529-55-5
529-55-5
Chemical Structure
Prunin
Synonym(s): Naringenin 7-0-glucoside
- No. CAS: 529-55-5
- Formula:C21H22O10
- Molecular Weight:434.39
IUPAC Name: (S)-5-hydroxy-2-(4-hydroxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)chroman-4-one
InChIKey: DLIKSSGEMUFQOK-SFTVRKLSSA-N
SMILES: O=C1C[C@@H](C2=CC=C(O)C=C2)OC3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=CC(O)=C13
Biological Activity: Prunin is a potent inhibitor of human enterovirus A71 (HEVA71). Prunin shows strong inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), with an IC50 of 5.5 μM[1][2].
| Referencia número | Nombre del producto | Pureza | Descripciòn | Pricing | |||||||||||||||||||
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Prunin | 99.24% | Prunin is a potent inhibitor of human enterovirus A71 (HEVA71). Prunin shows strong inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), with an IC50 of 5.5 μM. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.91
HY-N4296Isosakuranin -
Similarity Score 0.90
HY-N6963Choerospondin -
Similarity Score 0.88
HY-N177164'-O-β-D-Glucosyl-5,3'-dihydroxy-7-methoxyflavanone -
Similarity Score 0.88
HY-N6616RPinocembrin-7-O-β-D-glucopyranoside (Standard) -
Similarity Score 0.87
HY-N17943(2R)-Naringenin-5-O-β-D-glucopyranoside -
Similarity Score 0.86
HY-N13190(2R)-Eriodictyol-7-O-β-D-glucopyranoside -
Similarity Score 0.86
HY-N3847Eriodictyol-7-O-glucoside -
Similarity Score 0.85
HY-N2123Neoliquiritin -
Similarity Score 0.84
HY-125130Hesperetin 7-O-glucoside -
Explore the MedChemAI to find more analogs
References
- [1]. Gunaseelan S, et al. Prunin suppresses viral IRES activity and is a potential candidate for treating enterovirus A71 infection. Sci Transl Med. 2019 Oct 30;11(516). pii: eaar5759. [Content Brief]
- [2]. Jung HA, et al. Prunin is a highly potent flavonoid from Prunus davidiana stems that inhibits protein tyrosine phosphatase 1B and stimulates glucose uptake in insulin-resistant HepG2 cells. Arch Pharm Res. 2017 Jan;40(1):37-48. [Content Brief]
