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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
Topotecan Hydrochloride
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "Topotecan Hydrochloride" in MCE Product Catalog:
40
40 Publications Verification
Synonyms: SKF 104864A Hydrochloride; NSC 609669 Hydrochloride
Category:
Alkaloids Monophenols Phenols Quinoline Alkaloids Camptotheca acuminata Decne. Plants Nyssaceae Disease Research Fields Cancer
Target:
40
40 Publications Verification
Cat. No.: HY-13768
CAS No.: 123948-87-8
Synonyms: SKF 104864A; NSC 609669
Target:
Research Areas:
Topotecan (SKF 104864A; NSC 609669) is an orally active and potent Topoisomerase I inhibitor. Topotecan induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan shows anticancer activity .
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PV-1019 (NSC 744039) is a potent, selective Chk2 inhibitor with an IC50 value of 24 nM. PV-1019 inhibits the Topotecan (HY-13768)-induced Chk2 autophosphorylation. PV-1019 inhibits IR-induced apoptosis .
Cat. No.: HY-161853
CAS No.: 2446767-14-0
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TX-2552 is an orally active tyrosine DNA phosphodiesterase 1 (TDP1) inhibitor with an IC50 value of 0.62 μM. TX-2552 can enhance the clastogenic activity of Topotecan (HY-13768) in mouse bone marrow cells, as well as the anti-tumor effect of Topotecan (HY-13768) in Krebs-2 ascites tumor mice .
Cat. No.: HY-161152
CAS No.: 2190506-29-5
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Research Areas:
DNA relaxation-IN-1 (Compound 27) is a DNA ligase 1 DNA Lig1) inhibitor. DNA relaxation-IN-1 inhibits DNA ligation and disrupts the DNA relaxing activity of DNA Lig1. DNA relaxation-IN-1 induces Apoptosis. DNA relaxation-IN-1, in combination with Topotecan (HY-13768), exhibits synergistic antiproliferative effects against colorectal cancer .
Cat. No.: HY-13768S1
CAS No.: 1044904-10-0
Cat. No.: HY-132685AS
CAS No.: 2701830-42-2
Cat. No.: HY-132685S
CAS No.: 1217633-79-8
Cat. No.: HY-13768C
CAS No.: 1044663-62-8
Synonyms: SKF 104864A Hydrochloride hydrate; NSC 609669 Hydrochloride hydrate
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Research Areas:
Topotecan hydrochloride hydrate is an orally active and potent Topoisomerase I inhibitor. Topotecan hydrochloride hydrate induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan hydrochloride hydrate shows anticancer activity .
Cat. No.: HY-13768AR
CAS No.: 119413-54-6
Synonyms: SKF 104864A Hydrochloride (Standard); NSC 609669 Hydrochloride (Standard)
Cat. No.: HY-13768D
CAS No.: 123948-88-9
Synonyms: SKF 104864A acetate; NSC 609669 acetate
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Research Areas:
Topotecan acetate is a topoisomerase inhibitor.
Cat. No.: HY-13768S
CAS No.: 1133355-98-2
Synonyms: SKF 104864A-d5; NSC 609669-d5
Cat. No.: HY-W740425
Cat. No.: HY-W740426
CAS No.: 190710-79-3
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N-Desmethyltopotecan is a metabolite of Topotecan (HY-13768), and it can be detected in plasma, urine and feces .
Cat. No.: HY-13768S2
Synonyms: SKF 104864A-d6 diHydrochloride; NSC 609669-d6 diHydrochloride
Cat. No.: HY-121857
CAS No.: 66528-28-7
NSC636795 is an inhibitor of the ABCG2 transporter. NSC636795 inhibits ABCG2-mediated PhA efflux. NSC636795 also partially reverses ABCG2-mediated resistance to Topotecan (HY-13768). NSC636795 can be used in studies related to ABCG2-mediated antitumor drug resistance .
Cat. No.: HY-183546
Research Areas:
TDP1-IN-6 is a TDP1 inhibitor with an IC50 of 1.52 μM. Combination of TDP1-IN-6 with Topotecan (HY-13768) enhances DNA damage, induces Apoptosis, triggers S-phase cell cycle arrest, and promotes Ferroptosis. TDP1-IN-6 can be used for the research of cervical cancer .
Cat. No.: HY-187719
CAS No.: 318262-42-9
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NIK-12192 is an orally active inhibitor of vacuolar H +-ATPase. NIK-12192 reduces intracellular pH, decreases lysosomal volume and acidity, and alters the intracellular localization of V-ATPase by inhibiting proton pumps . NIK-12192 induces αvβ5 integrin polarization, cytoskeletal disruption, cell detachment, anoikis-mediated delayed apoptosis and necrosis, a delayed reduction in mitochondrial membrane potential, and lysosomal/phagosomal accumulation. NIK-12192 inhibits tumor cell migration, invasion, and three-dimensional spheroid growth, and enhances the activity of Topotecan (HY-13768). NIK-12192 suppresses spontaneous lung metastasis in vivo. NIK-12192 is used in research related to colon cancer, ovarian cancer, lung cancer, breast cancer, renal cancer, prostate cancer, acute myeloid leukemia, and melanoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
