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heme proteins

" in MedChemExpress (MCE) Product Catalog:

28

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7

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2

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4

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Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P2995
    Hemoglobin
    4 Publications Verification

    Biochemical Assay Reagents Heme Oxygenase (HO) Others
    Hemoglobin is a iron-containing protein in red blood cells with oxygen binding properties. Hemoglobin is an inducer of HO-1. Hemoglobin consits of heme, which binds to oxygen. Hemoglobin also transports other gases, such as carbon dioxide, nitric oxide, hydrogen sulfide and sulfide. Hemoglobin absorbs unneeded oxygen in tissues, as an antioxidant .
    Hemoglobin
  • HY-B0754A
    Hematoporphyrin dihydrochloride
    10+ Cited Publications

    Hematoporphyrin IX dihydrochloride

    Apoptosis Endogenous Metabolite Cancer
    Hematoporphyrin dihydrochloride (Hematoporphyrin IX dihydrochloride), a photosensitizer, is a substrate for affinity chromatography of heme-binding proteins. Hematoporphyrin dihydrochloride can induce apoptosis in U87 glioma cells and decrease tumor growth in vivo when exposed to red light .
    Hematoporphyrin dihydrochloride
  • HY-D2869

    Fluorescent Dye Drug Intermediate Others
    Ac-H-FluNox is an acetylated cell-compatible prodrug of H-FluNox (HY-D2339). Ac-H-FluNox undergoes intracellular hydrolysis of its acetyl group by esterases to generate H-FluNox, which then undergoes a deoxygenation reaction with labile heme to form a fluorescent product. Ac-H-FluNox detects fluctuations of labile heme in living cells, acute labile heme release upon nitric oxide stimulation, and accumulation of labile heme following inhibition of heme export proteins .
    Ac-H-FluNox
  • HY-W073080

    MOFs Others
    Coproporphyrin I dihydrochlorideIt is an organic compound belonging to the class of porphyrins. It is a derivative of heme, an iron-containing molecule found in hemoglobin and other proteins. Coproporphyrin I dihydrochlorideOften used as a biomarker in the assessment of certain liver and metabolic diseases, especially those related to bile synthesis and transport. It can also be used as a reference standard for analytical chemistry and pharmacological research.
    Coproporphyrin I dihydrochloride
  • HY-P99934
    Eftozanermin alfa
    1 Publications Verification

    ABBV-621

    Apoptosis Caspase TNF Receptor Cancer
    Eftozanermin alfa (ABBV-621) is a tumor necrosis factor-related apoptosis-inducing ligand receptor (TRAIL-R) agonist. Eftozanermin alfa is a fusion protein consisting of a mutant immunoglobulin G1-Fc linked to 2 single-chain trimers of TRAIL. Eftozanermin alfa induces apoptosis in tumor cells by activation of death receptors (DR4 receptor and DR5 receptor) with Kds of 780 nM and 635 nM. Eftozanermin alfa can be used for the research of multiple solid and heme malignancies .
    Eftozanermin alfa
  • HY-B0754

    Hematoporphyrin IX

    Apoptosis Endogenous Metabolite Cancer
    Hematoporphyrin (Hematoporphyrin IX), a photosensitizer, is a substrate for affinity chromatography of heme-binding proteins. Hematoporphyrin can induce apoptosis in U87 glioma cells and decrease tumor growth in vivo when exposed to red light .
    Hematoporphyrin
  • HY-125859B

    Bacterial Infection
    Lactoperoxidase, bovine milk is an antimicrobial protein that belongs to the mammalian heme peroxidase family. Lactoperoxidase, bovine milk uses H2O2 to catalyze the oxidation of its preferred halide substrates including I , Br , F , or the pseudohalide SCN .
    Lactoperoxidase, bovine milk
  • HY-N0381
    Maackiain
    1 Publications Verification

    DL-​Maackiain

    Keap1-Nrf2 p38 MAPK NOD-like Receptor (NLR) NF-κB mTOR Monoamine Oxidase Nuclear Factor of activated T Cells (NFAT) PKC Apoptosis Pyroptosis Autophagy Dengue Virus Infection Neurological Disease Metabolic Disease
    Maackiain (DL-Maackiain) is an orally active multi-target inhibitor with anti-tumor activity and neuroprotective effects. Maackiain activates the AMPK, NLRP3 and Nrf2/HO-1 pathways, and inhibits key targets such as NF-κB, mTOR, MAO-B, NFATc1 and PKCδ, thereby precisely regulating processes including apoptosis, autophagy and pyroptosis. Maackiain also effectively inhibits microglial activation, osteoclast formation, and proliferation and invasion of tumor cells, and protects dopaminergic neurons from damage. Maackiain is applicable to the research of various diseases such as Alzheimer's disease, osteoporosis, sepsis and dengue fever 。
    Maackiain
  • HY-132188

    Endogenous Metabolite Others
    Manganese peroxidase is a heme protein that oxidizes Mn2+ to Mn3+. Manganese peroxidase catalyzes plant lignin de-polymerization. Manganese peroxidase can be used for the biodegradation of hazardous environmental contaminants, and especially for dye wastewater decolorization .
    Manganese peroxidase
  • HY-118487
    OB-24
    2 Publications Verification

    Heme Oxygenase (HO) Reactive Oxygen Species (ROS) Cancer
    OB-24 is a selective small-molecule HO-1 inhibitor (IC50 = 1.9 μM for HO-1 and IC50 for HO-2 >100 μM). OB-24 possesses anti-tumor and anti-metastatic properties. OB-24 can be studies in research such as prostate cancer, melanoma, ovarian carcinoma and lung metastasis .
    OB-24
  • HY-147517

    Keap1-Nrf2 Neurological Disease Inflammation/Immunology
    Keap1-Nrf2-IN-9 (Compound 11) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) inhibitor with an IC50 of 0.575 μM. Keap1-Nrf2-IN-9 increases the expression of Nrf2 target genes including heme oxygenase 1 (Hmox1), glutathione S-transferase P (GstP), and glutamate-cysteine ligase catalytic (Gclc) and modulatory (Gclm) subunits. Keap1-Nrf2-IN-9 shows no cytotoxic activity in ARPE19 cells .
    Keap1-Nrf2-IN-9
  • HY-P2995A

    Biochemical Assay Reagents Others
    Hemoglobin porcine is an oxygen-transporting protein present in the blood of domestic pigs, and also an oxygen carrier with higher oxygen affinity than human hemoglobin. Hemoglobin porcine exhibits cooperative oxygen-binding properties, with weaker heme-heme interactions than those of human hemoglobin .
    Hemoglobin porcine
  • HY-P2995B

    Biochemical Assay Reagents Heme Oxygenase (HO) Others
    Mouse Hemoglobin is a hemoglobin derived from mouse. Hemoglobin is a iron-containing protein in red blood cells with oxygen binding properties. Hemoglobin is an inducer of HO-1. Hemoglobin consits of heme, which binds to oxygen. Hemoglobin also transports other gases, such as carbon dioxide, nitric oxide, hydrogen sulfide and sulfide. Hemoglobin absorbs unneeded oxygen in tissues, as an antioxidant .
    Mouse Hemoglobin
  • HY-34887

    Drug Derivative Others
    Acridone-4-carboxylic acid (ACA) (Compound 2c) is a heme-interacting acridone derivatives that prevents free heme-mediated protein oxidation and degradation. Acridone-4-carboxylic acid inhibits protein carbonyl formation with an IC50 of 43 μM .
    Acridone-4-carboxylic acid
  • HY-118487A

    Endogenous Metabolite Cancer
    OB-24 free base is a compound that potently and selectively inhibits heme oxygenase 1 (HO-1) and has the potential to inhibit advanced prostate cancer. OB-24 significantly reduces protein carbonylation and the formation of reactive oxygen species by selectively inhibiting HO-1 activity in prostate cancer cells. OB-24 significantly inhibited cell proliferation in vitro and inhibited tumor growth and lymph node and lung metastasis in vivo. OB-24 exhibits powerful synergy when used in combination with Taxol .
    OB-24 free base
  • HY-E70728

    Eukaryotic Initiation Factor (eIF) Inflammation/Immunology
    Heme-regulated inhibitory (HRI) is an eIF2α kinase, which induces a cytosolic unfolded protein response to prevent aggregation of innate immune signalosomes. HRI Recombinant Human Active Protein Kinase is a recombinant HRI protein that can be used to study HRI-related functions .
    HRI Recombinant Human Active Protein Kinase
  • HY-W000450S

    5-ALA-13C; δ-Aminolevulinic acid-13C; 5-Amino-4-oxopentanoic acid-13C

    Isotope-Labeled Compounds Endogenous Metabolite Cardiovascular Disease
    5-Aminolevulinic acid- 13C is the 13C-labeled 5-Aminolevulinic acid. 5-Aminolevulinic acid (5-ALA) is a non-protein amino acid that plays a rate-limiting role in heme biosynthesis.
    5-Aminolevulinic acid-13C
  • HY-P2995C

    Biochemical Assay Reagents Heme Oxygenase (HO) Others
    Rabbit Hemoglobin is a hemoglobin derived from rabbit. Hemoglobin is a iron-containing protein in red blood cells with oxygen binding properties. Hemoglobin is an inducer of HO-1. Hemoglobin consits of heme, which binds to oxygen. Hemoglobin also transports other gases, such as carbon dioxide, nitric oxide, hydrogen sulfide and sulfide. Hemoglobin absorbs unneeded oxygen in tissues, as an antioxidant .
    Rabbit Hemoglobin
  • HY-P2995E

    Biochemical Assay Reagents Heme Oxygenase (HO) Others
    Guinea Pig Hemoglobin is a hemoglobin derived from guinea pigs. Hemoglobin is a iron-containing protein in red blood cells with oxygen binding properties. Hemoglobin is an inducer of HO-1. Hemoglobin consits of heme, which binds to oxygen. Hemoglobin also transports other gases, such as carbon dioxide, nitric oxide, hydrogen sulfide and sulfide. Hemoglobin absorbs unneeded oxygen in tissues, as an antioxidant .
    Guinea Pig Hemoglobin
  • HY-E71170

    Biochemical Assay Reagents Others
    1,8-Cineole 2-endo-monooxygenase (EC 1.14.13.156) is a heme-thiolate protein (P-450) which uses a flavodoxin-like redox partner to reduce the heme iron.
    1,8-Cineole 2-endo-monooxygenase
  • HY-E71123

    Biochemical Assay Reagents Others
    (S)-Limonene 7-monooxygenase (EC 1.14.13.49) is a heme-thiolate protein (P-450) .
    (S)-Limonene 7-monooxygenase
  • HY-E71122

    Biochemical Assay Reagents Others
    (S)-Limonene 6-monooxygenase (EC 1.14.13.48) is a heme-thiolate protein (P-450) .
    (S)-Limonene 6-monooxygenase
  • HY-E71121

    Biochemical Assay Reagents Others
    (S)-Limonene 3-monooxygenase (EC 1.14.13.47) is a heme-thiolate protein (P-450) .
    (S)-Limonene 3-monooxygenase
  • HY-E71171

    Biochemical Assay Reagents Others
    1,8-Cineole 2-exo-monooxygenase (EC 1.14.13.157) is a heme thiol protein (P-450) that catalyzes the oxidation of a variety of structurally unrelated compounds, including steroids, fatty acids, and exogenous substances.
    1,8-Cineole 2-exo-monooxygenase
  • HY-E70992

    Endogenous Metabolite Metabolic Disease
    Eosinophil Peroxidase, Human (EC 1.11.1.7) is an enzyme found in eosinophils (innate immune cells of humans and mammals). Eosinophil Peroxidase, Human (EC 1.11.1.7) is a heme peroxidase whose activities include oxidizing halide ions to reactive oxygen species with bactericidal effects, disrupting bacterial cell walls with cations, and performing post-translational modifications on protein amino acid residues.
    Eosinophil Peroxidase, Human
  • HY-W174480

    Drug Derivative Others
    5-deazaflavin is a flavin analogue with redox activity. 5-deazaflavin is a photocatalyst in biological redox systems .
    5-Deazaflavin
  • HY-W679138

    E1/E2/E3 Enzyme Heme Oxygenase (HO) Neurological Disease
    N,N-dimethyldithiocarbamate potassium is a ubiquitin-activating enzyme E1 inhibitor. N,N-dimethyldithiocarbamate potassium inhibits the activation of E1 and reduces the level of activated ubiquitinated E1 (ub-E1). N,N-dimethyldithiocarbamate potassium increases intracellular copper levels, enhances oxidative stress, elevates protein carbonyl levels, and upregulates the expression of HO-1 . N,N-dimethyldithiocarbamate potassium is applicable to research related to Parkinson's disease .
    N,N-dimethyldithiocarbamate potassium
  • HY-P11589

    PPAR Reactive Oxygen Species (ROS) Keap1-Nrf2 Metabolic Disease
    PIISVYWK is an orally active PPARγ Inhibitor, heme oxygenase-1 Activator, and Nrf2 Activator. PIISVYWK mediates activity via the HO-1/Nrf2 pathway, ameliorates oxidative stress, reduces inflammation, and mediates anti-obesity activity. PIISVYWK can be used for the research of obesity .
    PIISVYWK

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