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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
human PTP1B
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "human PTP1B" in MCE Product Catalog:
5
Category:
other families Flavonoids Flavonones Metabolic Disease Phenols Polyphenols Plants Disease Research Fields
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3
3 Cited Publications
Cat. No.: HY-N4185
CAS No.: 61153-77-3
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1 Cited Publications
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MurA-IN-1 (compound 1a) is a PTPRR inhibitor, with IC50 values of 0.23 μM, 0.8 μM, 0.75 μM and 0.09 μM for PTP1B, PTPN5, PTPN7 and PTPRR, respectively . (A family of human MAPK-specific protein tyrosine phosphatases)
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Cat. No.: HY-N3266
CAS No.: 99353-00-1
Cat. No.: HY-N2217
CAS No.: 20137-37-5
Cat. No.: HY-N4177
CAS No.: 24577-90-0
Synonyms: Rubrofusarin-6-β-gentiobioside
Category:
Seeds of Cassia tora Linn. other families Monophenols Leguminosae Metabolic Disease Phenols Plants Disease Research Fields
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Lobaric acid is a depsipeptide metabolite isolated from Stereocaulon lichen with antioxidant, antiproliferative, antiviral and enzyme inhibitory activities. Lobaric acid scavenges superoxide free radicals (IC50=97.9 μM) and inhibits cancer cell proliferation (EC50 of 15.2-63.9 μg/mL against leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic and lung cancer cell lines). Lobaric acid inhibits protein tyrosine phosphatase 1B (PTP1B; IC50=0.87 μM for human recombinant enzyme) and 12(S)-HETE produced by 12(S)-lipoxygenase (IC50=28.5 μM). Lobaric acid (250 μM) also reduced pathological changes in tobacco leaves infected with tobacco mosaic virus (TMV).
Cat. No.: HY-N8200
CAS No.: 218155-40-9
Cat. No.: HY-181239
CAS No.: 77500-30-2
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PTP1B-IN-33 is a PTP1B inhibitor with a human IC50 of 2.45 μM and over 20-fold selectivity for PTP1B over SHP2. PTP1B-IN-33 enhances π-Alkyl interaction with PTP1B to increase WPD loop closure degree. PTP1B-IN-33 can be used for the research of cancer, diabetes, autoimmune deficiency diseases .
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Cat. No.: HY-181700
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PTP1B-IN-34 is an orally active, selective, non-competitive PTP1B inhibitor, with an IC50 value of 0.64 μM and a Ki value of 1.15 μM against human PTP1B. PTP1B-IN-34 reduces blood glucose levels in diabetic mice. PTP1B-IN-34 can be used in research related to type 2 diabetes .
Cat. No.: HY-184743
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PTP1B-IN-35 is an orally active protein tyrosine phosphatase 1B (PTP1B) inhibitor, with an IC50 of 32.7 μM, a Kis of 18.8 μM, a Kii of 45.3 μM, and a Kd of 36 μM against human PTP1B. PTP1B-IN-35 promotes glucose uptake, improves glucose tolerance, enhances insulin sensitivity, and reduces blood glucose levels. PTP1B-IN-35 can be used in the research of type 2 diabetes .
Cat. No.: HY-N17424
CAS No.: 83474-71-9
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Cat. No.: HY-182463
CAS No.: 173792-68-2
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Moreollic acid is a PTP1B inhibitor, with an IC50 of 4.44 μM and a Ki of 1.75 μM against human targets. Moreollic acid blocks cell cycle progression from the G1 to S phase and inhibits tumor cell proliferation. Moreollic acid can be used in research related to type 2 diabetes, obesity, colon cancer and other cancers .
Cat. No.: HY-N17326
CAS No.: 242794-72-5
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Cat. No.: HY-183688
CAS No.: 3104354-58-4
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MptpB-IN-3 is a selective inhibitor of Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) with an IC50 of 0.19 μM. MptpB-IN-3 blocks MptpB-mediated inhibition of the macrophage MAPK pathway and restores the phosphorylation levels of Erk1/2 and p38. MptpB-IN-3 exhibits direct anti-tuberculosis activity against Mycobacterium tuberculosis and reduces the Mycobacterium tuberculosis load in mouse macrophages. MptpB-IN-3 can be used for tuberculosis research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
