PKA Inhibitor Fragment (6-22) amide TFA
Based on 5 publication(s) in Google Scholar
PKA Inhibitor Fragment (6-22) amide TFA is an inhibitor of cAMP-dependent protein kinase A (PKA), with a Ki of 2.8 nM. PKA Inhibitor Fragment (6-22) amide TFA can significantly reverse antinociceptive tolerance in mice.
For research use only. We do not sell to patients.
- Purity : 99.77%
- Formula: C80H130N28O24·xC2HF3O2
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Storage:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) PKA Inhibitor Fragment (6-22) amide TFA
More
Biological Activity
Description
IC50 & Target
[1]|
PKA 2.8 nM (Ki) |
Chemical Information
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Appearance Solid
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Formula C80H130N28O24·xC2HF3O2
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Color White to off-white
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Synonyms
PKI-(6-22)-amide TFA
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Sequence
Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2
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Sequence Shortening
TYADFIASGRTGRRNAI-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Publications (5)
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Journal Impact Factor
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Most Recent
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Cell Mol Immunol
Chaperone- and PTM-mediated activation of IRF1 tames radiation-induced cell death and the inflammatory response. [Abstract]2024 Aug;21(8):856-872. PMID: 38849539 -
Theranostics
Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma. [Abstract]2021 Mar 24;11(12):5650-5674. PMID: 33897873 -
Acta Pharmacol Sin
Endothelial Gsα deficiency promotes ferroptosis and exacerbates atherosclerosis in apolipoprotein E-deficient mice via the inhibition of NRF2 signaling. [Abstract]2025 May;46(5):1289-1302. PMID: 39806063 -
Chin Med
Grain-sized moxibustion activates dendritic cells to enhance the antitumor immunity of cancer vaccines. [Abstract]2025 May 27;20(1):73. PMID: 40426190 -
Elife
2023 Jan 16:12:e81438. PMID: 36645741
Solvent & Solubility
In Vitro:
H2O : 50 mg/mL (Need ultrasonic)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Katz BM, et, al. Synthesis, characterization and inhibitory activities of (4-N3[3,5-3H]Phe10)PKI(6-22)amide and its precursors: photoaffinity labeling peptides for the active site of cyclic AMP-dependent protein kinase. Int J Pept Protein Res. 1989 Jun;33(6):439-45. [Content Brief]
[2]. Dalton GD, et, al. Alterations in brain Protein Kinase A activity and reversal of morphine tolerance by two fragments of native Protein Kinase A inhibitor peptide (PKI). Neuropharmacology. 2005 Apr; 48(5): 648-57. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PKA Inhibitor Fragment (6-22) amide TFA Related Classifications
HY-P1290A Related Classifications
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