2387510-81-6
2387510-81-6
Chemical Structure
aTAG 2139
Synonym(s): CFT-2139
- CAS No.: 2387510-81-6
- Formula:C42H38N8O8
- Molecular Weight:782.80
InChIKey: IKLCDLVLZPLJRR-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C2=CC=C3N=CC(C(NC)=O)=C(C3=C2)NC4=CC=CC=C4)C=N1)NCCCCNC(COC5=CC=CC(C(N6C7C(NC(CC7)=O)=O)=O)=C5C6=O)=O
Biological Activity: aTAG 2139 (CFT-2139) is a bifunctional tag-targeted PROTAC-class degrader that induces the degradation of the MTH1 aTAG fusion protein by recruiting cereblon, with a DC50 of 1.1 nM (in Jurkat T cells). aTAG 2139 is applicable to the research of CD19-positive cancers[1].
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aTAG 2139 | aTAG 2139 (CFT-2139) is a bifunctional tag-targeted PROTAC-class degrader that induces the degradation of the MTH1 aTAG fusion protein by recruiting cereblon, with a DC50 of 1.1 nM (in Jurkat T cells). aTAG 2139 is applicable to the research of CD19-positive cancers. | |||||||||||||||||||||
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