DKK-3 Protein, Mouse (HEK293, His)

The DKK-3 protein antagonizes canonical Wnt signaling by inhibiting LRP5/6-Wnt interaction. It forms a ternary complex with KREMEN, facilitating LRP5/6 internalization. DKK-3, along with other DKKs, plays a critical role in vertebrate development, regulating processes like axial patterning, limb development, somitogenesis, and eye formation. In adults, DKK-3 is implicated in bone formation, bone diseases, cancer, and Alzheimer's disease. DKK-3 also interacts with LRP5 and LRP6, but lacks carboxypeptidase or dipeptidyl-peptidase IV activity. DKK-3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived DKK-3 protein, expressed by HEK293, with C-His labeled tag. The total length of DKK-3 Protein, Mouse (HEK293, His) is 349 a.a., with molecular weight of ~65 kDa.

The DKK-3 protein is involved in antagonizing canonical Wnt signaling by inhibiting the interaction between LRP5/6 and Wnt. It achieves this through the formation of a ternary complex with the transmembrane protein KREMEN, which facilitates the internalization of LRP5/6. DKKs, including DKK-3, are crucial in vertebrate development as they locally inhibit Wnt-regulated processes such as antero-posterior axial patterning, limb development, somitogenesis, and eye formation. In adult organisms, DKKs are implicated in bone formation, bone diseases, cancer, and Alzheimer's disease. Additionally, DKK-3 interacts with LRP5 and LRP6 proteins. It is important to note that DKK-3 does not possess carboxypeptidase activity or dipeptidyl-peptidase IV type activity.

Mouse

HEK293

C-His

Q9QUN9 (M1-I349)

50781  [NCBI]

Approximately 65 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.