PTP1B-IN-34
PTP1B-IN-34 is an orally active, selective, non-competitive PTP1B inhibitor, with an IC50 value of 0.64 μM and a Ki value of 1.15 μM against human PTP1B. PTP1B-IN-34 reduces blood glucose levels in diabetic mice. PTP1B-IN-34 can be used in research related to type 2 diabetes.
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- Formule: C39H49F3N2O4
- Masse moléculaire:666.81
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
PTP1B-IN-34 (compound 5a) potently inhibits full-length recombinant human PTP1B (hPTP1B1-400) with an IC50 of 0.64 μM[1].
PTP1B-IN-34 inhibits truncated recombinant human PTP1B (PTP1B1-285) with an IC50 of 3.93 μM. The potency of this compound is reduced compared with full-length PTP1B, indicating that its optimal inhibitory activity depends on the disordered C-terminal domain[1].
PTP1B-IN-34 (1 μM) significantly enhances insulin-induced GLUT4 mRNA expression in C2C12 myoblasts[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Insulin-treated C2C12 cells
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Concentration:1 μM
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Incubation Time:/
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Result:Increased the levels of GLUT4.
In Vivo
PTP1B-IN-34 (50 mg/kg; p.o.; single dose) significantly reduces blood glucose levels and improves insulin sensitivity in Streptozotocin (HY-13753)-induced diabetic CD1 mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CD1 mice (Streptozotocin-induced diabetic)[1]
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Dosage:50 mg/kg
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Administration:p.o.; single dose
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Result:Markedly decreased glucose levels during the ITT, indicating improved insulin sensitivity.
Chemical Information
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Masse moléculaire 666.81
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Formule C39H49F3N2O4
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SMILES
C[C@@]12CC[C@]3(CC[C@@](C(NCC(O)=O)=O)(C[C@]3(C1=CC(C4[C@@]5(C)CC6=C(C(C)(C5CC[C@]42C)C)NC7=C6C=C(C=C7)C(F)(F)F)=O)[H])C)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PTP1B-IN-34 Related Classifications
HY-181700 Related Classifications
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