Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
45 Results for "
folate receptor-alpha
" in MedChemExpress (MCE) Product Catalog:
Products (45)
45 Results for "folate receptor-alpha" in MCE Product Catalog:
4
4 Cited Publications
Synonyms: IMGN853 (solution)
Research Areas:
Mirvetuximab soravtansine (IMGN853) solution is an anti-folate receptor α (FRα) antibody drug-conjugate (ADC) consisting of the cytotoxic maytansinoid, DM4, covalently linked to the humanized monoclonal antibody M9346A, and the drug-linker conjugate for ADC is sulfo-SPDB-DM4 (HY-101141). Mirvetuximab soravtansine selectively binds to folate receptor 1 (FOLR1). Mirvetuximab soravtansine has an anti-proliferative effect via growth arrest and augmented DNA damage .
3
Target:
Research Areas:
3
Target:
Research Areas:
2
2 Cited Publications
Target:
Research Areas:
EC-17 disodium salt is a folate receptor alpha (FRα) targeting contrast agent with fluorescent properties in the visible light spectrum. The EC-17 maximum excitation and emission wavelengths are 490 nm and 520 nm, respectively .
2
Target:
Research Areas:
Folate-FITC (EC-17) is a folate receptor alpha (FRα) targeting contrast agent with fluorescent properties in the visible light spectrum. The Folate-FITC maximum excitation and emission wavelengths are 490 nm and 520 nm, respectively .
Synonyms: ZD 9331; BGC9331
Target:
Research Areas:
Plevitrexed (ZD 9331; BGC 9331) is an orally active and potent thymidylate synthase (TS) inhibitor with a Ki of 0.44 nM. Plevitrexed is taken up via the α-folate receptor as well as the reduced folate carrier. Plevitrexed is used for gastric cancer in clinical . Plevitrexed is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-P99153
CAS No.: 896723-44-7
Synonyms: MORAb-003
Target:
Research Areas:
Cat. No.: HY-P99612
CAS No.: 2407465-18-1
Synonyms: MORAb-202
Target:
Research Areas:
Farletuzumab ecteribulin (MORAb-202) is an antibody-drug conjugate (ADC), consisting of the humanized anti-human folate receptor alpha (FRA) antibody Farletuzumab (HY-P99153) conjugated via reduced interchain disulfide bonds to Mal-PEG2-Val-Cit-PAB-eribulin. Farletuzumab ecteribulin has a agent-to-antibody ratio of 4.0. Farletuzumab ecteribulin is highly cytotoxic to FRA-positive cells in vitro. Farletuzumab ecteribulin has potent antitumor activity.
Cat. No.: HY-P10762
CAS No.: 2082631-84-1
Synonyms: CBP-1008; LDC 10B
Research Areas:
Cat. No.: HY-10822
CAS No.: 501332-69-0
Synonyms: BGC 945; ONX-0801; CB 300945
Target:
Research Areas:
Idetrexed (ONX 0801) is a thymidylate synthase (TS) inhibitor with a Ki of 1.2 nM. Idetrexed can be specifically transported into α-folate receptor (α-FR)-overexpressing tumors, such as ovarian cancer .
Cat. No.: HY-P10501A
Target:
Research Areas:
Cat. No.: HY-175428
CAS No.: 518063-75-7
Target:
Research Areas:
Antifolate agent 1 is a 6-substituted pyrrolopyrimidine antifolate with a 1-carbon bridge. Antifolate agent 1 shows no activity against cells expressing FRα and FRβ, and has no GARFTase inhibitory activity. Antifolate agent 1 can be used as a negative control in the development of folate receptor-targeted antifolates .
Cat. No.: HY-10822A
CAS No.: 1097638-00-0
Synonyms: BGC 945 trisodium; ONX 0801 trisodium; CB 300945 trisodium
Target:
Research Areas:
Idetrexed (ONX 0801) trisodium is a thymidylate synthase (TS) inhibitor with a Ki of 1.2 nM. Idetrexed trisodium can be specifically transported into α-folate receptor (α-FR)-overexpressing tumors, such as ovarian cancer .
Cat. No.: HY-P10501
CAS No.: 2159055-74-8
Target:
Research Areas:
Cat. No.: HY-147699
CAS No.: 2028296-64-0
Target:
Research Areas:
FRα-IN-1 (Compound 4) is a tumor-targeting agent. FRα-IN-1 shows selective anticancer activity towards folate receptors (FRα and FRβ) expression cells .
Cat. No.: HY-P705962
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FOLR1; KB Cells FBP; Prev. FOLR; FBP; Ovarian Tumor-Associated Antigen MOv18; folate Binding Protein; Adult folate-Binding Protein; FRalpha; folate receptor 1 (Adult); NCFTD; folate receptor, Adult; FRα; folate receptor 1; FRA; folate receptor alpha; FR-A
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-P70296
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FOLR1; KB Cells FBP; Prev. FOLR; FBP; Ovarian Tumor-Associated Antigen MOv18; folate Binding Protein; Adult folate-Binding Protein; FRalpha; folate receptor 1 (Adult); NCFTD; folate receptor, Adult; FRα; folate receptor 1; FRA; folate receptor alpha; FR-alpha
Species:
Human
Source:
HEK293
Cat. No.: HY-P705023
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FOLR1; KB Cells FBP; Prev. FOLR; FBP; Ovarian Tumor-Associated Antigen MOv18; folate Binding Protein; Adult folate-Binding Protein; FRalpha; folate receptor 1 (Adult); NCFTD; folate receptor, Adult; FRα; folate receptor 1; FRA; folate receptor alpha; FR-A
Species:
Human
Source:
HEK293
Cat. No.: HY-P704292
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: FOLR1; KB Cells FBP; Prev. FOLR; FBP; Ovarian Tumor-Associated Antigen MOv18; folate Binding Protein; Adult folate-Binding Protein; FRalpha; folate receptor 1 (Adult); NCFTD; folate receptor, Adult; FRα; folate receptor 1; FRA; folate receptor alpha; FR-A
Species:
Human
Source:
HEK293
Cat. No.: HY-P72371
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FOLR1; KB Cells FBP; Prev. FOLR; FBP; Ovarian Tumor-Associated Antigen MOv18; folate Binding Protein; Adult folate-Binding Protein; FRalpha; folate receptor 1 (Adult); NCFTD; folate receptor, Adult; FRα; folate receptor 1; FRA; folate receptor alpha; FR-A
Species:
Human
Source:
HEK293
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
