136 Results for "

Tf

" in MedChemExpress (MCE) Product Catalog:
Products (136)

136 Results for "Tf" in MCE Product Catalog:

76
76 Publications Verification
Cat. No.: HY-100388
CAS No.: 1801747-42-1
Purity:  99.81%
Target:  

SHP2 Phosphatase

Research Areas:  

Cancer

SHP099 is an allosteric SHP2 inhibitor, with IC50s of 0.690, 1.241, 0.416, 1.968, 2.896 μM for SHP2, SHP2 D61Y, SHP2E69K, SHP2 A72V, SHP2 E76K. SHP099 inhibits cancer cell growth, such as MV4-11 and TF-1 cell (IC50: 0.32 and 1.73 μM). SHP099 inhibits RAS-ERK signaling and inhibits tumor growth .
loading...
    loading...
9
9 Cited Publications
Cat. No.: HY-N1992
CAS No.: 30462-35-2
Synonyms: Tf-3; ZP10
Theaflavin 3,3'-digallate (TF-3) is a potent Zika virus (ZIKV) protease inhibitor with an IC50 of 2.3 μM. Theaflavin 3,3'-digallat directly binds to ZIKVpro (Kd=8.86 μM) and inhibits ZIKV replication. Theaflavin 3,3'-digallat inhibits the activity of gp41 and NS2B-3 protease and has antiviral activity against HSV and HIV-1 . Theaflavin 3,3'-digallate, the typical pigment in black tea, is a potent antitumor agent .
loading...
    loading...
8
8 Cited Publications
Cat. No.: HY-P80839
Synonyms: Phospho-NF-κB p65; NFKB3; RELA; Tf65; Transcription factor p65; p65; NFkB

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF

Reactivity:  

Human, Mouse, Rat

loading...
    loading...
7
7 Cited Publications
Cat. No.: HY-P80765
Synonyms: NFKB3; RELA; Tf65; Transcription factor p65; p65; NFkB

Host:  

Rabbit

Application:  

WB, IHC-F, IHC-P, ICC/IF, IP

Reactivity:  

Human, Mouse

loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-P0171
CAS No.: 664334-36-5
Synonyms: BKT140 (4-fluorobenzoyl); BL-8040; Tf14016
Target:  

CXCR

Research Areas:  

Endocrinology Cancer

Motixafortide (BKT140 4-fluorobenzoyl) is a novel CXCR4 antagonist with an IC50 vakue of ~1 nM.
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-P81238
Synonyms: Phospho-NF-KB p65 (Ser536) ; NF-kB p65 (phospho S536); p-NF-κB p65(Phospho-Ser536); RELA(phospho S536); NF kB P65; NF-kB p65; NFKBp65; NF-κBp65; p65 NF kappaB; p65 NFkB; NFKBp65; RELA; Transcription Factor p65; v rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B cells 3 (p65)); V Rel Avian Reticuloendotheliosis Viral Oncogene Homolog A; v rel reticuloendotheliosis viral oncogene homolog A (avian); v-rel reticuloendotheliosis viral oncogene homolog A; p65NFKB; Avian reticuloendotheliosis viral (v rel) oncogene homolog A; MGC131774; NFKB 3; NFKB3; Nuclear Factor NF Kappa B p65 Subunit; Nuclear factor of kappa light polypeptide gene enhancer in B cells 3; Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B Cells; Tf65_HUMAN. NFκB-p65; NFκB p65; NF κB-p65; NFκBp65;

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF, IP, ELISA

Reactivity:  

Human, Mouse, Rat, Monkey

loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-134094
CAS No.: 59756-60-4
Purity:  99.93%
Fluridone is a herbicide, particularly to eliminate aquatic plant growth in water reservoirs and irrigation channels. Fluridone is a potent Abscisic acid (ABA) biosynthesis inhibitor, and has anti-inflammatory effects .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-18763
CAS No.: 63610-08-2
Synonyms: Ibustrin
Target:  

COX

Research Areas:  

Cardiovascular Disease

Indobufen is a platelet aggregation inhibitor. Indobufen is a reversible platelet cyclooxygenase (Cox) activity inhibitor. Indobufen suppresses thromboxane A2 (TxA2) synthesis. Indobufen down-regulates tissue factor (TF) in monocytes .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-N2099
CAS No.: 35906-36-6
Synonyms: Senegin III
Onjisaponin B is an orally active natural product derived from Polygala tenuifolia. Onjisaponin B inhibits NF-κB p65. Onjisaponin B enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin. Onjisaponin B reduces β-amyloid (Aβ) production. Onjisaponin B reduces radiation-induced cell apoptosis. Onjisaponin B has anti-oxidant and anti-inflammatory activities. Onjisaponin B can be used for neurological disease and radiation injury study, and its metabolite tenuifolin (TF) can enter the brain through the BBB .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P99271
CAS No.: 1418628-81-5
Synonyms: Anti-Human F3 Recombinant Antibody

Target:  

ADC Antibodies

Research Areas:  

Cancer

Tisotumab (Anti-Human F3 Recombinant Antibody) is a human IgG1 monoclonal antibody and ADC antibody. Tisotumab targets tissue factor (TF). Tisotumab can be used to synthesize antibody-drug conjugates (ADCs) targeting tissue factor (TF), Tisotumab vedotin (HY-152963). Tisotumab can be used for the research of solid tumors .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-NP0182
Synonyms: PNA (Biotinylated)
Peanut Agglutinin (PNA) Biotinylated is a biotinylated lectin that specifically recognizes and binds to the Galβ1-3GalNAc sequence, thereby targeting SPESP1 and TF blood group antigens. As an acrosome-specific marker, Peanut Agglutinin Biotinylated stains mouse spermatocytes and sperm acrosomes with high specificity, and this binding depends not only on SPESP1 but also recognizes other testicular acrosomal glycoproteins. Peanut Agglutinin Biotinylated accurately identifies TF antigens in Reed-Sternberg cells, histiocytosis X cells, and esophageal squamous cell carcinoma, without cross-reacting with non-specific cells. Peanut Agglutinin Biotinylated maintains staining stability in both B-5 and formalin fixatives, and serves as an important tool for the study of Hodgkin's disease, histiocytosis X, and various malignant tumors .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-153480A
Purity:  93.65%
Synonyms: BAX499 sodium
ARC19499 sodium is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 sodium blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 sodium corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.
loading...
    loading...
Cat. No.: HY-152963
CAS No.: 1418731-10-8
Purity:  99.69%
Tisotumab vedotin is an antibody drug conjugate (ADC) targeting tissue factor (TF), formed by covalently linking a fully human monoclonal antibody (TF-011) against TF with the microtubule disruptor Monomethyll Auristatin E (MMAE) (HY-15162), and the drug-linker conjugate for ADC is VcMMAE (HY-15575). Tisotumab vedotin has immunomodulatory and anti-tumor activities, and can be used in the study of advanced or metastatic solid tumors such as cervical cancer .
loading...
    loading...
Cat. No.: HY-P990090
CAS No.: 2648260-80-2
Synonyms: CBP-201

Research Areas:  

Inflammation/Immunology

Rademikibart (CBP-201) is a human monoclonal antibody targeting IL-4Rα and IL-4Rα inhibitor with a KD of 20.7 pM when binding to human IL-4Rα epitopes . Rademikibart does not bind to IL-4Rα from other species. Rademikibart inhibits IL-4 and IL-13-mediated STAT6 signaling, TF-1 cell proliferation and thymus activation regulated chemokine (TRAC) production. Rademikibart can be used for the research of atopic dermatitis and asthma .
loading...
    loading...
Cat. No.: HY-P5533
CAS No.: 2414254-70-7
Research Areas:  

Cancer

CRT, an iron peptide mimic, can bind to apo-transferrin (apo-Tf). CRT can be used to modify nanoparticles, and enhances drug delivery efficiency .
loading...
    loading...
Cat. No.: HY-P5152
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

Scorpion toxin Tf2 is a selective human voltage-gated sodium channel Nav1.3 (hNav1.3) activator. Scorpion toxin Tf2 selectively shifts the channel's activation voltage to more negative values, enabling channel opening at resting membrane potentials. Scorpion toxin Tf2 can be used for the research of epilepsy, nociception (after spinal cord injury) .
loading...
    loading...
Cat. No.: HY-134094R
CAS No.: 59756-60-4
Research Areas:  

Inflammation/Immunology

Fluridone (Standard) is the analytical standard of Fluridone. This product is intended for research and analytical applications. Fluridone is a herbicide, particularly to eliminate aquatic plant growth in water reservoirs and irrigation channels. Fluridone is a potent Abscisic acid (ABA) biosynthesis inhibitor, and has anti-inflammatory effects .
loading...
    loading...
Cat. No.: HY-153480
CAS No.: 1350667-54-7
Synonyms: BAX499
ARC19499 is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.
loading...
    loading...
Cat. No.: HY-162490
CAS No.: 2425563-60-4
Target:  

ROR

Research Areas:  

Inflammation/Immunology

TF-S14 is a reverse agonist of RORγt. TF-S14 reduces Th17 cell-associated cytokine production, including IL-17A, IL-21, and IL-22 by binding to and inhibiting RORγt activity. TF-S14 can be used in the study of autoimmune diseases and rejection in allotransplantation .
loading...
    loading...
Cat. No.: HY-N1992R
CAS No.: 30462-35-2
Synonyms: Tf-3 (Standard); ZP10 (Standard)
Theaflavin 3,3'-digallate (Standard) is the analytical standard of Theaflavin 3,3'-digallate. This product is intended for research and analytical applications. Theaflavin 3,3'-digallate (TF-3) is a potent Zika virus (ZIKV) protease inhibitor with an IC50 of 2.3 μM. Theaflavin 3,3'-digallat directly binds to ZIKVpro (Kd=8.86 μM) and inhibits ZIKV replication. Theaflavin 3,3'-digallat inhibits the activity of gp41 and NS2B-3 protease and has antiviral activity against HSV and HIV-1 . Theaflavin 3,3'-digallate, the typical pigment in black tea, is a potent antitumor agent .
loading...
    loading...