14 Results for "

human Fyn

" in MedChemExpress (MCE) Product Catalog:
Products (14)

14 Results for "human Fyn" in MCE Product Catalog:

5
5 Cited Publications
Cat. No.: HY-N2259
CAS No.: 19431-84-6
Synonyms: (+)-Curcumenol
Curcumenol ((+)-Curcumenol) is a natural compound with oral efficacy, exhibiting an IC50 of 12.6 μM and a Ki of 10.8 μM against human CYP3A4. Curcumenol inhibits TNFα-induced phosphorylation/degradation of IκBα, phosphorylation/nuclear translocation of NF-κB p65, as well as the upregulation of MMP3, MMP9, MMP13, TRAF3, IL1RL1, TNFα and IL-1β. Curcumenol suppresses LPS-induced phosphorylation of Akt and p38 MAPK, as well as the production of pro-inflammatory mediators/proteins, and downregulates the SLC7A11/NF-κB/TGF-β pathway. Curcumenol binds to and inhibits the activation of Fyn and Lyn, blocks the function of downstream FcεRI signaling components, and reduces the release of allergic mediators/cytokines. Curcumenol upregulates the expression of KDM6B, and promotes chondrocyte proliferation and cartilage repair. Curcumenol induces ferroptosis and apoptosis, regulates the EMT process, and inhibits tumor growth and metastasis of triple-negative breast cancer. Curcumenol possesses anti-inflammatory, neuroprotective, antioxidant, antitumor, antiviral and hepatoprotective activities. Curcumenol can be used in research related to intervertebral disc degeneration, cancer, inflammation, central nervous system neurodegenerative diseases, allergic reactions and knee osteoarthritis .
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1 Cited Publications
Cat. No.: HY-N4099
CAS No.: 53527-42-7
Luteolin-3-O-beta-D-glucuronide, a glucuronide derivative of Luteolin (HY-N0162), is found in the leaves of Rosmarinus officinalis L. Luteolin-3-O-beta-D-glucuronide inhibits nitrite production in macrophages and binds strongly to FYN kinase .
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Cat. No.: HY-176892
CAS No.: 574-77-6
Research Areas:  

Neurological Disease

Papaveroline is a Fyn tyrosine kinase inhibitor, Na +,K +-ATPase inhibitor with an IC50 of 0.20 mM, Mg 2+-ATPase inhibitor, K +-activated pNPPase inhibitor with an IC50 of 1.51 mM, and apoptosis inducer . Papaveroline binds to the active site of Fyn tyrosine kinase and forms stable interactions with pocket amino acid residues . Papaveroline induces cell apoptosis, produces pycnotic and fragmented cell nuclei, and does not reduce intracellular ATP levels . Papaveroline is a dopamine-derived neurotoxin candidate associated with the pathogenesis of Parkinson's disease . Papaveroline can be used in the research of Alzheimer's disease and Parkinson's disease .
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Cat. No.: HY-RS05174
Research Areas:  

Others

FYN Human Pre-designed siRNA Set A contains three designed siRNAs for FYN gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-E70726
Target:  

Src

Research Areas:  

Cancer

FYN Y531F Recombinant Human Active Protein Kinase is an oncogene that directly activated YANK2 through phosphorylation its Y110, and Fyn-mediated YANK2 phosphorylation at Y110 site promotes glioma growth by increasing its stability .
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Cat. No.: HY-N2259R
CAS No.: 19431-84-6
Synonyms: (+)-Curcumenol (Standard)
Curcumenol (Standard) ((+)-Curcumenol (Standard)) is the analytical standard of Curcumenol (HY-N2259). This product is intended for research and analytical applications. Curcumenol ((+)-Curcumenol) is a natural compound with oral efficacy, exhibiting an IC50 of 12.6 μM and a Ki of 10.8 μM against human CYP3A4. Curcumenol inhibits TNFα-induced phosphorylation/degradation of IκBα, phosphorylation/nuclear translocation of NF-κB p65, as well as the upregulation of MMP3, MMP9, MMP13, TRAF3, IL1RL1, TNFα and IL-1β. Curcumenol suppresses LPS-induced phosphorylation of Akt and p38 MAPK, as well as the production of pro-inflammatory mediators/proteins, and downregulates the SLC7A11/NF-κB/TGF-β pathway. Curcumenol binds to and inhibits the activation of Fyn and Lyn, blocks the function of downstream FcεRI signaling components, and reduces the release of allergic mediators/cytokines. Curcumenol upregulates the expression of KDM6B, and promotes chondrocyte proliferation and cartilage repair. Curcumenol induces ferroptosis and apoptosis, regulates the EMT process, and inhibits tumor growth and metastasis of triple-negative breast cancer. Curcumenol possesses anti-inflammatory, neuroprotective, antioxidant, antitumor, antiviral and hepatoprotective activities. Curcumenol can be used in research related to intervertebral disc degeneration, cancer, inflammation, central nervous system neurodegenerative diseases, allergic reactions and knee osteoarthritis .
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Cat. No.: HY-E70725
Target:  

Src

Research Areas:  

Cancer

FRK Recombinant Human Active Protein Kinase, a non-receptor tyrosine kinase Fyn-related kinase, is a member of the BRK family kinases (BFKs). FRK may be involved in tumor progression .
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Cat. No.: HY-187803
Target:  

VEGFR Bcr-Abl Src

Research Areas:  

Others

Tyrosine kinase-IN-12 is a selective kinase inhibitor with inhibitory activity against human tyrosine kinases KDR, Abl, Lyn and Fyn .
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Cat. No.: HY-P702727
Purity:  ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: Fyn; MGC45350; Fyn Proto-Oncogene, Src Family Tyrosine Kinase; P59-Fyn; SLK; OKT3-Induced Calcium Influx Regulator; Tyrosine-Protein Kinase Fyn; Tyrosine Kinase P59Fyn(T); Proto-Oncogene C-Fyn; Src/Yes-Related Novel; SYN; C-Syn Protooncogene; Fyn Oncogene
Species:  
Human
Source:  
Sf9 insect cells
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Cat. No.: HY-P85545
Synonyms: C syn protooncogene; Fyn; Fyn oncogene related to SRC FGR YES; Fyn_human; MGC45350; OKT3 induced calcium influx regulator; P59 Fyn; p59-Fyn; Protein tyrosine kinase Fyn; Proto oncogene tyrosine protein kinase Fyn; Proto-oncogene c-Fyn; Proto-oncogene Syn; Protooncogene Syn; SLK; Src like kinase; Src yes related novel gene; Src-like kinase; Src/yes related novel; Src/yes related novel gene; SYN; Tyrosine kinase p59Fyn T; Tyrosine kinase p59Fyn; T; Tyrosine-protein kinase Fyn.

Host:  

Mouse

Application:  

WB, ICC/IF

Reactivity:  

Human, Monkey, Rat, Mouse

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Cat. No.: HY-P705576
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: FRK; PTK5 Protein Tyrosine Kinase 5; Prev. PTK5; Protein-Tyrosine Kinase 5; RAK; Fyn-Related Kinase; GTK; Fyn-Related Src Family Tyrosine Kinase; Nuclear Tyrosine Protein Kinase RAK; Fyn-Related Kinase; Fyn Related Src Family Tyrosine Kinase; Tyrosine-Pro
Species:  
Human
Source:  
Sf9 insect cells
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Cat. No.: HY-184113
Synonyms: DHP
Target:  

Integrin Arp2/3 Complex

Research Areas:  

Cancer

Dihydropelitinib (DHP) is a ILK ligand with a Kd value of 252 nM. Dihydropelitinib acts as a cytoskeleton modulator that induces actin (Actin) cytoskeleton rearrangement. Dihydropelitinib exhibits anticancer activity against liver cancer and lung adenocarcinoma. Dihydropelitinib can be used in studies related to liver cancer and lung adenocarcinoma .
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Cat. No.: HY-208740
CAS No.: 2488951-93-3
Target:  

PKC

Research Areas:  

Inflammation/Immunology

PKCζ-IN-2 is an orally active, selective PKCζ inhibitor with an IC50 of 0.1 nM. As an anti-inflammatory agent, PKCζ-IN-2 reduces joint swelling and ameliorates disease progression in a mouse collagen-induced arthritis model. PKCζ-IN-2 can be used for the research of rheumatoid arthritis .
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Cat. No.: HY-187341
CSF1R/c-Kit-IN-2 is a dual CSF-1R/c-Kit inhibitor with a c-Kit-biased profile, exhibiting inhibitory activity against CSF-1R (IC50 = 6.84 nM), c-Kit (IC50 = 0.95 nM), FYN (IC50 = 11.4 nM), ABL1 (IC50 = 14.2 nM), and CSK (IC50 = 118 nM). CSF1R/c-Kit-IN-2 can be used for the research of neuroinflammation-associated neurodegenerative diseases .
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