260 Results for "

cyclodextrin

" in MedChemExpress (MCE) Product Catalog:
Products (260)

260 Results for "cyclodextrin" in MCE Product Catalog:

388
388 Publications Verification
Cat. No.: HY-14648C
CAS No.: 50-02-2
Purity:  ≥98.0%
Synonyms: Dexamethasone cyclodextrin complex
Dexamethasone (Hexadecadrol) Water Soluble is a water-soluble form of Dexamethasone (HY-14648). Dexamethasone is a glucocorticoid receptor agonist, apoptosis inducer, and a common disease inducer in experimental animals. It can be used to construct models of muscle atrophy, hypertension, and depression. Dexamethasone can inhibit the production of inflammatory miRNA-155 exosomes in macrophages and significantly reduce the expression of inflammatory factors in neutrophils and monocytes. Dexamethasone also has the potential to be used in COVID-19 research .(Sale size is the weight of dexamethasone)
loading...
    loading...
166
166 Cited Publications
Cat. No.: HY-17031
CAS No.: 182410-00-0
Synonyms: Sulfobutylether-β-cyclodextrin
SBE-β-CD is a sulfobutylether β-cyclodextrin derivative used as an excipient or a formulating agent to increase the solubility of poorly soluble agents .
loading...
    loading...
114
114 Cited Publications
Cat. No.: HY-101461
CAS No.: 128446-36-6
Purity:  99.95%
Synonyms: Methyl-beta-cyclodextrin
Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) is a cyclic heptasaccharide used to deliver hydrophobic agents based on its property of solubilizing non-polar substances. Methyl-β-cyclodextrin is also extensively used as a cholesterol-depleting reagent . Methyl-β-cyclodextrin strongly reduces clathrin-dependent endocytosis . Methyl-β-cyclodextrin blocks cell migrasome formation .
loading...
    loading...
92
92 Cited Publications
Cat. No.: HY-N0322A
Cholesterol Water Soluble is a major sterol in mammals, constituting 20-25% of the structural composition of the plasma membrane. The plasma membrane is highly permeable to water but relatively impermeable to ions and protons. Cholesterol Water Soluble plays an important role in determining the fluidity and permeability characteristics of membranes and the function of transporters and signaling proteins. Cholesterol Water Soluble is also an endogenous estrogen-related receptor alpha (ERRα) agonist. Cholesterol Water Soluble can be used to study the effects of cholesterol on potassium currents in inner hair cells .
(Note: This product is a mixture of Cholesterol and Methyl-β-cyclodextrin. The product specifications below only indicate the effective content of Cholesterol.)
loading...
    loading...
32
32 Cited Publications
Cat. No.: HY-101103
CAS No.: 128446-35-5
Purity:  99.74%
Synonyms: (2-Hydroxypropyl)-β-cyclodextrin
HP-β-CD ((2-Hydroxypropyl)-β-cyclodextrin) is a widely used drug delivery vehicle to improve the stability and bioavailability.
loading...
    loading...
32
32 Cited Publications
Cat. No.: HY-P0023
CAS No.: 161552-03-0
Target:  

Integrin

Research Areas:  

Cancer

Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM. Cyclo(-RGDfK) potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface .
loading...
    loading...
32
32 Cited Publications
Cat. No.: HY-P0023A
CAS No.: 500577-51-5
Target:  

Integrin

Research Areas:  

Cancer

Cyclo(-RGDfK) TFA is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM . Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface .
loading...
    loading...
17
17 Cited Publications
Cat. No.: HY-12559
CAS No.: 254435-95-5
Purity:  98.08%
Synonyms: Debio-025; DEB-025
Target:  

Cyclophilin HCV

Research Areas:  

Infection

Alisporivir (Debio-025) is a cyclophilin inhibitor molecule with potent anti-hepatitis C virus (HCV) activity.
loading...
    loading...
11
11 Cited Publications
Cat. No.: HY-107201
CAS No.: 7585-39-9
Purity:  99.95%
Synonyms: Betadex
Research Areas:  

Infection

β-Cyclodextrin is a cyclic polysaccharide composed of seven units of glucose (α-D-glucopyranose) linked by α-(1,4) type bonds. β-Cyclodextrin has often been used to enhance the solubility of agents. β-Cyclodextrin has anti-influenza virus H1N1 activities.
loading...
    loading...
7
7 Cited Publications
Cat. No.: HY-W019711
CAS No.: 14371-10-9
trans-Cinnamaldehyde can be used to prepare highly polyfunctionalized furan ring by reaction of alkyl isocyanides with dialkyl acetylenedicarboxylate . trans-Cinnamaldehyde can be used to synthesize trans-cinnamaldehyde -β-cyclodextrin complex, an antimicrobial edible coating that increases the shelf life of fresh-cut fruits .
loading...
    loading...
7
7 Cited Publications
Cat. No.: HY-P1934
CAS No.: 14705-60-3
Synonyms: Cyclo(phenylalanylprolyl); A-64863
Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)) is a quorum-sensing molecule of Vibrio vulnificus that specifically interacts with RIG-I, inhibiting RIG-I polyubiquitination, suppressing IRF-3 activation, and reducing type I interferon production. Cyclo(Phe-Pro) enhances susceptibility to HCV and influenza virus and also alleviates plant aluminum toxicity stress. The mechanism of Cyclo(Phe-Pro) involves the regulation of host immune signaling pathways, bacterial virulence gene expression, and plant antioxidant systems, making it a promising candidate for research in viral infections, bacterial virulence regulation, and agricultural stress resistance .
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-100563A
CAS No.: 217099-14-4
Purity:  99.83%
Target:  

Integrin

Research Areas:  

Cancer

Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-100563
CAS No.: 250612-42-1
Purity:  99.92%
Target:  

Integrin

Research Areas:  

Cancer

Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-12378
CAS No.: 136553-81-6
Purity:  99.82%
Target:  

Endothelin Receptor

Research Areas:  

Cardiovascular Disease

BQ-123 is a potent and selective endothelin A (ETA) receptor antagonist with an IC50 of 7.3 nM and a Ki of 25 nM. BQ-123 inhibits endothelin-1-mediated proliferation of human pulmonary artery smooth muscle cells and lowers blood pressure in different rat models of hypertension .
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-P0257
CAS No.: 170809-51-5
Target:  

CRFR

Research Areas:  

Neurological Disease

Astressin is a potent corticotropin releasing factor (CRF) antagonist.
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-P1674A
CAS No.: 3053070-05-3
Synonyms: POL7080 TFA
Target:  

Bacterial Antibiotic

Research Areas:  

Infection

Murepavadin (POL7080) (TFA), a 14-amino-acid cyclic peptide, is a highly potent, specific antibiotic. Murepavadin exhibits a potent antimicrobial activity for P. aeruginosa with MIC50 and MIC90 values both of 0.12 mg/L. Murepavadin also can target the lipopolysaccharide transport portin D. Murepavadin can be used for the research of bacterial resistance .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-P2300
CAS No.: 862772-11-0
Synonyms: Cyclo(RGDfC)
Target:  

Integrin

Research Areas:  

Cancer

Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC), a cyclic RGD peptide which has high affinity to αvβ3, can disrupt cell integrin interactions. Cyclo(Arg-Gly-Asp-D-Phe-Cys) inhibits pluripotent marker expression in embryonic stem cells (ESCs) and the tumorigenic potential of mESCs in vivo. Cyclo(Arg-Gly-Asp-D-Phe-Cys) can be used in the research of tumors .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-B1513
CAS No.: 10016-20-3
α-Cyclodextrin (α-CD) is a soluble fiber derived from corn. α-Cyclodextrin can deplete sphingolipids and phospholipids from cell membranes. α-Cyclodextrin interacts with tubulin. α-Cyclodextrin improves defenses against SARS-CoV-2 infection. α-Cyclodextrin enhances the anticancer efficacy of Crcumin (HY-N0005) against breast, lung and cervical cancer. α-Cyclodextrin has beneficial effects on body weight and blood lipids .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-B1007
CAS No.: 149-16-6
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

Butacaine is a reversible nerve conduction blocker. Butacaine acts on the nervous system and nerve fibers, can cause both sensory and motor paralysis. Butacaine inhibits the NavBh currents. Butacaine can form inclusion complexes with α-cyclodextrin (α-CD) and β-cyclodextrin (β-CD). Butacaine is commonly used as a negative control for other local anesthetics .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-18593
CAS No.: 104723-60-6
Synonyms: 6-O-alpha-D-Maltosyl-beta-cyclodextrin
Mal-β-CD is a cellular cholesterol modifier which can form soluble inclusion complex with cholesterol.
loading...
    loading...