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Cat. No.: HY-W718401

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Belinostat glucuronide

Name: Belinostat glucuronide
Brand: MedChemExpress
SKU: HY-W718401
Availability: PreOrder

(Synonyms: Belinostat G)

Belinostat glucuronide (Belinostat G) is the major metabolite formed via UGT1A1-catalyzed O-glucuronidation of Belinostat (HY-10225), and exhibits no activity against cancer cells.

For research use only. We do not sell to patients.

CAS No.: 1486471-13-9
Formula: C₂₁H₂₂N₂O₁₀S
Molecular Weight:494.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Belinostat glucuronide Chemical Structure

CAS No.: 1486471-13-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Belinostat glucuronide (Belinostat G) is the major metabolite formed via UGT1A1-catalyzed O-glucuronidation of Belinostat (HY-10225), and exhibits no activity against cancer cells^[1].

In Vitro

Belinostat glucuronide (1 mg/mL; 24 h) exhibits high stability after 24 h of incubation at 37°C in acidic environments (pH 2.6-6.5), which confirms its O-conjugated structure^[1].
Belinostat glucuronide (0.1-10 μM; 72 h) exhibits no cytotoxic activity against HepG2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

human hepatocellular liver carcinoma HepG2 cells
Concentration:

0.1, 0.5, 1, 2, 5, 10 μM
Incubation Time:

72 h
Result:

Did not reduce the number of viable HepG2 cells in the Gentian Violet staining assay.
Showed no dose-dependent growth inhibition in the MTS assay, with an IC₅₀ value unable to be converged.

Chemical Information

CAS No. 1486471-13-9
Molecular Weight 494.47
Formula C₂₁H₂₂N₂O₁₀S
SMILES

O=S(C1=CC=CC(/C=C/C(NO[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)C(O)=O)=O)=C1)(NC3=CC=CC=C3)=O
Synonyms

Belinostat G
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang LZ, et al. Glucuronidation by UGT1A1 is the dominant pathway of the metabolic disposition of belinostat in liver cancer patients. PloS one. 2013;8(1):e54522.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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