774 Results for "

fragment

" in MedChemExpress (MCE) Product Catalog:

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β-Amyloid (25-35)

45 Publications Verification

Cat. No.: HY-P0128

CAS No.: 131602-53-4

Synonyms: Amyloid beta-peptide (25-35); Aβ25-35; β-Amyloid peptide (25-35)

Target:

Amyloid-β

Research Areas:

Neurological Disease

β-Amyloid (25-35) (Amyloid beta-peptide (25-35)) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide, has shown neurotoxic activities in cultured cells .

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β-Amyloid (25-35), HFIP-treated

45 Publications Verification

Cat. No.: HY-P0128A

CAS No.: 131602-53-4

Synonyms: Amyloid beta-peptide (25-35), HFIP-treated; Aβ25-35, HFIP-treated; β-Amyloid peptide (25-35), HFIP-treated

Target:

Amyloid-β

Research Areas:

Neurological Disease

β-Amyloid (25-35) (Amyloid beta-peptide (25-35)), HFIP-treated is a β-Amyloid (25-35) (HY-P0128) treated with HFIP. β-Amyloid (25-35) (Amyloid beta-peptide (25-35)) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide, has shown neurotoxic activities in cultured cells .

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PF-573228

39 Cited Publications

Cat. No.: HY-10461

CAS No.: 869288-64-2

Purity: 99.25%

Target:

FAK Apoptosis

Research Areas:

Cancer

PF-573228 is a potent and selective FAK inhibitor with IC₅₀ of 4 nM for purified recombinant catalytic fragment of FAK.

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β-Amyloid (1-42), human TFA

27 Cited Publications

Cat. No.: HY-P1363

Synonyms: Amyloid β-peptide (1-42) (human) TFA

Target:

Amyloid-β

Research Areas:

Neurological Disease

β-Amyloid (1-42) (Amyloid β-peptide (1-42), human TFA, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human TFA remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human TFA, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4 °C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37 °C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .

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β-Amyloid (1-42), human

27 Cited Publications

Cat. No.: HY-P1363A

CAS No.: 107761-42-2

Synonyms: Amyloid β-peptide (1-42) (human)

Target:

Amyloid-β

Research Areas:

Neurological Disease

β-Amyloid (1-42) (Amyloid β-peptide (1-42)), human, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4 °C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37 °C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .

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β-Amyloid (1-42), human, HFIP-treated

27 Cited Publications

Cat. No.: HY-P1363B

CAS No.: 107761-42-2

Target:

Amyloid-β

Research Areas:

Neurological Disease

β-Amyloid (1-42), human, HFIP-treated, a 42-amino acid peptide that has been treated with HFIP from β-Amyloid (1-42), human (HY-P1363A), is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human, HFIP-treated remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, HFIP-treated, after being dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4°C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37°C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .

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Santacruzamate A

22 Cited Publications

Cat. No.: HY-N0931

CAS No.: 1477949-42-0

Synonyms: CAY-10683

Category:

Alkaloids other families Microorganisms Other Alkaloids Plants Disease Research Fields Cancer

Target:

HDAC Amyloid-β

Santacruzamate A (CAY-10683, STA) is a potent and selective HDAC2 inhibitor with an IC₅₀ of 119 pM. STA also exerts neuroprotective property against amyloid-β protein fragment 25–35. STA can be used for cancer and neurological disease research .

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Jagged-1 (188-204)

18 Cited Publications

Cat. No.: HY-P1846

CAS No.: 219127-21-6

Target:

Notch

Research Areas:

Cancer

Jagged-1 (188-204) is a fragment of the Jagged-1 (JAG-1) protein with Notch agonist activity. JAG-1 is a Notch ligand highly expressed in cultured and primary multiple myeloma (MM) cells. JAG-1 induces maturation of monocyte-derived human dendritic cells .

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Jagged-1 (188-204) TFA

18 Cited Publications

Cat. No.: HY-P1846A

Target:

Notch

Research Areas:

Cancer

Jagged-1 (188-204) TFA is a fragment of the Jagged-1 (JAG-1) protein with Notch agonist activity. JAG-1 is a Notch ligand highly expressed in cultured and primary multiple myeloma (MM) cells. JAG-1 induces maturation of monocyte-derived human dendritic cells .

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Lysozyme

8 Cited Publications

Cat. No.: HY-P1068

CAS No.: 9001-63-2

Synonyms: Muramidase

Target:

Bacterial TNF Receptor Interleukin Related TGF-β Receptor

Research Areas:

Infection Inflammation/Immunology

Lysozyme (Muramidase) is a conserved antimicrobial protein. Lysozyme exerts its bactericidal effect by hydrolyzing bacterial cell wall peptidoglycan (PG). Lysozyme plays an important role in limiting bacterial growth on mucosal surfaces and other sites, not only controlling potential pathogens but also limiting overgrowth of microbiota to prevent dysbiosis. Extracellular lysozyme can also degrade polymeric PG into soluble fragments, activate NOD receptors in mucosal epithelial cells, and lead to the secretion of chemokines and activating factors by neutrophils and macrophages .

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Flagelin 22

6 Cited Publications

Cat. No.: HY-P1568

CAS No.: 304642-91-9

Synonyms: Flagellin 22

Target:

Bacterial

Research Areas:

Infection

Flagelin 22 (Flagellin 22), a fragment of bacterial flagellin, is an effective elicitor in both plants and algae .

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Flagelin 22 TFA

6 Cited Publications

Cat. No.: HY-P1568A

Synonyms: Flagellin 22 TFA

Target:

Bacterial

Research Areas:

Infection

Flagelin 22 TFA (Flagellin 22 TFA), a fragment of bacterial flagellin, is an effective elicitor in both plants and algae .

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TRAP-6

6 Cited Publications

Cat. No.: HY-P0078

CAS No.: 141136-83-6

Synonyms: PAR-1 agonist peptide; Thrombin Receptor Activator Peptide 6

Target:

Protease Activated Receptor (PAR)

Research Areas:

Inflammation/Immunology

TRAP-6 (PAR-1 agonist peptide), a peptide fragment, is a selective protease activating receptor 1 (PAR1) agonist. TRAP-6 activates human platelets via the thrombin receptor. TRAP-6 shows no activity at PAR4 .

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Elabela(19-32)

6 Cited Publications

Cat. No.: HY-P2106

CAS No.: 1886973-05-2

Target:

Arrestin Apelin Receptor (APJ)

Research Areas:

Cardiovascular Disease

Elabela(19-32) is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ). Elabela(19-32) activates the G_αi1 and β-arrestin-2 signaling pathways with EC₅₀s of 8.6 nM and 166 nM. Elabela(19-32) induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart .

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Elabela(19-32) TFA

6 Cited Publications

Cat. No.: HY-P2106A

Target:

Apelin Receptor (APJ) Arrestin

Research Areas:

Cardiovascular Disease

Elabela(19-32) TFA is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ). Elabela(19-32) TFA activates the G_αi1 and β-arrestin-2 signaling pathways with EC₅₀s of 8.6 nM and 166 nM. Elabela(19-32) TFA induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart .

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PKA Inhibitor Fragment (6-22) amide

5 Cited Publications

Cat. No.: HY-P1290

CAS No.: 121932-06-7

Synonyms: PKI-(6-22)-amide

Target:

PKA

Research Areas:

Neurological Disease

PKA Inhibitor Fragment (6-22) amide is a highly potent and specific competitive inhibitor of PKA, with K_i values of 1.7 nM and 1.6 nM against human and bovine PKA catalytic subunits, respectively. The IC₅₀ of PKA Inhibitor Fragment (6-22) amide targeting bovine PKA is 8.6 nM. PKA Inhibitor Fragment (6-22) amide effectively abolishes PKA activity in mouse brain and spinal cord, and exerts in vivo efficacy via intracerebroventricular administration. PKA Inhibitor Fragment (6-22) amide significantly reverses low-dose morphine analgesic tolerance in mice and blocks photoaffinity labeling of cAMP-dependent protein kinase. PKA Inhibitor Fragment (6-22) amide can be applied to research in fields related to the mechanism of morphine analgesic tolerance and skin wound healing .

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PKA Inhibitor Fragment (6-22) amide TFA

5 Cited Publications

Cat. No.: HY-P1290A

Synonyms: PKI-(6-22)-amide TFA

Target:

PKA

Research Areas:

Neurological Disease

PKA Inhibitor Fragment (6-22) amide TFA is an inhibitor of cAMP-dependent protein kinase A (PKA), with a K_i of 2.8 nM. PKA Inhibitor Fragment (6-22) amide TFA can significantly reverse antinociceptive tolerance in mice .

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SYBR green I chloride

5 Cited Publications

Cat. No.: HY-D1191

CAS No.: 2225748-05-8

SYBR Green I chloride is a highly sensitive fluorescent nucleic acid dye that binds specifically to the minor groove of double-stranded DNA or intercalates between base pairs. SYBR Green I chloride exhibits weak fluorescence in the unbound state but emits bright fluorescence upon binding, and it preferentially binds to large-fragment DNA and DNA with high G+C content. SYBR Green I chloride is suitable for real-time PCR technology; its fluorescence intensity correlates with the amount and size of amplification products, enabling accurate quantification of gene expression and discrimination of amplicons via melting curve analysis without additional post-processing. SYBR Green I chloride is widely used in preclinical in vitro nucleic acid detection .

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Myosin H Chain Fragment, mouse

4 Cited Publications

Cat. No.: HY-P2464

Target:

Peptides

Research Areas:

Inflammation/Immunology

Myosin H Chain Fragment, mouse is a fragment of the α-Myosin heavy chain peptide. Myosin H Chain Fragment can be used to induce experimental autoimmune myocarditis (EAM) mouse model .

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Activated Protein C (390-404), human

4 Cited Publications

Cat. No.: HY-P1918

CAS No.: 146340-20-7

Target:

APC

Research Areas:

Cardiovascular Disease

Activated Protein C (390-404), human is a polypeptide fragment of vitamin K-dependent serine protease activated protein C (APC), which inhibits the anticoagulant activity of APC. Activated Protein C (390-404), human inhibits APC-catalyzed inactivation of factor Va .

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