47 Results for "

effector translocation

" in MedChemExpress (MCE) Product Catalog:
Products (47)

47 Results for "effector translocation" in MCE Product Catalog:

24
Erythromycin
Erythromycin
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24 Publications Verification
Cat. No.: HY-B0220
CAS No.: 114-07-8
Category:  

Disease Research Antibacterial Infection Microorganisms Macrolide Antibiotics Antibiotics Animal Husbandry Mammalian Cell Culture Anticancer Disease Research Fields

Target:  

Bacterial Antibiotic DNA/RNA Synthesis

Erythromycin is a macrolide antibiotic produced by actinomycete?Streptomyces erythreus?with a broad spectrum of antimicrobial activity. Erythromycin binds to bacterial 50S ribosomal subunits and inhibits?RNA-dependent protein synthesis?by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid [1][2]. Erythromycin also exhibits antitumor and neuroprotective effect in different fields of research [3][4].
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24
Erythromycin lactobionate
Erythromycin lactobionate
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24 Publications Verification
Cat. No.: HY-B0220A
CAS No.: 3847-29-8
Target:  

Antibiotic Bacterial DNA/RNA Synthesis

Research Areas:  

Infection Cancer

Erythromycin lactobionate is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin lactobionate binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid [1][2]. Erythromycin lactobionate also exhibits antitumor and neuroprotective effect in different fields of research [3][4].
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24
Erythromycin thiocyanate
Erythromycin thiocyanate
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24 Publications Verification
Cat. No.: HY-B0220D
CAS No.: 7704-67-8
Category:  

Infection Microorganisms Macrolide Antibiotics Antibiotics Disease Research Antibacterial Anticancer Disease Research Fields

Target:  

Bacterial Antibiotic DNA/RNA Synthesis

Erythromycin thiocyanate is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin thiocyanate binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid [1][2]. Erythromycin thiocyanate also exhibits antitumor and neuroprotective effect in different fields of research [3][4].
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5
SN52
SN52
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5 Cited Publications
Cat. No.: HY-P3229
CAS No.: 1071173-56-2
Target:  

NF-κB

Research Areas:  

Cancer

SN52 is a potent, competitive, and cell-permeable inhibitor of NF-κB2. SN52 is a variant of the SN50 peptide and inhibits the nuclear translocation of p52-RelB heterodimers. SN52 has a strong radiosensitization effect on prostate cancer cells. SN52 can be used for cancer research .
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3
Ergolide
Ergolide
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3 Cited Publications
Cat. No.: HY-N6893
CAS No.: 54999-07-4
Category:  

Phyllodium pulchellum (L.) Desv. Ketones, Aldehydes, Acids Plants Compositae Disease Research Fields Inflammation/Immunology Piptanthus nepalensis (Hook.) D. Don

Target:  

NF-κB NOD-like Receptor (NLR) Apoptosis Autophagy

Ergolide is an orally active dual inhibitor targeting NF-κB/p65 and NLRP3. Ergolide blocks the NF-κB signaling pathway and the nuclear translocation of p65, and irreversibly binds to the NACHT domain of NLRP3 to inhibit inflammasome assembly. Ergolide significantly reduces the production of inflammatory mediators (e.g., NO, PGE2) and cytokines, induces cancer cell apoptosis, autophagy and ROS generation. Ergolide also enhances the anti-tumor effect of vincristine. Ergolide alleviates acute lung injury via an NLRP3-dependent mechanism, and effectively improves the survival rate and behavioral function of septic mice and inflammatory zebrafish models. Ergolide is used in the research of metastatic uveal melanoma, neurodegenerative diseases (such as Alzheimer's disease, Parkinson's disease), sepsis and acute lymphoblastic leukemia .
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2
Ophiopogonin D
Ophiopogonin D
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2 Cited Publications
Cat. No.: HY-N0515
CAS No.: 945619-74-9
Category:  

Cardiovascular Disease Ophiopogon japonicus (L. f.) Ker-Gawl. Liliaceae Plants Disease Research Fields Steroids

Target:  

PPAR NF-κB Calcium Channel Reactive Oxygen Species (ROS) ERK

Ophiopogonin D can be isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside. Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca 2+ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D can inhibit isteoclastic differentiation in RAW264.7 cells. Ophiopogonin D has protective effect as an antioxidant in H2O2-induced endothelial injury. Ophiopogonin D blocks ERK signaling cascades. Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice. Ophiopogonin D has been used against inflammatory, metabolic and cardiovascular diseases .
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2
STAT1/3-IN-1
STAT1/3-IN-1
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2 Cited Publications
Cat. No.: HY-170621
CAS No.: 2958649-56-2
Target:  

STAT NO Synthase COX Interleukin Related TNF Receptor

Research Areas:  

Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

STAT1/3-IN-1 is a potent STAT1/3 inhibitor with potent anti-inflammatory effect. STAT1/3-IN-1 inhibits phosphorylation and nuclear translocation of STAT1/3 to modulate microglial inflammation, reduces LPS (HY-D1056)-induced pro-inflammatory cytokines (NO, IL-1β, IL-6, and TNF-α) and inflammatory mediators (iNOS, COX-2). STAT1/3-IN-1 exhibits low toxicity in mice. STAT1/3-IN-1 can be used for the research of neuroinflammation .
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2
Glaucocalyxin A
Glaucocalyxin A
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2 Cited Publications
Cat. No.: HY-N2112
CAS No.: 79498-31-0
Category:  

Labiatae Terpenoids Diterpenoids Plants Glycyrrhiza lepidota Pursh Disease Research Fields Cancer

Target:  

PI3K Akt Apoptosis

Glaucocalyxin A, an ent-kauranoid diterpene from Rabdosia japonica var., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Glaucocalyxin A has antitumor effect .
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1
Rhoifolin
Rhoifolin
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1 Cited Publications
Cat. No.: HY-N0755
CAS No.: 17306-46-6
Category:  

Rhus succedanea Flavonoids Flavones Plants Disease Research Fields Endocrinology Cancer Anacardiaceae

Target:  

Insulin Receptor GLUT NF-κB p38 MAPK Autophagy

Rhoifolin is a flavone glycoside can be isolated from Rhus succedanea. Rhoifolin has anti-diabetic effect acting through enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and glucose transporter 4 (GLUT 4) translocation. Rhoifolin has an anti-inflammatory action via multi-level regulation of inflammatory mediators. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. Rhoifolin also has cytotoxic activity against different cancer cell lines .
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Peptide P60
Peptide P60
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1 Cited Publications
Cat. No.: HY-P1684
CAS No.: 1319725-20-6
Synonyms: FOXP3 inhibitor P60
Target:  

FOXP NF-κB Nuclear Factor of activated T Cells (NFAT)

Research Areas:  

Infection Inflammation/Immunology Cancer

Peptide P60 is a FOXP3 inhibitor. Peptide P60 reduces the nuclear translocation of FOXP3 and impairs FOXP3-mediated inhibition of NF-κB and NFAT activity. Peptide P60 inhibits the immunosuppressive activity of regulatory T cells and restores the proliferation and activation of effector T cells. Peptide P60 induces lymphoproliferative autoimmune syndrome in neonatal ICR mice and reduces the number of CD4 +CD25 +Foxp3 + T cells in the spleen. Peptide P60 enhances the efficacy of AH1 (HY-P4193) peptide vaccine and recombinant adenovirus-based HCV NS3 vaccine in BALB/c mice, including protective effects against CT26 tumor implantation. Peptide P60 can be used in studies related to tumor immunity, viral infection and lymphoproliferative autoimmune syndrome .
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1
Voacamine
Voacamine
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1 Cited Publications
Cat. No.: HY-N6932
CAS No.: 3371-85-5
Category:  

Alkaloids other families Metabolic Disease Plants Disease Research Fields Indole Alkaloids

Target:  

Cannabinoid Receptor P-glycoprotein PI3K Akt mTOR Apoptosis Autophagy EGFR

Voacamine is an indole alkaloid with cannabinoid 1 (CB1) antagonistic activity. Voacamine can inhibit nuclear translocation. Voacamine is effective in enhancing the effect of Doxorubicin (HY-15142A) as it interferes with the P-glycoprotein (P-gp) function. Voacamine promotes apoptosis-independent autophagic cell death in human osteosarcoma cells. Voacamine activates mitochondrial-associated apoptosis signaling pathway and inhibition of PI3K/Akt/mTOR signaling pathway to suppress breast cancer progression. Voacamine inhibits EGFR to exert oncogenic activity against colorectal cancer .
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GTPγS tetralithium
GTPγS tetralithium
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Cat. No.: HY-137677B
CAS No.: 94825-44-2
Purity:  96.04%
Synonyms: Guanosine 5'-[γ-thio]triphosphate tetralithium
Target:  

GLUT

Research Areas:  

Metabolic Disease

GTPγS (Guanosine 5'-[γ-thio]triphosphate) tetralithium is a G-protein activator that protects proteins from proteolytic degradation, stimulates GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization. GTPγS tetralithium to couple with G- protein α, to study its effect on kinase activity. GTPγS tetralithium acts as a component of lysis buffer .
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Humanin
Humanin
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Cat. No.: HY-P1928
CAS No.: 330936-69-1
Target:  

Bcl-2 Family

Research Areas:  

Neurological Disease Endocrinology

Humanin, an anti-apoptotic peptide of 24 amino acids, is a Bax inhibitor. Humanin prevents the translocation of Bax from cytosol to mitochondria, blocks Bax from the inactive to active conformation. Humanin is a mitochondria-associated peptide with a neuroprotective effect against AD-related neurotoxicity. Humanin also improves overall insulin sensitivity in animal. Humanin are related to aging .
Humanin analogue, in which the serine at position 14 is replaced by glycine, names HNG .
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Hirudin (54-65)
Hirudin (54-65)
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Cat. No.: HY-P1636
CAS No.: 113274-56-9
Target:  

Thrombin YAP Calcium Channel

Research Areas:  

Metabolic Disease

Hirudin (54-65) is a thrombin antagonist and YAP suppressor with anticoagulatory properties.Hirudin (54-65) blocks thrombin's anion binding site, acts on soluble and thrombus-bound thrombin.Hirudin (54-65) suppresses thrombin-induced profibrotic YAP activity, reduces YAP expression, nuclear translocation, and downstream effector signaling in vascular endothelial cells.Hirudin (54-65) ameliorates obstructive cholestasis, attenuates liver fibrosis symptoms, fibrosis-associated angiogenesis, and endothelial-to-mesenchymal transition.Hirudin (54-65) reduces liver inflammation and tissue hypoxia.Hirudin (54-65) promotes extracellular calcium influx through L-type calcium channels in canine coronary artery smooth muscle, mediates contraction.Hirudin (54-65) induces endothelium-independent contraction of canine coronary arterial segments; this response is not affected by indomethacin pretreatment.Hirudin (54-65) can be used for the research of liver obstructive cholestasis, liver fibrosis .
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5-O-Methylvisammioside
5-O-Methylvisammioside
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Cat. No.: HY-N0442
CAS No.: 84272-85-5
Synonyms: 4'-O-β-D-Glucosyl-5-O-methylvisamminol
Category:  

Ophryosporus axilliflorus Hieron. Ketones, Aldehydes, Acids Other Diseases Plants Umbelliferae Disease Research Fields

Target:  

NF-κB p38 MAPK JNK Src TNF Receptor NOD-like Receptor (NLR) Amyloid-β MEK ERK Ferroptosis VEGFR Anaplastic lymphoma kinase (ALK) Reactive Oxygen Species (ROS)

5-O-Methylvisammioside (4'-O-β-D-Glucosyl-5-O-methylvisamminol) is an orally active natural chromone glycoside and multiple biological activities. 5-O-Methylvisammioside inhibits ferroptosis by activating the Nrf2/HO-1 signaling axis. 5-O-Methylvisammioside alleviates intestinal barrier damage by inhibiting the ROS/NF-κB/NLRP3 pathway. 5-O-Methylvisammioside exerts a protective effect against acute liver injury by reducing ALT/AST, decreasing inflammatory infiltration, and inhibiting IκB-α phosphorylation and NF-κB nuclear translocation. 5-O-Methylvisammioside blocks the HMGB1/RAGE/MEK/ERK signaling axis to exert anti-tumor and anti-angiogenic effects. 5-O-Methylvisammioside improves depression-like behaviors by inhibiting Src kinase and the NF-κB pathway .
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1,2-Diarachidonoyl-sn-glycero-3-phosphoethanolamine
1,2-Diarachidonoyl-sn-glycero-3-phosphoethanolamine
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Cat. No.: HY-147071
CAS No.: 5634-86-6
Synonyms: DAPE
Target:  

Liposome

Research Areas:  

Metabolic Disease

1,2-Diarachidonoyl-sn-glycero-3-phosphoethanolamine (DAPE) is a phospholipid phosphatidylethanolamine. Unlike other phospholipid phosphatidylethanolamines, 1,2-Diarachidonoyl-sn-glycero-3-phosphoethanolamine has no significant effect on protein phosphatase PP2A activity and does not inhibit insulin-stimulated GLUT4 translocation .
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Erythromycin-d3
Erythromycin-d3
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Cat. No.: HY-B0220S2
CAS No.: 959119-26-7
Erythromycin-d3 is the deuterium labeled Erythromycin . Erythromycin is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid. Erythromycin also exhibits antitumor and neuroprotective effect in different fields of research .
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Isocryptotanshinone
Isocryptotanshinone
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Cat. No.: HY-N6651
CAS No.: 22550-15-8
Category:  

Quinones Labiatae Samanea saman (Jacq.) Merr. Plants Disease Research Fields Naphthalene Quinones Cancer

Target:  

STAT Phosphatase Apoptosis Autophagy p38 MAPK EGFR JAK Bcl-2 Family Survivin Akt mTOR PARP Caspase Atg8/LC3 CDK

Isocryptotanshinone is a dual STAT3 and PTP1B (IC50 = 56.1 μM) inhibitor. Isocryptotanshinone inhibits STAT3 by binding to the STAT3 SH2 domain to block phosphorylation and nuclear translocation [1][2]. Isocryptotanshinone exerts its anti-proliferative effect via the induction of cell cycle arrest, apoptosis, and pro-death autophagy, through the regulation of STAT3, AKT/mTOR and MAPK signaling pathways. Isocryptotanshinone suppresses the xenograft gastric cancer (GC) tumor growth in BALB/c nude mice. Isocryptotanshinone can be used for cancer research, such as lung cancer, breast cancer and GC .
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Ganglioside GD1a
Ganglioside GD1a
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Cat. No.: HY-141569
CAS No.: 12707-58-3
Target:  

Toll-like Receptor (TLR)

Research Areas:  

Inflammation/Immunology

Ganglioside GD1a modulates toxic and inflammatory effects of E. coli lipopolysaccharide by preventing TLR4 translocation into lipid rafts. Ganglioside GD1a significantly reduces the effect of LPS on the decrease of cell survival and on stimulation of reactive oxygen species production .
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Resolvin D5
Resolvin D5
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Cat. No.: HY-145491
CAS No.: 578008-43-2
Category:  

Ketones, Aldehydes, Acids Endogenous metabolite

Target:  

ERK NF-κB CCR

Resolvin D5 is an anti-inflammatory and analgesic agent produced in M2 macrophages. Resolvin D5 alleviates Paclitaxel (HY-B0015)-induced mechanical allodynia and inflammatory pain by activating the GPR32 receptor, with gender specificity (effective only in male mice) and independence from TRPV1 or TRPA1 channels. Resolvin D5 attenuates LPS-induced ERK phosphorylation and NF-κB nuclear translocation, downregulates proinflammatory mediators such as IL-6 and CCL5, inhibits Th17 cell differentiation and osteoclastogenesis, promotes regulatory T cell differentiation, and shows no cytotoxicity to human monocytes. The level of Resolvin D5 is elevated in arthritic SKG mice, but Resolvin D5 has no effect on dendritic cell differentiation or M1 macrophage polarization, nor does it prevent ZyA-induced arthritis progression. Resolvin D5 is suitable for research related to chemotherapy-induced peripheral neuropathy, inflammatory pain and rheumatoid arthritis .
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