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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
kat6a inhibitor
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "kat6a inhibitor" in MCE Product Catalog:
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15 Publications Verification
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WM-1119, a chemical probe, is a highly potent and selective KAT6A inhibitor, with an IC50 of 0.25 μM for KAT6A in lymphoma cells, the binding KD values of WM-1119 with KAT6A, KAT5 and KAT7 are 2 nM, 2.2 μM, 0.5 μM , respectively .
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PF-9363 (CTx-648) is a first-in-class potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer .
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CTX-0124143 is a KAT6A inhibitor with a sulfonyl hydrazine skeleton .
Synonyms: PF-07248144
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Prifetrastat (PF-07248144), a first-in-class, selective, and orally active KAT6A and KAT6AB inhibitor. Prifetrastat can be used for the study of ER+/HER2− breast cancer .
Cat. No.: HY-177046
CAS No.: 3092067-21-2
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KAT6A/KAT7-IN-4 is a KAT6A and KAT7 inhibitor. KAT6A/KAT7-IN-4 has IC50 values of both ≤ 1 nM for KAT6A and KAT7. KAT6A/KAT7-IN-4 can inhibit the acetylation of H3K14 and H3K23. KAT6A/KAT7-IN-4 also inhibits tumor cell proliferation, with an IC50 of ≤ 100 nM for CAMA-1. KAT6A/KAT7-IN-4 can be used in the study of breast cancer .
Cat. No.: HY-177045
CAS No.: 3092066-83-3
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KAT6A/KAT7-IN-3 is a KAT6A and KAT7 inhibitor. KAT6A/KAT7-IN-3 can inhibit the acetylation of H3K14 and H3K23. KAT6A/KAT7-IN-3 also inhibits tumor cell proliferation and can be used in the study of cancer .
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MOZ-IN-3 is an orally active KAT6A (MOZ) inhibitor with an IC50 of 0.03 μM against human targets, and it exhibits high selectivity over other MYST family histone acetyltransferases. MOZ-IN-3 modulates monocyte function, exerts anti-tumor effects, increases the nucleocytoplasmic ratio, and enhances cellular resistance to chemotherapeutic drug-induced cell death. MOZ-IN-3 is applicable to leukemia-related research .
Cat. No.: HY-159957
CAS No.: 2520347-03-7
BAY-184 is a selective and orally active KAT6A and KAT6B inhibitor. BAY-184 inhibits KAT6A/KAT6B activity with an IC50 of 71 nM and 83 nM. respectively BAY-184 inhibits ERα transcriptional activity. BAY-184 inhibits proliferation of diverse breast cancer subtypes, and inhibits tumor growth .
Cat. No.: HY-177044
CAS No.: 3092066-69-5
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KAT6A/KAT7-IN-2 is a KAT6A and KAT7 inhibitor. KAT6A/KAT7-IN-2 has IC50 values of both ≤ 1 nM for KAT6A and KAT7. KAT6A/KAT7-IN-2 can inhibit the acetylation of H3K14 and H3K23. KAT6A/KAT7-IN-2 also inhibits tumor cell proliferation. KAT6A/KAT7-IN-2 can be used in the study of cancer .
Cat. No.: HY-177043
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KAT6A/KAT7-IN-1 is a KAT6A and KAT7 inhibitor with IC50 for KAT6A of within the range of 1-10 nM, and for KAT7 of ≤ 1 nM. KAT6A/KAT7-IN-1 can inhibit the acetylation of H3K14 and H3K23. KAT6A/KAT7-IN-1 can be used in the research of breast adenocarcinoma .
Cat. No.: HY-162994
CAS No.: 2991087-72-8
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KAT6A-IN-1 is a KAT6A inhibitor with an IC50 of <10 μM. KAT6A-IN-1 can be used for the research of cancer .
Cat. No.: HY-162995
CAS No.: 2991087-74-0
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KAT6A-IN-2 (compund 7) is a KAT6A inhibitor .
Cat. No.: HY-187466
CAS No.: 3068205-08-0
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KAT6A/B-IN-1 is a KAT6A/KAT6B inhibitor (IC50 = 3.2 nM and 25.2 nM) that inhibits lysine acetyltransferase activity. KAT6A/B-IN-1 inhibits cancer cell proliferation and tumor growth in xenograft models. KAT6A/B-IN-1 exhibits chemical and physical stability, low hygroscopicity, and reduced sensitivity to heat, humidity, and light. KAT6A/B-IN-1 is used in the study of breast cancer .
Cat. No.: HY-102058R
CAS No.: 2055397-28-7
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WM-1119 (Standard) is the analytical standard of WM-1119 (HY-102058). This product is intended for research and analytical applications. WM-1119, a chemical probe, is a highly potent and selective KAT6A inhibitor, with an IC50 of 0.25 μM for KAT6A in lymphoma cells, the binding Kd values of WM-1119 with KAT6A, KAT5 and KAT7 are 2 nM, 2.2 μM, 0.5 μM , respectively .
Cat. No.: HY-182468
CAS No.: 3056105-63-3
Synonyms: OP-3136
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Omvitrastat (OP-3136) is an orally active, highly selective inhibitor of KAT6A and KAT6B. Omvitrastat inhibits the proliferation of prostate cancer, ovarian cancer and non-small cell lung cancer cells that express or overexpress KAT6A. Omvitrastat reduces the proliferative capacity of cancer cells and suppresses cell growth in ER + breast cancer cell models with KAT6 overexpression. Omvitrastat induces tumor regression and inhibits tumor growth in an ovarian cancer xenograft model in immunodeficient mice. Omvitrastat inhibits tumor growth in a non-small cell lung cancer xenograft model in immunodeficient mice. Omvitrastat can be used in research related to HR +/HER 2- breast cancer, prostate cancer, ovarian cancer and non-small cell lung cancer (NSCLC) .
Cat. No.: HY-183256
CAS No.: 2767642-46-4
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BAY-7728 is an orally active and selective dual inhibitor of KAT6A (IC50: 45 nM)/KAT6B (IC50: 95 nM). BAY-7728 can effectively inhibit tumor growth and regulate the acetylation level of histone H3K23. BAY-7728 can be used for tumor research.
Cat. No.: HY-187357
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PROTAC KAT6 Degrader-2 is a KAT6A PROTAC degrader. PROTAC KAT6 Degrader-2 induces ubiquitination and proteasomal degradation of KAT6A. PROTAC KAT6 Degrader-2 exhibits high maximum fold activity in ternary complex formation assays. PROTAC KAT6 Degrader-2 can be used in studies related to breast cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
