1. Protein Tyrosine Kinase/RTK
    Stem Cell/Wnt
  2. PKA
  3. PKA Inhibitor Fragment (6-22) amide TFA

PKA Inhibitor Fragment (6-22) amide TFA (Synonyms: PKI-(6-22)-amide TFA)

Cat. No.: HY-P1290A
Handling Instructions

PKA Inhibitor Fragment (6-22) amide TFA is an inhibitor of cAMP-dependent protein kinase A (PKA), with a Ki of 2.8 nM. PKA Inhibitor Fragment (6-22) amide TFA can significantly reverse low-level morphine antinociceptive tolerance in mice.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

PKA Inhibitor Fragment (6-22) amide TFA Chemical Structure

PKA Inhibitor Fragment (6-22) amide TFA Chemical Structure

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Other Forms of PKA Inhibitor Fragment (6-22) amide TFA:

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Description

PKA Inhibitor Fragment (6-22) amide TFA is an inhibitor of cAMP-dependent protein kinase A (PKA), with a Ki of 2.8 nM. PKA Inhibitor Fragment (6-22) amide TFA can significantly reverse low-level morphine antinociceptive tolerance in mice[1][2].

IC50 & Target[1]

PKA

2.8 nM (Ki)

Molecular Weight

1982.08

Formula

C₈₂H₁₃₁F₃N₂₈O₂₆

Sequence Shortening

TYADFIASGRTGRRNAI-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

PKA Inhibitor Fragment (6-22) amidePKI-(6-22)-amidePKAProtein kinase AcAMP-dependentproteinkinaseAmorphineantinociceptivetoleranceInhibitorinhibitorinhibit

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Product Name:
PKA Inhibitor Fragment (6-22) amide TFA
Cat. No.:
HY-P1290A
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