69304-49-0
Chemical Structure
(E)-5-(2-Bromovinyl)pyrimidine-2,4(1H,3H)-dione
Synonym(s): (E)-5-(2-Bromovinyl)uracil; BVU
- CAS No.: 69304-49-0
- Formula:C6H5BrN2O2
- Molecular Weight:217.02
IUPAC Name: (E)-5-(2-Bromovinyl)pyrimidine-2,4(1H,3H)-dione
InChIKey: BLXGZIDBSXVMLU-OWOJBTEDSA-N
SMILES: O=C1NC(C(/C=C/Br)=CN1)=O
Biological Activity: (E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner. It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil (HY-90006) in a P388 murine leukemia model when administered at a dose of 200 μmol/kg, increasing survival time.
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(E)-5-(2-Bromovinyl)pyrimidine-2,4(1H,3H)-dione | (E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner. It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil (HY-90006) in a P388 murine leukemia model when administered at a dose of 200 μmol/kg, increasing survival time. | |||||||||||||||||||||
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