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cytosolic Hsp90

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HSP (2) Apoptosis (1) Drug Derivative (1)
By Research Areas:	Cancer (2)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Targets Recommended: Hsp-targeting Chimeras HSP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-120909

YK5	HSP Apoptosis	Cancer
YK5 is a potent and selective *Hsp70* inhibitor. YK5 selectively and tightly binds to the cytosolic Hsp70s in cancer cells. YK5 has biological activity partly by interfering with the formation of active oncogenic Hsp70/Hsp90/client protein complexes .

HY-182302

SMTIN-P01	Drug Derivative HSP	Cancer
SMTIN-P01 is a TRAP1 inhibitor that is selective for cytosolic *Hsp90* and accumulates in mitochondria. SMTIN-P01 binds to the ATP-binding site of TRAP1 as an ATP mimic, thereby inhibiting ATPase and foldase activities. SMTIN-P01 induces mitochondrial membrane depolarization and proteolytic degradation in cancer cells. SMTIN-P01 exhibits significant cytotoxicity, but shows extremely low toxicity to primary mouse hepatocytes, and does not interfere with SIRT3-related functions or the levels of cytosolic Hsp90 substrates. SMTIN-P01 has important application value in cancer-related research .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P72238

	HSP90AA1 Protein, Human (His-SUMO) 2 Publications Verification Heat shock 86 kDa; Heat shock protein 90kDa alpha cytosolic class A member 1; Heat shock protein 90kDa alpha cytosolic class B member 1; Heat shock protein Hsp 90 alpha ; Heat shock protein Hsp 90 beta; Heat shock protein Hsp 90-alpha; HS90A_HUMAN; Hsp 84; Hsp 86; Hsp 90; Hsp86; Hsp90A; Hsp90AA1; Hsp90AB1; Hsp90B; HspC1; HspC2; HspCAL1 ; HspCAL4; Renal carcinoma antigen NY-REN-38	Human	E. coli
	The HSP90AA1 protein is an important molecular chaperone that coordinates the maturation and regulation of specific target proteins critical for cell cycle control and signal transduction. Its ATPase activity drives a functional cycle that induces conformational changes in client proteins for activation. HSP90AA1 Protein, Human (His-SUMO) is the recombinant human-derived HSP90AA1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

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Host:	Mouse (1) Rabbit (2)
Reactivity:	Human (3) Rat (3) Mouse (3) Monkey (1) Hamster (1)
Application:	ICC/IF (3) IP (3) WB (3)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

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HY-P85596

	Hsp90 beta Antibody (YA5288) Hsp90AB1; 90 kda heat shock protein beta Hsp90 beta; D6S182; FLJ26984; Heat shock 84 kDa; Heat shock 90kD protein 1, beta; Heat shock 90kDa protein 1 beta; Heat shock protein 90kDa alpha; cytosolic; class B member 1; Heat shock protein beta; Heat shock protein Hsp 90 beta; Heat shock protein Hsp 90-beta; HS90B_HUMAN; Hsp 84; Hsp 90; Hsp 90 b; Hsp 90b; Hsp84; Hsp90 BETA; Hsp90ab1; Hsp90B; HspC2; HspCB.	WB, ICC/IF, IP	Human, Mouse, Rat, Monkey, Hamster
	Hsp90 beta Antibody (YA5288) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Hsp90 beta.

HY-P83386

	p23 Antibody (YA3131) PTGES3; P23; TEBP; Prostaglandin E synthase 3; cytosolic prostaglandin E2 synthase; cPGES; Hsp90 co-chaperone; Progesterone receptor complex p23; Telomerase-binding protein p23	WB, ICC/IF, IP	Human, Mouse, Rat
	p23 Antibody (YA3131) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p23.

HY-P83386A

	p23 Antibody (YA3131)(PBS only) PTGES3; P23; TEBP; Prostaglandin E synthase 3; cytosolic prostaglandin E2 synthase; cPGES; Hsp90 co-chaperone; Progesterone receptor complex p23; Telomerase-binding protein p23	WB, ICC/IF, IP	Human, Mouse, Rat
	p23 Antibody (YA3131) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p23.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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