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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
dihydropyrimidine dehydrogenase
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "dihydropyrimidine dehydrogenase" in MCE Product Catalog:
3
3 Cited Publications
Target:
Research Areas:
TAS-114 is an orally active dual dUTPase/dihydropyrimidine dehydrogenase (DPD) inhibitor, can improving the therapeutic efficacy of fluoropyrimidine .
3
Research Areas:
Gimeracil, a component of an oral fluoropyrimidine derivative S-1, inhibits DNA DSB repair and is a potent inhibitor of DPYD (dihydropyrimidine dehydrogenase, DPD) .
1
Category:
Natural Products Microorganisms Disease markers Metabolic Disease Endocrine diseases Endogenous metabolite Disease Research Fields
Target:
1
1 Cited Publications
Cat. No.: HY-W010450
CAS No.: 65-71-4
Target:
Research Areas:
Thymine, one of the four bases of DNA, is a substrate for rat liver dihydropyrimidine dehydrogenase (DPD), with a Km value of 2.2 μM, Ki of 24 μM (using 5-FU as the DPD substrate), and a specific activity of 0.68 nmol/min/mg .
1
1 Cited Publications
Synonyms: 5-Ethynyluracil; GW776C85
Target:
Research Areas:
Eniluracil (5-Ethynyluracil) is an orally active dihydropyrimidine dehydrogenase (DPD) inhibitor. Eniluracil irreversibly inhibits DPD, increases the oral bioavailability of 5-fluorouracil to 100%, and facilitates the uniform absorption and toxicity of 5-fluorouracil. Eniluracil can be used in cancer research of combination with fluoropyrimidines (including 5-fluorouracil) . Eniluracil is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-W012926S1
CAS No.: 334473-41-5
Synonyms: 5,6-Dihydrouracil-d4
Synonyms: 5-DHFU; 5-Fluorodihydropyrimidine-2,4-dione; 5-Fluorodihydrouracil
Target:
Research Areas:
5,6-Dihydro-5-Fluorouracil (5-DHFU; 5-Fluorodihydropyrimidine-2,4-dione) is the active metabolite of the thymidylate synthase inhibitor prodrug 5-fluorouracil (HY-90006), which is formed from 5-fluorouracil by dihydropyrimidine dehydrogenase (DPD). 5,6-Dihydro-5-Fluorouracil is cytotoxic to HaCaT keratinocytes (IC50=13.5 μM). Intravenous administration of 5,6-Dihydro-5-Fluorouracil (90 mg/kg/wk) in combination with 5-fluorouracil and the DPD inhibitor eniluracil (HY-10533) slows tumor growth in a rat colon cancer model.
Cat. No.: HY-W012926S
CAS No.: 360769-22-8
Synonyms: 5,6-Dihydrouracil-13C4,15N2
Cat. No.: HY-W001983
CAS No.: 696-07-1
Research Areas:
5-Iodouracil (Compound 4b) is an irreversible dihydropyrimidine dehydrogenase (DPD) inhibitor (IC50=0.22 μM). 5-Iodouracil is promising for research of DPD-overexpressing solid tumors like non-small cell lung cancer (NSCLC) .
Cat. No.: HY-W012926R
CAS No.: 504-07-4
Synonyms: 5,6-Dihydrouracil (Standard)
Cat. No.: HY-134160S
CAS No.: 1189492-99-6
Synonyms: 5-DHFU-13C,15N2; 5-Fluorodihydropyrimidine-2,4-dione-13C,15N2; 5-Fluorodihydrouracil-13C,15N2
Cat. No.: HY-17469R
CAS No.: 103766-25-2
Synonyms: Gimestat (Standard)
Research Areas:
Gimeracil (Standard) is the analytical standard of Gimeracil. This product is intended for research and analytical applications. Gimeracil, a component of an oral fluoropyrimidine derivative S-1, inhibits DNA DSB repair and is a potent inhibitor of DPYD (dihydropyrimidine dehydrogenase, DPD) .
Cat. No.: HY-W777340
CAS No.: 1184979-29-0
Synonyms: Gimestat-13C3
Cat. No.: HY-17469S
CAS No.: 1261394-32-4
Synonyms: Gimestat-13C3,15N
Cat. No.: HY-W779020
CAS No.: 181516-96-1
Synonyms: 5,6-Dihydrouracil-13C,15N2
Cat. No.: HY-W014109
CAS No.: 69304-49-0
Synonyms: (E)-5-(2-Bromovinyl)uracil; BVU
Target:
Research Areas:
(E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner. It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil (HY-90006) in a P388 murine leukemia model when administered at a dose of 200 μmol/kg, increasing survival time.
Cat. No.: HY-10533R
CAS No.: 59989-18-3
Synonyms: 5-Ethynyluracil (Standard); GW776C85 (Standard)
Research Areas:
Eniluracil (Standard) is the analytical standard of Eniluracil. This product is intended for research and analytical applications. Eniluracil (5-Ethynyluracil) is an orally active dihydropyrimidine dehydrogenase (DPD) inhibitor. Eniluracil irreversibly inhibits DPD, increases the oral bioavailability of 5-fluorouracil to 100%, and facilitates the uniform absorption and toxicity of 5-fluorouracil. Eniluracil can be used in cancer research of combination with fluoropyrimidines (including 5-fluorouracil) . Eniluracil is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-19413
CAS No.: 216449-60-4
Research Areas:
Ro-09-4889 is a prodrug. Ro-09-4889 can inhibit dihydropyrimidine dehydrogenase (DPD) activity and its effect is dose-dependent. Ro-09-4889 can be used for cancer research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
