2. Cell Cycle/DNA Damage Others
  3. DNA/RNA Synthesis Biochemical Assay Reagents
  4. PreQ1-DBCO

PreQ1-DBCO is a strained cyclooctyne commonly used in click chemistry. PreQ1-DBCO undergoes TGT-catalyzed guanine base exchange in DNA oligonucleotide stem-loops to replace guanine. PreQ1-DBCO functionalizes custom DNA oligonucleotide sequences. DBCO-modified DNA oligonucleotides are conjugated with azide peptides via strain-promoted azide-alkyne click chemistry (SPAAC). PreQ1-DBCO can be used in studies of hemophilia B (Christmas disease).

For research use only. We do not sell to patients.

PreQ1-DBCO

PreQ1-DBCO Chemical Structure

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PreQ1-DBCO Related Antibodies

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Description

PreQ1-DBCO is a strained cyclooctyne commonly used in click chemistry. PreQ1-DBCO undergoes TGT-catalyzed guanine base exchange in DNA oligonucleotide stem-loops to replace guanine. PreQ1-DBCO functionalizes custom DNA oligonucleotide sequences. DBCO-modified DNA oligonucleotides are conjugated with azide peptides via strain-promoted azide-alkyne click chemistry (SPAAC). PreQ1-DBCO can be used in studies of hemophilia B (Christmas disease)[1].

Molecular Weight

593.72

Formula

C34H39N7O3
SMILES

O=C(NCCCCCCNCC1=CNC(N=C(N2)N)=C1C2=O)CCCCC(N3CC4=C(C#CC5=C3C=CC=C5)C=CC=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PreQ1-DBCO Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PreQ1-DBCODNA/RNA SynthesisBiochemical Assay Reagentshemophilia bSPAACDNA oligonucleotide-peptide conjugateazide-modified peptidesDNA oligonucleotide stem loopsTGTstrain-promoted azide-alkyne cycloadditionDBCO-modified DNAtriazole linkagesE. coli tRNA guanine transglycosylaseInhibitorinhibitorinhibit

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