1. Immunology/Inflammation TGF-beta/Smad
  2. PD-1/PD-L1 TGF-β Receptor
  3. SHR-1701

SHR-1701  (Synonyms: Retlirafusp alfa)

Cat. No.: HY-P99944

SHR-1701 (Retlirafusp alfa) is a bifunctional fusion protein targeting PD-L1 and TGF-β for cancer research.

For research use only. We do not sell to patients.

SHR-1701 Chemical Structure

SHR-1701 Chemical Structure

CAS No. : 2891860-17-4

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SHR-1701 (Retlirafusp alfa) is a bifunctional fusion protein targeting PD-L1 and TGF-β for cancer research[1].

In Vitro

SHR-1701 (10 μg/mL) can inhibit TGF-β signaling pathway, activate PI3K/Akt/Erk signaling pathway, rescue lymphocytes and restore the anti-tumor function of peripheral blood CD8+ T cells in patients with lung cancer[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.


[Retlirafusp alfa]


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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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