334473-41-5
334473-41-5
Chemical Structure
Dihydrouracil-d4
Synonym(s): 5,6-Dihydrouracil-d4
- CAS No.: 334473-41-5
- Formula:C4H2D4N2O2
- Molecular Weight:118.13
IUPAC Name: dihydropyrimidine-2,4(1H,3H)-dione-5,5,6,6-d4
InChIKey: OIVLITBTBDPEFK-LNLMKGTHSA-N
SMILES: O=C1NC(NC([2H])([2H])C1([2H])[2H])=O
Biological Activity: Dihydrouracil-d4 is the deuterium labeled Dihydrouracil[1]. Dihydrouracil (HY-W012926), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient[2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Dihydrouracil-d4 | 99.97% | Dihydrouracil-d4 is the deuterium labeled Dihydrouracil. Dihydrouracil (HY-W012926), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient. | ||||||||||||||||||||
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Dihydrouracil (Standard) | 99.90% | Dihydrouracil (Standard) is the analytical standard of Dihydrouracil. This product is intended for research and analytical applications. Dihydrouracil (5,6-Dihydrouracil), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient. | ||||||||||||||||||||
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Dihydrouracil-13C,15N2 | Dihydrouracil-13C,15N2 (5,6-Dihydrouracil-13C,15N2) is the 13C- and 15N-labeled Dihydrouracil (HY-W012926). Dihydrouracil (5,6-Dihydrouracil), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient. | |||||||||||||||||||||
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Dihydrouracil | 99.73% | Dihydrouracil (5,6-Dihydrouracil), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Henricks LM, et, al. Food-effect study on uracil and dihydrouracil plasma levels as marker for dihydropyrimidine dehydrogenase activity in human volunteers. Br J Clin Pharmacol. 2018 Dec;84(12):2761-2769. [Content Brief]
- [3]. Jacobs BAW, et, al. The impact of liver resection on the dihydrouracil:uracil plasma ratio in patients with colorectal liver metastases. Eur J Clin Pharmacol. 2018 Jun;74(6):737-744. [Content Brief]
