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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
UGT1A1-IN-1
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "UGT1A1-IN-1" in MCE Product Catalog:
Cat. No.: HY-160250
CAS No.: 2097024-37-6
Target:
Research Areas:
UGT1A1-IN-1 is a UGT1A1 inhibitor and fluorescent probe (Ex=370 nm, Em=520 nm), with an IC50 of 1.33 μM and a Ki of 5.02 μM. UGT1A1-IN-1 is selectively glucuronidated by UGT1A1 at the bilirubin homologous binding site, and its PET effect is blocked along with this reaction, triggering fluorescence changes. UGT1A1-IN-1 can serve as a substitute for bilirubin to detect UGT1A1 activity and perform high-throughput screening of UGT1A1 modulators .
6
6 Cited Publications
Cat. No.: HY-N0762
CAS No.: 31524-62-6
2
Target:
Cat. No.: HY-N4267
CAS No.: 13060-14-5
Cat. No.: HY-124364
CAS No.: 1578153-27-1
Target:
Research Areas:
RO6889678 is a highly potent HBV capsid formation inhibitor with a complex absorption, distribution, metabolism, and excretion (ADME) profile. RO6889678 is a potent inducer of CYP3A4 and coregulated proteins in human hepatocytes. RO6889678 is metabolized by a combination of CYP3A4-mediated oxidation and UDP-glucuronosyltransferase UGT1A3- and UGT1A1-mediated direct glucuronidation .
Cat. No.: HY-W718401
CAS No.: 1486471-13-9
Synonyms: BelINostat G
Target:
Research Areas:
Belinostat glucuronide (Belinostat G) is the major metabolite formed via UGT1A1-catalyzed O-glucuronidation of Belinostat (HY-10225), and exhibits no activity against cancer cells .
Cat. No.: HY-W739842
CAS No.: 17834-04-7
Synonyms: 8-OH WarfarIN
Target:
Research Areas:
8-Hydroxywarfarin (8-OH Warfarin) is a CYP2C9 inhibitor. 8-Hydroxywarfarin inactivates the anticoagulant activity of Warfarin (HY-B0687) via 8-hydroxylation. 8-Hydroxywarfarin serves as a glucuronidation substrate for UGT1A1, UGT1A8, UGT1A9, as well as wild-type/mutant UGT1A10. This reaction enhances its polarity, solubility and excretion efficiency, and the process is independent of phenylalanine 90 of UGT1A10. 8-Hydroxywarfarin can be used in studies related to thromboembolic diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
