PKA Inhibitor Fragment (6-22) amide TFA (Synonyms: PKI-(6-22)-amide TFA)

Name: PKA Inhibitor Fragment (6-22) amide TFA
Brand: MedChemExpress
SKU: HY-P1290A
Rating: 5.0 (5 reviews)

Cat. No.: HY-P1290A Pureza: 99.77%: Ficha de datos
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PKA Inhibitor Fragment (6-22) amide TFA is an inhibitor of cAMP-dependent protein kinase A (PKA), with a K_i of 2.8 nM. PKA Inhibitor Fragment (6-22) amide TFA can significantly reverse antinociceptive tolerance in mice.

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PKA Inhibitor Fragment (6-22) amide TFA Estructura química

Tamaño	Stock	Cantidad
1 mg	En stock	Estimated Time of Arrival: December 31
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
50 mg	Obtener un presupuesto
100 mg	Obtener un presupuesto

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Revisión del cliente

Based on 5 publication(s) in Google Scholar

Other Forms of PKA Inhibitor Fragment (6-22) amide TFA:

PKA Inhibitor Fragment (6-22) amide In-stock

5 Publications Citing Use of MCE PKA Inhibitor Fragment (6-22) amide TFA

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas PKA:

Ver todas las isoformas

PKA PKAR PKACα

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Descripciòn

IC₅₀ & Target^[1]

PKA

2.8 nM (Ki)

Fòrmula

C₈₀H₁₃₀N₂₈O₂₄·xC₂HF₃O₂

Appearance

Solid

Color

White to off-white

Sequence

Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2

Sequence Shortening

TYADFIASGRTGRRNAI-NH2

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvente y solubilidad

In Vitro:

H₂O : 50 mg/mL (Need ultrasonic)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

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Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureza y Documentación

Purity: 99.77%

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Ficha de datos (272 KB) SDS (252 KB)

COA (245 KB) LCMS (96 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Katz BM, et, al. Synthesis, characterization and inhibitory activities of (4-N3[3,5-3H]Phe10)PKI(6-22)amide and its precursors: photoaffinity labeling peptides for the active site of cyclic AMP-dependent protein kinase. Int J Pept Protein Res. 1989 Jun;33(6):439-45. [Content Brief]

[2]. Dalton GD, et, al. Alterations in brain Protein Kinase A activity and reversal of morphine tolerance by two fragments of native Protein Kinase A inhibitor peptide (PKI). Neuropharmacology. 2005 Apr; 48(5): 648-57. [Content Brief]

PKA Inhibitor Fragment (6-22) amide TFA Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PKA Inhibitor Fragment (6-22) amidePKI-(6-22)-amidePKAProtein kinase AcAMP-dependentproteinkinaseAmorphineantinociceptivetoleranceInhibitorinhibitorinhibit

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PKA Inhibitor Fragment (6-22) amide TFA (Synonyms: PKI-(6-22)-amide TFA)

Revisión del cliente

Other Forms of PKA Inhibitor Fragment (6-22) amide TFA:

PKA Inhibitor Fragment (6-22) amide TFA Related Antibodies

5 Publications Citing Use of MCE PKA Inhibitor Fragment (6-22) amide TFA

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas PKA:

Actividad biológica

Pureza y Documentación

Referencias

Revisión del cliente

Calculadora de molaridad

Calculadora de dilución

PKA Inhibitor Fragment (6-22) amide TFA Related Classifications

Keywords:

Productos vistos recientemente:

Revisión del cliente

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