94825-44-2
Chemical Structure
GTPγS tetralithium
Synonym(s): Guanosine 5'-[γ-thio]triphosphate tetralithium
- CAS No.: 94825-44-2
- Formula:C10H12Li4N5O13P3S
- Molecular Weight:562.98
InChIKey: AMQXJFWJOAWCPV-ZVQJTLEUSA-J
SMILES: O[C@H]1[C@@H](O)[C@H](N2C(NC(N)=NC3=O)=C3N=C2)O[C@@H]1COP(OP(OP(S[Li])(O[Li])=O)(O[Li])=O)(O[Li])=O
Biological Activity: GTPγS (Guanosine 5'-[γ-thio]triphosphate) tetralithium is a G-protein activator that protects proteins from proteolytic degradation, stimulates GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization. GTPγS tetralithium to couple with G- protein α, to study its effect on kinase activity. GTPγS tetralithium acts as a component of lysis buffer[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GTPγS tetralithium | 95.1% | GTPγS (Guanosine 5'-[γ-thio]triphosphate) tetralithium is a G-protein activator that protects proteins from proteolytic degradation, stimulates GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization. GTPγS tetralithium to couple with G- protein α, to study its effect on kinase activity. GTPγS tetralithium acts as a component of lysis buffer. | ||||||||||||||||||||
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References
- [1]. Wu X, et al. Rab27a is an essential component of melanosome receptor for myosin Va. Mol Biol Cell. 2002;13(5):1735-1749. [Content Brief]
- [2]. Liu LB, et al. Insulin recruits GLUT4 from distinct compartments via distinct traffic pathways with differential microtubule dependence in rat adipocytes. J Biol Chem. 2003;278(32):30157-30169. [Content Brief]
- [3]. Hensler JG, et al. Differential regulation of 5-HT1A receptor-G protein interactions in brain following chronic antidepressant administration. Neuropsychopharmacology. 2002;26(5):565-573. [Content Brief]
- [4]. Sánchez-Blázquez P, et al. Brain-specific Galphaz interacts with Src tyrosine kinase to regulate Mu-opioid receptor-NMDAR signaling pathway. Cell Signal. 2009;21(9):1444-1454. [Content Brief]
