in prostate cancer research . HYNIC-PSMA can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
    HYNIC-PSMA
  • HY-B0254R
    Glipizide (Standard)

    CP 28720 (Standard); K 4024 (Standard)

    		 Reference Standards Potassium Channel Metabolic Disease
    Glipizide (Standard) is the analytical standard of Glipizide. This product is intended for research and analytical applications. Glipizide (CP 2872; K 4024) a potent, orally active and sulfonylurea class anti-diabetic agent and can be used for type 2 diabetes mellitus research but not type 1. Glipizide acts by partially blocking ATP-sensitive potassium (KATP) channels among β cells of pancreatic islets of Langerhans .
    Glipizide (Standard)
  • HY-126987
    Mesosulfuron-methyl

    		Environmental Pollutants Acetolactate Synthase (ALS) Others
    Mesosulfuron-methyl is a sulfonylurea herbicide that inhibits acetolactate synthase (ALS) and is used in research for post-emergence control of ryegrass and Avena spp. (wild oat) in wheat fields .
    Mesosulfuron-methyl
  • HY-B0104R
    Glimepiride (Standard)

    Glimperide (Standard); HOE-490 (Standard)

    		 Amyloid-β Reference Standards Metabolic Disease
    Glimepiride (Standard) is the analytical standard of Glimepiride. This product is intended for research and analytical applications. Glimepiride (Glimperide) is a medium-to-long acting sulfonylurea anti-diabetic compound with an ED50 of 182 μg/kg.
    Glimepiride (Standard)
  • HY-B0089R
    Acarbose (Standard)

    BAY g 5421 (Standard)

    		 Reference Standards Glycosidase Metabolic Disease Cancer
    Acarbose (Standard) is the analytical standard of Acarbose. This product is intended for research and analytical applications. Acarbose (BAY g 5421), antihyperglycemic agent, is an orally active alpha-glucosidase inhibitor (IC50=11 nM). Acarbose can potentiate the hypoglycemic effects of sulfonylureas or insulin .
    Acarbose (Standard)
  • HY-100641S
    4-Hydroxytolbutamide-d9

    Hydroxytolbutamide-d9

    		 Potassium Channel Autophagy Metabolic Disease Cancer
    4-Hydroxytolbutamide-d9 is the deuterium labeled 4-Hydroxytolbutamide. 4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic .
    4-Hydroxytolbutamide-d9
  • HY-B0254S
    Glipizide-d11

    		Isotope-Labeled Compounds Potassium Channel Metabolic Disease
    Glipizide-d11 is the deuterium labeled Glipizide. Glipizide (CP 2872; K 4024)?a potent, orally active and sulfonylurea class anti-diabetic agent and can be used for type 2?diabetes mellitus research but not type 1. Glipizide acts by partially blocking ATP-sensitive potassium?(KATP) channels among β cells of pancreatic islets of Langerhans .
    Glipizide-d11
  • HY-153261
    NLRP3-IN-17

    		NOD-like Receptor (NLR) Inflammation/Immunology
    NLRP3-IN-17 is a potent, selective and orally active NLRP3 inflammasome inhibitor with an IC50 value of 7 nM. NLRP3-IN-17 significantly inhibits NLRP3 dependent IL-1β secretion in mice and can be used for chronic inflammatory diseases research .
    NLRP3-IN-17
  • HY-B1869
    Metsulfuron-methyl
    2 Publications Verification

    		 Environmental Pollutants Herbicide Others
    Metsulfuron-methyl is a systemic sulfonylurea herbicide that has been widely used to control broadleaf weeds and annual grasses in rice, corn, wheat, and barley. Metsulfuron-methyl exhibits high herbicidal activity and low mammalian toxicity, with an LD50 for rats exceeding 5000 mg/kg .
    Metsulfuron-methyl
  • HY-B0401S
    Tolbutamide-d9

    		Potassium Channel Autophagy Metabolic Disease Cancer
    Tolbutamide-d9 is the deuterium labeled Tolbutamide. Tolbutamide is a first generation potassium channel blocker, sulfonylurea oral hypoglycemic agent.
    Tolbutamide-d9
  • HY-P5292A
    HYNIC-iPSMA TFA

    		Radionuclide-Drug Conjugates (RDCs) PSMA Cancer
    HYNIC-iPSMA TFA is a ligand for molecular imaging of tumors. Hynic-ipsma consists of two components: HYNIC (6-hydrazinonicotinamide) and iPSMA (Inhibitor of Prostate-Specific Membrane Antigen). HYNIC is a compound used to attach radioactive isotopes to targeted molecules. iPSMA is a specific inhibitor used to inhibit prostate-specific membrane antigen (PSMA). 68GA-labeled iPSMA has been used to detect prostate cancer by PET imaging. The further 99mTc-EDDA/HYNIC-iPSMA TFA has excellent specificity and sensitivity . HYNIC-iPSMA TFA can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
    HYNIC-iPSMA TFA
  • HY-A0176
    Glisoxepide

    		Potassium Channel Cardiovascular Disease Metabolic Disease
    Glisoxepide, a sulphonamide derivative, is an orally available nonselective K(ATP) channel blocker, with antihyperglycemic activity and cardiovascular regulation effect .
    Glisoxepide
  • HY-121079
    Azimsulfuron
    2 Publications Verification

    DPX-A8947

    		 Environmental Pollutants Herbicide Others
    Azimsulfuron (DPX-A8947) is a sulfonylurea herbicide useful in controlling weeds in paddy fields .
    Azimsulfuron
  • HY-P5292
    HYNIC-iPSMA

    		Radionuclide-Drug Conjugates (RDCs) PSMA Cancer
    HYNIC-iPSMA is a ligand for molecular imaging of tumors. Hynic-ipsma consists of two components: HYNIC (6-hydrazinonicotinamide) and iPSMA (Inhibitor of Prostate-Specific Membrane Antigen). HYNIC is a compound used to attach radioactive isotopes to targeted molecules. iPSMA is a specific inhibitor used to inhibit prostate-specific membrane antigen (PSMA). 68GA-labeled iPSMA has been used to detect prostate cancer by PET imaging. The further 99mTc-EDDA/HYNIC-iPSMA has excellent specificity and sensitivity . HYNIC-iPSMA can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
    HYNIC-iPSMA
  • HY-B0870S
    Bensulfuron-methyl-d6

    		Isotope-Labeled Compounds Herbicide Others
    Bensulfuron-methyl-d6 is a deuterated Bensulfuron-methyl (HY-B0870). Bensulfuron-methyl is a kind of sulfonylurea herbicide widely used to control broad-leaf weeds in rice paddies .
    Bensulfuron-methyl-d6
  • HY-B1876S
    Nicosulfuron-d6

    		Acetolactate Synthase (ALS) Others
    Nicosulfuron-d6 is the deuterium labeled Nicosulfuron . Nicosulfuron is a selective herbicide belonging to the sulfonylurea family. Nicosulfuron is commonly used as a post-emergence herbicide to protect maize crops from weeds. Nicosulfuron inhibits acetolactate synthase (ALS) enzyme activity .
    Nicosulfuron-d6
  • HY-117160
    4-trans-Hydroxy-glibenclamide

    4-trans-hydroxycyclohexyl Glyburide; 4-trans-hydroxy Glibenclamide

    		 Potassium Channel Neurological Disease
    rac-trans-4-hydroxy Glyburide is an active metabolite of the SUR1/Kir6.2 sulfonylurea inhibitor glyburide (HY-15206). It is formed from glyburide by the cytochrome P450 (CYP) isoforms CYP2C8 and CYP2C9. rac-trans-4-hydroxy Glyburide inhibits glyburide binding to rat brain synaptosomes at the high and low affinity sites of SUR1/Kir6.2 with IC50 values of 0.95 and 100 nM, respectively.
    4-trans-Hydroxy-glibenclamide
  • HY-W020020
    Thifensulfuron-methyl

    		Environmental Pollutants Herbicide Others
    Thifensulfuron-methyl is a sulfonylurea herbicide and mainly used for control of broadleaved weeds in wheat, corn, and soybean fields .
    Thifensulfuron-methyl
  • HY-B0870
    Bensulfuron-methyl

    		Environmental Pollutants Herbicide Others
    Bensulfuron-methyl is a kind of sulfonylurea herbicide widely used to control broad-leaf weeds in rice paddies .
    Bensulfuron-methyl
  • HY-B1850
    Halosulfuron-methyl

    Inpool; MON 12000; Manage

    		 Environmental Pollutants Herbicide Others
    Halosulfuron-methyl is a pyrazole sulfonylurea herbicide .
    Halosulfuron-methyl
  • HY-133085
    Rimsulfuron

    DPX-E9636

    		 Environmental Pollutants Herbicide Others
    Rimsulfuron (DPX-E9636) is a sulfonylurea herbicide for postemergence use in maize to control grasses and some broadleaf weeds .
    Rimsulfuron
  • HY-W422402
    Foramsulfuron

    		Acetolactate Synthase (ALS) Herbicide Others
    Foramsulfuron is a postemergence herbicide used for selective control of grass and some broadleaved weeds in maize (Zea mays L.). Foramsulfuron is a sulfonylurea herbicide that exerts its herbicidal activity by inhibiting acetolactate synthase (ALS), a key enzyme in the biosynthesis of branched chain amino acids .
    Foramsulfuron
  • HY-B1876R
    Nicosulfuron (Standard)

    		Reference Standards Acetolactate Synthase (ALS) Others
    Nicosulfuron (Standard) is the analytical standard of Nicosulfuron. This product is intended for research and analytical applications. Nicosulfuron is a selective herbicide belonging to the sulfonylurea family. Nicosulfuron is commonly used as a post-emergence herbicide to protect maize crops from weeds. Nicosulfuron inhibits acetolactate synthase (ALS) enzyme activity .
    Nicosulfuron (Standard)
  • HY-178953
    NLRP3-IN-84

    		NOD-like Receptor (NLR) Caspase Interleukin Related Inflammation/Immunology
    NLRP3-IN-84 (Compound 32) is a NLRP3 inflammasome inhibitor. NLRP3-IN-84 can interfere with the oligomerization process of NLRP3 by inhibiting the activity of NLRP3 ATPase (IC50 = 158.4 nM). NLRP3-IN-84 inhibits Caspase-1 (IC50 = 27.7 nM), IL-1β release (PBMC: IC50 = 19.5 nM; mPBMC: IC50 = 24.2 nM), and ASC plaque formation (IC50 = 131 nM). NLRP3-IN-84 has no inhibitory activity on NLRC4 and AIM2 inflammasomes. NLRP3-IN-84 exhibits significant in vivo anti-inflammatory effects in a mouse acute peritonitis model. NLRP3-IN-84 can be used for the study of NLRP3-related inflammatory diseases .
    NLRP3-IN-84
  • HY-155517
    INF200

    		NOD-like Receptor (NLR) Pyroptosis Inflammation/Immunology
    INF200 (compound 5) is a sulfonylurea-based inhibitor of NLRP3 and NLRP3-mediated pyroptosis. INF200 has beneficial cardiometabolic effects in rat model of high-fat diet (HFD)-induced metaflammation，and shows anti-inflammatory activity to (10 μM) decreases IL-1β release in human macrophages. INF200 improves glucose and lipid profiles，and attenuates systemic inflammation and biomarkers of cardiac dysfunction (particularly BNP). INF200 also improves myocardial damage-dependent ischemia/reperfusion injury (IRI) in hemodynamic evaluation .
    INF200
  • HY-115963
    Anticancer agent 38

    		Drug Derivative Cancer
    Anticancer agent 38 (compound 19), a sulfonylurea derivative, is a potent anticancer agent. Anticancer agent 38 inhibits A431 cell growth with an IC50 of 5.2 µg/mL .
    Anticancer agent 38
  • HY-115962
    Anticancer agent 37

    		Drug Derivative Cancer
    Anticancer agent 37 (compound 18), a sulfonylurea derivative, is a potent anticancer agent. Anticancer agent 37 inhibits HePG2 cell growth with an IC50 of 17.2 µg/mL .
    Anticancer agent 37
  • HY-121079R
    Azimsulfuron (Standard)

    DPX-A8947 (Standard)

    		 Herbicide Reference Standards Others
    Azimsulfuron (Standard) is the analytical standard of Azimsulfuron. This product is intended for research and analytical applications. Azimsulfuron (DPX-A8947) is a sulfonylurea herbicide useful in controlling weeds in paddy fields .
    Azimsulfuron (Standard)
  • HY-W011651R
    Carbutamide (Standard)

    BZ-55 (Standard)

    		 Phosphatase Reference Standards Metabolic Disease
    Carbutamide (Standard) is the analytical standard of Carbutamide. This product is intended for research and analytical applications. Carbutamide (BZ-55) is an orally active and first-generation sulfonylurea with hypoglycemic activity .
    Carbutamide (Standard)
  • HY-B0870R
    Bensulfuron-methyl (Standard)

    		Herbicide Reference Standards Others
    Bensulfuron-methyl (Standard) is the analytical standard of Bensulfuron-methyl (HY-B0870). This product is intended for research and analytical applications. Bensulfuron-methyl is a kind of sulfonylurea herbicide widely used to control broad-leaf weeds in rice paddies .
    Bensulfuron-methyl (Standard)
  • HY-115960
    Anticancer agent 35

    		Others Cancer
    Anticancer agent 35 (compound 10), a sulfonylurea derivative, is a potent anticancer agent. Anticancer agent 35 inhibits A549, A431, PACA2 cell growth with IC50s of 18.1 µg/mL, 4.0 µg/mL, 18.9 µg/mL, respectively .
    Anticancer agent 35
  • HY-B1869R
    Metsulfuron-methyl (Standard)

    		Herbicide Reference Standards Others
    Metsulfuron-methyl (Standard) is the analytical standard of Metsulfuron-methyl. This product is intended for research and analytical applications. Metsulfuron-methyl is a systemic sulfonylurea herbicide that has been widely used to control broadleaf weeds and annual grasses in rice, corn, wheat, and barley. Metsulfuron-methyl exhibits high herbicidal activity and low mammalian toxicity, with an LD50 for rats exceeding 5000 mg/kg .
    Metsulfuron-methyl (Standard)
  • HY-115959
    Anticancer agent 34

    		Bacterial Inflammation/Immunology Cancer
    Anticancer agent 34 (compound 9), a sulfonylurea derivative, is a potent antimicrobial and anticancer agent. Anticancer agent 34 inhibits the microbial growth of B. mycoides, E. coli, and C. albicans with a MIC between 0.156 and 0.039 mg/ml. Anticancer agent 34 inhibits A549, PC3 cell growth with IC50s of 8.4 µg/ml, 7.8 µg/ml, respectively .
    Anticancer agent 34
  • HY-115961
    Anticancer agent 36

    		Bacterial Inflammation/Immunology Cancer
    Anticancer agent 36 (compound 11), a sulfonylurea derivative, is a potent antimicrobial and anticancer agent. Anticancer agent 36 inhibits the microbial growth of B. mycoides, E. coli, and C. albicans with a MIC between 0.156 and 0.039 mg/L. Anticancer agent 36 inhibits A549, PC3 cell growth with IC50s of 19.7 µg/mL, 11.9 µg/mL, respectively .
    Anticancer agent 36
  • HY-B0920R
    Tolazamide (Standard)

    U-17835 (Standard)

    		 Reference Standards Potassium Channel Metabolic Disease Endocrinology
    Tolazamide (U-17835) (Standard) is the analytical standard of Tolazamide. This product is intended for research and analytical applications. Tolazamide is an orally active sulfonylurea agent that inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (IC50 = 4.2 µM in HEK293 cells transfected with the human receptor). Tolazamide has anti-diabetic properties. Tolazamide can lower blood glucose in sulfonylurea class. Tolazamide decreases insulin dose while continuing to maintain adequate metabolic control. Tolazamide is able to improve or normalize hyperglycemia and HbA .
    Tolazamide (Standard)
  • HY-B0401S1
    Tolbutamide-13C

    		Isotope-Labeled Compounds Potassium Channel Autophagy Metabolic Disease Cancer
    Tolbutamide- 13C is the 13C-labeled Tolbutamide. Tolbutamide is a first generation potassium channel blocker, sulfonylurea oral hypoglycemic agent.
    Tolbutamide-13C

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