1 Result for "

lncRNA H19

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "lncRNA H19" in MCE Product Catalog:

11β,13-Dihydrolactucopicrin
11β,13-Dihydrolactucopicrin
0 Images
Cat. No.: HY-N9932
CAS No.: 125519-47-3
Category:  

Terpenoids Sesquiterpenes Plants Compositae Extract Sophora tomentosa L.

Target:  

Glycosidase Interleukin Related TNF Receptor BCRP

11β,13-Dihydrolactucopicrin is a sesquiterpene lactone and the main bitter component of chicory root. 11β,13-Dihydrolactucopicrin inhibits yeast α-glucosidase activity (IC50 = 27.49 μM) and inhibits Crz1 activation and nuclear accumulation. 1β,13-Dihydrolactucopicrin possesses blood-brain barrier penetration capacity in an in vitro HBMEC blood-brain barrier model and can generate cysteine-conjugated metabolites within brain microvascular endothelial cells. 11β,13-Dihydrolactucopicrin can regulate the lncRNA H19/miR-21-3p signaling axis; it upregulates the expression of ABCG2 and lncRNA H19, downregulates miR-21-3p, inhibits the release of IL-6, TNF-α, and hs-CRP pro-inflammatory mediators, and alleviates urate-induced inflammatory injury in renal epithelial cells. 11β,13-Dihydrolactucopicrin can be used in research on diabetes and renal urate deposition .
loading...
    loading...
View All Sizes
Assay Types