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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
hemophilia b
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "hemophilia b" in MCE Product Catalog:
20
20 Publications Verification
C12-200 is a type of ionizable cationic lipid and helper lipid commonly used for mRNA delivery. In the hemophilia B mouse model, mRNA encoding human erythropoietin (EPO) and coagulation factor IX (FIX) can be successfully delivered and expressed using C12-200. C12-200 is utilized in research related to hemophilia B .
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Research Areas:
ARC19499 sodium is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 sodium blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 sodium corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.
1
1 Cited Publications
Cat. No.: HY-P70231
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: F9; Autoprothrombin IIA; Coagulation Factor IX; Coagulant Factor IX; FIX; Christmas Disease; Plasma Thromboplastic Component; hemophilia B; Plasma Thromboplastin Component; Factor IX F9; Christmas Factor; Factor IX; PTC; Factor 9; Truncated Coagulation Fa
Species:
Human
Source:
HEK293
Synonyms: ALN-AT3SC; SAR439774
Research Areas:
Fitusiran (ALN-AT3SC) is a siRNA strategy. Fitusiran delivers siRNA targeting the SERPINC1 gene in hepatocytes to inhibit antithrombin synthesis. Fitusiran enhances thrombin activity and increases Thrombin generation, thereby restoring hemostatic function. Fitusiran can be used in hemophilia-related research .
Cat. No.: HY-E70541B
CAS No.: 9001-28-9
Target:
Research Areas:
Canine Factor IX is a functional coagulation factor. Canine Factor IX shortens whole blood clotting time and activated partial thromboplastin time, and restores coagulation function. After intramuscular administration via rAAV vector in hemophilia B dogs, Canine Factor IX maintains a sustained circulating level for at least 1 year, partially corrects the hemophilia B phenotype in a dose-dependent manner, and its plasma expression persists for more than 17 months. Canine Factor IX is applicable to relevant research on hemophilia B .
Cat. No.: HY-132587A
Purity: 94.68%
Synonyms: ALN-AT3SC sodium; SAR439774 sodium
Research Areas:
Fitusiran (ALN-AT3SC) sodium is a siRNA strategy. Fitusiran delivers siRNA targeting the SERPINC1 gene in hepatocytes to inhibit antithrombin synthesis. Fitusiran sodium enhances thrombin activity and increases Thrombin generation, thereby restoring hemostatic function. Fitusiran sodium can be used in hemophilia-related research .
Cat. No.: HY-P99875
CAS No.: 2252477-42-0
Synonyms: BIVV-001; Altuvoct
Target:
Research Areas:
Cat. No.: HY-153480
CAS No.: 1350667-54-7
Synonyms: BAX499
Research Areas:
ARC19499 is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.
Cat. No.: HY-P991213
Synonyms: Rixubis
Target:
Research Areas:
Cat. No.: HY-185423
Research Areas:
PreQ1-DBCO is a strained cyclooctyne commonly used in click chemistry. PreQ1-DBCO undergoes TGT-catalyzed guanine base exchange in DNA oligonucleotide stem-loops to replace guanine. PreQ1-DBCO functionalizes custom DNA oligonucleotide sequences. DBCO-modified DNA oligonucleotides are conjugated with azide peptides via strain-promoted azide-alkyne click chemistry (SPAAC). PreQ1-DBCO can be used in studies of hemophilia B (Christmas disease) .
Cat. No.: HY-P992152
CAS No.: 897936-89-9
Synonyms: NN-1731
Target:
Research Areas:
Cat. No.: HY-P74240
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: F9; Autoprothrombin IIA; Coagulation Factor IX; Coagulant Factor IX; FIX; Christmas Disease; Plasma Thromboplastic Component; hemophilia B; Plasma Thromboplastin Component; Factor IX F9; Christmas Factor; Factor IX; PTC; Factor 9; Truncated Coagulation Fa
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P705987
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: F9; Autoprothrombin IIA; Coagulation Factor IX; Coagulant Factor IX; FIX; Christmas Disease; Plasma Thromboplastic Component; hemophilia B; Plasma Thromboplastin Component; Factor IX F9; Christmas Factor; Factor IX; PTC; Factor 9; Truncated Coagulation Fa
Species:
Cynomolgus
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
