1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. P-1075

P-1075 

Cat. No.: HY-108573
Handling Instructions

P-1075 is a potent activator of sulfonylurea receptor 2-associated ATP-sensitive potassium channels (SUR2-KIR6), with an EC50 value of 45 nM for SUR2B-KIR6 channel activation. P-1075 also P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts.

For research use only. We do not sell to patients.

P-1075 Chemical Structure

P-1075 Chemical Structure

CAS No. : 60559-98-0

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Description

P-1075 is a potent activator of sulfonylurea receptor 2-associated ATP-sensitive potassium channels (SUR2-KIR6), with an EC50 value of 45 nM for SUR2B-KIR6 channel activation[1]. P-1075 also P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts[2].

IC50 & Target

EC50: 45 nM (SUR2-KIR6)[1].

Molecular Weight

231.30

Formula

C₁₂H₁₇N₅

CAS No.

60559-98-0

SMILES

CCC(N/C(NC#N)=N/C1=CC=CN=C1)(C)C

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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P-1075
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