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Results for "

intracellular ROS

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Reactive Oxygen Species (ROS) (164) ACSL Family (2) Acyltransferase (3) Adrenergic Receptor (5) Akt (12) Aldehyde Dehydrogenase (ALDH) (3) AMPK (3) Amyloid-β (4) Anaplastic lymphoma kinase (ALK) (1) Antibiotic (1) AP-1 (5) Apoptosis (95) Arrestin (1) Aryl Hydrocarbon Receptor (1) ATP Synthase (1) Aurora Kinase (1) Autophagy (10) Bacterial (17) Bcl-2 Family (10) Biochemical Assay Reagents (4) c-Myc (2) Calcineurin (1) Cannabinoid Receptor (2) Carbonic Anhydrase (2) Carnitine Palmitoyltransferase (CPT) (2) Caspase (20) CD47 (2) CDK (5) Cholinesterase (ChE) (8) Complement System (1) COX (2) Creatine Kinase (1) Cuproptosis (3) Cyclin G-associated Kinase (GAK) (1) Cytochrome P450 (6) Deubiquitinase (2) DNA Alkylator/Crosslinker (2) DNA/RNA Synthesis (12) Dopamine Receptor (2) Drug Metabolite (2) EGFR (3) Endogenous Metabolite (3) Environmental Pollutants (4) ERK (18) FABP (1) FAK (1) Ferroptosis (25) FLT3 (1) Fluorescent Dye (8) Fungal (7) FXR (1) GLUT (1) Glutaminase (1) Glutathione Peroxidase (15) Glutathione S-transferase (1) Glycosidase (1) HBV (1) HCV (1) HDAC (4) Heme Oxygenase (HO) (1) HIF/HIF Prolyl-Hydroxylase (1) HSP (2) IAP (1) iGluR (1) IKK (1) Insecticide (4) Insulin Receptor (1) Integrin (1) Interleukin Related (9) Isotope-Labeled Compounds (8) JAK (6) JNK (13) Keap1-Nrf2 (14) Lactate Dehydrogenase (2) LDLR (3) Lipoxygenase (1) mAChR (1) MDM-2/p53 (5) Methylenetetrahydrofolate Dehydrogenase (MTHFD) (2) Microtubule/Tubulin (6) Mitochondrial Metabolism (12) Mitophagy (1) Mixed Lineage Kinase (2) MMP (12) MOFs (1) Monoamine Oxidase (5) mTOR (7) NADPH Oxidase (1) Necroptosis (4) NF-κB (20) NO Synthase (6) NOD-like Receptor (NLR) (2) P-glycoprotein (2) P2Y Receptor (1) p38 MAPK (16) Parasite (5) PARP (5) PD-1/PD-L1 (3) PDGFR (1) PERK (2) PGC-1α (1) Phosphodiesterase (PDE) (1) Photosensitizer (1) PI3K (13) PKA (5) Potassium Channel (1) PPAR (1) PROTACs (1) Protease Activated Receptor (PAR) (1) PSMA (1) Pyroptosis (3) Reference Standards (20) RIP kinase (3) SARS-CoV (1) SHMT (1) Sirtuin (1) SOD (2) STAT (4) Tau Protein (3) TGF-beta/Smad (1) TGF-β Receptor (1) Thrombopoietin Receptor (2) Thymidylate Synthase (1) TNF Receptor (9) Toll-like Receptor (TLR) (1) Topoisomerase (4) Transferrin Receptor (1) TrxR (3) VEGFR (4) Wnt (1) Xanthine Oxidase (3) β-catenin (2)
By Research Areas:	Cancer (117) Cardiovascular Disease (15) Endocrinology (4) Infection (32) Inflammation/Immunology (55) Metabolic Disease (15) Neurological Disease (40)
Click Chemistry:	Alkynes (4)

207

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

GMP Molecules

Targets Recommended: ROS Kinase Reactive Oxygen Species (ROS)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D0940

H2DCFDA 745+ Cited Publications DCFH-DA; 2',7'-Dichlorodihydrofluorescein diacetate	Fluorescent Dye Reactive Oxygen Species (ROS)	Others
H2DCFDA (DCFH-DA) is a cell-permeable probe used to detect intracellular reactive oxygen species (ROS) (Ex/Em=488/525 nm) .

HY-B0240

Disulfiram 140+ Cited Publications Tetraethylthiuram disulfide; TETD	Aldehyde Dehydrogenase (ALDH) Interleukin Related Pyroptosis Apoptosis Cuproptosis	Metabolic Disease Cancer
Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. Disulfiram, a copper ion carrier, with Cu ²⁺ increases intracellular ROS levels and induces cuproptosis .

HY-111330

Hydroxyphenyl Fluorescein 10+ Cited Publications HPF; 3'-p-(Hydroxyphenyl) fluorescein	Fluorescent Dye Reactive Oxygen Species (ROS)	Others
Hydroxyphenyl Fluorescein (HPF) is a stable ROS fluorescent probe dye. Hydroxyphenyl Fluorescein has stronger specificity and stability than H2DCFDA (HY-D0940). Hydroxyphenyl Fluorescein can produce strong green fluorescence through hydroxyl radical reaction with intracellular peroxynitroso. Hydroxyphenyl Fluorescein can be applied for fluorescence microscopy, high-throughput imager, luciferase microplate reader or flow cytometry. Ex/Em=490/515 nm .

HY-100202

TPEN 20+ Cited Publications TPEDA	MOFs Reactive Oxygen Species (ROS) Apoptosis Autophagy	Cancer
TPEN (TPEDA) is a specific cell-permeable heavy metal chelator. TPEN has a higher affinity for Zn ²⁺, but a lower affinity for Mg ²⁺ and Ca ²⁺. TPEN induces DNA damage and increases intracellular *ROS* production. TPEN also inhibits cell proliferation and induces apoptosis .

HY-N0502

Mogroside V 5 Publications Verification	Reactive Oxygen Species (ROS)	Metabolic Disease Cancer
Mogroside V is a the major active constituent of a traditional Chinese medicine Siraitiae Fructus. Mogroside V reduces the intracellular reactive oxygen species (ROS) levels and enhances mitochondrial function. Mogroside V has anti-oxidative, anti-diabetic and anti-carcinogenic effects. Mogroside V can be used for diabetic diseases research .

HY-119977

APF 1 Publications Verification	Fluorescent Dye Reactive Oxygen Species (ROS)	Others
APF is a cell-permeable fluorogenic probe to measure hydroxyly radical of ROS. APF is nonfluorescent and produces bright green fluorescence upon reaction with hydroxyl radical. APF can be used to detect intracellular reactive oxygen species (ROS) (Ex/Em=490/525 nm) .

HY-100900

ML364 20+ Cited Publications	Deubiquitinase	Cancer
ML364 is a selective ubiquitin specific peptidase 2 (USP2) inhibitor (IC₅₀=1.1 μM) with anti-proliferative activity, which direct binds to USP2 (K_d=5.2 μM), induces an increase in cellular cyclin D1 degradation and causes cell cycle arrest. ML364 increases the levels of mitochondrial ROS and decreases in the intracellular content of ATP .

HY-N2410

N-trans-Feruloyltyramine N-feruloyltyramine; Moupinamide	Reactive Oxygen Species (ROS) Apoptosis	Inflammation/Immunology
N-trans-Feruloyltyramine (N-feruloyltyramine), an alkaloid, is a potent antioxidant. N-trans-Feruloyltyramine improves H₂O₂-induced intracellular ROS generation and decreases apoptosis. N-trans-Feruloyltyramine has the potential for oxidative stress-related neurodegenerative conditions and cancer research .

HY-121360

Cylindrospermopsin	DNA/RNA Synthesis Reactive Oxygen Species (ROS)	Cancer
Cylindrospermopsin, a cyanotoxin, is a polycyclic uracil derivative containing guanidine and sulfate groups, which can inhibit protein synthesis and covalently modify DNA or RNA. Cylindrospermopsin induces hepatocellular hypertrophy, renal cellular hypertrophy, intracellular reactive oxygen species (ROS), DNA strand breaks, mitochondrial hyperpolarisation, ultrastructural damage, and altered gene expression in liver, kidney, and intestinal cells. Cylindrospermopsin can be used in research including hepatocellular carcinoma and water quality testing .

HY-100581

CORM-3 4 Publications Verification	NF-κB NOD-like Receptor (NLR)	Inflammation/Immunology
CORM-3, a carbon monoxide-releasing molecule, attenuates NF-κB p65 nuclear translocation, reduces ROS generation and enhances intracellular glutathione and superoxide dismutase levels. CORM-3 reduces NLRP3 inflammasome activation .

HY-153006

2,7-Dichlorodihydrofluorescein 5+ Cited Publications DCFH2	Biochemical Assay Reagents	Others
2,7-Dichlorodihydrofluorescein (DCFH2) is a non-fluorescent reactive oxygen species (ROS) probe with an excitation wavelength of 485-500 nm and an emission wavelength of 515-530 nm. 2,7-Dichlorodihydrofluorescein is first hydrolyzed by intracellular esterases and then oxidized by ROS to generate non-biomembrane-permeable, highly fluorescent 2,7-dichlorofluorescein (DCF). The fluorescence intensity of DCF is positively correlated with the ROS concentration. 2,7-Dichlorodihydrofluorescein can undergo oxidation reactions with a variety of ROS (such as ·OH, H₂O₂, ONOO ^-, etc.) and is used to quantitatively detect the level of oxidative stress inside and outside cells. It is suitable for oxidative stress analysis in in vitro cell models and in vivo targeted delivery (such as liver-targeted liposomes) .

HY-N2406

Dihydrocaffeic acid 2 Publications Verification 3,4-Dihydroxy-benzenepropanoic acid	p38 MAPK Endogenous Metabolite Reactive Oxygen Species (ROS) NO Synthase	Inflammation/Immunology
Dihydrocaffeic acid is a microbial metabolite of flavonoids. Dihydrocaffeic acid scavenges intracellular *ROS* and increases nitric oxide synthase activity. Dihydrocaffeic acid reduces phosphorylation of MAPK p38 and prevent UVB-induced skin damage. Dihydrocaffeic acid has antioxidant, anti-inflammatory and anti-cartilage degradation activities .

HY-125862

Glutathione Reductase, baker's yeast EC 1.6.4.2; GR	Calcineurin Reactive Oxygen Species (ROS)	Cardiovascular Disease Neurological Disease
Glutathione reductase, baker's yeast (EC 1.6.4.2) is a reductase. Glutathione reductase, baker's yeast eliminates intracellular *ROS. Glutathione reductase, baker's yeast reduces oxidized glutathione (GSSG) to reduced glutathione (GSH) using NADPH as an electron donor. Glutathione reductase, baker's yeast exerts antioxidant activity. Glutathione reductase is mainly used to study diseases associated with oxidative stress, such as Parkinson's disease and sickle cell* anemia .

HY-149394

PRDX1-IN-1 2 Publications Verification	Apoptosis Reactive Oxygen Species (ROS)	Cancer
PRDX1-IN-1 is a selective inhibtor of PRDX1 with an IC₅₀ value of 0.164 μM. PRDX1-IN-1 can be used in researches related to cancer.PRDX1-IN-1 promots intracellular *ROS* accumulation, and inhibits the proliferation, invasion and migration of cancer cells besides inducing apoptosis. PRDX1-IN-1 could be used in cancer research .

HY-N6929

Angelic acid 1 Publications Verification	Ferroptosis Keap1-Nrf2 Reactive Oxygen Species (ROS)	Neurological Disease Cancer
Angelic acid is a ferroptosis inducer, targeting NRF2 degradation. Angelic acid binds to NRF2 protein and promotes NRF2 degradation via ubiquitination-proteasome pathway, relieves the inhibitory effect of NRF2 on oxidative stress and lipid peroxidation. Then, Angelic acid induces ferroptosis in tumor cells. Angelic acid can enhance the accumulation of intracellular reactive oxygen species (ROS), upregulate ferroptosis-related markers CHAC1 and PTGS2, and synergize with ferroptosis inducers to enhance anti-tumor effects. Angelic acid also has the activity of scavenging UVA-induced ROS in vitro, inhibiting skin fibroblast senescence and extracellular matrix degradation. Angelic Acid helps wound healing with sedative activity .

HY-B0240R

Disulfiram (Standard) Tetraethylthiuram disulfide (Standard); TETD (Standard)	Reference Standards Aldehyde Dehydrogenase (ALDH) Interleukin Related Pyroptosis Apoptosis Cuproptosis	Metabolic Disease Cancer
Disulfiram (Standard) is the analytical standard of Disulfiram. This product is intended for research and analytical applications. Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. Disulfiram + Cu ²⁺ increases intracellular ROS levels triggering apoptosis of ovarian cancer stem cells ^[1-6].

HY-D1078

5(6)-Carboxy-2',7'-dichlorofluorescein diacetate	Fluorescent Dye Reactive Oxygen Species (ROS) P-glycoprotein	Others
5 (6)-Carboxy-2',7'-dichlorofluorescein diacetate is a fluorescein-based reactive oxygen species (ROS) probe and also a MRP2 substrate. 5 (6)-Carboxy-2',7'-dichlorofluorescein diacetate serves as a substrate for intracellular esterases, which cleave its acetate groups to generate a fluorescent product capable of detecting intracellular ROS. 5 (6)-Carboxy-2',7'-dichlorofluorescein diacetate is ATP-dependent and is transported via a single MRP2 binding site; it competes with LTC₄ for MRP2 binding sites and inhibits MRP2-mediated LTC₄ transport (Ex/Em = 496/525 nm) .

HY-B0916

Propoxur	Environmental Pollutants MMP Insecticide Cholinesterase (ChE) ERK Keap1-Nrf2 Reactive Oxygen Species (ROS)	Infection Neurological Disease Cancer
Propoxur is a reversible, competitive, orally active AChE inhibitor that can cross the blood-brain barrier. Propoxur inhibits AChE activity to induce neurotoxicity, while promoting MMP-2 expression and enhancing tumor cell migration and invasion by inducing intracellular *ROS* generation and activating the ERK/Nrf2 signaling pathway. On the one hand, Propoxur inhibits AChE, leading to acetylcholine accumulation and causing neurological dysfunction; on the other hand, it promotes Nrf2 nuclear translocation through ROS-dependent ERK1/2 phosphorylation, and upregulates MMP-2 and other invasion-related proteins. Propoxur is also a carbamate insecticide used to combat turf, forestry, and household pests .

HY-16992A

W-54011 5+ Cited Publications	Complement System Reactive Oxygen Species (ROS)	Inflammation/Immunology
W-54011 is a potent and orally active non-peptide C5a receptor antagonist. W-54011 inhibits the binding of ¹²⁵I-labeled C5a to human neutrophils with a K_i value of 2.2 nM. W-54011 also inhibits C5a-induced intracellular Ca ²⁺ mobilization, chemotaxis, and generation of *ROS* in human neutrophils with IC₅₀s of 3.1 nM, 2.7 nM, and 1.6 nM, respectively .

HY-135008

J14 2 Publications Verification	Reactive Oxygen Species (ROS)	Cancer
J14 is a reversible sulfiredoxin inhibitor with an IC₅₀ of 8.1 μM. J14 induces oxidative stress (intracellular *ROS* accumulation) by inhibiting sulfiredoxin, leading to cytotoxicity and cancer cell death .

HY-N1195

Sugiol (+)-Sugiol; 10-Deoxoxanthoperol	p38 MAPK ERK JNK Interleukin Related TNF Receptor	Inflammation/Immunology
Sugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages .

HY-113978

6-Formylpterin	Xanthine Oxidase Apoptosis Reactive Oxygen Species (ROS)	Metabolic Disease
6-Formylpterin is an inhibitor of Xanthine Oxidase. 6-Formylpterin induces intracellular ROS generation and apoptosis in HL-60 cells. 6-Formylpterin suppresses cell proliferation in PanC-1 cells .

HY-DY1002

H2DCFDA (solution)	Reactive Oxygen Species (ROS) Fluorescent Dye	Others
H2DCFDA (DCFH-DA) (solution) is a cell-permeable probe used to detect intracellular *reactive oxygen species (ROS)* (Ex/Em=488/525 nm) . Solvent and concentration: DMSO: 10 mM. The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

HY-N1921

Edpetiline 2 Publications Verification	NF-κB p38 MAPK TNF Receptor Reactive Oxygen Species (ROS) COX Interleukin Related	Inflammation/Immunology
Edpetiline is an anti-inflammatory agent. Edpetiline inhibits the phosphorylation of IκB, nuclear transcription/translocation of NF-κB p65, as well as the phosphorylation of p38 MAPK and ERK MAPK. Edpetiline reduces intracellular *ROS* levels, inhibits the expression of TNF-α, IL-6, iNOS, COX-2, and promotes the expression of IL-4. Edpetiline is applicable to the research of diseases associated with inflammation and oxidative stress .

HY-P5589

Plantaricin A PlnA	Bacterial Reactive Oxygen Species (ROS)	Infection Inflammation/Immunology
Plantaricin A is an antimicrobial peptide that can be derived from Lactobacillus plantarum. Plantaricin A has a synergistic effect with Ciprofloxacin. Plantaricin A shows anti-microbial activity. Plantaricin A increases the membrane potential of S. aureus and the level of intracellular *ROS. Plantaricin A inhibits the function of the efflux pump by binding it and altering the structure of MepA, NorA, and LmrS. Plantaricin A significantly relieves inflammation, and promotes wound healing. Plantaricin A permeabilizes cancerous rat pituitary cells* ^[1][2].

HY-139369

QD394 1 Publications Verification	Reactive Oxygen Species (ROS)	Cancer
QD394 is a reactive oxygen species (ROS) inducer that can induce lipid peroxidation, increase intracellular ROS accumulation, inhibit STAT3 phosphorylation, and induce ferroptosis .

HY-178239

DX-8951 Hydroxy-acid	Drug Metabolite AMPK Reactive Oxygen Species (ROS)	Inflammation/Immunology
DX-8951 Hydroxy-acid is a prodrug of phosphoramide. ProAX can effectively increase intracellular ATP levels. DX-8951 Hydroxy-acid activates the AMPK signaling pathway by increasing the AMP/ATP ratio. DX-8951 Hydroxy-acid can enhance mitochondrial function and antioxidant capacity while reducing reactive oxygen species (ROS) levels. DX-8951 Hydroxy-acid has shown significant anti-aging and longevity effects in both human fibroblast and nematode models .

HY-N3344

Macrocarpal C	Fungal	Others
Macrocarpal C can be isolated from the 95 % ethanol extract of fresh leaves of E. globulus. Macrocarpal C inhibits the growth of T. mentagrophytes via an increase in the permeability of the fungal membrane. Macrocarpal C increases the production of intracellular *ROS* and? induces apoptosis as a consequence of DNA fragmentation .

HY-W748509

Pipernonaline	Caspase Apoptosis	Cancer
Pipernonaline is a piperine derivative with antiprostate cancer activity. Pipernonaline inhibits the proliferation of androgen-dependent/independent LNCaP/PC-3 prostate cells. Pipernonaline activates caspase-3 and promotes procaspase-3/PARP cleavage. Pipernonaline also mediates reactive oxygen species (ROS) production, increased intracellular Ca(2+), and mitochondrial membrane depolarization .

HY-W654078

Bisphenol AF-13C12 BPAF-¹³C₁₂; 4,4'-(Perfluoropropane-2,2-diyl)diphenol-¹³C₁₂	Isotope-Labeled Compounds	Others
Bisphenol AF- ¹³C₁₂ is an isotopic label of Bisphenol AF. Bisphenol AF is used in polycarbonate plastic and epoxy resin manufacturing. Bisphenol AF can significantly increase intracellular ROS levels .

HY-W724853

Dimethyl tetrasulfide 1,4-Dimethyltetrasulfane	Apoptosis Caspase Reactive Oxygen Species (ROS)	Cancer
Dimethyl tetrasulfide (1,4-Dimethyltetrasulfane) is an apoptosis inducer targeting leukemia cells. Dimethyl tetrasulfide exerts cytotoxic effects through the induction of intracellular reactive oxygen species (ROS) production and activation of caspase-3 enzyme. Dimethyl tetrasulfide is promising for research of cancers, such as leukemia .

HY-34765

Propiolamide	Glutathione Peroxidase Reactive Oxygen Species (ROS) Ferroptosis Apoptosis	Cancer
Propiolamide is a monooxygenase (MMO) system activator and glutathione peroxidase 4 (GPX4) inhibitor. Propiolamide induces *ROS* production through interaction with the MMO system. Propiolamide promotes the accumulation of intracellular cytotoxic lipid peroxides and induces ferroptosis. Propiolamide induces programmed cell death via the apoptosis pathway. Propiolamide can be used in cancer research .

HY-173403

TrxR-IN-8	TrxR Reactive Oxygen Species (ROS) Apoptosis	Cancer
TrxR-IN-8 (Compound 6f) is a selective TrxR inhibitor (IC₅₀: 10.2 μM). TrxR-IN-8 induces apoptosis through oxidative stress by stimulating the production of reactive oxygen species (ROS), reducing intracellular thiols, and lowering the glutathione/glutathione ratio. TrxR-IN-8 exhibits significant cytotoxicity against non-small cell lung cancer (NSCLC) cells .

HY-P11205A

Cys-PKHB1 TFA Cys-txCD47 TFA	CD47 Reactive Oxygen Species (ROS) Thrombopoietin Receptor	Inflammation/Immunology Cancer
Cys-PKHB1 (Cys-txCD47) TFA is a peptide conjugated to PKHB1, a CD47 agonist peptide and a thrombospondin-1 peptide mimic with antitumor effects. PKHB1 induces mitochondrial alterations, ROS generation, intracellular Ca ⁺ accumulation, and calcium-dependent cell death in breast cancer cells. PKHB1 induces immune system activation in breast cancer cells through immunogenic cell death .

HY-136778

INH2BP	PARP Reactive Oxygen Species (ROS) Bcl-2 Family Caspase ERK p38 MAPK	Cardiovascular Disease
INH2BP is a poly(ADP-ribose) polymerase (PARP) inhibitor with antioxidant and anti-apoptotic activities. INH2BP reduces the production of intracellular reactive oxygen species (ROS), modulates the expression of apoptosis-related proteins such as Bax, Bcl-2 and cleaved caspase-3 and enhances cell survival through the activation of the ERK1/2 and p38 MAPK signaling pathways. INH2BP is promising for research of cardiovascular diseases .

HY-178239A

DX-8951 Hydroxy-acid sodium	Drug Metabolite AMPK Reactive Oxygen Species (ROS)	Inflammation/Immunology
DX-8951 Hydroxy-acid sodium is a prodrug of phosphoramide. DX-8951 Hydroxy-acid sodium can effectively increase intracellular ATP levels. DX-8951 Hydroxy-acid sodium activates the AMPK signaling pathway by increasing the AMP/ATP ratio. DX-8951 Hydroxy-acid sodium can enhance mitochondrial function and antioxidant capacity while reducing reactive oxygen species (ROS) levels. DX-8951 Hydroxy-acid sodium has shown significant anti-aging and longevity effects in both human fibroblast and nematode models .

HY-152207

LWG-301	Glutaminase Apoptosis	Cancer
LWG-301 is an allosteric inhibitor of Glutaminase 1 (GLS1) with an IC₅₀ value of 7 nM. LWG-301 significantly block glutamine metabolism, increases intracellular *ROS, thus induces apoptosis*. LWG-301 exhibits moderate antitumor effects in HCT116 xenograft model .

HY-175301

TH16	Bacterial Reactive Oxygen Species (ROS)	Infection
TH16 is an antibacterial agent (MIC=2 μg/mL against methicillin-resistant Staphylococcus aureus, MRSA). TH16 disrupts bacterial cytoplasmic membrane integrity, elevating intracellular reactive oxygen species (ROS) levels to induce bacterial death. TH16 is promising for research of bacterial infection .

HY-N1214A

(E/Z)-Squalene (E/Z)-Super Squalene; (E/Z)-AddaVax	Apoptosis	Cancer
(E/Z)-Squalene ((E/Z)-Super Squalene; (E/Z)-AddaVax) is a triterpenic compound. (E/Z)-Squalene accumulates and reduces liver cholesterol and triglycerides in the liver. (E/Z)-Squalen regulates the production of intracellular active oxidants (ROS) and induces apoptosis and necrosis in a concentration-and time-dependent manner .

HY-149837

PRO-F	Fluorescent Dye	Inflammation/Immunology
PRO-F is a photoactivable H₂S donor with ROS scavenging ability. PRO-F can be activated by light to produce fluorescent signal, for real-time tracking of released H₂S. PRO-F activation doesn’t consume endogenous substances. deliver H₂S in an intracellular environment to protect cells from excessive reactive oxygen species (ROS) induced damage. PRO-F shows enhancement on chronic wound healing, researched in diabetic models as well .

HY-113978R

6-Formylpterin (Standard)	Xanthine Oxidase Apoptosis Reference Standards Reactive Oxygen Species (ROS)	Metabolic Disease
6-Formylpterin (Standard) is the analytical standard of 6-Formylpterin. This product is intended for research and analytical applications. 6-Formylpterin is an inhibitor of Xanthine Oxidase. 6-Formylpterin induces intracellular ROS generation and apoptosis in HL-60 cells. 6-Formylpterin suppresses cell proliferation in PanC-1 cells .

HY-155474

Me4Phen	Apoptosis	Cancer
Me4Phen (compound 3) is an oxygen rhenium (V) complex that depletes mitochondrial membrane potential and upregulates intracellular reactive oxygen species (ROS), leading to endoplasmic reticulum stress-mediated necrosis of cancer cells. Me4Phen is highly lipophilic and effectively overcomes Cisplatin (HY-17394) resistance in a variety of cancer cells .

HY-178370

Ferroptosis inducer-12	Ferroptosis Reactive Oxygen Species (ROS)	Cancer
Ferroptosis inducer-12 is a potent and selective ferroptosis inducer. Ferroptosis inducer-12 exhibits potent antiproliferative activity against HT1080 and OS-RC-2, with IC₅₀ values of 3 nM and 5 nM, respectively. Ferroptosis inducer-12 strongly inhibits GPX4 enzymatic activity, induces intracellular *ROS* and elevates intracellular Fe ²⁺ levels in OS-RC-2 cells. Ferroptosis inducer-12 significantly inhibits tumor growth in BALB/c nude mice bearing OS-RC-2 xenografts. Ferroptosis inducer-12 can be used for the study of cancer .

HY-N0502R

Mogroside V (Standard)	Reactive Oxygen Species (ROS) Reference Standards	Metabolic Disease Cancer
Mogroside V (Standard) is the analytical standard of Mogroside V. This product is intended for research and analytical applications. Mogroside V is a the major active constituent of a traditional Chinese medicine Siraitiae Fructus. Mogroside V reduces the intracellular reactive oxygen species (ROS) levels and enhances mitochondrial function. Mogroside V has anti-oxidative, anti-diabetic and anti-carcinogenic effects. Mogroside V can be used for diabetic diseases research .

HY-N2410R

N-trans-Feruloyltyramine (Standard) N-feruloyltyramine (Standard); Moupinamide (Standard)	Reference Standards Reactive Oxygen Species (ROS) Apoptosis	Inflammation/Immunology
N-trans-Feruloyltyramine (Standard) is the analytical standard of N-trans-Feruloyltyramine. This product is intended for research and analytical applications. N-trans-Feruloyltyramine (N-feruloyltyramine), an alkaloid, is a potent antioxidant. N-trans-Feruloyltyramine improves H2O2-induced intracellular ROS generation and decreases apoptosis. N-trans-Feruloyltyramine has the potential for oxidative stress-related neurodegenerative conditions and cancer research .

HY-170416

ROS inducer 6	Reactive Oxygen Species (ROS)	Cancer
ROS inducer 6 (compound 9) is a reactive oxygen species (ROS) inducer. ROS inducer 6 (compound 9) acts as an anticancer agent by inducing ROS generation through the depletion of intracellular glutathione .

HY-169253

ROS inducer 5	Reactive Oxygen Species (ROS) Apoptosis	Cancer
ROS inducer 5 (compound 6e) can induce intracellular *ROS* accumulation and subsequent nuclear fragmentation. ROS inducer 5 can induce apoptosis in MCF-7 cells, with an IC₅₀ value of 3.85 μM. ROS inducer 5 can be used in anticancer research .

HY-169957

ROS-ERS inducer 2	Reactive Oxygen Species (ROS)	Cancer
ROS-ERS inducer 2 (Complex 3f) triggers intracellular *ROS* generation and affect the function of mitochondria. promote the release of damage-associated molecular patterns (DAMPs), induce immunogenic cell death (ICD) and activates endoplasmic reticulum stress (ERS). ROS-ERS inducer 2 plays an important role in anti-liver cancer research .

HY-156360

Xanthine oxidase-IN-12	Xanthine Oxidase Reactive Oxygen Species (ROS)	Inflammation/Immunology
Xanthine oxidase-IN-12 (Compound 11) is a xanthine oxidase (XO) inhibitor with an IC₅₀ of 91 nM. Xanthine oxidase-IN-12 also has antioxidant activity and reduces intracellular ROS .

HY-131616

Ethyl α-eleostearate	Reactive Oxygen Species (ROS)	Inflammation/Immunology
Ethyl α-eleostearate is isolated from the ethanolic extract of Pseudo-nitzschia australis (PAEE). The PAEE of Pseudomonas australis has anti-neuroinflammatory effects, inhibiting intracellular ROS as well as pro-inflammatory mediators and cytokines .

Cat. No.	Product Name	Type

HY-D0940

H2DCFDA 745+ Cited Publications DCFH-DA; 2',7'-Dichlorodihydrofluorescein diacetate	Fluorescent Dyes
H2DCFDA (DCFH-DA) is a cell-permeable probe used to detect intracellular reactive oxygen species (ROS) (Ex/Em=488/525 nm) .

HY-111330

Hydroxyphenyl Fluorescein

10+ Cited Publications

HPF; 3'-p-(Hydroxyphenyl) fluorescein

Fluorescent Dyes

Hydroxyphenyl Fluorescein (HPF) is a stable ROS fluorescent probe dye. Hydroxyphenyl Fluorescein has stronger specificity and stability than H2DCFDA (HY-D0940). Hydroxyphenyl Fluorescein can produce strong green fluorescence through hydroxyl radical reaction with intracellular peroxynitroso. Hydroxyphenyl Fluorescein can be applied for fluorescence microscopy, high-throughput imager, luciferase microplate reader or flow cytometry. Ex/Em=490/515 nm .

HY-D1078

5(6)-Carboxy-2',7'-dichlorofluorescein diacetate

Fluorescent Dyes

5 (6)-Carboxy-2',7'-dichlorofluorescein diacetate is a fluorescein-based reactive oxygen species (ROS) probe and also a MRP2 substrate. 5 (6)-Carboxy-2',7'-dichlorofluorescein diacetate serves as a substrate for intracellular esterases, which cleave its acetate groups to generate a fluorescent product capable of detecting intracellular ROS. 5 (6)-Carboxy-2',7'-dichlorofluorescein diacetate is ATP-dependent and is transported via a single MRP2 binding site; it competes with LTC₄ for MRP2 binding sites and inhibits MRP2-mediated LTC₄ transport (Ex/Em = 496/525 nm) .

HY-DY1002

H2DCFDA (solution)	Fluorescent Dyes
H2DCFDA (DCFH-DA) (solution) is a cell-permeable probe used to detect intracellular *reactive oxygen species (ROS)* (Ex/Em=488/525 nm) . Solvent and concentration: DMSO: 10 mM. The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

HY-DY1035

Hydroxyphenyl Fluorescein (solution)

Fluorescent Dyes

Hydroxyphenyl Fluorescein (HPF) (solution) is a stable ROS fluorescent probe dye. Hydroxyphenyl Fluorescein has stronger specificity and stability than H2DCFDA (HY-D0940). Hydroxyphenyl Fluorescein can produce strong green fluorescence through hydroxyl radical reaction with intracellular peroxynitroso. Hydroxyphenyl Fluorescein can be applied for fluorescence microscopy, high-throughput imager, luciferase microplate reader or flow cytometry. Ex/Em=490/515 nm .
Solvent and concentration: DMSO: 10 mM

HY-16658BG

Z-VAD-FMK

Fluorescent Dyes

Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .

HY-D3376

6-Carboxy-H2DCFDA 6-Carboxy-2',7'-dichlorodihydrofluorescein	Fluorescent Dyes
6-Carboxy-H2DCFDA (6-Carboxy-2',7'-dichlorodihydrofluorescein) is a non-fluorescent, cell-permeable intracellular *ROS* indicator. 6-Carboxy-H2DCFDA undergoes oxidation to highly fluorescent carboxy-dichlorofluorescein (Ex/Em = 488/520 nm) .

Cat. No.	Product Name	Type

HY-W015551

trans-2-Decenal

(E)-Dec-2-enal

Biochemical Assay Reagents

trans-2-Decenal ((E)-Dec-2-enal) acts as a urease inhibitor and antibacterial agent against Helicobacter pylori, with an IC₅₀ of 9.484 μg/mL against Helicobacter pylori urease. trans-2-Decenal reduces the urease activity of Helicobacter pylori, and possesses antibacterial, bactericidal, anti-biofilm and anti-migratory activities. It alters the morphology of Helicobacter pylori, induces bacterial rupture, inhibits biofilm formation, reduces the number of mature biofilms and impairs the migratory capacity of Helicobacter pylori. trans-2-Decenal disrupts the cell wall integrity of Phytophthora capsici, damages membrane integrity and permeability, triggers intracellular reactive oxygen species (ROS) accumulation, decreases glutathione levels and disrupts the mitochondrial membrane potential of Phytophthora capsici. trans-2-Decenal is applicable to studies related to Helicobacter pylori and plant diseases induced by and Phytophthora capsici .

HY-D1078

5(6)-Carboxy-2',7'-dichlorofluorescein diacetate

Biochemical Assay Reagents

HY-16658BG

Z-VAD-FMK

Biochemical Assay Reagents

HY-W015551R

trans-2-Decenal (Standard)

(E)-Dec-2-enal (Standard)

Biochemical Assay Reagents

trans-2-Decenal ((E)-Dec-2-enal)) Standard is the analytical standard of trans-2-Decenal (HY-W015551). This product is intended for research and analytical applications. trans-2-Decenal ((E)-Dec-2-enal) acts as a urease inhibitor and antibacterial agent against Helicobacter pylori, with an IC₅₀ of 9.484 μg/mL against Helicobacter pylori urease. trans-2-Decenal reduces the urease activity of Helicobacter pylori, and possesses antibacterial, bactericidal, anti-biofilm and anti-migratory activities. It alters the morphology of Helicobacter pylori, induces bacterial rupture, inhibits biofilm formation, reduces the number of mature biofilms and impairs the migratory capacity of Helicobacter pylori. trans-2-Decenal disrupts the cell wall integrity of Phytophthora capsici, damages membrane integrity and permeability, triggers intracellular reactive oxygen species (ROS) accumulation, decreases glutathione levels and disrupts the mitochondrial membrane potential of Phytophthora capsici. trans-2-Decenal is applicable to studies related to Helicobacter pylori and plant diseases induced by and Phytophthora capsici.

Cat. No.	Product Name	Target	Research Area

HY-P5589

Plantaricin A PlnA	Bacterial Reactive Oxygen Species (ROS)	Infection Inflammation/Immunology
Plantaricin A is an antimicrobial peptide that can be derived from Lactobacillus plantarum. Plantaricin A has a synergistic effect with Ciprofloxacin. Plantaricin A shows anti-microbial activity. Plantaricin A increases the membrane potential of S. aureus and the level of intracellular *ROS. Plantaricin A inhibits the function of the efflux pump by binding it and altering the structure of MepA, NorA, and LmrS. Plantaricin A significantly relieves inflammation, and promotes wound healing. Plantaricin A permeabilizes cancerous rat pituitary cells* ^[1][2].

HY-P11205A

Cys-PKHB1 TFA Cys-txCD47 TFA	CD47 Reactive Oxygen Species (ROS) Thrombopoietin Receptor	Inflammation/Immunology Cancer
Cys-PKHB1 (Cys-txCD47) TFA is a peptide conjugated to PKHB1, a CD47 agonist peptide and a thrombospondin-1 peptide mimic with antitumor effects. PKHB1 induces mitochondrial alterations, ROS generation, intracellular Ca ⁺ accumulation, and calcium-dependent cell death in breast cancer cells. PKHB1 induces immune system activation in breast cancer cells through immunogenic cell death .

HY-P11093

Papiliocin	Antibiotic Bacterial Fungal Apoptosis Reactive Oxygen Species (ROS) TNF Receptor NO Synthase Interleukin Related NF-κB Toll-like Receptor (TLR)	Infection Inflammation/Immunology
Papiliocin is a potent peptide antibiotic with both anti-inflammatory and antibacterial activities. Papiliocin is primarily active against Gram-negative bacteria. Papiliocin exhibits strong anti-inflammatory activity against cell, exerting its anti-inflammatory activity by inhibiting the production of NO and the secretion of TNF-α and MIP-2. Papiliocin participates in the innate defense response mechanism by inhibiting the Toll-like receptor pathway and NF-κB. Papiliocin induces apoptosis in fungal cells and increases the total level of intracellular *ROS*. Papiliocin acts as an effective antiseptic peptide in sepsis models. Papiliocin is useful in anti-inflammatory and antibacterial research .

HY-P5553

cPcAMP1/26	Bacterial	Infection
cPcAMP1/26 is an antimicrobial peptide. cPcAMP1/26 effectively kills A.hydrophila and S. aureus. cPcAMP1/26 induces depolarization of the bacterial plasma membrane, and increases intracellular ROS levels .

HY-P11205

Cys-PKHB1 Cys-txCD47	CD47 Reactive Oxygen Species (ROS) Thrombopoietin Receptor	Inflammation/Immunology Cancer
Cys-PKHB1 (Cys-txCD47) is a peptide conjugated to PKHB1, a CD47 agonist peptide and a thrombospondin-1 peptide mimic with antitumor effects. PKHB1 induces mitochondrial alterations, ROS generation, intracellular Ca ⁺ accumulation, and calcium-dependent cell death in breast cancer cells. PKHB1 induces immune system activation in breast cancer cells through immunogenic cell death .

HY-175824

PSD-95/nNOS PPI-IN-1	iGluR NO Synthase Apoptosis Reactive Oxygen Species (ROS)	Neurological Disease
PSD-95/nNOS PPI-IN-1 is a inhibitor targeting the PSD-95/nNOS interaction with potential blood-brain barrier penetration. PSD-95/nNOS PPI-IN-1 binds to the PSD-95 PDZ2 domain with high affinity (K_i = 19.45 μM). PSD-95/nNOS PPI-IN-1 inhibits glutamate-induced excitotoxicity by reducing intracellular *ROS* levels and inhibiting apoptosis. PSD-95/nNOS PPI-IN-1 significantly reduces cerebral infarct volume in rat tMCAO models. PSD-95/nNOS PPI-IN-1 can be used for the study of acute ischemic stroke .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113324

NADPH Maximum Cited Publications 18 Publications Verification	Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite
NADPH is a coenzyme of glutathione reductase (GR), thioredoxin reductase (TrxR) and NADPH oxidase (NOX), and participates in redox reactions as a hydrogen donor. NADPH has the characteristic of selectively participating in the regulation of cellular redox homeostasis. NADPH exerts antioxidant activity and resists reactive oxygen species (ROS) damage by providing reducing equivalents for the regeneration of glutathione (GSH) and thioredoxin (Trx); at the same time, it acts as a substrate of NOX to generate superoxide anions, mediating oxidative stress and immune response. NADPH participates in maintaining the intracellular reducing environment, biosynthesis and regulating gene expression (such as the Nrf2 pathway), and is mainly used in the study of oxidative stress-related diseases (such as cardiovascular diseases, neurodegenerative diseases, cancer) and immune regulation mechanisms .

HY-N0502

Mogroside V 5 Publications Verification	Triterpenes Classification of Application Fields Terpenoids Cucurbitaceae Metabolic Disease Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields Sweeteners Source Classification Food Research	Reactive Oxygen Species (ROS)
Mogroside V is a the major active constituent of a traditional Chinese medicine Siraitiae Fructus. Mogroside V reduces the intracellular reactive oxygen species (ROS) levels and enhances mitochondrial function. Mogroside V has anti-oxidative, anti-diabetic and anti-carcinogenic effects. Mogroside V can be used for diabetic diseases research .

HY-N2515

Ginsenoside Rk1 5+ Cited Publications	Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Plants Inflammation/Immunology Disease Research Fields Araliaceae Source Classification	NF-κB PI3K JAK Apoptosis
Ginsenoside Rk1 is a unique component created by processing the ginseng plant (mainly Sung Ginseng, SG) at high temperatures . Ginsenoside Rk1 has anti-inflammatory effect, suppresses the activation of Jak2/Stat3 signaling pathway and NF-κB . Ginsenoside Rk1 has anti-tumor effect, antiplatelet aggregation activities, anti-insulin resistance, nephroprotective effect, antimicrobial effect, cognitive function enhancement, lipid accumulation reduction and prevents osteoporosis . Ginsenoside Rk1 induces cell apoptosis by triggering intracellular reactive oxygen species (ROS) generation and blocking PI3K/Akt pathway .

HY-N2410

N-trans-Feruloyltyramine N-feruloyltyramine; Moupinamide	Alkaloids Classification of Application Fields Other Alkaloids Phenols Polyphenols Piperaceae Plants Inflammation/Immunology Disease Research Fields Piper nigrum Linn. Source Classification	Reactive Oxygen Species (ROS) Apoptosis
N-trans-Feruloyltyramine (N-feruloyltyramine), an alkaloid, is a potent antioxidant. N-trans-Feruloyltyramine improves H₂O₂-induced intracellular ROS generation and decreases apoptosis. N-trans-Feruloyltyramine has the potential for oxidative stress-related neurodegenerative conditions and cancer research .

HY-121360

Cylindrospermopsin	Microorganisms Source Classification	DNA/RNA Synthesis Reactive Oxygen Species (ROS)
Cylindrospermopsin, a cyanotoxin, is a polycyclic uracil derivative containing guanidine and sulfate groups, which can inhibit protein synthesis and covalently modify DNA or RNA. Cylindrospermopsin induces hepatocellular hypertrophy, renal cellular hypertrophy, intracellular reactive oxygen species (ROS), DNA strand breaks, mitochondrial hyperpolarisation, ultrastructural damage, and altered gene expression in liver, kidney, and intestinal cells. Cylindrospermopsin can be used in research including hepatocellular carcinoma and water quality testing .

HY-N0316

Mollugin 2 Publications Verification	Monophenols Classification of Application Fields Terpenoids Sesquiterpenes Rubiaceae Phenols Plants Disease Research Fields Rubia cordifolia L. Source Classification Cancer	JAK NF-κB Reactive Oxygen Species (ROS) Apoptosis VEGFR c-Myc
Mollugin is an orally active and potent NF-κB inhibitor. Mollugin induces S-phase arrest of HepG2 cells, and increased intracellular reactive oxygen species (ROS) levels. Mollugin induces DNA damage in HepG2 cells, as well as an increase in the expression of p-H2AX. Mollugin shows anti-cancer effect by inhibiting TNF-α-induced NF-κB activation. Mollugin enhances the osteogenic action of BMP-2 (bone morphogenetic protein 2) via the p38-Smad signaling pathway .

HY-N2593

Isorhapontigenin 4 Publications Verification	Structural Classification Stilbenes Classification of Application Fields Gnetum cleistostachyum C. Y. Cheng Phenols Polyphenols Gnetaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	Carnitine Palmitoyltransferase (CPT) Reactive Oxygen Species (ROS) Autophagy Apoptosis NF-κB PI3K Akt MMP Keap1-Nrf2
Isorhapontigenin is an orally active dietary polyphenol. Isorhapontigenin acts as a potent antioxidant that reduces the production of reactive oxygen species (ROS). Isorhapontigenin promotes the binding of JUN to the AP-1 site on the SESN2 promoter, induces SESN2 transcription, triggers MAPK8-dependent JUN activation, and upregulates the expression of PPAR-α, PGC-1α and CPT-1A to facilitate fatty acid oxidation. Isorhapontigenin induces autophagy, apoptosis and preadipocyte differentiation; it inhibits tumor growth, cell invasion, NF-κB transcriptional activity, the PI3K/Akt signaling pathway, STAT1 phosphorylation and MMP-2 expression. Isorhapontigenin alleviates oxidative stress, inflammatory cytokine release and triglyceride accumulation; it increases intracellular ATP levels and promotes Nrf2 nuclear translocation. Isorhapontigenin improves insulin sensitivity in adipose tissue and glucose tolerance, and reduces postprandial blood glucose, insulin and free fatty acid levels. Isorhapontigenin is applicable to research on bladder cancer, liver injury, chronic obstructive pulmonary disease, acute lung injury and type 2 diabetes .

HY-133968

24-Methylenecholesterol 2 Publications Verification Ostreasterol	Microorganisms other families Animals Classification of Application Fields Anti-aging Marine natural products Other marine organisms Plants Inflammation/Immunology Disease Research Fields Steroids Source Classification	Acyltransferase Reactive Oxygen Species (ROS)
24-Methylenecholesterol (Ostreasterol) is a regulator targeting acyl-CoA cholesterol acyltransferase (ACAT) with anti-aging and neuroprotective effects. 24-Methylenecholesterol mimics the effects of nerve growth factor (NGF), can extend yeast lifespan through an anti-oxidative stress mechanism, and exhibits neuroprotective activity in PC12 cells. 24-Methylenecholesterol can reduce intracellular reactive oxygen species (ROS) and malondialdehyde (MDA) levels, activate anti-oxidative stress pathways (such as UTH1, SOD-related genes), and promote synaptic growth .

HY-N2406

Dihydrocaffeic acid 2 Publications Verification 3,4-Dihydroxy-benzenepropanoic acid	Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Phenols Polyphenols Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	p38 MAPK Endogenous Metabolite Reactive Oxygen Species (ROS) NO Synthase
Dihydrocaffeic acid is a microbial metabolite of flavonoids. Dihydrocaffeic acid scavenges intracellular *ROS* and increases nitric oxide synthase activity. Dihydrocaffeic acid reduces phosphorylation of MAPK p38 and prevent UVB-induced skin damage. Dihydrocaffeic acid has antioxidant, anti-inflammatory and anti-cartilage degradation activities .

HY-N5060

Estragole 4-Allylanisole	Structural Classification Pandanus amaryllifolius Roxb. Simple Phenylpropanols Phenylpropanoids Plants Pandanaceae Source Classification	Environmental Pollutants Parasite Apoptosis Keap1-Nrf2 NF-κB
Estragole (4-Allylanisole) is a relatively nontoxic volatile terpenoid ether and major component of the essential oil from many plants. Estragole significantly triggers Apoptosis, suppresses LPS-induced intracellular *ROS* production. Estragole activats Nrf-2 and regulates NF-κB. Estragole has anti-toxoplasma, anti-inflammatory, anti-edema, antioxidant and immunomodulatory properties. Estragole blocks DRG neuron excitability. Estragole has improves gastric ulcer activity .

HY-W015551

trans-2-Decenal (E)-Dec-2-enal	Structural Classification Natural Products Vaccinium vitis-idaea L. Ericaceae Plants Source Classification	Bacterial Reactive Oxygen Species (ROS)
trans-2-Decenal ((E)-Dec-2-enal) acts as a urease inhibitor and antibacterial agent against Helicobacter pylori, with an IC₅₀ of 9.484 μg/mL against Helicobacter pylori urease. trans-2-Decenal reduces the urease activity of Helicobacter pylori, and possesses antibacterial, bactericidal, anti-biofilm and anti-migratory activities. It alters the morphology of Helicobacter pylori, induces bacterial rupture, inhibits biofilm formation, reduces the number of mature biofilms and impairs the migratory capacity of Helicobacter pylori. trans-2-Decenal disrupts the cell wall integrity of Phytophthora capsici, damages membrane integrity and permeability, triggers intracellular reactive oxygen species (ROS) accumulation, decreases glutathione levels and disrupts the mitochondrial membrane potential of Phytophthora capsici. trans-2-Decenal is applicable to studies related to Helicobacter pylori and plant diseases induced by and Phytophthora capsici .

HY-N6929

Angelic acid 1 Publications Verification	Structural Classification Ketones, Aldehydes, Acids Umbelliferae Plants Echinacea angustifolia DC. Source Classification	Ferroptosis Keap1-Nrf2 Reactive Oxygen Species (ROS)
Angelic acid is a ferroptosis inducer, targeting NRF2 degradation. Angelic acid binds to NRF2 protein and promotes NRF2 degradation via ubiquitination-proteasome pathway, relieves the inhibitory effect of NRF2 on oxidative stress and lipid peroxidation. Then, Angelic acid induces ferroptosis in tumor cells. Angelic acid can enhance the accumulation of intracellular reactive oxygen species (ROS), upregulate ferroptosis-related markers CHAC1 and PTGS2, and synergize with ferroptosis inducers to enhance anti-tumor effects. Angelic acid also has the activity of scavenging UVA-induced ROS in vitro, inhibiting skin fibroblast senescence and extracellular matrix degradation. Angelic Acid helps wound healing with sedative activity .

HY-N2484

Methylnissolin 2 Publications Verification Astrapterocarpan	Cardiovascular Disease Structural Classification Monophenols Flavonoids Classification of Application Fields Leguminosae Phenols Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Other Flavonoids Disease Research Fields Source Classification	PDGFR ERK
Methylnissolin (Astrapterocarpan) is an osteoclast inhibitor with anti-inflammatory, neuroprotective and antioxidant activities. Methylnissolin downregulates the activation of the MAPK and PI3K/AKT pathways, inhibits the phosphorylation of MAPK1 and AKT1, and blocks PDGF-BB-induced phosphorylation of ERK1/2. Methylnissolin reduces the expression and secretion of proinflammatory mediators, decreases intracellular *ROS* levels, upregulates antioxidant enzymes, and downregulates osteoclastogenesis markers. Methylnissolin is applicable to research related to ischemic stroke, osteoporosis, cardiovascular diseases, skin aging, etc.

HY-N2445

Flavokawain C 4 Publications Verification	Structural Classification Classification of Application Fields Piperaceae Plants Chalcones Flavonoids other families Phenols Polyphenols Piper methysticum G.Forst. Disease Research Fields Source Classification Cancer	Apoptosis Akt JNK PERK Caspase PARP MDM-2/p53 IAP Reactive Oxygen Species (ROS) SOD FABP Autophagy AMPK mTOR GLUT EGFR PI3K HSP VEGFR FAK
Flavokawain C is an orally active natural chalcone. Flavokawain C inhibits the proliferation of various cancer cells. Flavokawain C upregulates GADD153 in cancer cells, inhibits the phosphorylation of Akt and JNK, suppresses early ERK phosphorylation, activates late ERK phosphorylation, activates caspase related subtypes, induces PARP-1 cleavage, causes upregulation of p21 and p27, downregulation of mutant p53 and anti-apoptotic IAP proteins, elevates intracellular *ROS* levels, reduces SOD activity, and induces apoptosis. Flavokawain C downregulates FABP4, induces autophagy in cancer cells, and activates the AMPK/mTOR pathway . Flavokawain C decreases the expression of glycolysis-related proteins GLUT1 and HK2, and inhibits glycolysis in nasopharyngeal carcinoma cells. Flavokawain C inhibits the activation of the EGFR/PI3K/Akt/mTOR signaling pathway and reduces the expression of HSP90B1. Flavokawain C inhibits angiogenesis by decreasing the expression of angiogenic proteins Ang-1 and VEGF in human umbilical vein endothelial cells. Flavokawain C increases γ-H2AX levels in cells, inhibits the phosphorylation of FAK, PI3K and AKT in cells, and induces DNA damage in cells. Flavokawain C exerts anti-tumor activity in multiple tumor xenograft mouse models. Flavokawain C is applicable to research related to colorectal cancer, colon adenocarcinoma, nephroblastoma, nasopharyngeal carcinoma and liver cancer .

HY-N1195

Sugiol (+)-Sugiol; 10-Deoxoxanthoperol	Cupressaceae Terpenoids Diterpenoids Calocedrus formosana (Florin) Florin Plants	p38 MAPK ERK JNK Interleukin Related TNF Receptor
Sugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages .

HY-N1921

Edpetiline 2 Publications Verification	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Plants Inflammation/Immunology Disease Research Fields Source Classification	NF-κB p38 MAPK TNF Receptor Reactive Oxygen Species (ROS) COX Interleukin Related
Edpetiline is an anti-inflammatory agent. Edpetiline inhibits the phosphorylation of IκB, nuclear transcription/translocation of NF-κB p65, as well as the phosphorylation of p38 MAPK and ERK MAPK. Edpetiline reduces intracellular *ROS* levels, inhibits the expression of TNF-α, IL-6, iNOS, COX-2, and promotes the expression of IL-4. Edpetiline is applicable to the research of diseases associated with inflammation and oxidative stress .

HY-N3307

(+)-Medioresinol 1 Publications Verification	Cardiovascular Disease Oleaceae Fraxinus mandshurica Rupr. Neurological Disease Classification of Application Fields Phenols Polyphenols Plants Disease Research Fields Source Classification	Bacterial Fungal Reactive Oxygen Species (ROS) Apoptosis MMP Interleukin Related PI3K Akt mTOR PPAR PGC-1α Pyroptosis
(+)-Medioresinol is a furofuran-type lignan with antifungal and antibacterial properties. (+)-Medioresinol synergizes with antibiotics to exert antimicrobial and antibiofilm effects. (+)-Medioresinol induces intracellular *ROS* accumulation and mitochondrial-mediated apoptosis in Candida albicans. (+)-Medioresinol inhibits LPS (HY-D1056)-stimulated IL-12p40 production. (+)-Medioresinol is a PGC-1α activator that protects against endothelial cell pyroptosis in ischemic stroke via the PPARα-GOT1 axis. (+)-Medioresinol can be used in research on fungal and bacterial infection, inflammation, and ischemic stroke .

HY-N0597

Panaxatriol 3 Publications Verification	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Other Diseases Plants Disease Research Fields Araliaceae Source Classification	Akt Insulin Receptor Apoptosis Reactive Oxygen Species (ROS)
Panaxatriol is an orally active dammarane-type tetracyclic triterpene sapogenin. Panaxatriol enhances the phosphorylation levels of Akt, insulin receptor and p70S6K in skeletal muscle. Panaxatriol reduces the mRNA expression level of Atrogin1 in skeletal muscle. Panaxatriol induces apoptosis, pre-G1 cell cycle arrest and increased intracellular *ROS* levels in prostate cancer cells, decreases mitochondrial membrane potential, inhibits cell migration and reduces colony formation. Panaxatriol can be used in research related to insulin resistance, myocardial ischemia/reperfusion injury and prostate cancer ^[1][2][3].

HY-N3344

Macrocarpal C	Phenols Polyphenols Myrtaceae Plants Eucalyptus globulus Labill. Source Classification	Fungal
Macrocarpal C can be isolated from the 95 % ethanol extract of fresh leaves of E. globulus. Macrocarpal C inhibits the growth of T. mentagrophytes via an increase in the permeability of the fungal membrane. Macrocarpal C increases the production of intracellular *ROS* and? induces apoptosis as a consequence of DNA fragmentation .

HY-W748509

Pipernonaline	Piper longum Linn. Alkaloids Piperidine Alkaloids Piperaceae Plants Source Classification	Caspase Apoptosis
Pipernonaline is a piperine derivative with antiprostate cancer activity. Pipernonaline inhibits the proliferation of androgen-dependent/independent LNCaP/PC-3 prostate cells. Pipernonaline activates caspase-3 and promotes procaspase-3/PARP cleavage. Pipernonaline also mediates reactive oxygen species (ROS) production, increased intracellular Ca(2+), and mitochondrial membrane depolarization .

HY-N0887

Isoastragaloside I 2 Publications Verification Isoastragaloside-I	Triterpenes Structural Classification other families Classification of Application Fields Leguminosae Terpenoids Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Metabolic Disease Plants Disease Research Fields Source Classification	Akt NF-κB p38 MAPK PI3K FXR Keap1-Nrf2 NO Synthase COX Interleukin Related Integrin TGF-β Receptor Reactive Oxygen Species (ROS)
Isoastragaloside I is a natural compound found in Astragalus membranaceus, with oral activity and multiple biological activities such as anti-inflammatory and antioxidant properties. Isoastragaloside I inhibits Akt, NF-κB, MAPKs and PI3K, enhances the activity of hepatic FXR, regulates the TGF-β/Smads signaling pathway, and upregulates antioxidant molecules downstream of Nrf2. Isoastragaloside I inhibits the expression of NO, TNF-α, iNOS, COX-2, IL-1β and VCAM-1, and reduces intracellular *ROS* levels. Isoastragaloside I attenuates blood-brain barrier disruption, restores intestinal barrier function, increases β-cell mass, improves glucose homeostasis, and elevates circulating adiponectin levels. Isoastragaloside I can be used for the study of neuroinflammation-related neurodegenerative diseases, cholestatic liver disease, and diabetes .

HY-N1214A

(E/Z)-Squalene (E/Z)-Super Squalene; (E/Z)-AddaVax	Triterpenes Structural Classification Animals Terpenoids Source Classification	Apoptosis
(E/Z)-Squalene ((E/Z)-Super Squalene; (E/Z)-AddaVax) is a triterpenic compound. (E/Z)-Squalene accumulates and reduces liver cholesterol and triglycerides in the liver. (E/Z)-Squalen regulates the production of intracellular active oxidants (ROS) and induces apoptosis and necrosis in a concentration-and time-dependent manner .

HY-N0502R

Mogroside V (Standard)	Triterpenes Structural Classification Terpenoids Cucurbitaceae Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Source Classification	Reactive Oxygen Species (ROS) Reference Standards
Mogroside V (Standard) is the analytical standard of Mogroside V. This product is intended for research and analytical applications. Mogroside V is a the major active constituent of a traditional Chinese medicine Siraitiae Fructus. Mogroside V reduces the intracellular reactive oxygen species (ROS) levels and enhances mitochondrial function. Mogroside V has anti-oxidative, anti-diabetic and anti-carcinogenic effects. Mogroside V can be used for diabetic diseases research .

HY-N2410R

N-trans-Feruloyltyramine (Standard) N-feruloyltyramine (Standard); Moupinamide (Standard)	Alkaloids Structural Classification Other Alkaloids Phenols Polyphenols Piperaceae Plants Piper nigrum Linn. Source Classification	Reference Standards Reactive Oxygen Species (ROS) Apoptosis
N-trans-Feruloyltyramine (Standard) is the analytical standard of N-trans-Feruloyltyramine. This product is intended for research and analytical applications. N-trans-Feruloyltyramine (N-feruloyltyramine), an alkaloid, is a potent antioxidant. N-trans-Feruloyltyramine improves H2O2-induced intracellular ROS generation and decreases apoptosis. N-trans-Feruloyltyramine has the potential for oxidative stress-related neurodegenerative conditions and cancer research .

HY-N6929R

Angelic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Umbelliferae Plants Echinacea angustifolia DC. Source Classification	Reference Standards Ferroptosis Keap1-Nrf2 Reactive Oxygen Species (ROS)
Angelic acid (Standard)) is the analytical standard of Angelic acid (HY-N6929). This product is intended for research and analytical applications. Angelic acid is a ferroptosis inducer, targeting NRF2 degradation. Angelic acid binds to NRF2 protein and promotes NRF2 degradation via ubiquitination-proteasome pathway, relieves the inhibitory effect of NRF2 on oxidative stress and lipid peroxidation. Then, Angelic acid induces ferroptosis in tumor cells. Angelic acid can enhance the accumulation of intracellular reactive oxygen species (ROS), upregulate ferroptosis-related markers CHAC1 and PTGS2, and synergize with ferroptosis inducers to enhance anti-tumor effects. Angelic acid also has the activity of scavenging UVA-induced ROS in vitro, inhibiting skin fibroblast senescence and extracellular matrix degradation. Angelic Acid helps wound healing with sedative activity .

HY-N3248

Momordicoside G Momordicacoside G	Triterpenes Terpenoids Cucurbitaceae Plants Source Classification Momordica charantia Linn.	Endogenous Metabolite Reactive Oxygen Species (ROS) Apoptosis
Momordicoside G (Momordicacoside G) is an orally active cucurbitane-type triterpene glycoside. Momordicoside G selectively induces apoptosis of M1-like macrophages, without affecting M2-like macrophages. Momordicoside G reduces intracellular ROS levels and promotes autophagy. Momordicoside G also has anticancer activity, inhibiting the growth of cancer cell lines. Momordicoside G stimulates M2-associated lung injury repair and prevents inflammatory lung cancer injury .

HY-N0316R

Mollugin (Standard)	Structural Classification Monophenols Terpenoids Sesquiterpenes Rubiaceae Phenols Plants Rubia cordifolia L. Source Classification	JAK Reference Standards NF-κB Reactive Oxygen Species (ROS) Apoptosis VEGFR c-Myc
Mollugin (Standard) is the analytical standard of Mollugin. This product is intended for research and analytical applications. Mollugin is an orally active and potent NF-κB inhibitor. Mollugin induces S-phase arrest of HepG2 cells, and increased intracellular reactive oxygen species (ROS) levels. Mollugin induces DNA damage in HepG2 cells, as well as an increase in the expression of p-H2AX. Mollugin shows anti-cancer effect by inhibiting TNF-α-induced NF-κB activation. Mollugin enhances the osteogenic action of BMP-2 (bone morphogenetic protein 2) via the p38-Smad signaling pathway .

HY-N2199

Sotetsuflavone	Structural Classification Flavonoids Classification of Application Fields Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Disease Research Fields Source Classification Cancer	Apoptosis Autophagy PI3K JNK mTOR p38 MAPK CDK MMP TGF-beta/Smad STAT β-catenin Reactive Oxygen Species (ROS) Bcl-2 Family Caspase
Sotetsuflavone is a flavonoid that can be isolated from Cycas revolute. Sotetsuflavone inhibits phosphorylation of PI3K, Akt, mTOR, JNK, and p38 MAPK; modulates expression of Cyclin D1, CDK4, Bcl-2, Bax, cleaved caspases 3/9, MMP-9, TGF-β, STAT3, and β-catenin. Sotetsuflavone induces G₀/G₁ cell cycle arrest, apoptosis, autophagy, and intracellular *ROS* elevation, inhibits cancer cell proliferation. Sotetsuflavone inhibits tumor growth in mouse tumor xenograft models. Sotetsuflavone can be used for the research of non-small cell lung cancer and Crohn’s disease .

HY-131616

Ethyl α-eleostearate	Natural Products other families Padina australis Plants Source Classification	Reactive Oxygen Species (ROS)
Ethyl α-eleostearate is isolated from the ethanolic extract of Pseudo-nitzschia australis (PAEE). The PAEE of Pseudomonas australis has anti-neuroinflammatory effects, inhibiting intracellular ROS as well as pro-inflammatory mediators and cytokines .

HY-N11887

Linocinnamarin	Natural Products Rosaceae Plants Source Classification Fragaria × ananassa Duch.	Reactive Oxygen Species (ROS)
Linocinnamarin is a nature product that could be isolated from Fragaria ananassa Duch. Linocinnamarin has anti-inflammatory activity. Linocinnamarin inhibits antigen-stimulated elevation of intracellular free Ca ²⁺ concentration and reactive oxygen species (ROS) .

HY-N2852

α-Terthienylmethanol	Natural Products Alysicarpus ovalifolius (Schumacher) J. Leonard Plants Compositae Source Classification	Reactive Oxygen Species (ROS)
α-Terthienylmethanol is a terthiophene isolated from the n-hexane fraction of E. prostrata. α-Terthienylmethanol has potent cytotoxic activity against human endometrial cancer cells (Hec1A and Ishikawa) (IC₅₀ < 1 μM). α-Terthienylmethanol increases the intracellular level of *ROS* and decreases that of GSH .

HY-N0025

Jionoside D	Phenols Polyphenols Scrophulariaceae Plants Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey Source Classification	Reactive Oxygen Species (ROS) Apoptosis
Jionoside D is a hydroxycinnamic acid ester with antioxidant property. Jionoside D has scavenging activity of intracellular reactive oxygen species (ROS) and of DPPH radical, and lipid peroxidation inhibitory activity. Jionoside D reduces the apoptotic cells induced by H₂O₂ in V79-4 cells. Jionoside D increases the activities of cellular antioxidant enzymes, SOD and catalase .

HY-N11648

Ganoderic acid T1	Triterpenes Microorganisms Terpenoids Source Classification	Apoptosis Caspase
Ganoderic acid T1 is a deacetylated derivative of Ganoderic acid T. Ganoderic acid T1 attenuates antioxidant defense system and induces apoptosis of cancer cells. Ganoderic acid T1 decreases mitochondrial membrane potential and activates caspase-9 and caspase-3, to trigger apoptosis. Ganoderic acid T1 also increases the generation of intracellular ROS to produce pro-oxidant activities and cytotoxicity .

HY-N0597R

Panaxatriol (Standard)	Panax ginseng C. A. Meyer Triterpenes Structural Classification Terpenoids Plants Araliaceae Source Classification	Reference Standards Others
Panaxatriol (Standard) is the analytical standard of Panaxatriol. This product is intended for research and analytical applications. Panaxatriol is an orally active dammarane-type tetracyclic triterpene sapogenin. Panaxatriol enhances the phosphorylation levels of Akt, insulin receptor and p70S6K in skeletal muscle. Panaxatriol reduces the mRNA expression level of Atrogin1 in skeletal muscle. Panaxatriol induces apoptosis, pre-G1 cell cycle arrest and increased intracellular *ROS* levels in prostate cancer cells, decreases mitochondrial membrane potential, inhibits cell migration and reduces colony formation. Panaxatriol can be used in research related to insulin resistance, myocardial ischemia/reperfusion injury and prostate cancer .

HY-133968R

24-Methylenecholesterol (Standard) Ostreasterol (Standard)	Structural Classification Microorganisms other families Animals Marine natural products Other marine organisms Plants Steroids Source Classification	Reference Standards Acyltransferase Reactive Oxygen Species (ROS)
24-Methylenecholesterol (Ostreasterol) (Standard) is the analytical standard of 24-Methylenecholesterol (HY-133968). This product is intended for research and analytical applications. 24-Methylenecholesterol (Ostreasterol) is a regulator targeting acyl-CoA cholesterol acyltransferase (ACAT) with anti-aging and neuroprotective effects. 24-Methylenecholesterol mimics the effects of nerve growth factor (NGF), can extend yeast lifespan through an anti-oxidative stress mechanism, and exhibits neuroprotective activity in PC12 cells. 24-Methylenecholesterol can reduce intracellular reactive oxygen species (ROS) and malondialdehyde (MDA) levels, activate anti-oxidative stress pathways (such as UTH1, SOD-related genes), and promote synaptic growth .

HY-N2515R

Ginsenoside Rk1 (Standard)	Panax ginseng C. A. Meyer Triterpenes Structural Classification Terpenoids Plants Araliaceae Source Classification	Reference Standards NF-κB PI3K JAK Apoptosis
Ginsenoside Rk1 (Standard) is the analytical standard of Ginsenoside Rk1. This product is intended for research and analytical applications. Ginsenoside Rk1 is a unique component created by processing the ginseng plant (mainly Sung Ginseng, SG) at high temperatures . Ginsenoside Rk1 has anti-inflammatory effect, suppresses the activation of Jak2/Stat3 signaling pathway and NF-κB . Ginsenoside Rk1 has anti-tumor effect, antiplatelet aggregation activities, anti-insulin resistance, nephroprotective effect, antimicrobial effect, cognitive function enhancement, lipid accumulation reduction and prevents osteoporosis . Ginsenoside Rk1 induces cell apoptosis by triggering intracellular reactive oxygen species (ROS) generation and blocking PI3K/Akt pathway .

HY-W015551R

trans-2-Decenal (Standard) (E)-Dec-2-enal (Standard)	Structural Classification Natural Products Vaccinium vitis-idaea L. Ericaceae Plants Source Classification	Biochemical Assay Reagents Reference Standards
trans-2-Decenal ((E)-Dec-2-enal)) Standard is the analytical standard of trans-2-Decenal (HY-W015551). This product is intended for research and analytical applications. trans-2-Decenal ((E)-Dec-2-enal) acts as a urease inhibitor and antibacterial agent against Helicobacter pylori, with an IC₅₀ of 9.484 μg/mL against Helicobacter pylori urease. trans-2-Decenal reduces the urease activity of Helicobacter pylori, and possesses antibacterial, bactericidal, anti-biofilm and anti-migratory activities. It alters the morphology of Helicobacter pylori, induces bacterial rupture, inhibits biofilm formation, reduces the number of mature biofilms and impairs the migratory capacity of Helicobacter pylori. trans-2-Decenal disrupts the cell wall integrity of Phytophthora capsici, damages membrane integrity and permeability, triggers intracellular reactive oxygen species (ROS) accumulation, decreases glutathione levels and disrupts the mitochondrial membrane potential of Phytophthora capsici. trans-2-Decenal is applicable to studies related to Helicobacter pylori and plant diseases induced by and Phytophthora capsici.

HY-N2593R

Isorhapontigenin (Standard)	Structural Classification Stilbenes Gnetum cleistostachyum C. Y. Cheng Phenols Polyphenols Gnetaceae Plants Source Classification	Reference Standards Carnitine Palmitoyltransferase (CPT) Reactive Oxygen Species (ROS) Autophagy Apoptosis NF-κB PI3K Akt MMP Keap1-Nrf2
Isorhapontigenin (Standard) is the analytical standard of Isorhapontigenin (HY-N2593). This product is intended for research and analytical applications. Isorhapontigenin is an orally active dietary polyphenol. Isorhapontigenin acts as a potent antioxidant that reduces the production of reactive oxygen species (ROS). Isorhapontigenin promotes the binding of JUN to the AP-1 site on the SESN2 promoter, induces SESN2 transcription, triggers MAPK8-dependent JUN activation, and upregulates the expression of PPAR-α, PGC-1α and CPT-1A to facilitate fatty acid oxidation. Isorhapontigenin induces autophagy, apoptosis and preadipocyte differentiation; it inhibits tumor growth, cell invasion, NF-κB transcriptional activity, the PI3K/Akt signaling pathway, STAT1 phosphorylation and MMP-2 expression. Isorhapontigenin alleviates oxidative stress, inflammatory cytokine release and triglyceride accumulation; it increases intracellular ATP levels and promotes Nrf2 nuclear translocation. Isorhapontigenin improves insulin sensitivity in adipose tissue and glucose tolerance, and reduces postprandial blood glucose, insulin and free fatty acid levels. Isorhapontigenin is applicable to research on bladder cancer, liver injury, chronic obstructive pulmonary disease, acute lung injury and type 2 diabetes.

HY-N19830

Guavenoic acid	Triterpenes Structural Classification Terpenoids Psidium guajava Linn. Myrtaceae Plants Source Classification	Reactive Oxygen Species (ROS) Apoptosis
Guavenoic acid is a triterpenoid compound that can be isolated from fresh leaves of Psidium guajava. Guavenoic acid protects cells in cellular oxidative damage models, inhibits intracellular *ROS* production, and suppresses cell apoptosis. Guavenoic acid significantly enhances cellular proliferation, promotes insulin synthesis and secretion, and upregulates the messenger RNA expression of insulin gene, PDX-1 and MafA. Guavenoic acid can be used in the research of diseases such as pancreatic islet β-cell tumors .

HY-N19463

Dicatenarin	Quinones Structural Classification Microorganisms Anthraquinones Source Classification	Caspase Reactive Oxygen Species (ROS) Apoptosis
Dicatenarin is a caspase‑3 activator with growth‑inhibitory activity against human cancer cells. Dicatenarin increases caspase‑3 activity, induces intracellular *ROS* generation, and activates the mitochondrial‑mediated apoptotic pathway. Dicatenarin exerts growth‑inhibitory effects against a panel of human cancer cell lines. Dicatenarin can be used in research on pancreatic cancer, lung cancer, colon cancer, breast cancer, prostate cancer, and ovarian cancer .

HY-N17855

Guavinoside B	Structural Classification Psidium guajava Linn. Phenols Polyphenols Myrtaceae Plants Source Classification	Glycosidase Reactive Oxygen Species (ROS)
Guavinoside B is an orally active α-glucosidase inhibitor with an IC₅₀ of 0.21 mM. Guavinoside B upregulates the expressions of Nrf2, GCLC and NQO1 induced by Acetaminophen (HY-66005), downregulates the expression of p-JNK, and reduces intracellular *ROS* levels. Guavinoside B decreases serum TNF-α levels induced by Acetaminophen, alleviates hepatocellular infiltration and necrosis, and improves liver-related biochemical parameters. Guavinoside B is applicable to the research of diabetes and Acetaminophen-induced liver injury .

Cat. No.	Product Name	Chemical Structure

HY-N5060S

Estragole-d4

Estragole-d₄ is deuterated labeled Estragole (HY-N5060). Estragole (4-Allylanisole) is a relatively nontoxic volatile terpenoid ether and major component of the essential oil from many plants. Estragole significantly triggers Apoptosis, suppresses LPS-induced intracellular ROS production. Estragole activats Nrf-2 and regulates NF-κB. Estragole has anti-toxoplasma, anti-inflammatory, anti-edema, antioxidant and immunomodulatory properties. Estragole blocks DRG neuron excitability. Estragole has improves gastric ulcer activity [10] .

HY-W015600S

2-Acetamidophenol-d3

2-Acetamidophenol-d₃ (Orthocetamol-d₃) is the deuterium labeled 2-Acetamidophenol (HY-W015600). 2-Acetamidophenol (Orthocetamol) is a regulator that targets ferroptosis and glutathione metabolic pathways, is the ortho-regioisomer of Paracetamol (HY-66005). 2-Acetamidophenol has anti-atherosclerotic activity, and inhibiting total cholesterol (TC) and triglyceride (TG) in a zebrafish hyperlipidemia model with IC50s for 30 μM and 40 μM, respectively. 2-Acetamidophenol upregulates the expression of glutathione synthesis-related genes (such as GCLC, GCLM, GSS) and iron ion transport genes (such as FPN1, FTH), reduces the accumulation of intracellular reactive oxygen species (ROS) and ferrous ions (Fe2+), and enhances the activity of glutathione peroxidase GPX4, thereby inhibiting macrophage phagocytosis of oxidized low-density lipoprotein (ox-LDL) and foam cell formation .

HY-W654078

Bisphenol AF-13C12
Bisphenol AF- ¹³C₁₂ is an isotopic label of Bisphenol AF. Bisphenol AF is used in polycarbonate plastic and epoxy resin manufacturing. Bisphenol AF can significantly increase intracellular ROS levels .

HY-B0916S

Propoxur-d3

Propoxur-d₃ is the deuterated form of Propoxur (HY-B0916). Propoxur is a reversible, competitive, orally active AChE inhibitor that can cross the blood-brain barrier. Propoxur inhibits AChE activity to induce neurotoxicity, while promoting MMP-2 expression and enhancing tumor cell migration and invasion by inducing intracellular ROS generation and activating the ERK/Nrf2 signaling pathway. On the one hand, Propoxur inhibits AChE, leading to acetylcholine accumulation and causing neurological dysfunction; on the other hand, it promotes Nrf2 nuclear translocation through ROS-dependent ERK1/2 phosphorylation, and upregulates MMP-2 and other invasion-related proteins. Propoxur is also a carbamate insecticide used to combat turf, forestry, and household pests .

HY-B1272AS

Desipramine-d4

Desipramine-d₄ is the deuterium labeled Desipramine (HY-B1272A). Desipramine is a first-generation tricyclic antidepressant. Desipramine selectively binds to norepinephrine transporter and blocks neuronal norepinephrine reuptake. Desipramine activates MAPK signaling via ERK1/2, JNK, and p38, represses NF-κB and AP-1 activity, and induces apoptosis via ROS elevation, mitochondrial membrane potential reduction, and intracellular calcium increase. Desipramine also shows anyi-inflammatory activity, inhibiting TNF-α production. Desipramine can be used for the research of hepatocellular cancer, inflammation, and neurological diseases .

HY-B1272AS1

Desipramine-d3

Desipramine-d₃ is the deuterium labeled Desipramine (HY-B1272A). Desipramine is a first-generation tricyclic antidepressant. Desipramine selectively binds to norepinephrine transporter and blocks neuronal norepinephrine reuptake. Desipramine activates MAPK signaling via ERK1/2, JNK, and p38, represses NF-κB and AP-1 activity, and induces apoptosis via ROS elevation, mitochondrial membrane potential reduction, and intracellular calcium increase. Desipramine also shows anyi-inflammatory activity, inhibiting TNF-α production. Desipramine can be used for the research of hepatocellular cancer, inflammation, and neurological diseases .

HY-133968S1

24-Methylenecholesterol-13C

24-Methylenecholesterol- ¹³C (Ostreasterol- ¹³C) is the ¹³C labeled 24-Methylenecholesterol (HY-133968) . 24-Methylenecholesterol (Ostreasterol) is a regulator targeting acyl-CoA cholesterol acyltransferase (ACAT) with anti-aging and neuroprotective effects. 24-Methylenecholesterol mimics the effects of nerve growth factor (NGF), can extend yeast lifespan through an anti-oxidative stress mechanism, and exhibits neuroprotective activity in PC12 cells. 24-Methylenecholesterol can reduce intracellular reactive oxygen species (ROS) and malondialdehyde (MDA) levels, activate anti-oxidative stress pathways (such as UTH1, SOD-related genes), and promote synaptic growth .

HY-W015551S

trans-2-Decenal-d2

trans-2-Decenal-d₂ ((E)-Dec-2-enal-d₂) is deuterated labeled trans-2-Decenal (HY-W015551). trans-2-Decenal ((E)-Dec-2-enal) acts as a urease inhibitor and antibacterial agent against Helicobacter pylori, with an IC₅₀ of 9.484 μg/mL against Helicobacter pylori urease. trans-2-Decenal reduces the urease activity of Helicobacter pylori, and possesses antibacterial, bactericidal, anti-biofilm and anti-migratory activities. It alters the morphology of Helicobacter pylori, induces bacterial rupture, inhibits biofilm formation, reduces the number of mature biofilms and impairs the migratory capacity of Helicobacter pylori. trans-2-Decenal disrupts the cell wall integrity of Phytophthora capsici, damages membrane integrity and permeability, triggers intracellular reactive oxygen species (ROS) accumulation, decreases glutathione levels and disrupts the mitochondrial membrane potential of Phytophthora capsici. trans-2-Decenal is applicable to studies related to Helicobacter pylori and plant diseases induced by and Phytophthora capsici .

HY-W750153

Propoxur-d7

Propoxur-d₇ is the deuterium labeled Propoxur. Propoxur is a reversible, competitive, orally active AChE inhibitor that can cross the blood-brain barrier. Propoxur inhibits AChE activity to induce neurotoxicity, while promoting MMP-2 expression and enhancing tumor cell migration and invasion by inducing intracellular ROS generation and activating the ERK/Nrf2 signaling pathway. On the one hand, Propoxur inhibits AChE, leading to acetylcholine accumulation and causing neurological dysfunction; on the other hand, it promotes Nrf2 nuclear translocation through ROS-dependent ERK1/2 phosphorylation, and upregulates MMP-2 and other invasion-related proteins. Propoxur is also a carbamate insecticide used to combat turf, forestry, and household pests .

Cat. No.	Product Name		Classification

HY-178370

Ferroptosis inducer-12		Alkynes
Ferroptosis inducer-12 is a potent and selective ferroptosis inducer. Ferroptosis inducer-12 exhibits potent antiproliferative activity against HT1080 and OS-RC-2, with IC₅₀ values of 3 nM and 5 nM, respectively. Ferroptosis inducer-12 strongly inhibits GPX4 enzymatic activity, induces intracellular *ROS* and elevates intracellular Fe ²⁺ levels in OS-RC-2 cells. Ferroptosis inducer-12 significantly inhibits tumor growth in BALB/c nude mice bearing OS-RC-2 xenografts. Ferroptosis inducer-12 can be used for the study of cancer .

HY-175852

Ferroptosis inducer-11		Alkynes
Ferroptosis inducer-11 is a ferroptosis inducer. Ferroptosis inducer-11 exhibits potent cytotoxicity against HCT-116, NCM-60 and HT-29 cells with IC₅₀ values of 0.43 μM, 3.14 μM and 0.48 μM, respectively. Ferroptosis inducer-11 strongly suppresses GPX4 enzymatic activity with an IC₅₀ of 1.86 μM. Ferroptosis inducer-11 induces ferroptosis, as well as increases intracellular lipid *ROS, malondialdehyde (MDA), and Fe ²⁺* levels, while decreasing glutathione (GSH) levels in colon cancer cells. Ferroptosis inducer-11 can be used for the study of colon cancer .

HY-180114

NSS-18		Alkynes
NSS-18 is a potent and reversible inhibitor of AChE and MAO-B, with IC₅₀ values of 1.53 and 1.51 μM respectively. NSS-18 can inhibit the self-aggregation of Aβ. NSS-18 inhibits the intracellular generation of *ROS* induced by Aβ. NSS-18 shows a moderate neuroprotective effect against 6-OHDA (HY-B1081)-induced neurotoxicity. NSS-18 can form chelates with metal ions such as Cu²⁺, Fe³⁺, and Zn²⁺, with the strongest chelation being with Cu²⁺. NSS-18 can be used for the study of Alzheimer's disease .

HY-183853

Arecaidine-propargyl ester		Alkynes
Arecaidine-propargyl ester is a selective M2 muscarinic receptor agonist with blood-brain barrier permeability, with a pK_i of 5.91 for hm1, 7.06 for hm2, 6.07 for hm3, 6.01 for hm4, and 6.03 for hm5. Arecaidine-propargyl ester stimulates central and peripheral muscarinic receptors. Arecaidine-propargyl ester increases intracellular *ROS, induces DNA* damage and Apoptosis, and upregulates the expression of MnSOD and SIRT1. Arecaidine-propargyl ester reduces sympathetic nerve outflow, induces dose-dependent hypotension, and triggers negative chronotropic effects at high peripheral doses. Arecaidine-propargyl ester can be used in research related to Alzheimer's disease and glioblastoma .

Targets Recommended: ROS Kinase Reactive Oxygen Species (ROS)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0764G

Bucladesine sodium Dibutyryl cAMP sodium; DBcAMP sodium	PKA Reactive Oxygen Species (ROS) Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Bucladesine (Dibutyryl cAMP; DBcAMP) sodium (GMP) is a Bucladesine sodium (HY-B0764) produced by using GMP guidelines. Bucladesine (Dibutyryl cAMP; DBcAMP) is a membrane-permeable 3′, 5′-cyclic adenosine monophosphate (cAMP) analog. Bucladesine selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine significantly attenuates MDMA-induced increases in hippocampal mitochondrial *ROS* formation, mitochondrial outer membrane damage, cytochrome c release, and hippocampal ADP/ATP ratio, thereby improving spatial learning and memory impairments. Bucladesine exhibit anti-nociceptive and anti-inflammation effect. Bucladesine can inhibit cancer cells proliferation, induce apoptosis. Bucladesine can be used for the researches of neurological disease, cancer, inflammation .

HY-16658BG

Z-VAD-FMK	Caspase Apoptosis	Cancer
Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .

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