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Results for "

aminopeptidase A

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aminopeptidase (89) MetAP (15) Amino Acid Derivatives (3) Amyloid-β (1) Androgen Receptor (2) Angiotensin Receptor (1) Angiotensin-converting Enzyme (ACE) (2) Antibiotic (13) Apoptosis (5) Bacterial (24) Biochemical Assay Reagents (12) Bradykinin Receptor (1) Carboxypeptidase (2) Caspase (1) COX (1) Dipeptidyl Peptidase (10) DNA Methyltransferase (1) DNA/RNA Synthesis (2) Dopamine Receptor (1) Drug Derivative (1) Drug Intermediate (4) Endogenous Metabolite (4) Endothelin Receptor (1) Enteropeptidase (2) Ephrin Receptor (1) Epoxide Hydrolase (1) ERK (2) Farnesyl Transferase (1) Fluorescent Dye (7) Fungal (1) GCGR (1) GnRH Receptor (1) HDAC (1) IAP (1) IKK (1) Insulin Receptor (1) Isotope-Labeled Compounds (3) Leukotriene Receptor (3) Ligands for Target Protein for PROTAC (1) Lipase (1) Melanocortin Receptor (1) MMP (4) Monoamine Oxidase (1) mTOR (2) MyD88 (1) Neprilysin (3) NF-κB (3) NO Synthase (1) NOD-like Receptor (NLR) (1) Opioid Receptor (5) p38 MAPK (1) Parasite (7) Phosphatase (3) Phosphorylase (1) Potassium Channel (2) PPAR (1) Prolyl Endopeptidase (PREP) (1) Proteasome (1) PSMA (2) Pyroptosis (1) Radionuclide-Drug Conjugates (RDCs) (4) Reference Standards (7) Renin (1) Ser/Thr Protease (2) Somatostatin Receptor (5) Toll-like Receptor (TLR) (1) Tyrosine Hydroxylase (1) VEGFR (1)
By Research Areas:	Cancer (51) Cardiovascular Disease (14) Endocrinology (4) Infection (32) Inflammation/Immunology (23) Metabolic Disease (28) Neurological Disease (24)

By Targets:

Aminopeptidase (89)

MetAP (15)

Amino Acid Derivatives (3)

Amyloid-β (1)

Androgen Receptor (2)

Angiotensin Receptor (1)

Angiotensin-converting Enzyme (ACE) (2)

Antibiotic (13)

Apoptosis (5)

Bacterial (24)

Biochemical Assay Reagents (12)

Bradykinin Receptor (1)

Carboxypeptidase (2)

Caspase (1)

COX (1)

Dipeptidyl Peptidase (10)

DNA Methyltransferase (1)

DNA/RNA Synthesis (2)

Dopamine Receptor (1)

Drug Derivative (1)

Drug Intermediate (4)

Endogenous Metabolite (4)

Endothelin Receptor (1)

Enteropeptidase (2)

Ephrin Receptor (1)

Epoxide Hydrolase (1)

ERK (2)

Farnesyl Transferase (1)

Fluorescent Dye (7)

Fungal (1)

GCGR (1)

GnRH Receptor (1)

HDAC (1)

IAP (1)

IKK (1)

Insulin Receptor (1)

Isotope-Labeled Compounds (3)

Leukotriene Receptor (3)

Ligands for Target Protein for PROTAC (1)

Lipase (1)

Melanocortin Receptor (1)

MMP (4)

Monoamine Oxidase (1)

mTOR (2)

MyD88 (1)

Neprilysin (3)

NF-κB (3)

NO Synthase (1)

NOD-like Receptor (NLR) (1)

Opioid Receptor (5)

p38 MAPK (1)

Parasite (7)

Phosphatase (3)

Phosphorylase (1)

Potassium Channel (2)

PPAR (1)

Prolyl Endopeptidase (PREP) (1)

Proteasome (1)

PSMA (2)

Pyroptosis (1)

Radionuclide-Drug Conjugates (RDCs) (4)

Reference Standards (7)

Renin (1)

Ser/Thr Protease (2)

Somatostatin Receptor (5)

Toll-like Receptor (TLR) (1)

Tyrosine Hydroxylase (1)

VEGFR (1)

By Research Areas:

Cancer (51)

Cardiovascular Disease (14)

Endocrinology (4)

Infection (32)

Inflammation/Immunology (23)

Metabolic Disease (28)

Neurological Disease (24)

173

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Bestatin Maximum Cited Publications 11 Publications Verification Ubenimex	Aminopeptidase Bacterial Antibiotic	Infection Cancer
Bestatin is a natural, broad-spectrum, and competitive *CD13 (Aminopeptidase* N)/APN and leukotriene A4 hydrolase** inhibitor. Bestatin has anticancer effects .

Bestatin hydrochloride Maximum Cited Publications 11 Publications Verification Ubenimex hydrochloride	Antibiotic Bacterial Aminopeptidase	Infection Cancer
Bestatin hydrochloride is an inhibitor of *CD13 (Aminopeptidase* N)/APN and leukotriene A4 hydrolase**, used for cancer research.

Tosedostat 5+ Cited Publications CHR-2797	Aminopeptidase	Cancer
Tosedostat (CHR-2797) is an orally active *aminopeptidase* inhibitor. CHR-2797 exerts antiproliferative effects against a range of tumor cell lines .

Actinonin 5+ Cited Publications (-)-Actinonin	Aminopeptidase Bacterial MMP Apoptosis Antibiotic	Infection Cancer
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a K_i of 0.28 nM. Actinonin also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with K_i values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities .

Amastatin hydrochloride 1 Publications Verification	Aminopeptidase Bacterial	Infection
Amastatin hydrochloride is a slow, tight binding, competitive aminopeptidase (AP) inhibitor with K_i values of 0.26 nM, 30 nM, 52 nM for Aeromonas aminopeptidase, cytosolic leucine aminopeptidase, microsomal aminopeptidase .

Enocyanin 3 Publications Verification	Phosphatase	Inflammation/Immunology
Enocyanin is an anthocyanin extracted from grapes. Enocyanin shows inhibitory effect on the leucine aminopeptidase, acid phosphatase, γ-glutamyl transpeptidase and esterase activity .

ERAP1-IN-1 5 Publications Verification	Aminopeptidase	Inflammation/Immunology
ERAP1-IN-1 is an *endoplasmic reticulum aminopeptidase* 1 (ERAP1)** inhibitor. ERAP1-IN-1 competitively inhibits ERAP1 activity towards a nonamer peptide representative of physiological substrates .

L-Leucine-7-amido-4-methylcoumarin hydrochloride Leu-AMC hydrochloride	Fluorescent Dye	Others
L-Leucine-7-amido-4-methylcoumarin (Leu-AMC) hydrochloride is a bright blue fluorogenic peptidyl substrate for LAP3 (leucine aminopeptidase). L-Leucine-7-amido-4-methylcoumarin hydrochloride can be used for leucine aminopeptidase inhibition assays in vitro .

Trilysine Lys-Lys-Lys; H-Lys-Lys-Lys-OH	Biochemical Assay Reagents	Others
Trilysine is a tripeptide and also a substrate for specific peptidases. Trilysine serves as a hydrolytic substrate for the tripeptide-specific aminopeptidase TP and the oligopeptidase OP .

TNP-470 2 Publications Verification AGM-1470	Aminopeptidase	Cardiovascular Disease Cancer
TNP-470 is a methionine aminopeptidase-2 inhibitor and also an angiogenesis inhibitor.

Aminopeptidase-IN-1	Aminopeptidase	Neurological Disease
Aminopeptidase-IN-1 is an insulin-regulated aminopeptidase (IRAP) inhibitor with an K_i value of 7.7 μM. Aminopeptidase-IN-1 can be used for the research of memory impairments .

*Microsomal aminopeptidase, Microorganism*	Endogenous Metabolite	Metabolic Disease
Microsomal aminopeptidase, Microorganism is first reported from C. elegans. The Microsomal aminopeptidase, Microorganism is beneficial for the development of molecular vaccines against parasitic nematodes .

GPDA 1 Publications Verification GPN; Glycylproline p-nitroanilide tosylate	Fluorescent Dye	Others
GPDA (GPN; Glycylproline p-nitroanilide tosylate) is a chromogenic substrate of prolyl dipeptidyl aminopeptidase. GPDA is used to detect the activity of prolyl dipeptidyl aminopeptidase in human serum .

L-Leucyl-4-nitroanilide	Biochemical Assay Reagents	Others
L-Leucyl-4-nitroanilide is a colorimetric substrate for leucine aminopeptidase assays.

Aminopeptidase N (rat) APN/CD13	Aminopeptidase	Cardiovascular Disease
Aminopeptidase N (rat) (APN/CD13) is a Zn ²⁺-dependent membrane-bound exopeptidase that preferentially degrades proteins and peptides with N-terminal neutral amino acids. Aminopeptidase N (rat) is inhibited by angiotensin IV and participates in the regulation of angiotensin IV half-life in the rat striatum .

M8891	MetAP	Cardiovascular Disease Cancer
M8891 is an orally active, reversible and brain penetrant *Methionine Aminopeptidase-2 (MetAP-2)* inhibitor with an IC₅₀ of 54 nM and a K_i of 4.33 nM. M8891 does not inhibit MetAP-1 (IC₅₀>10 µM) . M8891 inhibits growth of primary endothelial cells as well as tumor cells and demonstrates antiangiogenic and antitumoral activity .

L-Leucinol (+)-Leucinol	Aminopeptidase	Others
L-Leucinol ((+)-Leucinol) is a competitive *aminopeptidase* inhibitor with a K_i value of 17 μM. As a dietary intake inhibitor, L-Leucinol reduces the basal dietary leucine intake in rats via microinjection into the rat anterior piriform cortex .

PPI-2458	MetAP	Inflammation/Immunology Cancer
PPI-2458 is a potent, orally active, selective and irreversible inhibitor of methionine aminopeptidase-2 (MetAP-2). PPI-2458 can be used for arthritis and lymphoma research .

ARM1 1 Publications Verification 4BSA	Aminopeptidase Epoxide Hydrolase	Cancer
ARM1 (4BSA) is a potent *aminopeptidase* and epoxide hydrolase inhibitor. ARM1 shows aminopeptidase inhibitory activity with an IC₅₀ 7.61 µM and epoxide hydrolase inhibitory activity with an IC₅₀ 12.4 µM .

ecMetAP-IN-1	MetAP Bacterial	Infection
ecMetAP-IN-1 is an inhibitor of E. coli methionine aminopeptidase (ecMetAP) with an IC₅₀ of 2.086 μM. ecMetAP-IN-1 is applicable to research related to bacterial infections caused by E. coli .

Sitagliptin fenilalanil 1 Publications Verification	Dipeptidyl Peptidase	Metabolic Disease
Sitagliptin fenilalanil is a *dipeptidyl aminopeptidase* 4 (DPP-4)** inhibitor .

HFI-142 1 Publications Verification	Aminopeptidase	Neurological Disease
HFI-142 is an *insulin-regulated aminopeptidase* (IRAP) inhibitor with a K_i** of 2.01 μM .

EcMetAP1-IN-1	Bacterial	Infection
EcMetAP1-IN-1 (compound 4) is an inhibitor of Escherichia coli methionine aminopeptidase MetAP1 .

Diprotin B	Dipeptidyl Peptidase	Others
Diprotin B is a dipeptidyl aminopeptidase IV (DPP IV) inhibitor. The apparent competitive inhibition of DPP-IV by the diprotins is a kinetic artifact, derived from the substrate-like nature of tripeptides containing a penultimate proline residue .

Histargin	Carboxypeptidase	Metabolic Disease
Histargin is a selective carboxypeptidase B inhibitor with an IC₅₀ of 17 μg/mL and a K_i of 30 μM. Histargin exerts competitive inhibition with substrate, with inhibitory activity abolished by metal cations. Histargin shows no significant inhibitory activity against carboxypeptidase A, aminopeptidase A, or aminopeptidase B .

Spinorphin LVV-hemorphin-4	Carboxypeptidase	Neurological Disease
Spinorphin is an inhibitor of enkephalin-degrading enzymes. Spinorphin inhibits aminopeptidase, dipeptidyl aminopeptidase III, angiotensin-converting enzyme and enkephalinase. Spinorphin possesses an antinociceptive effect .

Spinorphin TFA LVV-hemorphin-4 TFA	Angiotensin Receptor	Neurological Disease
Spinorphin TFA is an inhibitor of enkephalin-degrading enzymes. Spinorphin inhibits aminopeptidase, dipeptidyl aminopeptidase III, angiotensin-converting enzyme and enkephalinase. Spinorphin possesses an antinociceptive effect .

(R)-M8891	MetAP	Others
(R)-M8891 (compound R-9) is a less active isomer of M8891. M8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor .

HFI-437	Aminopeptidase	Neurological Disease
HFI-437 is a potent non-peptidic *insulin-regulated aminopeptidase* (IRAP) inhibitor with a K_i** of 20 nM. HFI-437 is a cognitive enhancer .

Relzomostat	MetAP	Metabolic Disease
Relzomostat is a methionine aminopeptidase 2 (MetAP2) inhibitor.Relzomostat may be useful for the research of obesity, type 2 diabetes, and other obesity-associated conditions .

Apstatin TFA	Aminopeptidase	Cardiovascular Disease
Apstatin TFA is a potent aminopeptidase P (APP) inhibitor with K_i values of 2.6, 0.64 µM for rat and human APP, respectively. Apstatin TFA shows cardioprotection .

H-GLU-AMC-OH	Fluorescent Dye	Neurological Disease
H-GLU-AMC-OH is an amino acid derivative that can be used as A fluorescent peptide substrate for the determination of aminopeptidase A enzyme activity .

Aeromonas proteolytica aminopeptidase	Biochemical Assay Reagents Aminopeptidase	Others
Aeromonas proteolytica aminopeptidase is an aminopeptidase from Aeromonas proteolytica. Aeromonas proteolytica aminopeptidase can function as an esterase. Aeromonas proteolytica aminopeptidase can catalyze the hydrolysis of L-leucine ethyl ester (L-Leu-OEt) with a K_m of 700 µM .

Sitagliptin fenilalanil hydrochloride 1 Publications Verification	Dipeptidyl Peptidase	Metabolic Disease
Sitagliptin fenilalanil hydrochloride is a *dipeptidyl aminopeptidase* 4 (DPP-4)** inhibitor .

H-Glu(4MβNA)-OH H-Glu(4MbetaNA)-OH; L-Glutamic acid γ-(4-methoxy-β-naphthylamide)	Aminopeptidase	Others
H-Glu(4MβNA)-OH is a substrate of aminopeptidases (APs) .

H-D-Ala-D-Ala-D-Ala-D-Ala-OH	Aminopeptidase	Others
H-D-Ala-D-Ala-D-Ala-D-Ala-OH is a substrate for D-aminopeptidase .

Bradykinin (2-9) Des-Arg1-bradykinin	Bradykinin Receptor	Cardiovascular Disease Endocrinology
Bradykinin (2-9) is an amino-truncated Bradykinin peptide. Bradykinin (2-9) is a metabolite of Bradykinin, cleaved by Aminopeptidase P.

Glycylproline dipeptidyl aminopeptidase	Aminopeptidase	Metabolic Disease
Glycylproline dipeptidyl aminopeptidase is an enzyme that catalyzes the hydrolysis of N-terminal glycylproline from glycylprolyl-β-naphthylamide and glycylproline-β-nitroanilide .

Bestatin methyl ester	Aminopeptidase Ligands for Target Protein for PROTAC IAP	Cancer
Bestatin methyl ester is a cell permeable Zn2+-binding aminopeptidases inhibitor. Bestatin methyl ester inhibits spore cell differentiation .

TRH-βNA	Biochemical Assay Reagents	Others
TRH-βNA is a substrate for determining the membrane TRH-deamidating enzyme (TRH-DE) activity and membrane pyroglutamyl aminopeptidase II (PPII) activity .

H-Val-Ala-pNA	Dipeptidyl Peptidase	Others
H-Val-Ala-pNA is a substrate for the dipeptide aminopeptidase (DPAPase) of Streptococcus bovis. H-Val-Ala-pNA can be used to measure the activity of the protease .

Aminopeptidase N Ligand (CD13) NGR peptide	Aminopeptidase	Cancer
Aminopeptidase N Ligand (CD13) NGR peptide is a polypeptide targeting CD13 and can be used as a carrier to mediate intracellular transmission. Aminopeptidase N Ligand (CD13) NGR peptide is often used in cancer research .

*Aminopeptidase*	Biochemical Assay Reagents	Others Cancer
Aminopeptidase catalyzes the cleavage of amino acids from the amino terminus of protein or peptide substrates .

L-Arginine p-nitroanilide dihydrochloride, 98% H-Arg-pNA 2HCl, 98%	Biochemical Assay Reagents	Others
L-Arginine p-nitroanilide dihydrochloride, 98% (H-Arg-pNA 2HCl, 98%) is a chromogenic substrate for cathepsin H and aminopeptidases.

Amastatin	Aminopeptidase	Others
Amastatin is A slow, tightly bound, competitive inhibitor of aminopeptidase (AP) with an IC₅₀ of 0.54 μg/mL for AP-A .

Cat. No.	상품명	Type

HY-137844

L-Leucine-7-amido-4-methylcoumarin hydrochloride Leu-AMC hydrochloride	Fluorescent Dyes
L-Leucine-7-amido-4-methylcoumarin (Leu-AMC) hydrochloride is a bright blue fluorogenic peptidyl substrate for LAP3 (leucine aminopeptidase). L-Leucine-7-amido-4-methylcoumarin hydrochloride can be used for leucine aminopeptidase inhibition assays in vitro .

HY-16710

GPDA 1 Publications Verification GPN; Glycylproline p-nitroanilide tosylate	Fluorescent Dyes
GPDA (GPN; Glycylproline p-nitroanilide tosylate) is a chromogenic substrate of prolyl dipeptidyl aminopeptidase. GPDA is used to detect the activity of prolyl dipeptidyl aminopeptidase in human serum .

HY-137928

H-Ala-4MβNA hydrochloride	Fluorescent Dyes
H-Ala-4MβNA hydrochloride is a specific fluorogenic substrate for aminopeptidase M .

HY-D3191

L&M-D-MR

Fluorescent Dyes

L&M-D-MR is a highly specific fluorescent "AND" logic probe with response moieties for leucine aminopeptidase (LAP) and monoamine oxidase (MAO). The coexistence of both LAP and MAO is required for L&M-D-MR to trigger intramolecular cyclization, release fluorophores and activate fluorescence. In the presence of only a single enzyme, L&M-D-MR generates only an extremely weak signal. L&M-D-MR enables bioimaging in living cells and mouse models, and can effectively distinguish different subtypes of liver diseases via blood samples or test strips. L&M-D-MR is widely used in studies related to liver cirrhosis, hepatitis B and drug-induced liver injury .

Cat. No.	상품명	Type

HY-137895

L-Arginine p-nitroanilide dihydrochloride, 98% H-Arg-pNA 2HCl, 98%	Biochemical Assay Reagents
L-Arginine p-nitroanilide dihydrochloride, 98% (H-Arg-pNA 2HCl, 98%) is a chromogenic substrate for cathepsin H and aminopeptidases.

HY-137901

L-Alanine 4-nitroanilide hydrochloride, 99% Ala-4-nitroanilide, 99%; H-Ala-pNA, 99%	Biochemical Assay Reagents
L-Alanine 4-nitroanilide hydrochloride, 99% is a detection substrate for L-alanine aminopeptidase.

HY-W286423

L-Pyroglutamic acid 7-amido-4-methylcoumarin	Biochemical Assay Reagents
L-Pyroglutamic acid 7-amido-4-methylcoumarin is a fluorogenic substrate for *pyroglutamate aminopeptidase* 1 (PGP-1)** .

Cat. No.	상품명	Target	Research Area

HY-P4070

Insulin icodec	Insulin Receptor	Metabolic Disease
Insulin icodec is an Insulin (HY-P0035) analog that strongly but reversibly binds to albumin. Insulin icodec has long plasma half-life. Insulin icodec modulates insulin receptor activity, controls blood glucose levels, reduces HbA_1c levels, and binds reversibly to human serum albumin. Insulin icodec can be used for the research of type 2 diabetes mellitus .

HY-W009004

Trilysine Lys-Lys-Lys; H-Lys-Lys-Lys-OH	Biochemical Assay Reagents	Others
Trilysine is a tripeptide and also a substrate for specific peptidases. Trilysine serves as a hydrolytic substrate for the tripeptide-specific aminopeptidase TP and the oligopeptidase OP .

HY-105055

Didemnin B	Peptides	Cancer
Didemnin B is a depsipeptide extracted from the marine tunicate Trididemnin cyanophorum. Didemnin B can be used for the research of cancer .

HY-W345510

Opiorphin	Neprilysin	Neurological Disease
Opiorphin, an opioid peptide, is a potent enkephalin-inactivating zinc ectopeptidases in human inhibitor. Opiorphin inhibits two enkephalin-catabolizing ectoenzymes, human neutral ecto-endopeptidase, hNEP (EC 3.4.24.11) with an IC₅₀ value of 11 μM, and human ecto-aminopeptidase, hAP-N (EC 3.4.11.2). Opiorphin displays potent analgesic activity by activating endogenous opioid-dependent transmission .

HY-P5362

NODAGA-LM3	Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor	Neurological Disease Cancer
NODAGA-LM3 is a ligand that can cross the blood-brain barrier and targets somatostatin receptor SSTR2 with high affinity (IC₅₀ = 1.3 nM). NODAGA-LM3 does not trigger the internalization of SSTR2 and can inhibit agonist-induced internalization processes. NODAGA-LM3 shows low uptake in normal tissues such as the liver and spleen, but high uptake in the lungs and blood pool. ⁶⁸Ga-labeled NODAGA-LM3 can serve as a PET imaging agent for well-differentiated neuroendocrine tumors, and is applied in studies related to small cell lung cancer and well-differentiated neuroendocrine tumors .

HY-P2336A

CCZ01048 TFA 3 Publications Verification	Melanocortin Receptor	Cancer
CCZ01048 TFA, a α-MSH analogue, exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a K_i of 0.31 nM. CCZ01048 TFA shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 TFA is a promising candidate for PET imaging of malignant melanoma .

HY-111173

Diprotin B	Dipeptidyl Peptidase	Others
Diprotin B is a dipeptidyl aminopeptidase IV (DPP IV) inhibitor. The apparent competitive inhibition of DPP-IV by the diprotins is a kinetic artifact, derived from the substrate-like nature of tripeptides containing a penultimate proline residue .

HY-P10341

ZP3022	GCGR	Metabolic Disease
ZP3022 is a dual agonist of glucagon-like peptide-1 (GLP-1) and gastrin that has the ability to sustainably improve glycemic control. Additionally, ZP3022 can effectively increase β-cell mass, promote β-cell proliferation, and enhance the function of pancreatic islets. ZP3022 can be used in anti-diabetic research .

HY-P1044A

Spinorphin TFA LVV-hemorphin-4 TFA	Angiotensin Receptor	Neurological Disease
Spinorphin TFA is an inhibitor of enkephalin-degrading enzymes. Spinorphin inhibits aminopeptidase, dipeptidyl aminopeptidase III, angiotensin-converting enzyme and enkephalinase. Spinorphin possesses an antinociceptive effect .

HY-P2648

Suc-Ala-Ala-Pro-Leu-pNA N-Succinyl-AAPL-p-nitroanilide	Aminopeptidase	Endocrinology
Suc-Ala-Ala-Pro-Leu-pNA (N-Succinyl-AAPL-p-nitroanilide) is a tripeptidyl p-nitroanilide substrate that can be catalytically hydrolyzed by acyl amidase-like leucine aminopeptidase in seminal plasma. Amastatin (HY-129298) and Actinonin (HY-113952) exert potent inhibitory effects on this hydrolytic activity. Suc-Ala-Ala-Pro-Leu-pNA can be used for the research of diseases such as azoospermia .

HY-P4549

H-D-Ala-D-Ala-D-Ala-D-Ala-OH	Aminopeptidase	Others
H-D-Ala-D-Ala-D-Ala-D-Ala-OH is a substrate for D-aminopeptidase .

HY-P1490

Bradykinin (2-9) Des-Arg1-bradykinin	Bradykinin Receptor	Cardiovascular Disease Endocrinology
Bradykinin (2-9) is an amino-truncated Bradykinin peptide. Bradykinin (2-9) is a metabolite of Bradykinin, cleaved by Aminopeptidase P.

HY-P4584

TRH-βNA	Biochemical Assay Reagents	Others
TRH-βNA is a substrate for determining the membrane TRH-deamidating enzyme (TRH-DE) activity and membrane pyroglutamyl aminopeptidase II (PPII) activity .

HY-P4658

H-Val-Ala-pNA	Dipeptidyl Peptidase	Others
H-Val-Ala-pNA is a substrate for the dipeptide aminopeptidase (DPAPase) of Streptococcus bovis. H-Val-Ala-pNA can be used to measure the activity of the protease .

HY-P11334

Cyanostatin B	Aminopeptidase Phosphatase Angiotensin-converting Enzyme (ACE) DNA/RNA Synthesis	Cancer
Cyanostatin B, a cyanobacterial lipopeptide, is a leucine aminopeptidase M (LAP) inhibitor (IC₅₀ = 12 ng/mL). Cyanostatin B is a weak inhibitor of protein phosphatase (PP2A) and also exhibits weak inhibitory activity against angiotensin-converting enzyme (ACE), with an IC₅₀ value of 130 μg/mL. Cyanostatin B demonstrates both cytotoxic and genotoxic effects on human hepatocytes, although non-toxic to Artemia salina. Cyanostatin B inhibits the proliferation of HepG2 cells, induces DNA single-strand breaks, and causes genomic instability. .

HY-P4205

Aminopeptidase N Ligand (CD13) NGR peptide	Aminopeptidase	Cancer
Aminopeptidase N Ligand (CD13) NGR peptide is a polypeptide targeting CD13 and can be used as a carrier to mediate intracellular transmission. Aminopeptidase N Ligand (CD13) NGR peptide is often used in cancer research .

HY-P4553

H-Met-Pro-OH	Amino Acid Derivatives	Others
H-Met-Pro-OH is a dipeptide containing methionine and proline. H-Met-Pro-OH is a substrate for aminopeptidase P (APP) and skin fibroblast prolidase .

HY-P4553A

H-Met-Pro-OH acetate	Amino Acid Derivatives	Others
H-Met-Pro-OH acetate is a dipeptide containing methionine and proline. H-Met-Pro-OH acetate serves as a substrate for aminopeptidase P (APP) and skin fibroblast prolinase .

HY-W794670

H-Ala-Pro-Ala-OH	Aminopeptidase	Others
H-Ala-Pro-Ala-OH, tripeptide, is a substrate for Escherichia coli PepP (Xaa-Pro aminopeptidase). H-Ala-Pro-Ala-OH acts as a nitrogen source for wild-type Escherichia coli .

HY-P11004

A3-APO	Bacterial Antibiotic	Infection
A3-APO is an antimicrobial peptide. A3-APO has a significant antimicrobial activity by a dual mode of action with both membrane disintegration and intracellular target inhibition. A3-APO can deactivate bacterial toxins and increase the expression of anti-inflammatory cytokines (such as IL-4 and IL-10), without antimicrobial resistance. A3-APO accelerates burn wounds healing in mice infection model of Acinetobacter baumannii and Staphylococcus aureus .

HY-P10472

Azaline B	GnRH Receptor	Endocrinology
Azaline B is an antagonist for gonadotropin-releasing hormone (GnRH) with IC₅₀ of 1.37 nM, Azaline B can be used in research of sex hormone-related pathological states, ovulation induction and male contraception .

HY-P4757

N1-Glutathionyl-spermidine disulfide	Parasite	Others
N1-Glutathionyl-spermidine disulfide is a substrate of trypanothione reductase .

HY-P11243

EphA4 agonist compound 23	Ephrin Receptor	Neurological Disease
EphA4 agonist compound 23 is a novel EphA4 agonist peptide mimic. EphA4 agonist compound 23 exhibits high affinity, high selectivity, and significant receptor activation ability. EphA4 agonist compound 23 is commonly used in the study of neurodegenerative diseases .

HY-P2434

AP102	Somatostatin Receptor	Neurological Disease Metabolic Disease Cancer
AP102 is a dual SSTR2/SSTR5-specific somatostatin analog (SSA). AP102 is a disulfide-bridged octapeptide SSA containing synthetic iodinated amino acids. AP102 binds with subnanomolar affinity to SSTR2 and SSTR5 (IC₅₀: 0.63 and 0.65 nM, respectively). AP102 does not bind to SSTR1 or SSTR3. AP102 can be used for acromegaly and neuroendocrine tumors research .

HY-P5362A

NODAGA-LM3 TFA	Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor	Cancer
NODAGA-LM3 TFA is a ligand that can cross the blood-brain barrier and targets somatostatin receptor SSTR2 with high affinity (IC₅₀ = 1.3 nM). NODAGA-LM3 TFA does not trigger the internalization of SSTR2 and can inhibit agonist-induced internalization processes. NODAGA-LM3 TFA shows low uptake in normal tissues such as the liver and spleen, but high uptake in the lungs and blood pool. ⁶⁸Ga-labeled NODAGA-LM3 TFA can serve as a PET imaging agent for well-differentiated neuroendocrine tumors, and is applied in studies related to small cell lung cancer and well-differentiated neuroendocrine tumors .

HY-105168

TAK 044	Endothelin Receptor	Cardiovascular Disease
TAK 044 is an antagonist of Endothelin Receptor. TAK 044 strongly inhibits ET-induced deterioration in various animal models. TAK 044 can be used in study ET-related diseases such as acute myocardial infarction,acute renal failure, acute hepatic malfunction, and subarachnoid hemorrhage .

HY-P11642A

Sialorphin TFA	Enteropeptidase Aminopeptidase Opioid Receptor ERK mTOR Androgen Receptor	Inflammation/Immunology
Sialorphin TFA is a neutral endopeptidase (NEP) and aminopeptidase N (APN) inhibitor that responds to androgen signals. Sialorphin TFA blocks the degradation of endogenous opioid peptides and interacts with μ-, δ-, κ-opioid receptors. Sialorphin TFA regulates the ERK/mTOR signaling pathway by inducing cell cycle arrest, enhancing ERK1/2 activity, and reducing the phosphorylation levels of mTOR, 4E-BP1, p70S6K; accordingly, Sialorphin TFA exhibits antiproliferative activity against colorectal cancer, glioma and prostate cancer cells without cytotoxicity. In addition, Sialorphin TFA also produces antinociceptive responses, regulates sexual behavior, relaxes corpus cavernosum smooth muscle, and alleviates experimental colitis. Sialorphin TFA is also a copper (II) ion-binding ligand. Sialorphin TFA has been used in mechanistic studies related to cancer, pain management and inflammatory bowel disease .

HY-137946

L-Leucine 4-methoxy-β-naphthylamide hydrochloride	Aminopeptidase	Others
L-Leucine 4-methoxy-β-naphthylamide hydrochloride is an aminopeptidase M and leucine aminopeptidase substrate .

HY-P5607

Bombinin	Bacterial Antibiotic Aminopeptidase	Infection
Bombinin is an antimicrobial peptide derived from frog Bombina variegata. Bombinin has a protective effect on aminopeptidase .

HY-W009004B

Trilysine TFA Lys-Lys-Lys TFA; H-Lys-Lys-Lys-OH TFA	Aminopeptidase	Others
Trilysine TFA is a tripeptide and also a substrate for specific peptidases. Trilysine TFA serves as a hydrolytic substrate for the tripeptide-specific aminopeptidase TP and the oligopeptidase OP .

HY-P4461

Ala-Ala-Pro-pNA	Peptides	Others
Ala-Ala-Pro-pNA is a tripeptide, including chromophoric amino acids Pro-pNA. Ala-Ala-Pro-pNA is targeted by tripeptidyl aminopeptidase (SM-TAP) .

HY-P4393

H-Leu-Trp-Met-Arg-OH	Aminopeptidase	Others
H-Leu-Trp-Met-Arg-OH is a tetrapeptide. H-Leu-Trp-Met-Arg-OH can be used as a substrate for *aminopeptidase*-mediated hydrolysis studies .

HY-P4227A

WRVYEKC(dnp)ALK tetraTFA	Peptides	Metabolic Disease
WRVYEKC(dnp)ALK tetraTFA contains tryptophan that can be liberated from the dinitrophenol (DNP) quencher by aminopeptidase activity. WRVYEKC(dnp)ALK tetraTFA can be used as a hydrolysis reaction decapeptide substrate .

HY-115431

Antho-rwamide I	Aminopeptidase	Neurological Disease
Antho-rwamide I is a neuropeptide that can be isolated from the sea anemone Anthopleura elegantissima. Antho-rwamide I is resistant to nonspecific aminopeptidases, which increases the stability of the peptide after neuronal release .

HY-P4528

Ala-Phe-Pro-βNA	Ser/Thr Protease	Others
Ala-Phe-Pro-βNA is the subsrate of prolyl tripeptidyl aminopeptidase, which is from Porphyromonas gingivalis. Ala-Phe-Pro-βNA binds to H-Ala-Ile-pyrrolidin-2-yl boronic acid for PTP39 and the E636A mutant with K_i values of 88.1 nM and 48.8 nM, respectivley .

HY-P2075

EMD 55068	Renin	Endocrinology
EMD 55068 is a renin antagonist. EMD 55068 inhibits the uptake of taurocholate .

HY-P10876

mcK6A1	Amyloid-β	Neurological Disease
mcK6A1 is an inhibitor for the aggregation of amyloid-β (Aβ), that selectively binds to the 16KLVFFA21 segment of Aβ42, forms an extended β-folded structure, and inhibits the formation of Aβ42 oligomers. mcK6A1 can be used in research of Alzheimer's disease and other amyloid-related diseases .

HY-103294

R892	Endogenous Metabolite	Others
R892 is a selective and efficient bradyK_inin B1 receptor antagonist with significant antagonistic activity. The pA2 values of R892 in human and rabbit B1 receptors are 8.8 and 8.6 respectively, indicating its strong anti-activity at these receptors. R892 exhibits selectivity with ID50 values of 2.8 nM and >600 nM for B1 and B2 receptors, respectively, and has no endogenous agonist activity. R892 is resistant to aminopeptidase and kininase II (ACE) degradation and exhibits metabolic stability .

HY-P11488

JR11-PEG3-DOTA-PSMA-03	Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor PSMA	Cancer
JR11-PEG3-DOTA-PSMA-03 (Compound 2) is an RDC-related compound containing the chelating agent DOTA (HY-W053583), the JR11 peptide (SSTR2 antagonist), and the PSMA ligand. JR11-PEG3-DOTA-PSMA-03 shows SSTR2-binding affinities and PSMA-binding affinities, with IC₅₀ s of 94.0 nM, 81.8 nM, respectively. JR11-PEG3-DOTA-PSMA-03 can be radiolabeled with [ ⁶⁸Ga]. [ ⁶⁸Ga] radiolabeled JR11-PEG3-DOTA-PSMA-03 can be used in diagnostic studies of neuroendocrine differentiated prostate cancer .

HY-P11485

JR11-PEG3-HBED-CC-PSMA-03	Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor PSMA	Cancer
JR11-PEG3-HBED-CC-PSMA-03 (Compound 1) is an RDC-related compound containing the chelating agent HBED-CC, the JR11 peptide (SSTR2 antagonist), and the PSMA ligand. JR11-PEG3-HBED-CC-PSMA-03 shows SSTR2-binding affinities and PSMA-binding affinities, with IC₅₀ s of 59.2 nM, 57.0 nM, respectively. JR11-PEG3-HBED-CC-PSMA-03 can be radiolabeled with [ ⁶⁸Ga]. [ ⁶⁸Ga] radiolabeled JR11-PEG3-HBED-CC-PSMA-03 can be used in diagnostic studies of neuroendocrine differentiated prostate cancer .

HY-P11642

Sialorphin	ERK Androgen Receptor Opioid Receptor Enteropeptidase mTOR Aminopeptidase	Neurological Disease Inflammation/Immunology Cancer
Sialorphin is a neutral endopeptidase (NEP) and aminopeptidase N (APN) inhibitor that responds to androgen signals. Sialorphin blocks the degradation of endogenous opioid peptides and interacts with μ-, δ-, κ-opioid receptors. Sialorphin regulates the ERK/mTOR signaling pathway by inducing cell cycle arrest, enhancing ERK1/2 activity, and reducing the phosphorylation levels of mTOR, 4E-BP1, p70S6K; accordingly, Sialorphin exhibits antiproliferative activity against colorectal cancer, glioma and prostate cancer cells without cytotoxicity. In addition, Sialorphin also produces antinociceptive responses, regulates sexual behavior, relaxes corpus cavernosum smooth muscle, and alleviates experimental colitis. Sialorphin is also a copper (II) ion-binding ligand. Sialorphin has been used in mechanistic studies related to cancer, pain management and inflammatory bowel disease .

Species:	Human (1) Mouse (1) Rat (1)
Tag:	His (3)
Source:	Sf9 insect cells (3)

Cat. No.	Compare	상품명	Species	Source	Image

HY-P72826

	Aminopeptidase A Protein, Rat (sf9, His) Glutamyl aminopeptidase; EAP; AP-A; CD249; ENPEP	Rat	Sf9 insect cells
	Aminopeptidase A, modulated by calcium, regulates central hypertension by preferentially cleaving N-terminal acidic residues from peptides, including angiotensin II. Aminopeptidase A Protein, Rat (sf9, His) is the recombinant rat-derived Aminopeptidase A protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P72825

	Aminopeptidase A Protein, Mouse (sf9, His) Glutamyl aminopeptidase; EAP; AP-A; CD249; ENPEP	Mouse	Sf9 insect cells
	The aminopeptidase A protein is a key player in the regulation of central hypertension, exerting its effects by selectively cleaving the N-terminal acidic residues of peptides such as angiotensin II. The enzyme's preference for specific substrates is regulated by calcium levels, underscoring its critical role in controlling blood pressure and maintaining cardiovascular health. Aminopeptidase A Protein, Mouse (sf9, His) is the recombinant mouse-derived Aminopeptidase A protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P72824

	Aminopeptidase A Protein, Human (sf9, His) Glutamyl aminopeptidase; EAP; AP-A; CD249; ENPEP	Human	Sf9 insect cells
	Aminopeptidase A protein has calcium-regulating activity and plays a key role in central hypertension by preferentially cleaving N-terminal acidic residues, including angiotensin II. The specificity of this enzyme highlights its involvement in the regulation of blood pressure-related peptides, suggesting potential implications for the physiological mechanisms of hypertension. Aminopeptidase A Protein, Human (sf9, His) is the recombinant human-derived Aminopeptidase A protein, expressed by Sf9 insect cells , with N-His labeled tag.

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HY-B0134AS

Bestatin-d7 hydrochloride
Bestatin-d₇ (hydrochloride) is deuterium labeled Bestatin (hydrochloride). Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research.

HY-123193S

Avizafone-d5 dihydrobromide

Avizafone-d₅ dihydrobromide is the deuterium labeled Avizafone dihydrobromide . Avizafone (Pro-diazepam) dihydrobromide, a pro-drug of Diazepam, is an anticonvulsant agent. Avizafone dihydrobromide can be used as an antidote of nerve agent poisoning. In vivo, Avizafone is rapidly hydrolyzed by aminopeptidase to produce lysine and diazepam. Avizafone dihydrobromide has research areas including neurological disease, such as epilepsy.

HY-B0134S1

Bestatin-d10
Bestatin-d₁₀ (Ubenimex-d₁₀) is deuterium labeled Bestatin. Bestatin is a natural, broad-spectrum, and competitive *CD13 (Aminopeptidase* N)/APN and leukotriene A4 hydrolase** inhibitor. Bestatin has anticancer effects .

Host:	Rabbit (3)
Reactivity:	Human (3) Rat (2)
Application:	IHC-P (3) WB (3)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (2)
Modification:	Unmodified (2)

Cat. No.	Compare	상품명	Application	Reactivity	Image

HY-P82419

	AP-A Antibody (YA2164) AP-A; aminopeptidase A; APA; bp1; CD249; EAP; Enpep; Gp160; Ly51	WB, IHC-P	Human
	AP-A Antibody (YA2164) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AP-A.

HY-P82414

	ERAP1 Antibody (YA2159) ERAP1; APPILS; ARTS1; KIAA0525; Endoplasmic reticulum aminopeptidase 1; ARTS-1; Adipocyte-derived leucine aminopeptidase; A-LAP; aminopeptidase PILS; Puromycin-insensitive leucyl-specific aminopeptidase; PILS-AP; Type 1 tumor necrosis facto	WB, IHC-P	Human, Rat
	ERAP1 Antibody (YA2159) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ERAP1.

HY-P82414A

	ERAP1 Antibody (YA2159)(PBS only) ERAP1; APPILS; ARTS1; KIAA0525; Endoplasmic reticulum aminopeptidase 1; ARTS-1; Adipocyte-derived leucine aminopeptidase; A-LAP; aminopeptidase PILS; Puromycin-insensitive leucyl-specific aminopeptidase; PILS-AP; Type 1 tumor necrosis facto	WB, IHC-P	Human, Rat
	ERAP1 Antibody (YA2159) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ERAP1.

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Size	* This product has been "discontinued". Optimized version of product available: / 해외재고보유 - + 장바구니에 담기 견적 받기

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