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Results for "

bifunctional fusion protein

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

4

Inhibitory Antibodies

1

Oligonucleotides

Art. -Nr. Produktname Target Forschungsgebiete Chemical Structure
  • HY-P99480
    Bintrafusp alfa

    M7824; MSB0011359C

    		 TGF-β Receptor Cancer
    Bintrafusp alfa (M 7824) is a first-in-class bifunctional fusion protein composed of the extracellular domain of TGF-βRII fused to a human IgG1 mAb blocking programmed cell death ligand. Bintrafusp alfa can be used for the research of cancer .
    Bintrafusp alfa
  • HY-P99944
    SHR-1701

    Retlirafusp alfa

    		 PD-1/PD-L1 TGF-β Receptor Cancer
    SHR-1701 (Retlirafusp alfa) is a bifunctional fusion protein targeting PD-L1 and TGF-β for cancer research .
    SHR-1701
  • HY-P99687
    Latikafusp

    AMG 256

    		 PD-1/PD-L1 Cancer
    Latikafusp (AMG 256) is a bifunctional fusion protein comprising a PD-1-targeting antibody and IL-21 mutein designed to deliver IL-21 pathway stimulation to PD-1+ cells. Latikafusp is designed to prime and extend the activity of cytotoxic and memory T cells and induce anti-tumor immunity. Latikafusp has the potential for solid tumors research .Latikafusp may lead to the development of immunogenicity-mediated responses .
    Latikafusp
  • HY-177767
    EY-CBS

    		Biochemical Assay Reagents Others
    EY-CBS is a synthetic and rigid cross linker. EY-CBS reacts selectively with cysteines in a-helices, to stabilize the connecting helix. EY-CBS can be used for the study of the structural stability of protein polypeptides .
    EY-CBS
  • HY-P991084
    TQB-2858

    		PD-1/PD-L1 Cancer
    TQB-2858 is a bifunctional fusion protein composed of a monoclonal antibody against PD-L1 fused with the extracellular domain of TGF-β receptor. TQB-2858 has a high affinity for PD-L1, TGF-β1, and TGF-β3 and exhibited high PD-L1 target occupancy. TQB-2858 can be used for the study of osteosarcoma and alveolar soft part sarcoma (ASPS) .
    TQB-2858
  • HY-185051
    OTX-2002

    		mRNA Cancer
    OTX-2002 is an mRNA encoding two bifunctional fusion proteins (ZFBD-MQ1 and ZFBD-KRAB). OTX-2002 targets regulatory elements located within the MYC protection gene domain (IGD) and induces the methylation of DNA and histone, leading to the downregulation of MYC expression.
    OTX-2002
  • HY-182964
    WY165

    		ClpP Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
    WY165 is a bifunctional molecule comprising TR79, an activator of the mitochondrial protease complex caseinolytic protease P (ClpP), linked to desthiobiotin. WY165 mediates selective degradation of monomeric streptavidin (mSA) and its fusion proteins localized to the mitochondrial matrix with a DC50 of 197 nM. WY165 restores mitochondrial morphology by reducing the level of mSA fused to short transmembrane protein 1 (mSA-STMP1) in cells overexpressing mSA-STMP1. WY165 can be used for research in cancer, neurodegenerative diseases, cardiovascular diseases, and metabolic diseases .
    WY165

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