103766-25-2
103766-25-2
Chemical Structure
Gimeracil
Synonym(s): Gimestat
- CAS No.: 103766-25-2
- Formula:C5H4ClNO2
- Molecular Weight:145.54
IUPAC Name: 5-chloro-4-hydroxypyridin-2(1H)-one
InChIKey: ZPLQIPFOCGIIHV-UHFFFAOYSA-N
SMILES: O=C1C=C(O)C(Cl)=CN1
Biological Activity: Gimeracil, a component of an oral fluoropyrimidine derivative S-1, inhibits DNA DSB repair and is a potent inhibitor of DPYD (dihydropyrimidine dehydrogenase, DPD)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Gimeracil | 99.81% | Gimeracil, a component of an oral fluoropyrimidine derivative S-1, inhibits DNA DSB repair and is a potent inhibitor of DPYD (dihydropyrimidine dehydrogenase, DPD). | ||||||||||||||||||||
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Gimeracil (Standard) | ≥98% | Gimeracil (Standard) is the analytical standard of Gimeracil. This product is intended for research and analytical applications. Gimeracil, a component of an oral fluoropyrimidine derivative S-1, inhibits DNA DSB repair and is a potent inhibitor of DPYD (dihydropyrimidine dehydrogenase, DPD). | ||||||||||||||||||||
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Gimeracil-13C3,15N | Gimeracil-13C3,15N (Gimestat-13C3,15N) is 13C and 15N labeled Gimeracil. Gimeracil, a component of an oral fluoropyrimidine derivative S-1, inhibits DNA DSB repair and is a potent inhibitor of DPYD (dihydropyrimidine dehydrogenase, DPD). | |||||||||||||||||||||
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Gimeracil-13C3 | Gimeracil-13C3 (Gimestat-13C3) is the 13C-labeled Gimeracil (HY-17469). Gimeracil, a component of an oral fluoropyrimidine derivative S-1, inhibits DNA DSB repair and is a potent inhibitor of DPYD (dihydropyrimidine dehydrogenase, DPD). | |||||||||||||||||||||
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References
- [1]. Masaru Takagi, et al. Gimeracil sensitizes cells to radiation via inhibition of homologous recombination. Radiother Oncol. 2010 Aug;96(2):259-66. [Content Brief]
- [2]. Koh-Ichi Sakata, et al. Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination. Cancer Sci. 2011 Sep;102(9):1712-6. [Content Brief]
