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Results for "

dkk3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (1) LDLR (1) Small Interfering RNA (siRNA) (3) Wnt (2)
By Research Areas:	Cancer (1) Inflammation/Immunology (1) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

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Inhibitory Antibodies

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P990250

*Anti-Mouse DKK3* Antibody (DKK3-4.22)**	Wnt	Inflammation/Immunology
Anti-Mouse DKK3 Antibody (DKK3-4.22) is an anti-mouse *DKK3* IgG1 monoclonal antibody. Anti-Mouse DKK3 Antibody (DKK3-4.22) can improve kidney function and increases T cell infiltration. Anti-Mouse DKK3 Antibody (DKK3-4.22) can reduce skin inflammation by blocking the immunosuppressive function of DKK3. Anti-Mouse DKK3 Antibody (DKK3-4.22) can be used for researches on inflammation conditions such as unilateral ureteral obstruction (UUO) and experimental autoimmune encephalomyelitis (EAE) .

HY-W107409

Meridianin C	Others	Cancer
Meridianin C is a marine natural product with anticancer activity. Meridianin C has significant inhibitory effects on four different human tongue cancer cells (YD-8, YD-10B, YD-38 and HSC-3). Meridianin C most strongly reduced the growth of YD-10B cells, the most aggressive and tumorigenic of the cell lines tested. Meridianin C also induced significant accumulation of large vesicles in YD-10B cells, validating its function through macrophagocytosis. Meridianin C reduces cellular levels of Dickkopf-related protein-3 (DKK-3), a known negative regulator of macrophagy. Meridianin C affects macrophagocytosis by downregulating DKK-3, thereby affecting cell proliferation .

HY-RS16965

Dkk3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Dkk3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dkk3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dkk3 Mouse Pre-designed siRNA Set A Dkk3 Mouse Pre-designed siRNA Set A

HY-RS03789

DKK3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DKK3 Human Pre-designed siRNA Set A contains three designed siRNAs for DKK3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DKK3 Human Pre-designed siRNA Set A DKK3 Human Pre-designed siRNA Set A

HY-179459

SJ-300	Wnt LDLR Amyloid-β	Neurological Disease
SJ-300 is a potent and selective, orally active and brain-penetrat DKK3-LRP1 interaction inhibitor. SJ-300 restores Aβ clearance in AD models. SJ 300 binds to mLRPIV with a K_d of 7.9 μM, inhibits the DKK3 mLRPIV complex with an IC₅₀ of 3.2 μM, and does not disrupt the binding of Aβ to LRP1. SJ 300 rescues cognitive function and ameliorates neuropathology (Aβ plaque reduction ≈ 73.3 %) in vivo. SJ 300 can be employed for research in Alzheimer’s disease .

HY-RS23408

Dkk3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Dkk3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Dkk3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dkk3 Rat Pre-designed siRNA Set A Dkk3 Rat Pre-designed siRNA Set A

Cat. No.	Product Name	Target	Research Area	Image

HY-P990250

*Anti-Mouse DKK3* Antibody (DKK3-4.22)**	Wnt	Inflammation/Immunology
Anti-Mouse DKK3 Antibody (DKK3-4.22) is an anti-mouse *DKK3* IgG1 monoclonal antibody. Anti-Mouse DKK3 Antibody (DKK3-4.22) can improve kidney function and increases T cell infiltration. Anti-Mouse DKK3 Antibody (DKK3-4.22) can reduce skin inflammation by blocking the immunosuppressive function of DKK3. Anti-Mouse DKK3 Antibody (DKK3-4.22) can be used for researches on inflammation conditions such as unilateral ureteral obstruction (UUO) and experimental autoimmune encephalomyelitis (EAE) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W107409

Meridianin C	Alkaloids Other Alkaloids Marine natural products Source Classification	Others
Meridianin C is a marine natural product with anticancer activity. Meridianin C has significant inhibitory effects on four different human tongue cancer cells (YD-8, YD-10B, YD-38 and HSC-3). Meridianin C most strongly reduced the growth of YD-10B cells, the most aggressive and tumorigenic of the cell lines tested. Meridianin C also induced significant accumulation of large vesicles in YD-10B cells, validating its function through macrophagocytosis. Meridianin C reduces cellular levels of Dickkopf-related protein-3 (DKK-3), a known negative regulator of macrophagy. Meridianin C affects macrophagocytosis by downregulating DKK-3, thereby affecting cell proliferation .

Species:	Human (3) Mouse (1)
Tag:	His (4) Avi (1)
Source:	HEK293 (4)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P78681

	DKK-3 Protein, Human (R335G, HEK293, His) dkk3; REIC; RIG	Human	HEK293
	DKK-3 protein antagonizes canonical Wnt signaling by blocking LRP5/6-Wnt interactions and forming a ternary complex with KREMEN, thereby promoting LRP5/6 internalization.In vertebrate development, DKK-3, together with other DKKs, critically inhibits Wnt-regulated processes such as axial patterning, limb development, somitogenesis, and eye formation.DKK-3 Protein, Human (R335G, HEK293, His) is the recombinant human-derived DKK-3 protein, expressed by HEK293 , with C-6*His labeled tag and R335G, , , , mutation.

HY-P7812

	DKK-3 Protein, Human (HEK293, His) rHuDickkopf-related protein 3/dkk-3, His; Dickkopf-Related Protein 3; Dickkopf-3; dkk-3; hdkk-3; dkk3; REIC	Human	HEK293
	DKK-3 protein antagonizes canonical Wnt signaling by blocking LRP5/6-Wnt interactions and forming a ternary complex with KREMEN, thereby promoting LRP5/6 internalization.In vertebrate development, DKK-3, together with other DKKs, critically inhibits Wnt-regulated processes such as axial patterning, limb development, somitogenesis, and eye formation.DKK-3 Protein, Human (HEK293, His) is the recombinant human-derived DKK-3 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P75287

	DKK-3 Protein, Mouse (HEK293, His) Dickkopf-related protein 3; Dickkopf-3; dkk-3; mdkk-3	Mouse	HEK293
	DKK-3 protein antagonizes canonical Wnt signaling by inhibiting LRP5/6-Wnt interaction. It forms a ternary complex with KREMEN and promotes LRP5/6 internalization. DKK-3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived DKK-3 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77640

	DKK-3 Protein, Human (Biotinylated, HEK293, His-Avi) Dickkopf-3; dkk3; REIC; REICdkk-3; RIG; RIG-like 5-6; RIG-like 7-1; AW061014; C87148	Human	HEK293
	DKK-3 protein antagonizes canonical Wnt signaling by blocking LRP5/6-Wnt interactions and forming a ternary complex with KREMEN, thereby promoting LRP5/6 internalization.In vertebrate development, DKK-3, together with other DKKs, critically inhibits Wnt-regulated processes such as axial patterning, limb development, somitogenesis, and eye formation.DKK-3 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived DKK-3 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

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Host:	Mouse (3) Rabbit (1)
Reactivity:	Human (4) Rat (3) Mouse (3) Monkey (3) Rabbit (2)
Application:	IHC-P (2) ICC/IF (1) IP (1) WB (4) FC (3) ELISA (3)
Isotype:	IgG (1) IgG1 (2)
Conjugation:	Non-conjugated (4) Biotin (1)
Clonality:	Monoclonal (3) Recombinant (1)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85123

	DKK3 Antibody (YA4815) dkk3; REIC; Dickkopf-related protein 3; Dickkopf-3; dkk-3; hdkk-3	WB, FC, ELISA	Human, Monkey
	DKK3 Antibody (YA4815) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to DKK3.

HY-P82106

	DKK3 Antibody (YA1851) dkk3; REIC; Dickkopf-related protein 3; Dickkopf-3; dkk-3; hdkk-3	WB, ICC/IF, IP	Human, Mouse, Rat
	DKK3 Antibody (YA1851) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DKK3.

HY-P84857

	DKK3 Antibody (YA4554) RIG; REIC	WB, IHC-P, FC, ELISA	Human, Mouse, Rat, Rabbit, Monkey
	DKK3 Antibody (YA4554) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DKK3.

HY-P84857A

	DKK3 Antibody (YA4554)(PBS only) RIG; REIC	WB, IHC-P, FC, ELISA	Human, Mouse, Rat, Rabbit, Monkey
	DKK3 Antibody (YA4554) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DKK3.

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Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Dkk3 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Dkk3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dkk3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

DKK3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
DKK3 Human Pre-designed siRNA Set A contains three designed siRNAs for DKK3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dkk3 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Dkk3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Dkk3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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