1261394-32-4
1261394-32-4
Chemical Structure
Gimeracil-13C3,15N
Synonym(s): Gimestat-13C3,15N
- CAS No.: 1261394-32-4
- Formula:C213C3H4Cl15NO2
- Molecular Weight:149.52
InChIKey: ZPLQIPFOCGIIHV-XTJKMBSOSA-N
SMILES: O[13C](C(Cl)=C[15NH]1)=[13CH][13C]1=O
Biological Activity: Gimeracil-13C3,15N (Gimestat-13C3,15N) is 13C and 15N labeled Gimeracil. Gimeracil, a component of an oral fluoropyrimidine derivative S-1, inhibits DNA DSB repair and is a potent inhibitor of DPYD (dihydropyrimidine dehydrogenase, DPD)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Gimeracil-13C3,15N | Gimeracil-13C3,15N (Gimestat-13C3,15N) is 13C and 15N labeled Gimeracil. Gimeracil, a component of an oral fluoropyrimidine derivative S-1, inhibits DNA DSB repair and is a potent inhibitor of DPYD (dihydropyrimidine dehydrogenase, DPD). | |||||||||||||||||||||
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Gimeracil (Standard) | ≥98% | Gimeracil (Standard) is the analytical standard of Gimeracil. This product is intended for research and analytical applications. Gimeracil, a component of an oral fluoropyrimidine derivative S-1, inhibits DNA DSB repair and is a potent inhibitor of DPYD (dihydropyrimidine dehydrogenase, DPD). | ||||||||||||||||||||
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Gimeracil-13C3 | Gimeracil-13C3 (Gimestat-13C3) is the 13C-labeled Gimeracil (HY-17469). Gimeracil, a component of an oral fluoropyrimidine derivative S-1, inhibits DNA DSB repair and is a potent inhibitor of DPYD (dihydropyrimidine dehydrogenase, DPD). | |||||||||||||||||||||
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Gimeracil | 99.94% | Gimeracil, a component of an oral fluoropyrimidine derivative S-1, inhibits DNA DSB repair and is a potent inhibitor of DPYD (dihydropyrimidine dehydrogenase, DPD). | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Masakazu Fukushima, et al. Gimeracil, a component of S-1, may enhance the antitumor activity of X-ray irradiation in human cancer xenograft models in vivo. Oncol Rep. 2010 Nov;24(5):1307-13. [Content Brief]
