PTP1B-IN-34 

PTP1B-IN-34 is an orally active, selective, non-competitive PTP1B inhibitor, with an IC₅₀ value of 0.64 μM and a K_i value of 1.15 μM against human PTP1B. PTP1B-IN-34 reduces blood glucose levels in diabetic mice. PTP1B-IN-34 can be used in research related to type 2 diabetes^[1].

PTP1B-IN-34 (compound 5a) potently inhibits full-length recombinant human PTP1B (hPTP1B_1-400) with an IC₅₀ of 0.64 μM^[1].
PTP1B-IN-34 inhibits truncated recombinant human PTP1B (PTP1B_1-285) with an IC₅₀ of 3.93 μM. The potency of this compound is reduced compared with full-length PTP1B, indicating that its optimal inhibitory activity depends on the disordered C-terminal domain^[1].
PTP1B-IN-34 (1 μM) significantly enhances insulin-induced GLUT4 mRNA expression in C2C12 myoblasts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PTP1B-IN-34 (50 mg/kg; p.o.; single dose) administered 30 minutes prior to glucose loading significantly reduces the blood glucose peak in normoglycemic male CD1 mice^[1].
PTP1B-IN-34 (50 mg/kg; p.o.; single dose) significantly reduces blood glucose levels and improves insulin sensitivity in Streptozotocin (HY-13753)-induced diabetic CD1 mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

666.81

C₃₉H₄₉F₃N₂O₄

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• [1]. De-la-Cruz-Martínez L, et al. Targeting Protein Tyrosine Phosphatase 1B (PTP1B) to Improve Insulin Sensitivity Using Indole-Fused Glycyrrhetinic Acid Conjugates with Amino Acids. ACS Medicinal Chemistry Letters, 2026.